B 477019 1 13% | 1837 ARTES LIBRARY VERITAS SCIENTIA OF THE { UNIVERSITY OF MICHIGAN QUAERIS PENINSULAM AMOENAML - CIRCUMSPICE HOMOEOPATHIC LIBRARY 225 H618 I I 416 ① THE MEDICAL, SURGICAL, AND HYGIENIC TREATMENT OF DISEASES OF WOMEN, ESPECIALLY THOSE CAUSING STERILITY, THE DISORDERS AND ACCIDENTS OF PREGNANCY, AND PAINFUL AND DIFFICULT LABOR. い ​BY EDWIN MHALE, M.D., PROFESSOR OF MATERIA MEDICA AND THERAPEUTICS IN THE CHICAGO HOMEOPATHIC COLLEGE; AUTHOR OF THE "MATERIA MEDICA, SYMPTOMATOLOGY AND THERAPEUTICS OF NEW REMEDIES;" OF “LECTURES ON DISEASES OF THE HEART;" MEMBER OF THE AMERICAN INSTI- TUTE OF HOMEOPATHY; OF THE WESTERN ACADEMY OF HOMEOPATHY; HONORARY MEMBER OF THE HOMEOPATHIC STATE MEDICAL SOCIETIES OF ILLINOIS, INDIANA, MICHIGAN, NEW YORK, MASSACHUSETTS, IOWA, WISCONSIN, AND OF THE HOMEOPATHIC MEDICAL SOCIETY OF THE UNITED STATES OF COLOMBIA, SOUTH AMERICA; CORRESPONDING MEMBER OF THE MASSACHUSETTS SURGICAL AND GYNECOLOGICAL SOCIETY, ETC., ETC. BOERICKE & TAFEL : NEW YORK AND PHILADELPHIA. 1878. Entered according to Act of Congress, in the year 1878, BY BOERICKE & TAFEL, In the Office of the Librarian of Congress, at Washington, D C. SHERMAN & CO., PRINTERS, S. W. CORNER SEVENTH AND CHERRY STREETS, PHILADELPHIA. f hom Нас ! то SAMUEL LILIENTHAL, M.D., PROFESSOR OF CLINICAL AND PSYCHOLOGICAL MEDICINE IN THE NEW YORK HOMEOPATHIC MEDICAL COLLEGE, IN TOKEN OF ADMIRA- TION OF HIS PROFESSIONAL HONESTY, LIBERALITY, AND EXTENSIVE LEARNING; OF GRATITUDE FOR NU- MEROUS FAVORS, UNIFORM COURTESY, AND UNINTERRUPTED FRIENDLY SYMPATHY; This Mork IS INSCRIBED BY HIS FRIEND, THE AUTHOR. 171282 PREFACE. THIS work contains some of the results of the observation, study, and experience of a quarter of a century of active practice. It is not intended to take the place of such works as Jahr, Leadam, Guernsey, Ruddock, Richardson, or Ludlam. It occupies altogether another sphere in our literature, and instead of superseding the above authorities will serve to supple- ment them. I have purposely omitted the minute history, eti- ology, diagnosis and symptoms of many of the diseases treated of, referring the student to the larger systematic text-books, and the practical physician to his own knowledge and experi- ence in relation thereto. The time has arrived when Homœopathy must occupy a broader and more advanced position in the therapeutics relating to Gynecology and Obstetrics, or its usefulness as a healing Art will remain circumscribed and contracted. The Law of Cure must not be hampered by such rules as "the minimum dose, the single remedy, and the rejection of local treatment." The physician who practices according to this rule is only a half-homoeopathist. He avails himself of but half the capabilities of our Law of Cure, and his sphere of use- fulness is limited accordingly. There are conditions where material doses are as homeopathic as an immaterial attenuation. There are cases when medicines locally applied are as strictly homœopathic to the disease as when taken into the circulation by the mouth or stomach. The Law of Cure, enunciated by Hahnemann, is universal and all-embracing. Palliatives may be useful as aids to a cure- in the same manner as surgical, mechanical and chemical meas- ures—but no cure can be made by medicine, that is not a homœo- vi PREFACE. pathic cure. The dose, the method of administration, and the mode of application of the remedy are all of minor impòrtance, if the drug is selected under the law of similia. In the following work I have not, except in rare instances, advised any remedy that is not homoeopathic, either constitu- tionally or locally, or by virtue of its primary or secondary action. I yield to no one in my adherence to the law of simi- lia, or my devotion to the cause of the homœopathic healing art, but I will not be bound down to old dogmas, or antiquated therapeutic notions. I believe the "sole duty of the physician is to cure the sick." Hahnemann taught us this duty. To those who oppose all progress in therapeutics, outside of their restricted views, I would commend the following noble words of Hahnemann, written when he had been chastened by age and purified by adversity, and during the last years of his eventful life, when at last peace and happiness surrounded him: 'No reasonable physician can be satisfied with practicing within the limits of antiquated rules, derived from speculative theories, instead of pure experiments. His object is to cure the sick, and the innumerable powers of nature, WITHOUT EXCLUD- ING ANY, have been assigned to him to effect that process of re- generation. And to carry out such noble ends he ought to have a right to dispose of the curative powers of nature, for the pres- ervation or partial regeneration of the body is a more noble deed than any of the boasted deeds of history; but he ought likewise to be permitted to employ those powers in THAT FORM AND QUANTITY which seem to him the most adequate and the most conformable to experience and wisdom; in this respect no restriction ought to be imposed upon him as a free and indepen- dent man, provided he is endowed with the necessary power and knowledge to preserve human life, and with that delicate con- science which every one whom God has appointed a guardian of human life should possess." CHICAGO, August, 1878. EDWIN M. HALE. CONTENTS. PART I. STERILITY. PAGE PREFACE, V INTRODUCTION: Discussion of the Facts and Theories of Ovulation and its Relation to Menstruation and Conception, 9-42 CHAPTER I. ENUMERATION OF THE CAUSES OF STERILITY, 43-45 CHAPTER II. STATISTICS OF STERILITY, 46-49 CHAPTER III. CONSTITUTIONAL CAUSES AND THEIR TREATMENT: Chlorosis-Scrofula- Syphilis Obesity-Twin-Birth-Prostitution---Inordinate Sexual In- Mineral Waters Improper Diet, Exercise, and Cloth- tercourse ing, • CHAPTER IV. PSYCHICAL CAUSES: Incompatibility—Frigidity-Erotism, CHAPTER V. 50-55 56-57 OVARIAN CAUSES: Absence of Ovaries-Imperfect Development-Atrophy -Inflammation-Degeneration-Tumors-Dropsy, CHAPTER VI. 58-60 UTERINE CAUSES: Stricture of Fallopian Tubes-Obstructions-Absence or Defect of Uterus-Atresia of Uterus-Imperfectly Developed Uterus- Atrophy of Uterus-Obstructions of the Os and Canal of the Cervix- Stricture of the Canal-Displacements of the Uterus-Anteversion and Flexion-Retroversion and Flexion-Lateroflexion-Prolapsus-Ele- vation—Inversion—Tumors—Polypi-Fibroids-Endometritis—Endo- cervicitis Abrasion-Erosion - Ulceration-Leucorrhoea-Dysmenor- rhoea-Amenorrhea-Menstrual Irregularities-Areolar Hyperplasia- Abnormal shape of Cervix, 61-130 1 viii CONTENTS. PAGE CHAPTER VII.* VAGINAL CAUSES: Atresia. Absence of Non-retaining - Imperforate Hymen-Vaginismus-Leucorrhoea-Diseases of Clitoris, • 130-145 CHAPTER VIII. RENAL CAUSES: Diabetes Mellitus-Diabetes Insipidus, 146 CHAPTER IX. VESICAL CAUSES: Irritable bladder-Catarrh of Bladder, 147-150 CHAPTER X. URETHRAL CAUSES: Irritable Urethra-Chronic Catarrhal Urethritis- Caruncles of Urethra - Granular Erosion of Urethra-Fissure of Urethra-Vesico-vaginal Fistula-Vascular Tumor of Meatus, 151-154 CHAPTER XI. RECTAL CAUSES: Hæmorrhoids-Prolapsus Recti-Fissure of Anus-Fis- sure of Rectum-Ulcer of Rectum, . 155-158 CHAPTER XII. THE MECHANISM OF CONCEPTION: The Nature and Properties of Semen- Spermatozoa-Examination of Vaginal and Cervical Mucus for Sper- matozoa—Hale's Speculum-The Passage of Spermatozoa to the Ovule -The Successful Conditions of such Passages, 159-171 CHAPTER XIII. HYGIENIC AND OTHER ERRORS CAUSING STERILITY: Improprieties of Dress -Imprudence during Menstruation-Excessive Venery and Orgasm- Improper Time for Coition-Coition during Treatment of Uterine Dis- ease-Improper Position during Coition-Improper Conduct after Coi- tion-Means Used to Prevent Conception-Abortion as a Cause of Sterility, . 172-183 CHAPTER XIV. GENERAL THERAPEUTICS OF STERILITY: Indications for the Use of Various Medicines Miscellaneous Therapeutic Agents-Galvanism-Gymnas- tics-Hydropathy-Mammary Irritation-Injection of Semen into the Uterus, • 184-199 * Erroneously numbered V. CONTENTS. ix PART II. DISORDERS OF PREGNANCY, AND DYSTOCIA. PREFACE, CHAPTER I. PAGE 203 GENERAL DISORDERS OF PREGNANCY, REMEDIES FOR: Preventive Treat- ment of Dystocia, 205 CHAPTER II. SPECIAL DISORDERS AND ACCIDENTS OF PREGNANCY: Vomiting-Retro- flexion of the Uterus-Cases Illustrating-Use of Pessaries in-Albumi- nuria-Treatment of Uræmic Poisoning-Convulsions-Constipation— Treatment of, . 224 CHAPTER III. MEDICATION OF FŒTUS IN UTERO AS A MEANS OF PREVENTING DYSTOCIA: Dystocia Due to the Fœtus-Unnatural Ossification of the Skull-Hy- drocephalus of the Foetus-Tumors of-Monstrosities-Hardness of the Bones of Fruit Diet for Dystocia, . 253 CHAPTER IV. THE IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA: Extreme Slow- ness of Labor-Rigidity of Cervix-Spasmodic Contraction of the Cer- vix-Treatment of Second Stage of Labor-Feebleness of Contractions -Excessive Distension of the Uterine Walls-Sudden Cessation of Pains-Cramps in the Legs-Irregularity of the Pains-Position during Labor-Use of the Hale's Small Forceps during Difficult Labor, . 267 B : " t LIST OF ILLUSTRATIONS. FIG. 1. Fitch's Measuring Sound, 2. White's Hysterotome, . 3, 4. Jackson's Speculum, 5. Nelson's Tenaculum, · • · 6. Sims' Intrauterine Stem Pessary, 7. Chambers' Stem Pessary, 8. Thomas' Anteversion Pessary, 9. Thomas' Retroversion Pessary, 10. Albert Smith's Retroversion Pessary, . 11. Simpson's Sound, 12. Sims' Sound, PAGE 64 ΤΟ 71 72 • 74 2 2 2 75 76 76 77 77 13. Sims' Elevator, 77 14. Gardner's Elevator, 77 15. Elastic Ring Pessary, 81 • 16. Molesworth's Double Canula and Bulb Syringe, 93 17. Nott's Double Canula Catheters, . 93 18. Wylie's Cervical Protector, 94 19. Bozeman's Dressing Forceps, 99 20. Sims' Cervical Applicator, 101 • 21. Hale's Cervical and Intrauterine Applicator, 102 21 a. Sims' Porte-Tampon, 107 22. Chapman's Scarificator, 117 23. Buttles' Spear Scarificator, 117 • 24. Skeene's Hysterotome, . 25. Peaslee's Uterotome, 26. Conical Cervix, 27. Spermatozoa, • 28. Hale's Expanding Speculum, 127 128 129 160 166 29. Hale's Small Forceps, . 289 30. Hale's Small Forceps Applied, 293 : ON STERILITY. INTRODUCTION. IN the treatment of this subject I propose to adopt the generally accepted meaning of the term, namely: the want of the aptitude for being impregnated. This definition does not restrict barrenness to those cases where, from some cause, ovulation does not take place; for that function may be perfectly performed, and yet, from some abnormal condition of the organs of generation, the ovule cannot become impregnated. Impotence in the male cannot be considered as a cause of sterility, and the consideration of this condition does not fall within the province of this treatise. Sterility may be congenital or acquired; or it may exist for years, and a spontaneous cure result from the action of un- known causes. History relates many instances illustrating these condi- tions. Anne of Austria had been married to Louis XIV for fifteen years before she had a child. Another Anne of Austria, wife of Louis XIII, was sterile for twenty-two years. Catalina de Medicis, wife of Henry the Second, was unfruitful during the first ten years of her marriage, after which time she became so prolific that she had ten successive children. Many similar cases are reported in the various works on obstetrics. There is still another class of sterile women, who become so after having one or two children, and are afterwards bar- ren, even when no cause is apparent in the condition of the organs of reproduction. 2 10 ON STERILITY. C For a proper understanding of the subject, and a full ap- preciation of the various causes of sterility, the latest views. on the physiology of generation should be kept in mind. It is generally believed that conception consists in the con- tact of the fertilizing semen of the male with the ovum, somewhere in the Fallopian tubes, or the cavity of the uterus. It is taught by some authors, however, that the ovum may or does become impregnated in the ovary. It is established that the spermatozoa after being deposited in the vagina, even at its entrance, find their way to the cervical canal, which they enter, and thence proceed until they meet the ovun, which they enter. This is impregnation. The ovum passes into the cavity of the uterus, and if impregnated then or during its progress to the cavity, becomes attached to the interior surface of that organ. But the subject of ovulation, and its connection with men- struation and coition, is one which more concerns us, for un- less ovulation and coition coincide, even in a perfectly normal condition of all the organs of both sexes, impregnation will not result. It was my intention to collect and place before the student and physician the very latest observations and facts relating to ovulation; but I fortunately found a paper written by Dr. A. R. Jackson, of Chicago, published in the American Journal of Obstetrics, October, 1876, which contains all observations of importance up to the present date. By his permission I give his paper entire. After carefully reading it this deduction will be evident to any practical mind, namely, that in some cases of sterility the parties must be informed of the main facts of the process of ovulation, in order that they may try to make the period of ovulation and coition coincident. While I admit that probably no exact information as to the time of ovulation can be given by the physician, it is probable that careful experiment may enable the husband and wife to ascertain its occurrence. Dr. Jackson says: "It is my purpose, in this paper, to ex- amine the evidence upon which is based the ovular or ovula- tion theory of menstruation. INTRODUCTION. 11 "This subject has received a large share of attention during the past few years, and great discrepancy of opinion exists. in regard to many points connected with it. I do not ex- pect to reconcile these discordant views; indeed, in the present state of our knowledge, it would perhaps be impos- sible to do so. Our great need in this, as in many other problems of a physiological character, is an increased num- ber of well-observed facts; those which we have thus far are too few in number, and, apparently, too contradictory to warrant a definite and entirely satisfactory conclusion. "The progress of scientific knowledge is greatly retarded by the admission of what may be termed, paradoxically, false facts; that is to say, facts which by representing only partially the truth, lead to false results. Conclusions founded upon such premises must almost necessarily be erroneous. Truth in science is rarely found wholly unmixed with error, and, in order that we may rightly appreciate the former, we must properly estimate the latter also. Like the diamond, whose facets reflect a differently colored ray according to the angle from which they are seen, so may a scientific truth present a different aspect to those who behold it from dif- ferent points of observation. While to one person the gem appears green, to another it is red, and to a third yellow. He only who sees it from all directions can know the whole truth. Thus it is that imperfectly observed, partial or per- verted facts result in the formation of a false theory; and a false theory, once adopted, has a most injurious influence. He who is governed by it sees everything through a false medium. As observed by Paris, He who is guided by pre- conceived opinions, may be compared to a spectator who views the surrounding objects through colored glasses, each assuming a tinge similar to that of the glass employed.' The advocates of the ovulation theory are, it seems to me, some- what in this position. Many facts have been observed which give apparent support to their opinions, and on these they have been content to rest, overlooking, or, at least under- estimating other facts, equally well known, which strongly militate against those opinions. "The ovulation theory of menstruation implies the follow- ing essential propositions: 12 ON STERILITY. "1. At regular periods, of about twenty-eight days, in the human female, a matured ovule is discharged from the ovary, passes into the Fallopian tube, and is transmitted to the uterus. "2. Coincident with and dependent upon the maturing and bursting of the Graafiau vesicle and the extrusion of the ovule, certain changes occur in the mucous membrane of the body of the uterus, which result in a sanguineous dis- charge from that organ. "In support of these propositions, evidence consisting of certain facts and analogies has been adduced, as follows: (a) Observations made on the bodies of women who have died during or soon after the menstrual period have revealed the presence in one or other ovary of a ruptured Graafian vesicle, and its cavity filled with a blood-coagulum, or its remains, a corpus luteum, in various stages of development or deca- dence; (b) Physiologically, the period of menstruation in woman corresponds with the rut or astrus of other mam- malia, when, it is well known, ova are discharged from the ovaria; (e) The artificial removal of the ovaries causes an immediate cessation of the menstrual function. I purpose considering, seriatim, these propositions, together with the facts which have been advanced for their support. "1. AT REGULAR MONTHLY PERIODS IN THE HUMAN FEMALE, AND COINCIDENT WITH THE MONTHLY FLOW, AN OVULE IS DIS- CHARGED FROM THE OVARY, IS RECEIVED INTO THE FALLOPIAN TUBE, AND BY IT TRANSMITTED TO THE UTERUS. "The minor proposition, namely, that the matured ovule passes from the ovary to the uterus through the Fallopian tube is admitted on all hands, and, not being in dispute, need not detain us The essence of the controversy centres in the alleged periodicity of this process, and of its time relations with the menstrual discharge. "The Graafian vesicles, from the time of their description in 1673, by De Graaf, down to the year 1827, were thought to be the actual ova of manimalia. It was not until the last- named period that Baer discovered the true ovule and the relations it bore to its containing vesicle. However, as early INTRODUCTION. 13 as 1672, Kerkringius* advanced the idea that the ova were discharged at the time of menstruation, but it does not seen to have been founded upon any observations. The first writer who gives positive evidence upon the subject is Sir Everard Home, who noticed the ruptured follicle during menstruation, although its import was not then under- stood. In 1821, Dr. l'ower clearly enunciated the doctrine of the periodical ripening of the follicle at the menstrual period; and the discovery six years later by Baer, already alluded to, that this was only the enveloping structure of the ovule and not the ovule itself, made the rupture an in- telligible fact; and so we may regard this as the real birth of the ovulation theory. In 1831, Negrier,† working in- dependently, showed by anatomical preparations that the periodical discharge of menstruation was the consequence of an internal hidden function-ovulation. Fresh proofs were brought forward by Gendrin, Paterson, Barry, Raciborski, Bischoff, Pouchet, and others, all tending to show that ovu- lation and menstruation are simultaneous and necessarily connected one with the other; and the doctrine was so beau- tiful and reasonable, and seemed so well sustained by the evidence adduced, that we cannot wonder at the fact that it was generally received and adopted by physiologists. Still, there have always been some who were not convinced of its correctness, and who regarded the proofs alluded to as insufficient and inconclusive; who, in the language of Mr. Kesteven, looked upon the doctrine as a plausible and in- genious theory, wanting, however, in the true elements of an inductive theory; in short, an example of the post ergo propter line of argument."' † { "In examining the cases which have been cited in support. of the ovulation theory, one cannot fail to be struck with the complacency with which conclusions are frequently drawn from irrelevant, or, in some instances, even adverse facts. "An example of this is to be found in a review of Bischoff's * Tyler Smith, Lectures on Obstetrics, third edition, p. 80. † Recueil de Faits pour servir à l'Histoire des Ovaires. Angers, 1858. Lond. Med. Gazette, 1849. 14 ON STERILITY. work on Human Ovulation, in the American Journal of the Medical Sciences, vol. 28, p. 137. "These cases of Bischoff have always been regarded with especial favor and as of great value by the advocates of the ovular theory; and, as they are frequently alluded to, I feel constrained to present a very brief synopsis of them. "The observations* were thirteen in number. Of these, the time of the menstrual period was known in only ten; the remaining three have therefore no value so far as this inquiry is concerned. Of the ten, three died during men- struation, and in each of these there was found a ruptured follicle. A fourth died two days after menstruation; the right ovary contained a pretty large projecting follicle, which was still closed. Both ovaries contained small corpora lutea. In a fifth case, the menstrual period had just passed; the left ovary contained a very distinct corpus luteum, and the right ovary a ruptured Graafian vesicle filled with fresh blood. Number six died seven days after menstruation; in the right ovary was a recent corpus luteum. In the seventh, death occurred ten days after menstruation; the right ovary contained a very large Graafian follicle unopened. Number eight died ten days after menstruation; the right ovary con- tained a recently ruptured Graafian follicle and a fresh corpus luteum. In number nine, menstruation had occurred eighteen days before death; the right ovary contained a very large corpus luteum. Lastly, number ten died four weeks after menstruation; the right ovary contained a ruptured Graafian follicle. "After detailing these cases, the reviewer says: 'The re- sults here obtained show that in the human female, at each menstrual period, a Graafian follicle is ripened, swells, and usually bursts, discharging an egg,† and forming a corpus luteum.' Now, I submit to any candid inquirer that the cases cited do not show these things. Indeed, so far as they prove anything, it is that there is not even an approximate correspondence between the rupture of the follicle and the * Beiträge zur Lehre von der Menstruation und Befruchtung, 1853. + Notwithstanding the most diligent search, Bischoff was unable, in a sin- gle instance, to discover the ovule. INTRODUCTION. 15 menstrual period. In two of the cases menstruation had occurred without any such rupture at all. In Cases 5 and 8 the ovaries are described as containing a fresh corpus luteum and a recently ruptured follicle; yet, in the one case, men- struation had 'just passed,' and in the other had ceased ten days before death. Inasmuch as a corpus luteum is an older formation than a recently ruptured follicle, we should naturally refer the latter to the last menstrual period. But to what period or periods do the fresh corpora lutea belong? Dalton* says that the corpus luteum of menstruation 'reaches its greatest development about three weeks after ovulation, and from this time rapidly disappears, a small cicatrix only remaining.' This being the case, can we refer these 'fresh' corpora lutea to a menstrual period, in one case thirty, and the other thirty-eight days past? If we can do so,—if a re- cent corpus luteum signifies one which may be associated with a menstruation which occurred four to six weeks before, —then what shall we say of Case 6, where the presence of such a one is connected with a period seven days past? "Barnes, too, with a similar disregard of consistency, after stating that the preparations of Coste, preserved in the College of France, prove that the ripening of a Graafian fol- licle always coincides with the turgescence of the genital organs, and, according as the circumstances are more or less favorable, bursts at the commencement, towards the end, or at any time during the menstrual discharge-proceeds to state what these preparations are in detail, thus: In a wo- man who died on the first day of the appearance of the meuses, the ovarian vesicle was manifestly ruptured. In another, who died four or five days after the cessation of the menses, the right ovary presented a vesicle still intact, but so distended that the slightest pressure made it burst. Lastly, in a young virgin, who died fifteen days after men- struation, there was no recent trace of a yellow body, and it could not be doubted that the Graafian vesicle had been arrested in its development.' Surely, these cases, taken to- gether, so far from proving that a Graafian follicle bursts at * Prize Essay "On the Corpus Luteum of Menstruation and Pregnancy." † Diseases of Women, p. 147. 16 ON STERILITY. the menstrual period, show that menstruation occurs, in two-thirds of the cases, without such rupture, and in one- third without even a maturation of a follicle. For in one only of the three was there actually found a ruptured follicle; in one, menstruation had occurred and ceased several days before without any rupture, the follicle being burst by ex- ternal force post-mortem, and in the third there had not been even the ripening of one! "Such a course as is indicated in the foregoing instances. is more reprehensible than reasoning without facts; it is reasoning against them. Yet these are only samples of the sort of argumentation which is frequently found in connec- tion with this subject. "(A.) MENSTRUATION MAY OCCUR WITHOUT ACCOMPANYING OVULATION. "At first glance it would seem that we ought to accept the discovery of a rent follicle filled with blood, in persons who have died during menstruation, as a proof that the flow is, if not the result of, at least coincident with, ovulation. But such evidence is not at all conclusive, and may be erro- neous, for Ritchie* has 'repeatedly seen the opening of a discharged vesicle to be still patent, and sometimes the vesicle to be filled with a florid blood-clot in the third and fourth month of pregnancy; and, in one case, he found the corpus luteum of a woman in the ninth month to communi- cate with the surface by a distinct foramen.' "We must bear in mind, in the consideration of this sub- ject, that Graafian vesicles are maturing and rupturing, and corpora lutea are forming and disappearing continually; hence it should be expected that, in a woman dying at almost any time, some of these conditions would be found in the ovary. And when we further consider that the menstrual periods occupy from one-sixth to one-fourth of a woman's lifetime for thirty years, we may equally expect to find such ovarian changes at these periods also. So that it seems strange, indeed, that persons who are satisfied of the correct- * Tilt, Uterine and Ovarian Inflammation, p. 66. INTRODUCTION. 17 ness of the ovular theory because occasionally a ruptured follicle or a corpus luteum is found coincident with a men- strual period, should ever have a lack of evidence. And yet abundant as such evidence unquestionably is, it does some- times fail; for menstruation frequently occurs without any such contemporaneous change in the ovary. Many instances of this character have been recorded, but it is only necessary to call attention to a few of them. "Dr. W. W. Gerhard* presented to the College of Physi- cians of Philadelphia the uterus and appendages of a multi- para, twenty-five years old, who died of apoplexy during a menstrual period. At several points on the surface of the ovary there were minute dotlike orifices, each one corre- sponding to a Graafian follicle. Two of these being exam- ined under the microscope, were found to present a few granular nucleated cells floating in a homogeneous liquid.' Although this woman had been the subject of menorrhagia, the discharge latterly returning profusely every two weeks, there was no evidence of any recent ripening or rupture of a follicle. Again, Dr. Stedman† has reported the case of a mar- ried woman, forty-five years of age, who died of some pulmo- nary affection. Menstruation was regular nearly to the time of her death, and yet on examination there was found no trace of the left ovary, but in its place a thin and simple serous cyst nearly two and a half inches in diameter; while on the other side there was a collection of cysts, forming a mass twice the size of an English walnut, upon the surface of which were spread out the thin flattened atrophied remains of the ovary. 66 Furthermore, it is the experience of ovariotomists, that in many cases in which both ovaries have been removed, these organs have been found so thoroughly diseased as to preclude the idea that they could possibly have performed their function of ovulation normally, if at all, and yet the regularity of menstruation has suffered no interuption. "Some of the reported cases of hernia of the ovaries throw valuable light upon this question. For example, Dr. Oldham # * Amer. Jour. Med. Science, vol. xxxvi, p. 410. † Ib., vol. xxiv, p. 83. Ib., vol. xxxv, p. 284. 18 ON STERILITY. presented one to the Royal Society, the subject of which was a tall, well-formed woman, nineteen years of age, in whom both ovaries had descended through the inguinal canals, and occupied positions in the upper part of the labia majora. The mammæ and external genital organs were well developed, but neither uterus nor vagina could be detected. The left ovary was in a quiescent state, and had never been the seat of pain or swelling. She was under Dr. Oldham's observa- tion six years, during which time he had frequent opportu- nities of seeing her. For the first three years the right ovary was exclusively enlarged, the intervals varying from three weeks to three months. For the last two years the left ovary was most frequently affected, the right remaining quiescent. Occasionally both were tumid, but one always more so than the other. The swelling sometimes occurred suddenly, although usually it was gradual, the volume of the organ increasing slowly for four days, remaining sta- tionary for three days, and then slowly declining, the whole process lasting ten or twelve days. During this period the organ was tender when pressed, but was otherwise not pain- ful, and did not interrupt the patient's ordinary duties. There were no manifest sympathies excited in the mammary glands or other organs; and there was no vicarious flux, either of blood or other secretion. The ovary alone seemed engaged in the act. It was supposed, reasonably, that these periods of enlargement were those of ovulation, and I beg to call attention to the fact that they were quite irregular in their occurrence, the intervals varying from three weeks to as many months. "Dr. Alfred Meadows,* also, mentions a case of similar character. The patient was a single woman, twenty-three years of age, who began to menstruate at fifteen, and con- tinued doing so at regular intervals, with some pain, down to the age of twenty, when, after stooping, a swelling sud- denly appeared in the right inguinal region, caused, as was subsequently learned, by the prolapsed ovary. At the men- strual period following this she suffered violent pain of a character different from any she had experienced before; it * Amer. Jour. Obstetrics, etc., vol. vi, p. 231. INTRODUCTION. 19 preceded the hemorrhage; at the same time the tumor was much increased in size. From that time on she suffered in a similar way, sometimes more acutely, so that at every monthly period she was obliged to lie in bed for a week or more. Sometimes the tumor would swell up to the size of 'two fists,' and be exquisitely tender to the touch. She had no suffering during the intermenstrual periods. To what does this history point? Are we not prepared to accept it as an evidence of the truth of the ovular theory? Prior to the occurrence of each monthly flow, for a period of three years, the ovary enlarges, becomes the seat of pain, and the swelling does not subside until after the cessation of the dis- charge. What more ought we to require? "Mark the sequel. At the suggestion of Dr. Meadows the tumor was removed. It was not contained in any cyst or sac, and was readily separated from its fatty and cellular attachments. The upper portion or pedicle, which went through the abdominal ring, was found distended with fluid. This was punctured, and about an ounce of the contents let out. The pedicle was then tied, and the tumor removed. 'The tumor, which measured about two inches in diameter, proved, on section, to be the right ovary. It had, however, undergone remarkable structural change. Instead of pre- senting the usual dense compact appearance, it contained throughout numerous irregularly shaped spaces varying in size from a pin's head to a quarter or even half an inch, and all were filled with the same kind of fluid as flowed from the pedicle. These cells appeared to communicate with one an- other, and the whole organ to be infiltrated, as it were, with the fluid in question. There were no proper Graafian vesi- cles to be seen.' No Graafian vesicles,—no ovules-no ovu- lation, to account for the great increase in the size of the ovary preceding and during the catamenial period. What is the plain inference? Is it not that the swelling of the ovary was caused by the pelvic congestion attendant upon the menstrual period? And yet Dr. Meadows has intro- duced the account of this case in an argument affirming, among other things, the dominating influence of the ovaria, and the fact of ovulation producing the menstrual flow. "This last-mentioned case of ovarian hernia, as also one 20 ON STERILITY. reported by Dr. McCluer,* and another which I am informedt has been published by Dr. Joseph English, of Vienna, shows that the cystic degeneration of the prolapsed ovary, even when its essential vesicular structure is wholly destroyed, does not prevent the organ from enlarging and becoming painful during the menstrual epoch. In all of these cases the ovary, which had swollen month after month at regular periods corresponding with the menstrual flow, was found to be so diseased as to leave no vestige of Graafian vesicles, thus proving ovulation to be impossible. "Dr. Tilt says: 'In three cases in which Dr. Ashwell had opportunities of examining the ovaria of women who died. during the flow of the catamenia, there were no signs of the rupture of the Graafian vesicle and the escape of ovules. In one of these cases the woman had menstruated regularly for several years, and yet the ovaria were perfectly smooth; there was neither rent nor cicatrix marking the site of either a present or former maturation and escape of a Graafian vesicle.' Ritchie also reports five examples of menstruation which were not accompanied, and could not have been caused by ovulation. In one of these the woman died ten days after menstruation. The ovaries were filled with vesicles, but neither of them presented either a puncture or cicatrix. In another death occurred thirteen days after menstruation. Here, too, the ovaries contained numerous vesicles, one as large as a garden pea, but in neither of them was puncture or cicatrix. In a third menstruation had occurred a week before death, but there was neither scar nor opening on the surface of either ovary. Again, in another case where death occurred a fortnight after menstruation, neither ovary pre- sented any sign of recent rupture. "Dr. John Williams has published a series of cases bear- ing upon the temporal relations of the discharge of ova with the menstrual flow. He believes that the ova are discharged, usually, before the appearance of the catamenial flux, and de- tails observations made by him upon sixteen cases. In sev- * Amer. Jour. Obs., vol. vi, p. 613. + Dr. Paul F. Mundé, private letter + Ovarian Phys. and Path., London, 1865. ¿ Obstet. Jour. Great Britain and Ireland, vol. iii, p 620. INTRODUCTION. 21 eral of these, where death occurred during the intermenstrual period, his conclusions are drawn from the condition of the corpus luteum; but inasmuch as the changes in these bodies do not always take place uniformly, and, as it is always diffi- cult to determine the age of effused blood, the results found- ed upon these cannot be accepted as certainly accurate. Pass- ing by these, therefore, I wish to invite attention to those of his cases in which death occurred during the menstrual period. “(1.) Was a young woman who died on the fifth day of the flow. On the surface of the left ovary was a rough, brownish- colored, star-like cicatrix. On section there was seen under the cicatrix a corpus luteum dilated in the middle and narrow at both ends, nearly three-quarters of an inch in length and half an inch in width; its walls were in some parts of a pinkish, and in others of a yellowish color. In the ceutre was a partially decolorized clot.' (2.) Was a patient who died on the ninth day of typhoid fever and the fourth day of menstruation. One ovary contained a corpus luteum, simi- lar to that in case No. 1. In both of these rupture of the follicle had taken place evidently several days before. (3.) Woman had undergone operation for fistula in ano, and died five days after the appearance of menstruation; one ovary contained a follicle five-eighths of an inch by one-third of an inch, in which was found a bright-red, fresh, loose clot, and its walls were thin and smooth. No rupture had taken place. (4) Patient with fibroid tumor of the uterus; died on the third or fourth day of menstruation. Left ovary contained a fol- licle nearly an inch in length, in which was found a soft, dark-colored clot, which appeared to be several days old; fol- licle had not ruptured. (5.) Patient died when the menstrual flow had almost ceased. There was no rupture in either ovary, but the right ovary contained a Graafian follicle about the size of a small pea. (6.) Young suicide; died three days after cessation of the flow. There was no recent rupture in either ovary; the left contained a follicle similar to the pre- ceding. "Of the foregoing six cases, in only two did a ruptured Graafian vesicle even seem to correspond with a menstrual period; and in two of the cases, the follicles most advanced 22 } ON STERILITY. were so immature that Dr. Williams expresses the opinion that they would probably have ripened by the next return of the flow. "Mr. Paget* has reported a case of a woman who was exe- cuted for some crime, and the post-mortem appearances tell very forcibly against the ovular theory. The woman had begun to menstruate twelve hours before her execution. "The ovaries were of moderate size and presented numerous marks of cicatrices upon their surfaces. In the right ovary, three Graafian follicles projected slightly on the surface and looked healthy, containing clear serous fluid. A fourth was of a very large size and prominent. In the left ovary, one Graafian follicle was fully developed and promi- nent. We looked for ova in the contents of all these, but in vain. The surface of the ovaries was generally rather more than usually vascular, but there was no peculiarly vascular spot, nor any appearance of the recent rupture of a vesicle, or the discharge of an ovum. In the right ovary, near the surface, was a small cyst or cavity, containing what looked like a decolorized clot, and bounded by a thin layer of a bright yellow-ochre substance, an excellent example of a fibro-corpus luteum, of one or more months' date, certainly not more recent.' "Dalton, in the essay on the Corpus Luteum already re- ferred to, reports two cases, in one of which death occurred during the menstrual period and in the other at its termina- tion. In neither of them had a follicle recently ruptured, although in the second there was one on the point of doing So. "I have had two opportunities of examining the ovaries of women who died at or near the menstrual period. One was the case of a healthy unmarried woman, twenty-eight years of age, who died from an overdose of morphia, taken accident- ally. She had menstruated regularly, and a period had ceased four days before death. Both ovaries were normal in struc- ture and size, the right being somewhat larger than the left. It contained several Graafian vesicles scattered throughout the stroma. Two of these were larger than the rest, one be- Tilt's Uterine and Ovarian Inflammation, p. 64. INTRODUCTION. 23 ing about an eighth of an inch in diameter, and the other as large as a small currant. This latter was near the surface and caused a slight projection. It contained a clear serous fluid. The left ovary contained fewer vesicles, but had the indistinct remains of a corpus luteum not less, certainly. than four or five weeks old. The mucous membrane of the uterine body was pale and covered with a grayish-pink mu- cus. The other case was that of a young girl, fifteen years. old, who died from the effects of a burn. She had com- menced menstruating eighteen months before, but the func- tion had been regularly performed only for about ten months. A period had ceased twelve days prior to death. Neither ovary contained corpora lutea, nor bore the marks of recent rupture. The largest vesicle, which was about a quarter of an inch in diameter, was found in the left ovary about a six- teenth of an inch from the surface. (6 (B.) OVULATION MAY OCCUR WITHOUT ACCOMPANYING MENSTRUATION. "I will next proceed to adduce evidence to show that ovu- lation certainly and frequently takes place without men- struation. 66 ☀ Malpighi and Vallisneri long ago observed that fully de- veloped Graafian vesicles are occasionally found in the fully grown fœtus. Ritchie, also, has demonstrated by at least ten dissections that in the ovaries of newborn infants, and children as early as the sixth year, may be found highly vascular Graafian vesicles; and that at the age of fourteen, and prior to menstruation, they are found as large as small raisins, filled with their usual transparent granular fluid; that menstruation is not essential, either as cause or effect of these conditions; that prior to menstruation, the vesicles are found at every other period of life, in continual progres- sion towards the circumference of the ovaries, which they penetrate, discharging themselves through the peritoneal coat, thus proving that the catamenial flow is not an indis- pensable prerequisite to their rupture. *Loc. cit., p. 62. 24 ON STERILITY. "So, likewise, the more recent researches of Grohe, Slav- jansky, and Haussmann have shown that the growth of the Graafian vesicle is quite independent of the menstrual period ; and the last-named authority,* whose observations were made upon eighty-four subjects, asserts that such early develop- ment of the follicles as was noticed by Ritchie takes place in about ten per cent. of all cases. Dr. Sinetyt confirms these observations, and maintains that 'in the ovaries of the newly born, Graafian follicles are almost always visible to the naked eye; and they may at this time often be discovered as well developed as in the adult female, and constituting true cystic ovaries, in which are to be seen ovules whose origin is indu- bitable. In the ovaries of infants, there are often cicatrices and follicles in different stages of atrophy.' What, I would ask, canses the cicatrices? Is it aught but the rupture of the Graafian follicles which, as would seem from the forego- ing, may take place at any period of infantile and adult life? Slavjansky, who has devoted a great deal of time to re- searches on the physiology and pathology of the ovaries, thus summarizes the results obtained by him: 66 "1. The Graafian follicles develop themselves from the primordial follicles, and are growing towards maturity from the first month of birth to the fortieth year. 2. The larger number of follicles do not mature, do not rupture, do not discharge their contents, but pass over into a condition of atrophy which is analogous to the formation of the corpora lutea. 3. The development and ripening of the Graafian follicles do not take place periodically in a regular manner, and there is no connection between ovulation and menstrua- tion. 4. Menstruation is a physiological phenomenon un- connected with the development and ripening of the Graaf- ian follicle. 5. The rupture of the more or less ripe follicle is associated with congestion of the genital organs, and is, as yet, an unexplained matter. "On the other hand, ovulation may continue after the menopause. Lawson Taits says: The cessation of the menses at the climacteric, though it diminishes the activity † Le Progrès Mélical, * Centralblatt, No. 2. Allg. Med. Centr. Z., 54, 1874. Hastings, Prize Essay of 1873, London, p. 4. INTRODUCTION. 25 of the cell-growth at once to a marked extent, never extin- guishes it; for the development and extrusion of immature Graafian follicles ceases only with life itself. They are to be found of some size even fifteen or twenty years after the ces- sation of menstruation.' “Of course, ovulation is the necessary condition of im- pregnation, and it is admitted by all writers that conception may occur in the absence of menstruation. Our literature contains many instances of girls who have conceived prior to the first appearance of the flow; of women who have be- come pregnant subsequent to the menopause, and during lactation before menstruation has reappeared. Dr. James Young, Tanner,† Dubois,‡ Tilt, § and, indeed, almost every obstetric author, mention cases of this character. Leishman speaks of a woman who married at twenty-seven, and who menstruated the first time two months after her eighth labor. Raciborski states that he has seen on the ovaries one or two cicatrices, although the subjects had never menstruated. "An argument which has been frequently urged in support. of the ovular theory, is the fact that conception is more likely to take place shortly after a menstrual period than at any other time. "Dr. W. H. Studley, alluding to this, considers it as admitting of a very different explanation, and not at all as proving the coincidence of ovulation and the menstrual flow. He says: 'My opinion in regard to the rationale of the fact is this: impregnation is more likely to be secured at this time because of the recent deluging with menstrual blood, by which the secretions, especially of the cervical canal, have been washed away, which secretions often prevent im- pregnation either by their chemical incompatibility with the vitalizing fluid, or by the mechanical obstruction in the form of the firm mucous plug so often found in the canal.' "If the ovular theory were true, conception could take place only at or near a menstrual period; but there is abun- * Am. Jour. Med. Science, vol. 1x, p. 568. + Handbook of Pract. Obstetrics, p. 24. Journal de Méd., 1850. Uterine and Ovarian Inflammation, p. 49. Amer. Jour. Obstetrics, 1875, p. 487. 3 23 ON STERILITY. } dant evidence to show that it may and does frequently occur at times quite remote from it. My own experience has fur- nished me with a number of instances where married women, anxious to prevent an increase of family, have observed the 'physiological rule' of abstinence for a fortnight after a period, and who have found, to their chagrin, after a time, that their precaution had been unsuccessful. Dr. Oldham observes: 'I know of cases which I have carefully inquired into, where impregnation occurred at the respective times of ten, twelve, and twenty-one days after the menstrual period; and while, on one hand, I am quite ready to admit a greater disposition to impregnation shortly after a menstrual period, yet I know of no facts to disprove the opinion that the human female is susceptible of impreg- nation at any time between her monthly periods.' Hirsch,* likewise, has seen a case where impregnation took place twenty-two days after a normal menstrual period; and he observes that, as the Jewish women are obliged to abstain from intercourse five days before and seven days after men- struating, that race could not be so prolific as it is known to be if the ovular theory of menstruation is true.' Tilt,† also, mentions the case of a lady, aged forty-seven years, in whom menstruation had been irregular for two years, and who after a single coitus, seventeen days subsequent to a period, became pregnant. "An attempt has been made to explain these and similar cases, by supposing that the spermatozoa, on the one hand, and the ovule, on the other, may retain their vitality in the generative passages for a sufficiently long time to permit the occurrence of impregnation under the circumstances named. But the facts bearing upon the subject, so far as known, do not justify such an explanation. The ovule occupies from eight to ten days in its passage from the ovary to the uterus, and it may be impregnated at any time within that period, provided it meet with fertilizing material If, as maintained by Williams and others, the ovule is discharged at the com- mencement of a menstrual period, rather than at or near its termination, we can still understand how a coitus taking * Schmidt's Jahrbuch, 1853, No. 2. + Change of Life, p. 69. INTRODUCTION. 27 place within a few days prior to the flow might be fruitful as well as one had within eight or ten days subsequent to a period. But when a single intercourse takes place from twelve to twenty-two days after a menstrual period, or ten days before the next, and becomes fruitful, we cannot accept the explanation given by the ovulationists without addi- tional and different facts. "To meet the obvious difficulty here presented, it is urged that the spermatozoa may live a long time-indefinitely, in- deed-in the generative passages of the woman. While we are not able to say positively that such is not the truth, we do say, that so far as we have actual knowledge on the sub- ject, the tenor of life in the spermatozoa is quite limited. Dr. Sims,* who made many examinations of the semen in order to determine how long the spermatozoa may retain their vitality in the matrix, found none alive at a longer pe- riod than forty hours, although he admits that they may live longer under favorable circumstances. And he quotes Dr. S. G. l'ercy as reporting a case in which he found living spermatozoa, and many dead ones' issuing from the os uteri eight and a half days after the last sexual connection. If we admit the correctness of all these statements we have no right to assume the persistence of vitality in the human sper- matozoon for a longer period than that given. Granting this term of vitality,—which I feel assured must be quite excep- tional,―let us see whether it is sufficient to meet the require- ments of some of these cases of impregnation following a single coitus. For example, Moutgomery† reports a case in which the last menstruation occurred on the eth of October. Insemination took place on the 10th of November; preg- nancy resulted. Now, if the ovule impregnated were shed at the last menstrual period, twenty-three days must have elapsed between that time and insemination. We cannot suppose the ovule to have retained its vitality and capability of impregnation during this long period, for such a supposi- tion is quite at variance with all observed facts both as re- *Uterine Surgery, p. 374. † Signs, etc., of Pregnancy, p. 258. 28 ON STERILITY. gards it* and the history of the decidua (Aveling, Williams, Engelmann). On the other hand, if we suppose that the se- men remained in the generative tract until an ovule belonging to the next period was extruded, we must suppose the sper- matozoa to resist the mechanical washing away by means of the menstrual flow-a highly improbable notion, and one not made more reasonable by the fanciful idea that the uterus, by a sort of instinct, anticipates what is going to take place and governs itself accordingly.† Likewise, it implies the vitality of the spermatozoa for a period of eight days, plus the time necessary to meet the descending ovule—probably four or five days more. "It is well known that many women continue to menstru- ate, with entire regularity, for a considerable time prior to the final cessation without conceiving; and I believe that this fact is explainable by the gradual failure of the ovaries to furnish perfectly developed ovules. Indeed, it is quite probable that all ova which are thrown off are not capable of impregnation at any period of life; for, where other con- ditions are apparently equal, some females are impregnated every twelve or thirteen months, others every eighteen months or two years, while others have still longer intervals of rest. Dewees mentions an instance of a lady who con- ceived every seven years, and who bore four children at that interval; and I knew one who had a lapse of three years between each of six successive pregnancies. It would seem, therefore, that it requires a certain period to perfect an ovule, and that the time required is much greater in some instances than in others. And if menstruation is produced by ovulation, it appears scarcely probable that a succession of imperfectly developed ovules-so imperfect, indeed, as not to be susceptible of impregnation, or even of extrusion, as we have seen is frequently the fact-should yet be sufficient to maintain a completely normal monthly flow. * "How long after its maturation the ovum can retain its vitality and susceptibility to the seminal influence is not known, but probably the time is short."-DUNCAN, Fecundity, Fertility, and Sterility, p. 428. t "Under such circumstances menstruation often does not take place at all, or only very scantily; the uterine system, as it were, anticipating the conception and preventing the failure which might result from a free dis- charge of blood."-DUNCAN, Fecundity, Fertility, and Sterility, p. 431. INTRODUCTION. 29 66 Finally, it is not at all uncommon to find the menses sup- pressed for some months immediately after marriage, with- out the occurrence of pregnancy. Are these cases to be explained by supposing that marriage suppresses or retards the development of Graafian follicles? "From all the foregoing considerations, it seems to me conclusive that ovulation and menstruation may, and fre- quently do, occur independently of each other; that while they may be coincident, there certainly is no such constant connection between the two as to warrant the assertion that 'at every menstrual period a matured ovule escapes from the Ovary-an assertion which embodies the very essence of the ovular theory. 66 2. PHYSIOLOGICALLY, THE PERIOD OF THE MENSTRUATION IN WOMAN CORRESPONDS WITH THE ESTRUS OR RUT OF OTHER MAMMALIA. "It is well known that during certain periods, the inter- vals between which vary in different species of mammalia below man, ova are matured and extruded from the ovary, and that this process is attended by great excitement of the entire generative apparatus. Upon the supposed similarity of this function-termed rut, estrus, or œstruation-to men- struation in the human female is based one of the strongest arguments in favor of the ovular theory. Indeed, Cazeaux* and Pouchett lay especial stress upon it. "Down to the time of Martin Barry it was believed that sexual congress was the essential determining cause of the rupture of the Graafian follicle, but the experiments of Bis- choff, Coste, Pouchet, and others, proved that such rupture was spontaneous and entirely independent of male influence of any kind, both in man and the lower animals, although it was hastened in some instances by coitus. Reasoning, then, from the known analogy existing between this and many other of the vital processes in the lower mammalia and the corresponding ones in man, it was assumed that the conditions of rut and menstruation were analogous, and had the same significance. * Second Amer. ed., p. 9. † Théorie Positive de l'Ovulation Spontanée, p 227. 30 ON STERILITY. "While it is true that many physiological conditions in man and the other animals of the order to which he belongs are subject to the same general laws, these conditions differ in specific points just as much as do the different genera and species of that order in their anatomical features. "It may be well in this connection, and before enumerating the important points in which estruation and menstruation differ, to call attention to the fact, that even in those cases in which the oestrus and ovulation are synchronous, it has never been proven that the former is caused by the latter. Indeed, it is far more probable that they are both the result of a common cause-some erethism of the system resulting in congestion and excitement of the entire sexual apparatus. "The appeal to comparative physiology by the ovulation- iss has always seemed to me an unfortunate one, for the noteworthy differences between oestruation and menstrua- tion are quite sufficient, I think, to stamp the two processes as wholly dissimilar. These points of difference are as fol- lows: 1. When, during the astrus, there is a discharge from the genitals (which is not always the case), it is mucous in char- acter, and its source is chiefly the glands of the external organs; its object is to lubricate the parts, and, in some in- stances, by its odor to attract the male. In woman the dis- charge is blood, from vascular rupture; its seat, the mucous lining of the body of the uterus, and its presence an indica- tion of the disintegration of that structure. "2. The excitement characterizing the ostrus is the only period during which the male is received, and the only time when impregnation is possible. In woman, while pregnancy is posible at any time, it usually occurs during the period of rest, that is, in the intermenstrual period. "3. On the subsidence of the ostrus, there is a period of inappetence, during which the female not only no longer in- vites, but successfully resists the male approach. At the corresponding time in women, sexual desire is commonly in- creased, and in some, present at no other time. 4. The oestrus, or period of sexual desire, is necessary in the lower mammalia, for the reproduction of the species. In women, desire is not essential either for intercourse or impreg- nation. INTRODUCTION. 31 $ "5. Estruation and ovulation in many animals are deter- mined by changes in the seasons and other surrounding cir- cumstances,* and in some animals (deer) the semen is only elaborated at such times. In man, changes of season, etc., produce no such effect, and semen is secreted constantly. "6. The œstrus may be excited in some animals (the mare) by the importunities or teasing of the male. Menstruation is neither excited nor hastened by the presence of the male; on the contrary, undue excitement of the generative organs, or of the sexual passion, seems frequently to have a tendency to arrest it, as witnessed in newly married women. "7. During the estrus, both the male and female evince a desire for copulation. During menstruation, the female has a delicate shrinking from the act, and the male likewise feels more indifference than at any other time, amounting in many cases to positive repugnance. "8. The ovaries in the lower animals contain ripe ova only at the period of heat (Bischoff). In the human female, ripe ova are found at all times without reference to the period of menstruation. "The foregoing points of dissimilarity are so distinctive, aud refer to such important features, that I feel warranted in denying that oestruation and menstruation are correspond- ing processes. 3. THE REMOVAL OF THE OVARIES IS AT ONCE FOLLOWED BY CESSATION OF MENSTRUATION. "Percival Pott, Cazeaux, Wells, Battey, and others, have reported cases in which the artificial removal of the ovaries was followed by the immediate and permanent cessation of the menstrual function; and these facts have been cited to prove the necessity of these organs for the maintenance of the periodical flow. "It must be admitted that, if such an effect were the constant and certain result of double ovariotomy, it would * Barnes, Diseases of Women, p. 148, states that in the wild state the rabbit has only one or two litters a year, but when its young are taken away at a suitable time, it has perhaps seven. So likewise the period of ovular maturation is changed in the case of the pigeon, domestic hen, etc. 32 ON STERILITY. go far towards showing the necessity for ovarian influence. But such result is not constant; indeed, the instances in which both ovaries have been removed without interruption or discontinuance of the menstrual flow are so numerous and authentic, that recent writers, who, like Leishman, affirm as an admitted fact the invariable aud immediate cessation of menstruation when the ovaries have been removed,' sub- ject themselves fairly to charges either of ignorance or want of candor. “Dr. John Goodman* has compiled the following table showing the effect of double ovariotomy upon the menstrual function in all the cases of which he could obtain informa- tion down to the year 1872: "Table of Cases in which both Ovaries have been successfully removed from Women under Forty-five years of Age. No. 123 456 Operator. Pott, J. L. Atlee, Bird, • Peaslee,. Burnham, W. L. Atlee, Quoted from. Date. Age 178- 23 · • A. J. Med. Sci., 1844, Lancet, 1848, . 1843 29 1817 32 *** **S Menstruation uninterrunted; tendency to menorrhagia. Lyman's Table, Lyman's Table, Atlee on Ov. Tumors, 1854 1850 24 • 1853 42 35 7 W. L. Atlee, · Atlee on Ov. Tumors, 1855 19 8 W. L. Atlee, Atlee on Ov. Tumors, 1861 40 Menstruation regular. Ceased in 1864. forty-fifth year. Regular molimen, with white discharge. Menstruation regular to 1833, when last reported. 9 Peaslee,. 10 Peaslee,. 11 W. L. Atlee, A. J. Med. Sci., 1863, . A. J. Med. Sci., 1864, . Atlee on Ov. Tumors, 1862 35 1863 39 1864 34 • Last report 1870. Menstruation regular to that time. 12 13 23 Beattey, Storer,. • 1865 37 1866 • 14 Storer, Wells, Dis. of Ovaries, A. J. Med. Sci., 1868, Peaslee on Ov. Tumors, 1867 43 Menstruating regularly a year alter operation. 15 Wells, 16 Wells, Wells, Dis, of Óvaries, 1868 39 • Wells, Dis. of Ovaries, 1869 22 17 Hicks, Wells, Dis. of Ovaries, 1869 39 18 Monro, * • • 19 Mayer, · Wells, Dis. of Ovaries, Wells, Dis. of Ovaries, 1870 1871 34 29 20 Meadows, Lancet, 1872, 1871 ► 21 Priestly, Wells, Dis. of Ovaries, 1872 22 26 27 2** **7 22 23 A. R. Jackson, Le Fort, Peaslee, Ov. Tumors, . 1865 44 Peaslee, Ov. Tumors, 24 Baker Brown, Peaslee, Ov. Tumors, Last report one year after opera- tion. Menstruation regular. Last report 6 m'ths after opera- tion. Menstruation regular. Continued to menstruate to the forty-seventh year of her age. Menstruation regular. Menstruation, but not regularly from Menstruates regularly • 25 Baker Brown, Koeberle, Battey, Peaslee, Ov. Tumors, Peaslee, Ov. Tumo's, Personal information, • • cicatrix and vagina.† Menstruation regular. Menstruation regular. 1872 23 Irregular sanguineous dis- charges; sometimes profuse. Clay, of Manchester, had four cases in which there was subsequent sanguineous dis- charge.-(Peaslec.) * Richmond and Louisville Med. Jour., Dec. 1875. †The whole uterus, except cervix, removed with ovaries. INTRODUCTION. 33 "Dr. Goodman says: In order to determine as accurately as possible the effects of the removal of both ovaries upon the menstrual function, I have carefully examined and ar- ranged all the cases of which I could obtain reports; irregular sanguineous discharges, I have, of course, not counted as menstrual. "Of the twenty-seven cases here recorded, it will be ob- served that in nearly one-half menstruation was not affected by the removal of the ovaries; in one the hæmorrhagic dis- charge was increased; in one it was diminished; and in several sanguineous flows occurred at irregular intervals.' "Dr. Ely McClelland, of Louisville, Ky., in a private letter, dated March 18th, 1876, gives the following facts bearing upon this point, and kindly places them at my disposal. The cases referred to were operated upon for pernicious ovulation, by 'Battey's operation,' or that known as normal ovariotomy.' “CASE I.—But one ovary was removed. "CASE II. Both ovaries were removed, one in May, 1875, and the other in September, 1875. This lady has regularly and persistently menstruated since the operation. "CASE III. Both ovaries removed in August, 1875. This case had menstruated vicariously prior to the operation, and is still the subject of such disorder. "CASE IV. The ovaries of this lady were removed in September, 1875. She menstruates regularly. "So far as these Louisville cases go, the removal of both ovaries, after the menstrual function has been established, produces no influence upon the regularity of its occurrence. What may result after the lapse of a few more months, it is of course impossible to determine.' "Indeed, it is so well known that the removal of the ovaries does not necessarily induce the menopause, that many of those who formerly denied the fact now admit it; but they endeavor to explain the circumstance consistently with the ovular theory. Some of these allege that the ovaries are not the only source of Graafian vesicles. Spencer Wells, for example, states that occasionally the essential elements of the ovaries are sometimes scattered between the layers of the peritoneum, as in the lower animals; and that in some cases * Diseases of the Ovaries, p. 11. 34 ON STERILITY. 'Graafian follicles have been seen developing in some of the mammalia at a distance from the entire ovary, and that such vesicles have developed into unilocular tumors.' Sappey* likewise states that it is not rare to find a score or more cystic ovules, some of them the size of a pea, on the alar mesentery, in the neighborhood of the ovary, and he accounts for their presence in this unnatural situation by supposing that they failed to reach their destination owing to some abnormal relations on the part of the Fallopian tube.' 6 "Now, while it would be presumptuous to deny that such a condition of things as that mentioned by the last-named author is possible, surely it must be exceedingly rare; and, so far as I am aware, there is no instance in which such an anomaly has been found in the human female. I apprehend, therefore, that not the most ardent advocate of the ovular theory would be willing to advance such a hypothetical cir- cumstance to account for the appearance of a periodic monthly hæmorrhage in thirteen of twenty-seven cases of removal of the ovaries. For such an argument would involve the absurd assumption that an ovum which had failed to reach the uterus after maturation and extrusion, could return to the immature condition and ripen over again, and that, too, without its enveloping fluid and capsule! ' "The condition mentioned by Mr Wells must be equally rare, and seems equally weak as a foundation for an argu- ment. In regard to both of these conditions, Dr. Goodman, in the paper already referred to, says: I think it a very fair conclusion that if such vesicles really existed, they were totally extirpated in some, if not the greater part, of the thirteen cases in which menstruation continued after the re- moval of both ovaries. Even if some of them remained, it is clearly impossible that they could have been sufficiently numerous to have afforded a ripened vesicle every month for ten or more years. Their only effect would have been to stimulate the nervous system, and maintain in a more perfect degree the ovarian development.' "Others again have explained the persistence of menstrua- tion after extirpation of the ovaries by force of habit. * Quoted by Savage, on the "Female Pelvic Organs." INTRODUCTION. 35 ( Schroeder* expresses the argument thus: We prefer in such exceptional cases, instead of drawing the conclusion which is directly opposed to all our views, viz., that menstruation has absolutely nothing to do with the presence of ovaries, to assume that in these women, too, menstruation was caused by the growth of Graafian follicles in their ovaries, but that the organism had, in the course of years, become so accus- tomed to the regular discharge of blood that this still con- tinued, although the ovaries were removed.' "But, surely, this is no explanation; it is nothing more than a reiteration of the fact in other terms. The 'habits of our bodies are not causeless; they are all explainable on a rational basis. No act is performed in the animal economy without some antecedent cause, and the same may be said of every recurrence of such act. In the case of the menstrual flow, if its periodicity were maintained in the past by the successive evolution of ovules, such ovular action would be necessary still; and if the cause ceased at any time to act, so likewise would the effect cease. But even this alleged force of habit fails to meet the facts in a case reported by the writer in the Chicago Medical Journal, for October, 1870, and which appears in Dr. Goodman's table as No. 22. In this case, the patient, forty-four years of age, had both ovaries, together with a portion of the Fallopian tubes, removed. A men- strual period had ceased on the 30th August, 1865; the operation was performed the following day. On October 1st, thirty-one days afterwards, a sanguineous discharge appeared and lasted four days, attended by the usual symptoms of menstruation-lassitude, nervousness, backache, etc. There now occurred an interval of eighty-three days, the discharge reappearing December 22d. Its next appearance was on January 20th, 1866,--four weeks after, and from this last date it continued to return with entire regularity every twenty- eight or twenty-nine days, attended by all the ordinary menstrual accompaniments, and lasting each time from three to five days, down to October, 1867-a period of twenty- two months. It then ceased until February, 1867, when it appeared for the last time, the lady being then forty-seven years of age. * Discases of the Female Sexual Organs, p. 318. 36 ON STERILITY. "In this instance, the interval of nearly three months, during which the discharge was absent, was certainly suffi- ciently long to break up any mere habit, and shows that we must look to some other impelling force in order to account for the subsequent return to regularity. Here were no ovaries, no monthly developing ovules, an interruption for nearly three periods of the menstrual habit,' and yet menstrua- tion returned and continued regularly to reappear down to the normal time of final cessation. "The facts of periodicity in the human body are more numerous than generally supposed, and most interesting in their character. Without any intention of amplifying upon the subject, I will merely remark that it is now universally admitted that all forms of periodicity, whether of a physio- logical or pathological character, depend upon the nervous system; and there are numerous facts which warrant us in narrowing this dependence still further, and limiting it to a particular division of the nervous system-the sympathetic. It is well known that a frog's heart will continue its regular systole and diastole a considerable time after its removal from the thorax. The only motive agency left to it then, so far as we know, is that furnished by the sympathetic ganglia which are imbedded in its substance. The influence of these centres of nervous action is neither continuous nor occasional, but rhythmical-that is, periodic. The uterus resembles the heart in also possessing numerous sympathetic ganglia im- bedded in its walls, and in being wholly independent of the cerebro-spinal system in its movements. Furthermore, the recent researches of Goltz and Freusberg* seem to show that there exists in the lumbar portion of the spine a nervous centre for the sexual functions. These facts and investiga- tions may afford a clue to the explanation of the persistence of sexual appetite and functional activity of the generative organs after the destruction by disease, or removal of the ovaries—although in these organs undoubtedly originates the primary impelling force which sets this complex sexual machinery in motion. But whatever may be the nature or exact seat of this force, I believe that its action must be * See Dr. Duncan's Address, Obstet. Journ., Great Britain and Ireland, 1875, p. 361. INTRODUCTION. 37 persistent and, in a sense, continuous, although some of its results be ryhthmical. A pendulum may be set in motion by a single forcible impulse, and for a time it will continue to swing; but unless the application of the force be con- tinuous or repeated, the arc described by the moving body will become shorter and shorter, until finally the motion will cease wholly. "According to the light thrown upon the subject of men- struation by the latest researches, we are perhaps justified in propounding the following as embodying the main facts: "The reproductive organs of the female, including the ovaries, Fallopian tubes, uterus, and vagina, receive their vascular and nervous supplies from the same sources. Prior to the age of puberty, all these organs are in a state of com- parative quiescence, and the uterus of a girl of eleven or twelve years is scarcely larger than the organ in infancy. Notwithstanding the fact that ova undergo some degree of development and are discharged from the ovaries from early childhood onward, their growth proceeds slowly, and, so to speak, unperceived by the nervous system. At or about the fifteenth year, the uterine mucous membrane attains a high degree of development, and, at the same time, the erectile tissues of the other genital organs, external and internal, arrive at their structural completion. Like a wound-up clock, with its needed touch to the pendulum, these organs now only wait for some sufficient impulse to arouse them to functional activity. This is afforded by the next recurring period of ovulation. By the advancing growth of one or more vesicles, an irritation of the ovarian nerves is produced; the effect of this upon the sympathetic, and, by reflex action, upon the vaso-motor nerves, is an increased hyperæmia in the uterus and other genital organs. The uterine congestion thus produced especially affects the lining membrane of the organ, for the reason that, structurally, it is more liable to vascular turgescence than the parenchyma. This vascular activity is followed by a corresponding increase of nutrition and hypergrowth-this latter consisting both in multiplica- tion of the cellular elements of the parts and development of those already existing. The superficial vessels of the mem- brane are greatly enlarged around the glandular orifices, as 38 ON STERILITY. are also the glands themselves. The entire membrane is so thickened and convoluted that the uterine cavity seems scarcely large enough to contain it. This process-called 'nidation' by Aveling-takes place in order to supply the possible needs of an impregnated ovum, and should such a one reach the uterine cavity, the developed membrane be- comes its future nidus. But if not, a retrograde metamor- phosis now takes place. The supergrown parts of the uterus, consisting, as already stated, chiefly of the mucous membrane, lose their excess of blood-supply and die of starva- tion. The first elements which suffer death are the epithe- lial cells which line the mucous membrane; next, the new cells of the connective-tissue stratum below; and, finally, the vessels which are developing or may have developed from this surface. All these parts become infiltrated with fat, the new formations are carried off, the vessels open, and there results the active hæmorrhage which constitutes the men- strual flow. This process is repeated at regular intervals corresponding to the periodic life of the individual, and varying somewhat in different cases. "In the sense and to the extent just indicated, I regard ovulation as necessary to menstruation; it furnishes to the structurally completed uterus, through the medium of the ganglionic nervous system, a needed hyperæmia to originate the menstrual discharge. In order to do this, it is not neces- sary that a follicle should burst (Ritchie), although it may do so. Indeed, I have no doubt that a follicle may pass through several periods without discharging its contained ovule. Doubtless, the pelvic congestion of the menstrual period greatly stimulates the maturation of the follicle, just as does the excitement of sexual intercourse, and to a much greater extent, probably, because of its longer continuance; and a follicle which has been subject to these successive periods of excitement eventually matures and bursts, with, perhaps, an occasional exception. The increase in its fluid contents, the thinning of its walls, and its near approach to the surface of the ovary, all conduce to its easy rupture; and such rupture may occur at any time, although it is clearly more likely to do so during the menstrual conges- tion, the excitement of intercourse, or, when on the point of INTRODUCTION. 39 bursting, from a blow on the abdomen (Schroeder). Such is probably the usual course, although, as already intimated, not an invariable one; for all authorities admit that some follicles never attain full devolopment, but after arriving at a certain stage of growth, cease to enlarge and finally shrink and disappear. "Menstruation, with its phenomena of regularly recurring development and disintegration of the uterine mucous mem- brane, once established, proceeds side by side with the pro- cess of ovulation. The two, while accompanying and aiding each the other, are yet mutually independent; and menstru- ation, instead of being an effect of ovular maturation and dehiscence, is rather, in a certain sense, their cause. In men- struation, the organ chiefly, and the only one essentially em- ployed, is the mucous membrane of the body of the uterus; the other pelvic organs, that is to say, the uterus proper, the ovaries, Fallopian tubes and vagina, have no part in the pro- cess beyond their share in the attendant general pelvic con- gestion (Beigel). "There are many facts connected with menstruation which are not satisfactorily accounted for by the ovular theory, and I desire, in conclusion, to call attention briefly to a few of them. "(a) The first is that variety of the function known as remittent, where the habitual type is changed to another in which the flow occurs usually at shorter intervals—every fortnight, for example. These cases are strongly antagonistic to the received theory. Tilt* considers them as dependent upon some perversion of the nervous force presiding over the generative function, because those in whom the anomaly is observed are generally of a delicate and nervous tempera- ment,' and also because he has always succeeded in restoring menstruation to the monthly type by the exhibition of qui- nine, a remedy whose efficacy in controlling nervous derange- ment of a periodical character is well known. Negrier,t quoted by Tilt, after observing that several patients did not * Uterine and Ovarian Inflammation, third Lond. ed., p. 203. †This author believed that the ovaries alternated their action, one furnish- ing an ovule one month, and the other the next. This is likewise the opinion of Girdwood. 40 ON STERILITY. suffer from fortnightly menstruation, says: 'I do not believe that the ripening of the ovarian vesicles can take place in less than a month; so, in these cases, I think it more natural to suppose that the two ovaries might so progress monthly that, for instance, the right would contain a ripe vesicle on the first of the month, while in the left ovary a vesicle would ripen on the fifteenth.' Does any one regard ovulation as a process whose type of periodicity would be changed by the administration of quinine? "(b) Again, the ovular theory does not account for the regular recurrence of menstruation after the removal of one ovary. Ovariotomists are unanimous in the statement that in cases where a single ovary is removed, a healthy one being left, menstruation is not interrupted, or, at least, the func- tion is no more deranged than it would be by any other equally severe surgical operation. 'It is not known how the work of maturing ovules is divided between the two ovaries. Mr. Girdwood, from observations made in several cases, states that the number of cicatrices found in the ovaries corresponded with the known number of menstrual periods, and that they were equally distributed between the two organs. Others think that for many months in succession one ovary may furnish all the ovules, and then remaining quiescent, that the other assumes the work for an equal, or possibly an unequal length of time. But it is plain that if either of these hypotheses be accepted-if ovulation be regular in any manner, and its periodicity depend upon the presence of both ovaries, it would be interrupted necessarily by the removal of either of these organs. In the first case it would occur only at intervals of two months; and, in the second, according as the active or quiescent organ, for the time being, were removed, we should have an entire temporary cessation at once, or at the end of its term of activity; and if menstruation were dependent upon ovulation, a corresponding aberration of regularity would be observed in it also. But this never takes place, for, as already stated, single ovariotomy is, as a rule, followed by no change whatever in the menstrual periodicity. "It cannot be said, in answer to this, that, as in the case of the kidneys or testicles, the removal of one gland is INTRODUCTION. 41 followed by increased and compensating work by its fellow. The ovary is not a gland, and the Graafian vesicle is not a secretion. The office of the ovary is simply and only to furnish a suitable place for the development of the primordial follicles existent in its stroma from the beginning. "(c.) The remarkable regularity in the ripening and dis- charge of ovules, one after another, month after month, which is assumed by the ovular theory, is combated also by the frequent occurrence of a simultaneous discharge of two or more ova.* Multiparous pregnancies can, I think, only be rationally accounted for by the fact that the shedding of ovules is an irregular function, proceeding in both ovaries simultaneously and independently. 6 "(d.) The ovular theory wholly fails, too, to account for the menstrual irregularities caused by mental influence. Tilt says: I have patients in whom any unusual nervous emotion or overexertion will bring on the menstrual flow, with the usual menstrual symptoms, although they may have only just recovered from this discharge. How can it be supposed that an ovule can be ripened, and the dense ovarian envelope suddenly perforated, by the fatigue of a dinner-party, by hearing disagreeable news, or by an alterca- tion with a servant?' It is well known that influences such as those just mentioned may cause the discharge to appear, and may equally check it when present; and it is likewise known that these, or other similar disturbing causes, may at once change the menstrual regularity; the flow appearing after the usual interval, whether the last one occurred at the right or wrong time. This sudden shifting of periodic ac- tion is the special attribute of the nervous system; it shows the menstrual flow to be impelled by nervous influence, and explains how a strong emotion may repel it or alter the time of its appearance.' (Tilt.) "The argument which I have endeavored to make may be thus summarized: "1. Ovulation and menstruation may each occur inde- pendently of the other. * Ritchie, in a case reported by Cazeaux, found six ova in the uterus at one time. † Change of Life, p. 72. 4 42 ON STERILITY. "2. Ovulation is the irregular but constant function of the ovaries, while menstruation is the regular rhythmical func- tion of the uterus (Kesteven). "3. Ova are matured and discharged from the ovaries at all periods of female life, from early childhood to old age, both before puberty and after the menopause; hence the one can- not be the sign of the other. "4. Menstruation is the consequence of conditions estab- lished by the structurally completed uterus, and depends upon ovulation only for its origination. "5. The mucous membrane of the uterine body is the only organ essentially concerned in the menstrual act; the uterus proper, the ovaries, Fallopian tubes, and vagina have their functional activity increased, however, by receiving a share of the general pelvic congestion which accompanies the pro- cess. "6. The menstrual congestion of the pelvic organs—of the ovaries in particular-is, of all causes, the one most likely to determine the ovipont when a Graafian vesicle is suffici- ently mature, and hence ovulation and meustruation are fre- quently concurrent. "7. The theory that would make menstruation dependent upon ovulation fails to account for the possible occurrence of pregnancy at any and all times between the menstrual periods; for multiparous conceptions; for the frequent per- sistence of menstruation after the removal of both ovaries; for the non-interference with menstrual regularity by removal of one ovary, and for the menstrual derangements and the shift- ing of menstrual periodicity from mental emotion. "8. All the known facts in regard to both ovulation and menstruation are consistent with the theory that, after the latter is once established, the two functions proceed side by side, but independently of each other, the former occurring at irregular and the latter at regular intervals; while, on the contrary, many of these facts are wholly inconsistent with the theory that assumes a necessary ovular maturity and rupture at each menstrual period." CAUSES OF STERILITY. CHAPTER I. I WILL now proceed to enumerate the causes of sterility, viewed in the light of the present physiological and anatom- ical knowledge of the generative organs of woman. With a full appreciation of the imperfections which it contains, I submit the following arrangement or classifica- tion. I. CONSTITUTIONAL OR PREDISPONENT. a. Obesity. b. Chlorosis. c. Scrofula. d. Syphilis. e. Mercurialization. f. Twin birth. g. Prostitution. h. Inordinate sexual intercourse. i. Change of climate. j. Mineral waters. k. Improper diet, clothing, and exercise. II. PSYCHICAL. a. Incompatibility. b. Frigidity. c. Erotism. III. OVARIAN. a. Atrophy of the ovaries. b. Absence of the ovaries. c. Imperfect development of the ovaries. d. Inflammation-chronic-of the ovaries. 44 CAUSES OF STERILITY. e. Degeneration of the ovaries. f. Tumors of the ovaries. g. Dropsy of the ovaries. h. Dislocation of the ovaries. IV. UTERINE. 1. Fallopian tubes. a. Stricture. b. Obstruction. c. Inflammation. d. Inflammation of fimbriated extremity. e. Displacement of fimbriated extremity. 2. The Uterus. a. Absence of. b. Atresia; constrictions; occlusions of the uterus. Atresia; constrictions of cavity and cervix. Atresia; constrictions; acquired, con- genital. Imperfect development of uterus. c. Atrophy. d. Displacements. Anteflexion, and anteversion. Retroflexion, and retroversion. Lateroflexion. Prolapsus. Elevation. Inversion. e.. Tumors of. f. Inflammations, chronic. Endometritis. Endocervicitis. g. Ulceration. k. Leucorrhoea. ¿. Amenorrhoea. j. Dysmenorrhoea. k. Menstrual irregularities. l. Abortions. m. Areolar hyperplasia. n. Abnormal shape of the cervix. * STATISTICS OF STERILITY. 45 V. VAGINAL. a. Atresia. Congenital. Accidental. b. Absence of vagina. c. Non-retaining vagina. d. Imperforate hymen. e. Vaginismus. f. Leucorrhoea. VI. RECTAL. a. Hæmorrhoids. b. Prolapsus ani. c. Fissures of the anus. VII. MEDICINAL.* Agnus castus. Conium. Mercurius. Ruta graveolens. Apis mel. Cantharides. Asarum. Chimaphila. Morphine. Moschus. Sumbul. Senecio. Baryta carbonica. Ferrum. Sepia. Sabina. Cimicifuga. Iodine. Phytolacca. Secale cornutum. Capsicum. Iodide of Lead. Phosphorus. Trillium. Caladium seg. Kali brom. Platinum. Ustilago. Lachesis. Iodide of barium. Caulophyllum. Cannabis. *The above enumeration of the medicinal causes is necessarily imperfect, because much of the testimony relating to their sterility-causing power is unreliable. Their claims will be separately considered in another place. Plumbum. Pulsatilla. 46 CAUSES OF STERILITY. CHAPTER II. STATISTICS OF STERILITY. In general, it is stated by Sims and other authorities, that about every eighth marriage is sterile. This is certainly an astonishing statement. In no other age of the world than this could such a state of things exist. From what we can learn from ancient writers, both sacred and profane, sterility was a very uncommon occurrence among the Egyptians, Jews, Greeks, Romans, and the nations of Europe. If all the other evidence was lacking, the fact that sterility was considered a disgrace among the nations. enumerated above would be sufficient to prove its extreme rarity among their women. 20 In Dr. Duncan's work on Fecundity, Fertility, and Sterility, we find that in the cities of Edinburgh and Glasgow, 15 per cent. of all the marriages between fifteen and forty-four years of age are sterile. Dr. Lever (Org. Dis. of Uterus, p. 5) says: "It is found that th, or 5 per cent., of married women are wholly unprolific." Duncan does not ascribe much value to this estimate. Dr. Simpson (Obstetric Works, vol. i, p. 328) says it has been observed that in some por- tions of Sweden one barren woman is not met with for ten fertile. Frank asserts that only one marriage in fifty is unproduc- tive, but he gives no proof of his estimate. Thompson (Todd's Cyclopedia, vol. ii, p. 478) estimates from a census of two large cities, Grangemouth and Bath- gate, that 1 in every 10 married women were sterile. The same author gives the analysis of 503 marriages in the British Peerage, resulting as follows: Among 495 marriages 81 were unproductive, or 1 in 6 were without any family. Dr. West (Diseases of Women, p. 3) states that he found the general average of sterile marriages among his patients at St. Bartholomew's Hospital to be 1 sterile marriage in every 8.5. STATISTICS OF STERILITY. 47 Dr. Duncan's tables show that about 7 per cent. of all the marriages between 15 and 19 years of age, inclusive, are without offspring. Those that are married at ages from 20 to 24, inclusive, are almost all fertile; and that, after that age, sterility gradually increases, according to the greater age at the time of marriage. We have no means of ascertaining the exact proportion of sterile women among the older nations. Even at this day statisticians have been remiss in collecting, or unable to ob- tain any reliable tables. Dr. Nathan Allen* reports to the Social Science Congress that he has ascertained that in New England the birth-rate of the strictly American class is steadily diminishing. From a careful examination of the census and registration reports, as well as of town and city records, the following facts were developed : The average number of births to each married couple, and the relative number of children to adults, with the present generation of Americans, did not begin to compare with what it was in New England one or two hundred years ago. A census of Massachusetts, taken in 1765, reports almost one-half of the population as under sixteen years of age; whereas, from the best estimates that can be made, not more than one-fourth, or, perhaps, one-fifth, of the present Ameri- can population are under that age. An examination of the records also shows that the average number of chil- dren to each family, at the date above mentioned, was from eight to ten; aud that from the second, third, and fourth generations the average ranged from seven to eight; but when we come to the fifth and sixth generations the number of children diminished more rapidly, averaging only four or five to each married couple; and that of the present genera- tion, the number will not much, if any, exceed three children. Now, if we take into account the known increase in nis carriages from disease, as well as the greater frequency of criminal abortions, we shall find that this decrease in the birth-rate is due largely to the increase in the number of sterile women. * Psychological Journal, vol. ii, p. 214. 48 CAUSES OF STERILITY. It must be borne in mind that many of the causes of mis- carriage are also causes of sterility. A diseased condition causing the former in one woman, will in another cause the latter. The statistics of sterility are, therefore, closely con- nected with those of abortion. Now it is generally believed that miscarriage from causes not designated as criminal is one hundred times more frequent now than a few centuries ago; so we may safely assert the same of sterility. If, therefore, the present rate is one in eight, the ancient rate would be nearer one in eighty. The statistics of sterility, as connected with certain dis- eased conditions, have been only partially arrived at. We can, therefore, only give a few estimates. As regards the statistics of sterility connected with uterine displacements, Sims gives the following table, which shows. the influence displacements of the uterus exercise on the sterile condition: Of 250 cases of natural sterility, 103 had anteversion; 68 had retroversion. Of 255 cases of acquired sterility, 61 had anteversion, and 111 had retroversion. Or out of 505 cases of sterility, 343 had uterine displace- ments, or about two-thirds of the whole. The statistics of sterility connected with fibroid tumors of the uterus show that of 225 women who had once borne chil- dren and then become sterile, 38 had fibroid tumors of various sizes and variously seated, or 1 in 6.7. Of 250 women who had never borne children, the cause of sterility was found to be complicated with the presence of fibroid tumors in 57, being at the rate of about 1 in 4.3. In 100 virgins consulting for some uterine disease, 24 had fibroid tumors, or 1 in 4.6. These latter would probably be sterile. 66 Hewitt (Diseases of Women, p. 238,) gives the following: Influence of acquired deformities of the uterus in producing Sterility." "Of the 296 cases 235 were married or had had children, including 100 cases of retroflexion and 135 cases of ante- flexion. CONSTITUTIONAL OR PREDISPONENT. 49 "Of the 235 cases 81 were sterile, in the sense that they had either had no children or had only had abortions. "Of these 81 cases 57 were absolutely sterile, and 24 had only had abortions. "In a very considerable number of cases the patients had had one or more children, but had been subsequently sterile. These cases are not included in those just described, but their importance is equally great, and the interference with subsequent procreation of children was evidently connected with the presence of a deformity of the uterus acquired subsequently to the first pregnancies. An additional proof, if such were needed, of the effect of the flexion in produc- ing such secondary sterility' resides in the fact, presenting itself on looking over these cases, that the symptoms lead- ing the patient to seek for medical advice had very generally existed since the birth of the last child.” 50 CAUSES AND TREATMENT. CHAPTER III. CAUSES AND TREATMENT. I. CONSTITUTIONAL OR PREDISPONENT. CHLOROSIS.-In actual chlorotic conditions conception rarely occurs. If, with the chlorosis, amenorrhoea is present, fecundation is still more difficult. Treatment. Ferrum phos. is the preparation most valuable in this condition. Phosphoric acid is sometimes more useful than any iron preparation, especially when the chlorosis is due to mental causes. China, if from loss of fluids, or from latent malaria. Calcis hypophosphis is an excellent remedy in many cases. Nux, Ignatia, and Strychnia are remedies which powerfully stimulate the trophic nerves and thus affect the processes of sanguification. Pulsatilla, Helonias, Cuprum, Manganese, and Aletris are all useful in their sphere. SCROFULA. Scrofulous women are oftener fruitful than otherwise. There are cases, however, where the diathesis is well marked, and the ovaries or uterus become the seat of its local manifestations with resulting sterility. Treatment.-A careful study of Hahnemann's Chronic Diseases is essential to the proper selection of remedies for scrofulosis. Among the most important are Ars., Calc., Hepar sul., Iodine, Cistus, Graph, Kali hyd., Ferr. iod., Merc. iod., Oleum jecoris, Phytolacca, Stillingia, and Sulphur. SYPHILIS. This malady is doubtless a frequent cause of sterility. Whitehead* narrates a case of "sterility of fifteen years," caused by secondary syphilis. Treatment.--Syphilis in all its stages and manifestations is readily controlled by a few specific remedies, namely, Mercury com., Merc. iod., Kali hyd., Phytolacca, Stillingia. For many years I have rarely used any other remedy than the Iodohy- * Abortion and Sterility, p. 354. CONSTITUTIONAL OR PREDISPONENT. 51 drargyrate of potassa, mentioned in the New Remedies, 4th edition, p. 695, vol. ii. MERCURIALIZATION.—There can be no doubt in the minds of physicians who have closely studied cases of sterility, that Mercury sometimes causes a difficulty of conception. Treatment. Mercurial poisoning is successfully treated and the poison eliminated by the judicious use of Iodide of potassa, Hepar sulph., Kali chlor., Aurum, Nitric acid, Phyto- lacca, Stillingia, and Sulphur. OBESITY.—This condition is considered, both popularly and by the profession, to be alike the cause and consequence of sterility. Some authorities doubt if obesity is opposed to fecunda- tion. Why this condition should interfere with conception has never been fully explained. The fact, however, remains, and every physician in large practice has doubtless observed, that sterile women are oftener obese than lean. When a woman becomes normally sterile, i. e., after the climacteric period, she is quite apt to become adipose. This fact would seem to prove that there is some connection between barrenness and adiposis. This connection is recog- nized by all breeders of cattle and horses, who consider "fat- ness" a decided obstacle to conception. I have known many instances where a woman has had one or two children, and then suddenly become increased in size. and weight, with resulting barrenness. These same women, a few years after, from some illness or other cause, would become lean, and again bear children. Treatment. Obesity and plethora cannot be safely treated with drugs. In order to diminish the amount of fat or blood in the system by drugs, great damage may, and generally does, result to the general health. The safest medicine for obesity is a decoction of Seawrack or Fucus. A rigid meat diet, with active exercise, will generally diminish obesity. True plethora, on the contrary, diminishes when a meat diet is abandoned, and light farinaceous food takes its place. (Consult Banting, " On Obesity," and Griffin's "How to Grow Lean.") 52 CAUSES AND TREATMENT. TWIN BIRTH.—“There is a popular belief among a certain class that when a male and female are born at a twin birth, the female will be henceforward sterile. It is probable that this belief originated with the graziers, for it is stated as a fact that when a heifer and bull twins occur, the heifer will not conceive. Among cattle-growers this heifer is called a 'free-martin,' and so undoubted is this belief, that this free- martin is either killed as a calf, or, if raised, is regularly broken to the yoke, and worked like an ox. Many men of intelligence have made this statement to me, and it may be found in agricultural journals.” Among cattle such may be the fact, although I very much doubt it; but after a careful examination I am con- vinced that such is not the fact in respect to the human race, as I have known of numerous instances to the contrary, and do not now remember ever hearing one statement in corrob- oration of this opinion."* Professor Simpson, of Edinburgh, who has made consider- able research upon this subject, acknowledges the "infecun- dity of free-martin cows to be a very general fact, but by no means a universal one." He has also collected the facts relative to the married history of 123 females born co-twin with males, 112 of whom had offspring, and 11 none, al- though married several years. In other words, the marriages of the females born under the circumstances, were unproduc- tive in the proportion of one to ten."† PROSTITUTION.-Prostitutes are notoriously sterile. Any one who will wade through the horrible and sickening details of the effects of prostitution, as described by Sanger,‡ will be convinced that fecundation rarely takes place in utterly abandoned women. To the moralist this seems to be more a special providence than any physical results. If it were not so, it would be terrible to contemplate the vast increase of crime and misery that would result. According to Sanger, prostitutes who reform and marry, even if not affected with syphilis, are often barren, while others become prolific. * Gardener, On Sterility. † Simpson's Obstetric Memoirs, vol. i, p. 294. History of Prostitution. CONSTITUTIONAL OR PREDISPONENT. .53 INORDINATE SEXUAL INTERCOURSE. It is stated by some authorities that this habit, equally with prostitution, may be a cause of barrenness. It has been successfully recom- mended in such cases, that, in order to insure conception, coitus be indulged in only once during the ten days succeed- ing the menses. In several cases of sterility I have found this recommendation to be followed by pregnancy. In some cases coitus should be prohibited for a whole month, to allow the exhausted organs time to regain their tone. CHANGE OF CLIMATE.-According to Casanova, "change of climate will produce sterility, as it has been observed in women born in the region of South America which lies be- tween the rivers Amazon and Nepo. When such women leave their native home to reside in some of the limiting States, they will surely (like many plants, when transplanted from one climate to another) become, if not absolutely bar- ren, at any rate less prolific than in their own native land." This may be so, but the fact is equally apparent that change of climate often cures sterilty. I am informed by the physicians of Cleveland, Buffalo, and New York that women, sterile for years, have conceived. while on a visit to the Upper Great Lakes, or a few months' residence at Mack- inaw. I have known the same result to follow in cases of ladies from Chicago, who supposed themselves sterile until a visit to Mackinaw or a trip to Lake Superior resulted in a pregnancy. A visit to Europe or the West Indies is often recommended to sterile women, and with good results. Women sterile in New England become prolific in the West, and women who have never conceived in any part of the country east of the Rocky Mountains become pregnant soon after reaching California. Baudelocque mentions the case of a high personage who could not have any children by his wife. During an absence of two years from France his wife became pregnant, aud gave birth to a boy. After this his wife remained sterile for four years. After another absence from France, she had another child. The change of climate was evidently the cause of some favorable change in the condition of the repro- 54 CAUSES AND TREATMENT. ductive organs. This same couple, by making annual visits, became the parents of eleven children, five boys and six girls. MINERAL WATERS."Long residence near chalybeate springs, and the abuse of drinking or bathing in their waters, have been observed, on the continent, to produce sterility in prolific women." (Casanova.) This author be- lieves this result to be due to the iron contained in the water, and floating in the air. He accounts for the cure of sterility by Ferrum on homœopathic principles. Sterile women are often sent to mineral springs for the cure of barrenness, and it is asserted that some springs are noted for their good effects on this condition. Among the springs most noted for the cure of sterility are the "Sweet Springs," in Monroe County, West Virginia, and several in Europe. IMPROPER DIET AND WANT OF EXERCISE.-It is well known to all practical men that the diet has much to do with fecun- dity in the human subject, also in animals and plants. One of the best writers on this subject-Mr. Doubleday—says: "It is a fact admitted by all gardeners, as well as botanists, that if a tree, plant, or flower be placed in a mould either naturally or artificially made too rich for it, a plethoric state is produced, and fruitfulness ceases. In trees, the effect of strong manures and over-rich soils is, that they run to superfluous wood, blossom irregularly, and almost or entirely cease to bear fruit. In flowering shrubs or flowers the first effect is that the flower becomes double, and loses the power of producing seed; next, it ceases almost even to flower. On the other hand, when a gardener wishes to save seed, he does not give the plant an extra dose of manure, but he sub- jects it to some hardship, and selects the fruit that is the least fine-looking, knowing that it will be filled with seed; while the finest fruit will be nearly destitute. "In the animal kingdom, fecundity is totally checked by the plethoric state, while it is induced and increased by the deplethoric or lean state. Rabbits, swine, sheep, and horses, when overfed, will not reproduce; put them out of con- dition, and they instantly resume their fertility. Tame PSYCHICAL. 55 pigeons, sheep, mares, and numberless sorts of other ani- mals, when they are stuffed to satiety, do not want to, or do not care to raise, or are incapable of raising others." Mr. Doubleday's theory is that "the increase of popula- tion is connected with the food of the people." In other words, and the truth of the deduction is evident to all ob- serving men,—if the diet of women is composed of articles in which fatty constituents or carboniferous abound,-such as sugar, sweetmeats, nuts, and all the rich delicacies which are found on the tables of the rich and luxurious, they will become plethoric, adipose, and sterile. If, with this rich and unnatural diet, we find lack of exer- cise, an absence of outdoor life, and a condition of physical indolence, we have the two causes combined which as much if not more than all others conduce to render the female population of our large towns and cities unproduc- tive and sterile. If we contrast this sterile class with the hard-working, hardy, plainly fed, and plainly clad portion of the population, the Irish, German, and English,—we shall see at once the difference which exists between the two classes in the capacity for bearing children. Hippocrates was well aware of these facts, for he says: "The want of fruitfulness arises from sedentary life, in- dulgence in riding in carriages, want of exercise, profuseness in living, fatness, and muscular laxness in the female sex." Aristotle says: "The condition most favorable to procrea- tion is a habit of body inured to labor.” Lord Bacon says: "Repletion is an enemy to generation." Herbert Spencer, one of the profoundest writers and ob- servers of the age, has the same opinions. It is to be hoped that the renewed interest of the present generation in athletic outdoor exercises will have a favor- able effect on the organizations of women, and in time undo the evil caused by a century of false fashion. For a further consideration of this subject, so important as a cause of sterility, I refer the physician to that excellent paper on The Law of Human Increuse; or Population based on Physiology and Psychology* by Dr. Nathan Allen, of Lowell, Mass. * Quarterly Journal of Psychological Medicine, April, 1868, vol. ii, p. 209. 56 CAUSES AND TREATMENT. CHAPTER IV. II. PSYCHICAL CAUSES. THAT there are causes of sterility which exist solely in the mental constitution of women, no close observer will deny. The annals of medicine and jurisprudence abound in cases of this character. Among the psychical causes of barrenness may be enumerated: INCOMPATIBILITY.-There have been many instances known where, in spite of perfect development of all the organs of generation, together with a normal healthfulness of func- tions, in both husband and wife, conception did not occur. The reason why such marriages were unfruitful is said to be some antipathy or antagonism in the mental sphere. Goll- man* mentions such instances, and calls them relative causes. of sterility. He says: "Such causes are, for example, antipathy or antagonism between the married parties; extreme differences of age, constitution, and temperament, as when a very old man is married to a very young wife, or vice versa, a very old woman to a very young husband; or when a cold and phlegmatic husband has a wife of a very ardent tempera- ment. Such causes are quite frequent, although it is not always easy to find them out. There are instances of ster- ility of five, ten, or twenty years' standing, and when, after this period, conception took place in consequence of a change in the outward relation of the married partners." Several cases have come under my own observation, where husband and wife have lived together for ten or twenty years without the occurrence of conception. These parties became divorced, each married again, and had children. The case of Napoleon and Josephine is in point. The Emperor had children by his second wife, and Josephine's first marriage was fruitful. "We frequently see trials of divorce," says * Diseases of Urinary and Sexual Organs, p. 248. PSYCHICAL CAUSES. 57 Casanova, "reported in the newspapers, brought in by hus- bands against their wives for adultery, when the latter had been unfruitful during a number of years of matrimonial life, and became pregnant by other men. Infidelity in such cases was generally found to be the result of ill-treatment from their cruel husbands; consequently their wives could not possibly have had the least degree of love and affection, and therefore no power of reproduction during such behavior." This last sentence embodies the doctrine taught by this singular author in his unique, but illogical work,* hereto- fore referred to. FRIGIDITY.-Coldness, or an absence of sexual desire, was once supposed to be a cause of sterility; but the most emi- nent physiologists of this century do not teach that such a condition is a cause. Absence of sexual feeling may arise from some malformation of the external genitals, while at the same time the ovaries perform their functions properly. The consideration of this delicate question lies in the do- main of psychology. Treatment. When no organic cause is discovered, the rém- edies are: Kali brom., Agnus castus, Conium, or Baryta in the high attenuations; or Phosphorus, Helonias, Cantharides, Sumbul, Moschus, Ergot, or Nux in the low attenuations. EROTISM.-Excess of sexual excitation or enjoymeut in one or both, especially in hysterical and passionate women, is stated by some authors to be a cause of sterility. This, like the foregoing, is a subject which I do not propose to dis- cuss in this work. I prefer to adhere principally to the more practical details of the pathological causes of sterility. Treatment.-Erotism, or erotomania, is best removed by Cantharis, Phosphorus, Nux vom., Platina, Lilium, Origanum, Moschus, Sumbul, Cannabis ind., in the higher potencies; or, Kali brom., Lupulin, Camphor, or Ferrocyanuret of potassa in the low attenuations, or massive doses. * Contributions to Physiology. 5 LO 58 OVARIAN. CHAPTER V. OVARIAN. ABSENCE OF THE OVARIES.-Congenital absence of the ova- ries has been observed in a few instances. The persons so ab- normally constituted possessed some of the characteristics of woman, but were more masculine than feminine in their ap- pearance. They may menstruate, but they cannot conceive. IMPERFECT DEVELOPMENT.-This condition, which consists in a persistence of the foetal condition of the ovaries, is not very rare. It may exist on one side only, though it generally affects both. As in the case of absence, a certain conclusion is not easy; and, as in that case, also, we draw a presump- tive conclusion from want of development in the other or- gans of generation, absence of the usual signs of the men- strual crisis, and lack of general constitutional vigor and development. Prof. Thomas* gives three cases of this condition which came under his own observation. Their ages were respec- tively 24, 18, and 30. Each showed a want of development of the uterus, vagina, and external organs of generation. The first two never menstruated, the latter very scantily. Treatment. In imperfect development the treatment should consist in administering the remedies homeopathic to the condition, namely: Conium, Iodine, Chimaphila, Helonias, Ferrum, Phosphorus, Calc. phos., Baryta carb., Senecio, and the Hypophosphite of lime. The action of these medicines may be aided by careful and judicious irritation of the uterus by means of slippery elm tents introduced at or near the probable menstrual periods. Electricity has been successfully employed in such cases. It acts by arousing the dormant forces in those organs. One pole of a battery should be placed on the spine, and one over * On Diseases of Women. CAUSES AND TREATMENT. 59 1 the ovaries; or one pole in contact with the cervix uteri, and one over the ovaries. These means, together with proper bathing, exercise in the open air, a nutritious diet, etc., will be apt to arouse the undeveloped organs. ATROPHY.-Aside from the normal atrophy which occurs at the change of life, the ovaries may become atrophied at any age. It may result from acute ovaritis, pelvic cellulitis, and peritonitis. If both ovaries are affected in this manner, ster- ility will of course be absolute. Treatment.—If the atrophy be not too far advanced, it may be arrested by the same means recommended for undeveloped ovaries. An excellent paper on this subject will be found in the North American Journal of Homeopathy, vol. ii, p. 192,* in which the treatment is considered quite extensively. INFLAMMATION.-Acute inflammation of the ovaries may cause such an amount of suppuration and disorganization as to destroy forever their functions; or it may end in chronic inflammation, resulting in destruction of the capability of elaborating healthy ovules. If only one ovary be diseased, sterility will not result. Treatment. The specific remedies for ovaritis are: Aurum, Apis, Cantharis, Conium, Lachesis, Clematis, Pulsatilla, Rho- dodendron, Platina, Lilium, Thuja, Sabina, and Phytolacca. In very severe cases with high fever, Aconite, Veratrum vir., Gelseminum, and Belladonna must be given. DEGENERATION of the ovaries may result from acute or chronic inflammation. When the disease has reached this stage, no treatment is known that will restore their integrity; and if both ovaries are affected, permanent sterility must result. TUMORS of the ovary are not uncommon. They may be di- vided into: (1.) Those which are solid. (2.) Those which have cavities, more or less large, in their interior; dropsical tumors. (3.) Cancerous (scirrhous). The remedies recom- * On "Atrophic Ovarian Amenorrhoea." 60 UTERINE. mended are: Apis, Arnica, Belladonna, Conium, Graphites, La- chesis, Lycopodium, Zincum, and Lilium. Some remarkable cures have recently been made by means of electricity. Ova- rian tumors of large size have decreased notably, and in some instances apparently disappeared, under the use of Chlorate of Potassa, Kali bromatum, and Chimaphila. Dr. Guernsey has collected a number of cases supposed to be cured by homoeo- pathic remedies (Hahnemannian Monthly, Dec. 1877). DROPSY.-Ovarian dropsy is but a form of ovarian tumor; a local disease, and not dependent on disorder of the kidneys. CAUSES AND TREATMENT. 61 CHAPTER VI. UTERINE. Fallopian Tubes. ANY abnormal condition of the Fallopian tubes sufficient to prevent the passage of the ovum from the ovary to the cavity of the uterus is a cause of sterility. It matters not whether impregnation takes place in the ovary or the uterus, normal conception cannot occur unless the ovum attaches it- self to the internal wall of the uterus. Among the diseases of the Fallopian tubes, causing ster- ilty, may be mentioned, (a) STRICTURE. It is said by several European writers that stricture of the uterine end of the Fallopian tube may occur as a result of previous inflammation. The occurrence of a foetus being developed in the tube seems to prove that such a condition may occur. Such an abnormality, however, cannot be demonstrated during life, unless some unusual dilatation or organic change in the os uteri coexist. "Theo- retically," says Dr. Gardner, "there is little doubt of its existence; but practically there is an immense doubt of the possibility of recognizing it, save, perhaps, in some exceed- ingly rare instances." Treatment.--The recommendation of some recent English writers, Tyler Smith, the originator, of passing a bougie into the os and through the cervix, and thence into the Fallopian tubes, and by a series of graduated instruments removing the stricture, is itself so seemingly impossible that it is not now seriously recommended. It has never been performed, and doubtless never will be. Gardner gives cuts illustra- tive of the method of performing this theoretical operation. (6) OBSTRUCTIONS may occur anywhere in the course of the tubes, but generally at the two extremities. * Sterility, pp. 156-7. 62 UTERINE CAUSES. Tyler Smith says: "I have repeatedly observed that in cases where the Nabotbian bodies are met with, small cysts are found in the course of the Fallopian tube, or at its fim- briated extremities. Inflammation of the tube may result in exudation into the tube, blocking up the canal, and ren- dering it impervious. Catarrhal affections of the tubes may cause obstructions of a more or less persistent character. Polypoid tumors may also fill up the canal of a tube.” Treatment necessarily obscure. (c) INFLAMMATION of the Fallopian tubes may be discovered during life, but its diagnosis from ovarian inflammation is extremely difficult. The tube itself may be the seat of in- flammation, causing stricture or obstruction; or the fimbri- ated extremity may be affected, resulting in adhesions or displacements. (d) ABSENCE OR DEFECT OF THE UTERUS, in respect of de- velopment, will cause absolute sterility. "Complete absence of the uterus has been doubted by many, because a more careful study of cases recorded as authentic, rendered the presence of the rudiments of a uterus presum- able or evident; and partly because cases of absence of a uterus which are founded simply on examination of living women do not seem sufficiently conclusive. Notwithstanding this, it has been proved that the uterus may be entirely ab- sent, and in such cases both the oviducts and ovaries, es- pecially the former, may exist either in a rudimentary state, or may be also wanting."* Burggraeve relates cases where, with absence of the uterus, both the ovaries were normally developed, with Graafian follicles found in them; but the menstrual flow and sickness were absent. Scanzoni speaks of extravasatious of blood and formations of cysts, which cannot be imagined to take place without ovulation. The breasts are frequently well developed, the pelvis of the normal dimensions, and sexual desire not absent. In this anomaly, as well as the rudimentary uterus, described by Kolb, conception cannot occur. The absence of the menstrual flow is, in such cases, a valuable diagnostic symptom. * Kolb, Pathological Anatomy of the Uterus. UTERINE CAUSES. 63 ATRESIA of the uterus may be congenital or acquired. Of the former, Kolb writes:* "By congenital atresia we understand that arrest of de- velopment in which the external orifice, or, at the same time, a portion of the cervical canal, is either imperforate or en- tirely absent. As the extremest degree of this anomaly, we might consider that rudimentary form in which no cavity has been formed. However, the term atresia is only applied to the slighter anomalies just mentioned.' وو "The cervix of the uterus is, in rare instances, perfectly imperforate, and forms a slender cylindrical body, consisting of fibrous connective tissue, interspersed with muscular fibres. In such cases the vaginal portion of the cervix is either entirely absent or very imperfectly developed and small, and the vagina is always rudimentary. In other cases the atresia is limited to the external orifice; the occlusion being also effected by muscular and connective tissue. In such, the vaginal portion is generally small, but in some instances it is found normally developed. Finally, we meet with cases in which the vaginal portion and the cervix are perfectly permeable, but the atresia is formed by the mucous. membrane of the vagina passing over and occluding the ori- fice of the vaginal portion." Congenital atresia, in all its forms, is a very rare anomaly. It may exist unperceived up to the years of puberty, and acquire pathological importance only at the com- mencement of menstruation. The menstrual fluid accu- mulates in the uterine cavity, from which it cannot escape; and, consequently, distending the uterus, it causes that con- dition termed hamatometra, or retention of the menses. All these forms of atresia cause sterility. A uterus affected with atresia cannot be impregnated, yet after a successful operation, not only conception, but maturity of the fœtus and a normal delivery have been known to take place. Acquired atresia, occlusions, or contractions of the uterine cavity take place usually at its orifices; and as regards frequency, those at the internal orifice are more frequently observed than those of the external, whilst throughout the * Pathological Anatomy of the Uterus, p. 32. 64 f UTERINE CAUSES. remainder of the uterine cavity, stricture or occlusion is rarely found. Sometimes the entire uterine canal is dimin- ished by concentric hypertrophy or atrophy. Stricture of the uterine cavity may be caused by annular contractions at a certain point; by the external pressure of fibroid and other tumors; by partial or complete flexions of the uterus ; thickening of the mucous membrane from catarrh; enlarge- ment of the follicles, or from the growth of granulating tissues resulting in a constricting cicatrix. The abuse of caustics, such as Nitrate of silver, Chromic acid, and Potassa fusa, in the treatment of ulceration and inflammation of the cervix, is doubtless a frequent cause of occlusion. One such case came under my observation, and required an operation for its re- moval. In the treatment of ulceration during pregnancy, proper caution must be used or the edges of the os may unite. This has been known to occur when no local treat- ment was resorted to. Sterility may result from nearly every form of acquired atresia. Treatment.-- For complete congenital atresia of the uterine cavity, no surgical treatment can be of avail. In those forms of partial atresia, puncture or incision through the occluded portions, with the usual precautions against re- unions, will be attended with success. (For the purpose of diagnosing contractious of the uterine cavity, or atrophy of the uterus, Fitch's measuring-sound is best.) FIG. 1. SUEPARD & DUDLEY N Y. MANUALNE DIONNELMIAURINAMIRNET, Acquired occlusions or contractions, if confined to the canal of the cervix or its inner or outer orifices, may be success- fully treated by the same surgical means. If from flexions of the uterus, a proper pessary and tents will remove the stricture. (Fee Flexions and Versions of the Uterus.) Tumors may sometimes be removed by surgical operations, or the persevering use of such remedies as Conium, Hydrastia, and Iodide of arsenic. Simple occlusions from the adhesion of UTERINE CAUSES. 65 the lips of the os can readily be removed by the uterine sound, or in severe cases by the bistoury. Lacerations of - the os and cervix should be watched for after miscarriage and delivery. In closing up they often completely occlude the os, and it is not ascertained until after the menses occur at the close of lactation. Instances have been reported where occlusion of the cervical canal has resulted from the use of instruments used for the purpose of criminal abortion. These causes should not be forgotten, and their results. guarded against. If such a condition threatens to occur from any of the above causes, the os and cervical canal should be kept open by means of tents and bougies until the danger is past. cause. IMPERFECTLY DEVELOPED UTERUS.-I have known of sev- eral cases of sterility in otherwise healthy women from this Such women are nearly always inclined to obesity. Dr. Simpson* says he has seen a considerable number of cases of short or imperfectly developed uteri in the living subject. The imperfect development of the organ was as- certained, on examination by the finger, by the small and atrophied cervix uteri, and by actual measurement of the length of the cavity by the uterine sound. Instead of being two and a half inches in length, the cavity in such cases was only two inches, or more frequently only one and a half or one inch long. The subjects of this imperfect developement were often well made and well formed in other respects. But the malformation led to various functional defects, especially to amenorrhœa and sterility. The amenorrhea was usually persistent, and when a patient applied for medical relief who was already twenty-five or thirty years of age, this malfor- mation would in a large proportion of cases be found to be the organic cause. In some such cases of amenorrhea, there was great vascularity of the face, and occasionally a most unconquerable form of acne. He has seen in some of these instances the wearing of an intrauterine galvanic or zine and copper pessary followed by the best results, and even occasionally by the cure of the amenorrhoea. The uterus * Obstetric Memoirs, vol. i, p. 258. 66 UTERINE CAUSES. developed itself around such a foreign body when it filled its cavity as it did around à fibrous tumor or an ovum. Dr. Storer, in his note to this article, remarks that he has often seen galvanic pessaries used by Dr. S. in ordinary cases of amenorrhea which had resisted all the usual means of treatment, and with perfect success. Imperfect development will not only cause amenorrhea, with sterility, but it causes that kind of difficult menstrua- tion in which the flow is very scanty and sometimes delay- ing. This condition is nearly always attended with sterility. I do not think the imperfect development is always con- genital, but oftener arises from a sudden check to the first menstruation. I have now two such cases under treatment. In both a severe cold checked the first or second menses, which began profusely enough, but ever since that date they have been scanty and delaying. Each has been married thirty years, and never have been impregnated. Treatment. No medicinal agent is of any service after the condition has existed a few months. If Pulsatilla, Senecio, or some remedy appropriate to the sudden suppression were given immediately, the normal development would not have been arrested. ATROPHY of the uterus is an affection of mature age, and generally commences simultaneously with puerperal involu- tion, or it must be considered as marasmic degeneration of the organ. In chlorotic women also, a sort of atrophy of the uterus is sometimes met with, generally complicated with displacements and derangements of menstruation. Besides these causes, atrophy may result from pressure, or be due to mechanical causes. As regards the extent of the affection, we may distinguish between general and partial atrophy. The latter affects either the body, fundus, cervix, or vaginal portion of the uterus. As regards the cavity of the uterus, a distinction has been made between concentric atrophy, with diminution, and excentric atrophy, with dilatation of the cavity. (Kolb.) Concentric atrophy would doubtless be a cause of sterility; but it is doubtful if atrophy with dilatation would be inimi- cal to conception, although it might act as a cause of mis- UTERINE CAUSES. 67 carriage. Concentric atrophy generally occurs as a sequence to the puerperal state, and is probably one of the causes of that form of sterility which occurs after the woman has given birth to two or more children, and is often connected with atrophy of the ovaries. SENILE atrophy, occurring as it does after the climacteric age, does not belong to the causes of sterility. Scanzoni mentions as a cause of atrophy, imperfect innervation of the pelvic organs consequent upon paralytic conditions of the system (paralysis of the lower half of the body, followed by amenorrhoea), and of which he observed several cases. Treatment.—If the atrophy is from excess of puerperal sub- involution or from a psoric miasm: Iodine, if there is a gen- eral wasting of the body with great weakness of the joints. Baryta carb., if there is an appearance of premature old age, diminution of sexual desire, and the uterus feels hard and is diminished in size; menses scanty or suspended. Conium, if there has been swelling and soreness of the mammæ, followed by wasting, with induration and atrophy of the cervix uteri; sexual feeling abolished; menses scanty or wanting. Chimaphila, if the breasts have become atrophied and flabby, without previous soreness; the skin is dry and hard; and the urine deposits a profuse white sediment, like mucus and chalk. Graphites, Sepia, and Kali bromatum are indicated if the menses are very scanty. If it is caused or attended by chlorosis: Iodide of iron, if with the Iodine symptoms there is waxen complexion, bloated feet, etc. Ferrum, if the chlorosis is due to deficiency in the red corpuscles of the blood. Helonias, if there is chlorosis with dropsy or diabetes. Bromine is an excellent stimulant of the ultimate cells of the ovaries and uterus, and may avert atrophy of either of these organs. In atrophy from imperfect innervation, with paralysis of the lower half of the body, the remedies are: Nux vomica, Conium, Secale, Ustilago, and Phosphorus, or electricity. 68 UTERINE CAUSES. OBSTRUCTIONS from stricture of the os and of the canal of the cervix uteri, is of frequent occurrence, and often over- looked by ordinary practitioners. On the other hand, sur- geons who are always looking for stricture of the cervix often mistake the effects of the various flexions of the uterus for the former condition. Dr. Simpson has an excellent paper on the surgical treat- ment of this abnormality. He recommends incision, and mentions several cases of sterility from this cause cured by the operation. Dr. Mackintosh recommends dilatation by long, straight bougies of different sizes. Dr. Sims prefers the bilateral incision of the cervix. Dr. T. G. Comstock, of St. Louis, writes: "One case of sterility I treated successfully by dilating the cervical canal by means of the uterine probe, Atlee's dilator, sponge-tents, and Simpson's graduated gutta-percha plugs. This opera- tion, made in another case under treatment for a year past, has entirely failed, although the stricture has been over- For the last six months I have been experimenting in cases of dysmenorrhea, from a narrowing of the cervical canal, by relieving the stricture by incision; that is, divid- ing it, making the bilateral section of the os and cervix uteri, which is the operation proposed and performed successfully by Drs. Sims and Simpson. come. "This operation I consider preferable to dilatation, and the results of this practice I propose to make public at some future period. I am acquainted with a physician who claims to have performed this operation nearly fifty times, without any accident or untoward results, and to have cured many cases of sterility by it. "Whether this operation is unwarrantable or not, it is certainly worthy the attention of gynæcologists and surgeons of our school.” The July (1877) number of the American Journal of Obstet- rics contains a paper by Dr. Pallen, entitled, "Incision and Division of the Cervix Uteri for Dysmenorrhoea and Steril- ity." In that paper are published a number of questions addressed to Dr. J. Marion Sims, and relating to this oper- ation and its results. Dr. Sims states that he has for sev- UTERINE CAUSES. 69 eral years operated with the instrument figured in his work on Uterine Surgery, and which has since been greatly im- proved. With it he makes a bilateral incision up to the cavity of the uterus, then dilating the canal by a dilator, and introducing a plug of hard rubber to keep it from contract- ing, and retaining the plug by means of styptic cotton. This dressing is allowed to remain from two to six days. Great care should be taken not to incise the cervix too deeply. The incision should begin at the inner os, which need not be opened larger than one-fourth of an inch. From this point the incision can be carried deeper as the outer os is ap proached, making the canal funnel-shaped. Dr. Sims says he considers "the sponge and laminaria tents more dangerous." He states that he has operated nearly a thousand times and only lost two patients by it, who died of peritonitis. He pronounces the use of tents, for the purpose of enlarging and lengthening the cervical canal, as utterly useless for the permanent cure of dysmenorrhoea or sterility. I have found it so in my practice, for although it may relieve the dysmenorrhoea for two or three months, the stricture almost invariably returns. Incidentally, Dr. Sims mentions the impropriety of treating any case of supposed sterility without first ascertaining if the woman is really at fault, or whether the fault lies with the husband. He says be has met with many cases where the woman has been treated uselessly for years by various physicians, when at last the microscope demonstrated either that the spermatozoa were killed in the cervical canal by the abnormal secretions of the passages, or that they were dead or absent from the seminal fluids. I have myself met with very many similar cases, and I would advise every physician to examine the seminal fluid before and after it has been placed in the gener- ative passage of the woman. To omit this is to "work in the dark," and allow the blame to rest where it does not belong. There are several instruments for division of the cervix. Simpson's hysterotome, invented in 1843, was the first one used for this operation, and by it that dintinguished surgeon. gained a world-wide celebrity. It is single-bladed, the blade concealed, and cuts one side at a time. It is still used very 70 1 UTERINE CAUSES. successfully by many gynecologists. There are several double hysterotomes, with two blades, cutting both sides at once. Of these, Drs. Greenhalgh's, Stohlman's, and Skeene's are the most popular. Dr. Skeene's instrument is perfectly safe, for it can be set so as not to cut too deeply. I have operated several times with Skeene's hysterotome, and afterwards in- troducing a plug of slippery elm two inches long and one- fourth of an inch in diameter, retaining it in place by a small tampon of cotton wet in a solution of persulphate of iron, introduced just within the lips of the os. This is safer than Sims's formidable operation, an operation which, however safe in the hands of such a master surgeon as Sims, is one that the average practitioner should not at- tempt. Moreover, Sims's operation cannot be performed without using his speculum, which requires an assistant, while the operation with Skeene's hysterotome can be per- formed unaided and through any ordinary speculum with movable or expanding blades. There is another instrument, invented by Dr. Octavius White, of New York, nearly fifteen years ago. Q. NIEMANN CO. FIG. 2. This instrument is the safest ever invented, and incises the cervix and inner os as much as is ever necessary, namely, one- fourth of an inch. The instrument, when the blades are with- drawn, looks like a long uterine sound. It has two small semicircular or crescentic blades concealed near its point. It is used with or without a speculum, and in any position. the woman may assume. It is introduced up through the os internum, the two blades are thrown out by an action governed by a screw in the handle, and it is then withdrawn, cutting an opening only one-fourth of an inch, the normal size of the canal. I prefer to use this instrument through NOTE: My speculum has many improvements besides those mentioned above, but a cut of it could not be procured in time for insertion here. It will be for sale by Boericke & Tafel.-HALE. UTERINE CAUSES. 71 Jackson's speculum, for while it is nearly as convenient as Sims's, it needs no assistant. This is a bivalve speculum, the upper blade shorter than the lower-a very great im- provement, as the practical operator will soon ascertain. I have lately improved upon it by changing the shape of the blades and inserting a small hook near the opening of the upper blade, for the purpose of retaining in situ a tenaculum similar to Nelson's, but stronger. The following cuts show Jackson's speculum open and shut, with the tenaculum. FIG. 3. EH.SARGENT After the operation of incision of the cervix it is neces- sary to introduce some kind of a tent or plug to prevent contraction during the healing process. Sponge tents or laminaria are not always safe. I prefer the slippery elm. FIG. 4. EH.SARGENT tent, carbolized, made of the proper size, as mentioned above. This should be removed in twelve or twenty-four hours. and a plug of firmer material substituted. I have used 72 UTERINE CAUSES. Chambers's intrauterine stem pessary in some cases. They are effectual if tolerated. FIG. 5. O o O o O o 90 Dr. Sims figures an instrument which has some advantages over Chambers's, in that it is tubular and self-retaining. It allows the secretions from the cavity of the uterus to pass through it. It is about two inches long; it is introduced with the wings drawn into a straight line by means of a stilet, as shown in the figure. As soon as it is passed to the requisite depth the stilet is withdrawn; the wings spring back into the cavity of the uterus; the os internum grasps the instrument at its bifurcation, and the lower end rests outside of and against the os tincæ. It should be made of vulcanite. It should be worn, if possible, through one men- strual period. CHA FIG. 6. Dr. Coghlan's plan of using a tube of sheet-lead answers a very good purpose. Any physician of ordinary mechanical tact can make one in a few moments, and thus possess at hand a simple and inexpensive instrument. DISPLACEMENTS OF THE UTERUS.-Any of the displacements. of the uterus may be a cause of sterility. In the various flexions of that organ, the bent condition of the cervix causes a stricture at the point of flexion. This stricture may form an obstruction to the entrance of the spermatozoa. (See Atre- sia, Occlusion.) In versions of the uterus the os uteri is often placed in such situations that the seminal fluid cannot readily enter into the cervical canal. UTERINE CAUSES. 73 ANTEVERSION.-According to West,* anteversion or ante- flexion of the uterus may be a cause of sterility, but not more so than uterine diseases in general. Of thirty-three pa- tients affected with this displacement, thirty were married, of whom three were sterile. The remaining twenty-seven had given birth to seventy-three children, and had had twenty- one miscarriages; or, whose labors amounted to 2.7, their miscarriages to 4.7 to a marriage; while one in 8.5 of the total number proved sterile. "When anteflexion is so con- siderable as to nearly obliterate the uterine cavity at the point. of flexion, conception is rendered very improbable ; but still it may take place if no structural occlusion or atresia has recurred at the above-mentioned point, for there may be space enough left to allow passage to the spermatic fluid, and unless the uterus be held by false membranes, the flexion may be lessened in a horizontal position of the pelvis during coition by the weight of the fundus, and thus the occlusion of the cavity be diminished, and the impregnating fluid be allowed to pass. Considering, therefore, the fre- quency of sterility in the females affected with anteflexion (Moyer found 60 anteflexions in 272 sterile females), other circumstances should be taken into consideration, especially derangements of menstruation in the form of dysmenorrhoea or amenorrhea; perhaps, also, the altered position of the vaginal portion (the os uteri looking backwa:d) as well as a certain amount of cervical catarrh." (Kolb.) Treatment. The surgical treatment of anteversion is not attended with much success. The use of pessaries generally accomplishes but little in this displacement; but in excep tional cases they are of benefit, and should be tried. They act, not by rectifying the displacement, but by simply lifting up the uterus, and diminishing pressure on the bladder. Anteflexion is more apt to cause sterility than version. If we have in view only the cure of sterility, I know of no better means than Sims's operation, described by Thomas,† which consists in cutting through the posterior wall of the cervix, thus couverting a crooked into a straight canal, and affording a passage-way for the seminal fluid. If this is objected to, † Ib., p. 329. * Diseases of Women, p. 168. 6 74 UTERINE CAUSES. the use of the intrauterine pessary of Peaslee, Simpson, or Detschy may be tried. If these can be tolerated, the canal may be straightened. The use of intrauterine stem pessaries is nearly abandoned by gynecologists. The recent discus- sion in the American Gynecological Congress showed that to be the case. I have, however, benefited several cases of anteversion and flexion, by the introduction of Chambers's intrauterine split-stem pessary, which is the most efficient in- strument yet invented, and the least liable to cause irrita- tion. FIG. 7. 2 Better than any intrauterine pessary, however, is the simple bougie, or tent, made of dry slippery elm bark, such as is found in the shops. They are easily made with a pen- knife, and smoothed by means of a piece of glass or fine sand paper. They are very easily introduced after they have been soaked in water a few minutes; a mucilaginous. substance oozes out of them, and in this condition they will slip into the flexed uterus without difficulty. I usually make them about two inches long, and of such size as seems best suited to the cervical canal. The point should be tapering, the outer end blunt, with a strong thread attached. This end can also be fixed in a ball or button, so as not to irritate the vagina, but it usually suffices to place a cotton ball (with string attached) under the end. These bougies are to be placed in situ every few days, and removed in six or twelve hours, or sooner if they cause pain. The thread attached allows them to be removed by the patient. It requires two or three months to cure an ordinary case of anteflexion by these tents. To cure an anteversion requires a longer time, and the simultaneous use of one of Thomas's anteversion pessaries. Dr. Byford, of Chicago, speaking of the bougies, says: "The modus operandi of this instrument UTERINE CAUSES. 75 is different from the sponge, or sea-tangle tent. It dilates the cervical canal a little, but not forcing. It produces an influence upon the nervous vascular condition of the mucous membrane of the cervix which assists in removing the pathological state. I have succeeded in curing several cases. of sterility due to anteflexion by the use of Dr. Thomas's latest anteversion pessary. It lifts the fundus from off the bladder, and allows the cervix to assume its proper position. If the cervix has not acquired a permanently bent condi- FIG. 8. Thomas's anteversion pessary. tion, a cure of the sterility will result. It may be necessary, however, to incise the cervix after the version has been remedied." RETROFLEXION AND VERSION OF THE UTERUS may cause sterility. According to Kolb, a retroflexed uterus may frequently conceive. Still Meyer records 36 cases of retroflexion in 272 of sterility. "Retroversion," says Dr. Simpson, "is a cause of sterility," as shown by impregnation taking place after the displace- ment is rectified. With reference to the influence of retroversion or flexion on fecundity, West says: "Of twenty-three affected with this displacement, four gave birth to live children after the womb had been misplaced, one had five children in spite of a retroversion of fifteen years. In one of the above four, pregnancy was preceded by the replacement of the organ; but in the other two, not only was the womb misplaced at the time of conception, but was ascertained to continue so after delivery. Four having given birth to living children, miscarried after the development of symptoms of uterine 76 UTERINE CAUSES. displacement, and in one of the number miscarriage had twice occurred, while fourteen, having previously given birth to one or more living children, had passed more than a year since the commencement of the symptoms without conceiving. In three of this number, however, though still within the childbearing age, conception had not taken place for two years in one instance, and for four years in the other two, previous to the commencement of the symptoms of the mis- placement of the womb." My own observation goes to show that retroversion and flexion is oftener a cause of niscarriage than sterility. I have several patients in whom the uterus is permanently retro- flexed; the structural changes are such that no permanent. straightening of that orgau can be effected, yet conception. occurs readily; but in spite of all the precautions used to keep the womb from retroverting, miscarriage usually occurs between the second and third month. Treatment. I have had considerable experience in the treatment of this form of displacement, and the result is that the mechanical treatment of retroflexion, when we wish to cure sterility from that cause, should consist in: (a) The straightening of the uterus at its point of curva- ture by means of Chambers's stem pessary or the Slippery elm tent, allowing them to remain in the canal of the cervix only a few hours a day; or (b) The continuous use for several months of Dr. Albert Smith's pessary, Dr. T. G. Thomas's improved double lever FIG. 9. TIEMANN-CO FIG. 10. Thomas's retroversion pessary.. Albert Smith's pessary. pessary of hard rubber, or Dr. A. R. Jackson's soft rubber pessary of the same shape as Thomas's, framework left open at top and bottom. but with the wire When the uterus UTERINE CAUSES. 77 FIG. 11. cannot be replaced by the fingers and position alone, use the sound,* or Whitney's elevator. G. TIEMANN-Co FIG. 12. J.REYNDERS-CO Sims's Sound. Gardner's Elevator. Sims's Elevator. Simpson's Sound. * I prefer Sims's Sound on account of its lightness, and also that it is less liable to cause irritation. The above cuts will show the difference. FIG. 13. LBEYNDERS—CO FIG. 14. 78 • UTERINE CAUSES. (c) The administration of those specific remedies which have the power to remove some of the morbid conditions upon which the flexions depend. According to many excel- lent authorities the chief cause of flexions is inflammation or congestion of the parenchyma of the uterus. If this con- dition predominates in the posterior wall, retroflexion occurs, if in the anterior, anteflexion. I believe this theory to be true in the large majority of cases. There are medicines. which correspond to this causative condition, the most im- portant of which are Sepia, Murex, Belladonna, Cimicifuga, Helonias, Lilium, Podophyllum, Æsculus, Platinum, Palladium, and Ustilayo. If the retroflexion or version is of long stand- ing, the aim of treatment is to remove the abnormal deposit in the parenchyma of the uterus, and impart tone to its weakened ligaments. This can generally be done by the ad- ministration of Aletris, Hydrastis, Ferr. iod., Ferr. brom., Ignatia, Nux vomica, and the use of an appropriate pessary. In this case the persevering use of Sitz-baths of a moder- ately cool temperature for fifteen minutes daily will greatly aid the other medicinal measures, as will also the use of the electrical current. It will often occur that a sterility will be cured by the pessary alone if it is worn during coition. I observed this fact many years ago, before Sims's work was published. I have treated several ladies for retroversion, who objected to the use of the pessary for the reason that "if it was worn pregnancy would result;" and several have preferred to en- dure the pain and trouble of a retroflexion than to wear a pessary, for this same reason. Sims relates two cases of obstinate retroversion with sterility in which no sort of pessary could be worn except cotton; without the cotton pessary the uterus in each was turned back to an angle of more than 100° from a normal line; but with this pushed snugly up into the cul-de-sac the organ was comfortably sustained in position. Each of these patients conceived during the time of using this support. They were taught to apply the cotton pessary (a wad of cot- ton-wool of the proper size, tied in the middle with a strong thread, 8 or 10 inches long) on rising in the morning, and to remove it on going to-bed at night.* * Uterine Surgery, p. 286. UTERINE CAUSES. 79 FORCIBLE AND RAPID DILATATION.-When treating of the surgery of stricture of the cervix, I unaccountably omitted the method recently adopted by Dr. John Ball, of Brooklyn, N. Y. I refer to the rapid and forcible dilatation of the cervix by means of bougies and dilators. He thus describes his method of operating: “First evacuate the bowels very thoroughly beforehand, so as to prevent all effort in that direction for two or three days. I then place the patient upon her back, with her hips near the edge of the bed, and when she is profoundly under the influence of an anesthetic, I commence by introducing a three bladed self-retaining speculum,* which brings in view the os uteri, which I seize with a double hooked tenaculum, and draw down towards the vulva, when I introduce a metal bougie as large as the canal will admit, followed in rapid succession with others of larger size until I reach No. 7, which represents the size of my dilator. I then introduce. the dilator and stretch the cervix in every direction, until it is enlarged sufficiently to admit a No. 20 bougie, which is all that is generally necessary. Then I introduce a gum-elastic uterine pessary of about that size, and retain it in position by a stem, secured outside of the vulva, for about a week, in which time it has done its work and is ready to be removed." Dr. Ball says, "The operation is not only applicable to all cases of constriction of the cervix uteri, but its crowning glory consists in the complete and radical cure of flexions, for which there had previously been no really satisfactory treatment." In cases of flexion the relief is obtained by the straightening of the canal, which is produced by a change of the muscular tissues of the cervix from an abnormal to a normal condition. In the rapid dilatation of the parts, the constricting fibres are of course lacerated to some extent, and in healing up around the pessary must necessarily con- form to their new relation." Dr. Ball in his pamphlet gives several remarkable cases of cure, illustrative of the value of this method. He says he has never seen any dangerous symptoms result from this operation. I certainly would advise a trial of this method, in preference to Sims's method of incision of the cervix. He * My improved Jackson's bivalve speculum is better.—Hale. 80 UTERINE CAUSES. also enthusiastically recommends this operation in endocer- vicitis and conical cervix. LATEROFLEXION of the uterus may cause sterility in the same manner as the before-mentioned displacements. Inclination of the uterus to one or the other sides never attains a high degree; the fundus is inclined either to the right or left, whilst the vaginal portion takes the opposite. direction. Lateroversion is often combined with obliquity of the uterus. This displacement may be congenital or acquired. The latter form may be the result of metritis. I have ob- served that it occurs some time after labor or a miscarriage, when the woman persisted in lying all the time on one side. It may be caused by tumors in the body of the uterus, ova- rian tumors, or disease of the round ligaments. Treatment. The medicines must be selected by the char- acteristic symptoms of the case. Mechanical treatment by pessaries is of doubtful utility. I think I benefited one case, and partially removed the flexion, by placing between the cervix and the vaginal wall an air-filled rubber disc pessary of about two inches diameter. The fundus was first pushed up as far as possible. The patient was directed to lie alto- gether on the side opposite to that occupied by the fundus. uteri. PROLAPSUS UTERI.-Unless the prolapsus is attended by other morbid alterations in the uterine tissues, and is so com- plete as to constitute procidentia, it does not become a cause of sterility. A partial prolapsus may, indeed, favor impreg- nation, by allowing the spermatozoa a more ready entrance. Whenever the cervix uteri passes through the mouth of the vagina we call it a procidentia, whether it be to a slight or a great extent. A procidentia may be complete or incom- plete; complete, when the vagina is inverted and protruded externally; incomplete, when the cervix uteri alone projects between the labia for an inch or two, and remains thus sta- tionary for a long time; usually it goes from bad to worse, till it eventually passes entirely through the vulva, forming a tumor of great size, which, at its most depending part, presents the os tincæ often ulcerated and bleeding. Some- UTERINE CAUSES. 81 times the whole body of the uterus protrudes from the vagina; at others, the cervix, greatly hypertrophied and elongated, is the protruding portion. Treatment.*—The medicinal treatment of prolapsus con- sists in the administration of those remedies which will re- move the pathological condition upon which it depends. This is generally chronic congestion of the uterus, and, unless of too long continuance, will yield to Aurum, Belladonna, Sepia, Nux vomica, Platinum, Murex, Lilium, Cimicifuga, Aquaphobin, Ustilago, Secale, Podophyllum, Esculus, and Helonias. No remedy or support will be of value unless the woman dress properly. The use of tight corsets and heavy skirts must be abandoned, for the pressure on the abdomen will prevent any remedial measures from effecting a cure. The internal support which I prefer to all others is the soft rubber elastic pessary of Dr. Jackson, in which the copper wire which is inside the rubber is open at the top and bot- tom from half an inch to an inch, the widest opening to be placed upward. It should be bent or moulded by the fin- gers into a shape approximating the retroversion pessary of Thomas or Hewitt: when in the vagina it opens of its own accord, and the top, in which the wire is left out for an inch, passes up behind the cervix, and affords a soft, elastic spring for the fundus to rest upon, and also allows the free passage of faces along the rectum. The next best is the ordinary elastic ring, or oval pessary, which has been in use for many years. FIG. 15. Elastic Ring Pessary. In providentia it is evident that no me- dicinal means are of any value, unless the uterus can be re- placed by pressure, and kept in position by simple mechanical appliances. In complete procidentia surgical treatment should be re- sorted to. If the cervix is enlarged and elongated, the operation of amputation is quite successful. Dr. A. K. Gardner reports several cases, in one of which the amputated cervix weighed nine ounces, two drachms * An excellent monograph on the medicinal treatment of prolapsus uteri has lately appeared from the pen of Dr. Eggert, of Indianapolis, Indiana. 82 UTERINE CAUSES. and one scruple, "the largest on record as having been re- moved during life." He says: "The organ drew up far into the vagina after the portion was removed.”* Dr. Sims says: "I amputate the cervix only when its lower segment is too large and too long, and projects so far into the vagina as to present a mechanical obstacle to the retention of the uterus in situ when replaced." This operation may cure a sterility by allowing a fruitful coition, which is next to impossible when the cervix is hyper- trophied, elongated, and protruding. The so-called prolapsus uteri, without sinking of the fundus, to which Virchow has called attention, may act as a cause of sterility. In this variety there is complete inversion of the vagina, with the external orifice of the uterus situated at its extreme end. The enormous elongation of the uterus affects chiefly the cervix, the substance of which becomes dense and vas- cular. In this condition of hypertrophy and elongation of the cervix, the uterine cavity is sometimes narrowed, or atresia of the internal orifice may be found. The indications for treatment, aside from the elevation of the uterus by mechanical supports, are to dilate the in- ternal orifice by bougies or an operation, after which concep- tion will readily occur if no other obstacle is present. Dr. Sims's operation for the cure of complete procidentia uteri consists in removing a portion of the anterior wall of the vagina, bringing the edges together, and fastening them by metallic sutures. This simple operation seems to prevent the return of the uterus to its abnormal position. For a com- plete history of this successful operation see Sims's Uterine Surgery. It seems evident that this operation is vastly superior to the perineal operation as performed by Mr. Baker Brown, Dr. Savage, and others. In cases where this or any operation is objected to, we may do something to alleviate the condition of the patient, and, perhaps, bring the uterus into such a position as to be capable of being impregnated. Dr. Sims says that in such cases no pessary, except Zwang's, is of the slightest value; while the best support is simply a large tampon of cotton, Uterine Surgery, p. 294. * Amputation of the Cervix Uteri. UTERINE CAUSES. 83 wet with glycerin, which may be introduced in the morning, to be worn all day. It must be remembered that impregnation will occur whenever the seminal fluid is brought in contact with the cavity of the uterus, if the connection between that organ and the ovaries is not disturbed. If the uterus is so far pro- truding that the ovule cannot pass from the ovary into its cavity, conception cannot take place, even if the semen is thrown into its cavity. ELEVATION OF THE UTERUS-This displacement, together with its attending organic changes, may cause sterility. By elevation of the uterus is meant a displacement of the entire organ upward. The fundus ascends into the peritoneal cavity, both peritoneal cavities thereby becoming shallow, and the fornix of the vagina being so stretched as to cause it to become cone-shaped. At the same time, the vaginal portion disappears more or less, leaving merely a button- shaped rudiment. (Rokitansky.) The causes of elevation of the uterus lie either within or are external to the organ itself. The causes that originate in the organ itself are: an increase in volume of body and fundus, unless the latter has been previously bound down by adhesions in the pelvic cavity, in consequence of which, as- cent of the uterus would be hindered; distension of the uterine cavity by mucus or blood; formation of fibrous tumors, etc. To the class of external causes belong tumors of the broad ligaments or ovaries, adhesions formed during pregnancy or the puerperal state, previous to complete involution; also, vascular tumors of the vagina, tumors of the pelvis, etc. Slight degrees of elevation are found combined with flexions, and always with anteflexions. The effect of the elevation of the uterus, especially when produced by other causes than tumors pressing from below, is elongation of the organ, chiefly of the cervix, to sometimes twice or thrice its normal length; this elongation being gen- erally accompanied with diminution of its cavity and thinning of its walls. The diminution of the uterine cavity by longitu- dinal traction, is always more considerable near the internal 84 UTERINE CAUSES. orifice. Even complete occlusion of the canal may take place. In isolated cases, an obliteration of the canal at the above point occurs in consequence of rupture of so-called Nabothian glands, from the ruptured walls of which connective tissue is produced, which ultimately leads to complete atresia of the canal by agglutination. (Kolb.) Mere elevation of the uterus will not cause sterility, for the spermatozoa find no obstacle in distance, if the mucous mem- brane is healthy and the cervical canal open. But if occlusion or atresia occur with the elevation, sterility surely results. Treatment. The removal of the causes of the elevation by medicinal or surgical means constitute the indications for treatment. If occlusion or atresia is present, the canal should be opened by the operation recommended and prac- ticed by Sims. After this is done, conception will occur as readily as if the uterus was low in the pelvis. If large tumors of the pelvis or uterus caused the elevation, their removal by medicinal and surgical treatment should be attempted. If this is impossible, and the tumors are so large as to offer a probable impediment to childbirth, it is proper to advise the avoidance of pregnancy, or the operation referred to, unless a retention of the menses, or a dysmenorrhoea, render it necessary. INVERSION OF THE UTERUS.-This dangerous and infre- quent form of displacement consists in the turning of the uterus inside out. As the bottom of a bag may be pushed through its mouth so that the inner surface becomes the outer, so may that of the uterus. Inversion may be partial and complete; partial, when the body has become depressed, but has not passed through the os; complete, when the uterus has been completely turned inside out, and the inverted fundus and body hang in the vagina or between the thighs. Inversion of the uterus generally occurs shortly after labor, when the uterine tissues are relaxed. At such a time, undue traction on the cord, to expedite the birth of the placenta, coughing, sneezing, change of posture, straining at stool, etc., may cause the accident. It is possible that inversion may occur at other times; and UTERINE CAUSES. 85 3 there is evidence on record that a non-pregnant and undilated uterus may become inverted.* As this displacement may become chronic, it should be placed among the causes of sterility, although Gardner does not mention it. Chronic inversion may continue for many years, giving very little annoyance; or it may render the life of the patient miserable, on account of hæmorrhage and other attending symptoms, and nevertheless last for years. DIAGNOSIS.-Inversion may be mistaken for a polypus or a fibroid tumor. For accurate differentiation of this dis- placement from tumors, reference is made to Thomas, Sims, Guernsey, Lee, and other authorities: Treatment.—There are three plans of treatment: 1. To return the uterus to its place. 2. To leave it displaced, and adopt means preventive of hæmorrhage. 3. To remove it by amputation. For the cure of sterility depending on this displacement, the first plan is the only one to be adopted. In chronic cases, the second and third plans were consid- ered the only means possible; but it has been demonstrated by Dr. Tyler Smith, of London, and Dr. White, of Buffalo, that even after the continuance of inversion for ten or fifteen years, reduction is possible. Since these successful attempts, the operation has been performed by Sinis, Thomas, and many other obstetric surgeons. The diagnosis having been clearly made, and reduction determined upon, the bowels and bladder should be emptied, and the patient put under the influence of an anesthetic, and laid on her back on a strong table. The operator should always be attended by three or four reliable counsellors, upon whom he may call, not only for advice but physical aid. Having thoroughly oiled one hand, the nails of which have been pared, he should now slowly dilate the vagina so as to introduce it, and grasp in its palm the entire tumor. The other hand should be laid upon the abdomen, so as to press just over the ring which marks the non-inverted cervix, and * See Thomas's Diseases of Women, p. 339. 86 UTERINE CAUSES. oppose the force exerted through the vagina, so as to pre- vent too great stretching of this canal. In some cases, a conical boxwood plug has been used.* For other methods of reducing obstinate inversion, consult the authorities above named. After the reduction is effected, the patient should remain in bed, with the hips elevated, for a week or more, and the remedies indicated by the symptoms should be administered. (Consult―Aletris, Belladonna, Caulophyllin, Cimicifuga, Conium, Ferrum, Helonine, Ignatia, Mercurius, Nux vom., Podophyllin, Ustilago, Lilium, and Sepia.) TUMORS OF THE UTERUS.-Sterility may be caused by any of the varieties of abnormal growths known as tumors of the uterus. The most common are the polypi, and those de- nominated fibrous. They prevent conception, either by blocking up the canal of the cervix, the cavity of the uterus, or the orifices of the Fallopian tubes. POLYPI.-Dr. Simst describes the location and character of these polypi as follows: 1st. Those growing from or about the os tincæ. 2d. Those growing in the canal of the cervix. 3d. Those growing in the cavity of the uterus. The first may be fibro-cellular or mucous. almost always mucous. The third are almost always fibrous. The second are FIBROUS.—The uterus is particularly prone to the develop- ment of fibroid tumors. They frequently prevent conception, even when located in the parenchyma of the womb, but not necessarily so. They are classed according to the manner of their attachment to the walls of the uterus, as extrauterine, intrauterine, and intramural. EXTRAUTERINE fibroids, grow from any portion of the external surface of the uterus, and may be pedunculated, or they may be sessile, with a broad, immovable attachment to its outer muscular tissue. * See Thomas's Diseases of Women, p. 345. Uterine Surgery, p. 67. UTERINE CAUSES. 87 The INTRAUTERINE project into the cavity of the womb, and, like the first, may be pedunculated or sessile. The INTRAMURAL are so called because they are imbedded in the walls of the uterus, being interlaced and overlapped in all directions by its muscular fibres. By reference to the statistics it will be seen that fibroid tumors of the uterus were the cause of sterility in 95 out of 505 cases. Treatment.—The surgical treatment of all polypi may be summed up as follows: (a) Excision. (b) Torsion. (c) Liga- ture. (d) Ecrasement. (e) Pressure by the sponge-tent. Small polypi may be excised by the knife or scissors, if the pedicle can be reached; but large growths are apt to bleed profusely, and even dangerously, after the operation. Dr. Sims, however, regards the hemorrhage as easily managed by the use of perchloride or persulphate of iron. Small, and even large tumors, may be twisted off with the forceps, and the danger from bleeding is less than when excision has been resorted to. In intrauterine polypi, when it is necessary to expel them through the os, Ergot is gen- erally used. If this agent fails, I can favorably recommend the introduction of Slippery eim bougies, between the tumor and the uterine walls, for that purpose. (In a case occurring in my own practice, a small mucous polypi, attached to the canal of the cervix, near the os ex- ternum, was removed by one application of the solid nitrate to the pedicle).* The ligature, once so popular, is now rarely employed. Ecrasement constitutes the safest and most expeditious of all the operations. Dr. Simpson has used the sponge-tent with singular suc- cess in the treatment of polypi. For minute directions for operating on polypi, refer to Sims's Uterine Surgery, Thomas on Diseases of Women, Baker Brown on Surgical Diseases of Women, and Franklin's and Helmuth's works on Surgery. No homoeopathic physi- cian should neglect to place these valuable surgical works * See United States Medical and Surgical Journal, vol. ii, p. 235. 88 UTERINE CAUSES. in his library, for cases may arise where his reputation and that of our school in the locality of his practice may depend on his successful surgical treatment of uterine tumors. The medicinal treatment of polypi is not mentioned in allopathic works, because no medicines are believed by them to exert any curative action on such tumors. "The cure of polypus by medicinal agency," says Leadam,* "cannot be accomplished by the old school of medicine; ... but homoeopathy has rendered results which prove the curative power of its remedies." Staphisagria and Calcarea are those which have been recom- mended principally to remove the state of dyscrasia upon which the formation of polypi depends. The remedies which are pointed out by Jahr† are too numerous to be quoted. Guernsey‡ gives the characteristic indications in his peculiar manner for the following medicines: Aurum, Cale. carb., Conium, Lyc., Mercurius, Mezereum, Nitric acid, Petroleum, Phosphorus, Phosphoric acid, Platina, Pulsatilla, Silicia, Sta- phisagria, Teucrium, and Thuja. These remedies are also recommended for all varieties of tumors; but as the indications are mainly theoretical, but few clinical cases having verified them, we may consider their value in polypi, or fibroid tumors, as quite problemat- ical. The surgical treatment of fibroid tumors is thus summed up by Thomas, who seems to have consulted almost every surgical work: (a) Absorption. (b) Excision. (c) Ecrasement. (d) Enu- cleation. (e) Sloughing. (f) Gastrotomy. Thomas doubts if their absorption can be excited by any medicine (allo- pathic). Scanzoni says he does not know of a single case where medicines caused a complete cure. Sims believes that pressure, by means of sponge-tent or sea-tangle, may cause absorption. The treatment by excision or the ecraseur is fully described by the last-named author. Enucleation has been successfully practiced by Amussat, Atlee, West, * Diseases of Women, p. 274. Obstetrics, p. 99. † Ibid., p. 224. 2 Diseases of Women, p. 407. UTERINE CAUSES. 89 Ludlam, Danforth, Adams, Helmuth, Franklin, Beckwith, and others. Sloughing, once recommended by Dr. Baker Brown, has been abandoned. Gastrotomy, or removal of the tumors, and with them the uterus, is a rare and dangerous operation. According to Dr. H. R. Storer, who has written the history of such operations, there have been 21 opera- tions, with 18 deaths. The medicinal treatment of fibroids is not very satisfactory. In allopathic practice, Dr. Chan- ning, of Boston, claims to have cured many by internal medi- cation. Dr. Simpson seems to have great faith in the long- continued use of bromide of potassium. Dr. Sims says he has never seen the slightest effect produced on such tumors by internal medication. In homoeopathic practice no clinical experience has yet been published showing the effects of our remedies in this disease. Guernsey recommends the same medicines as for polypi. I have a case of intramural fibroid tumor which appears to have slightly diminished in size under the use of iodide of arsenic 3d, continued for two months. I would suggest the protracted use of hydrastis and turpentine. Within a few years the therapeutic measures for the treatment of uterine fibroids have been greatly increased by the discovery of the curative power of the persistent use of ergot. It has been found that, in a large proportion of cases, the tumors decreased under its use, and in many cases they nearly or altogether disappeared. ERGOT, to be of value in such tumors, must be administered. in large doses, large enough to institute and keep up its pri- mary action, viz., a contraction of the uterine arteries and the uterine muscular fibres. By this action it cuts off the nutri- tion of these tumors, and they cease to grow, or shrivel away.. because they are no longer fed by the blood. The Bromides undoubtedly act in the same manner. Also Ustilago, which is a very near relation of ergot. If either Ergot or Ustilago is given by the mouth, the dose must be from 15 to 60 drops three times a day. But sometimes the stomach will not tolerate ergot, and it must be administered by hypodermic injection. From 10 to 30 drops of Squibb's aqueous extract, or an aqueous solution of ergotin, is injected into the cellular tissues of the abdomen or thigh, once a day. Hildebrand injected about 3 grains at one injection, 7 90 UTERINE CAUSES. daily, of the aqueous ext. His formula was, 3 parts aqueous ext. Ergot, 7½ of Glycerin, 7½ of Water. Ustilago might be used in the same manner, and in the same doses, if we had an aqueous extract. The Iodide of barium is a powerful remedy against abnor- mal growths, and may become useful in removing uterine fibroids. The continuous current from a powerful galvanic battery of 20 to 60 cells has been found effectual. Diet in the Treatment of Uterine Fibroids.—In a recent number of the American Journal of Obstetrics (October, 1877), Dr. E. Cutter has a very interesting paper on the treatment of uterine fibroids by means of a peculiar diet. He says he got the idea from Dr. Salisbury, of Cleveland, who regards these growths as generally due to excess of carbohydrates, starches and sugar, fermentable food, in the diet; that they are usually caused by disorders of nutrition, and that by feed- ing patients on a diet composed of animal food, the condition which was most active in bringing on the diseased condition is removed, and the system is enabled to right itself by its own recuperative power. Dr. Cutter reports eight cases in which women with uterine fibroids were placed on such diet; all were greatly improved and some were cured. The follow- ing were the articles permitted and prohibited: PERMITTED. Beef in all forms. Tripe, veal. Calves' foot and head. Pork, fresh, salt and cured. Sausages and ham. Mutton. All kinds of game. Milk, butter, eggs. Cheese, cream. Vegetables, without or with little starch. Fish, fresh and salt. PROHIBITED. Starches and sugars. Common white flour, in all and every form. Bread, biscuits, crackers. Cakes, doughnuts, puddings. Rice. Potatoes in any shape. Sugar, candy. Corn-starch, arrowroot, etc. If the strict diet becomes very repulsive, a mixed diet can be allowed for a short time, of whole wheat, Graham bread, oat-meal, rye-meal, and corn-meal. UTERINE CAUSES. 91 INFLAMMATION OF THE UTERUS.-Acute and chronic inflam- mation of the uterus usually result in sterility; not only by the changes produced in the density of the tissues affected, but in the changes effected in the secretions from the dis- eased surfaces. The inflammatory affections of the uterus causing sterility are: (1.) Endometritis (inflammation of the lining membrane of the uterus). (2.) Endocervicitis (inflammation of the lining membrane of the cervix). ENDOMETRITIS has been described under the names of uterine catarrh, uterine leucorrhoea, and internal metritis. Its location extends from the os internum to all portions of the uterine cavity, or fundus. (A variety has been described by Dr. Routh, as fundal endometritis. In this variety, the inflam- mation is located in the fundus, occupying only a small spot.) As endometritis is a frequent cause of sterility, it will be well to devote a space to its consideration. Its chief symp- toms are: (a) Leucorrhoea. (b) Menstrual disorders. (c) Pain in back, groins, and hypogastrium. (d) Nervous disorders. (e) Tympanites. (f) Symptoms of pregnancy. (g) Sterility. Treatment.--No mention is specially made of endometritis by Marcy and Hunt, Leadam, Gollman, or Mintern. Jahr* treats of it in his own peculiar manner. Ludlam and Guern- sey† give the only good description we have in any work in our school. Jahr's remedies are: Alumina, Calcarea, Kreoso- tum, Mercurius, Pulsatilla, Sepia, etc., for which he gives the symptomatic indications. Guernsey gives the characteristic or key symptoms of seventy-two remedies, among which, Arsenicum, Bovista, Calcarea, Conium, Graphites, Lachesis, Kali bi., Kali hyd., Mercurius, Muriatic acid, Nitric acid, Platina, Podophyllum, Pulsatilla, Sabina, Sepia, Sulphur, and Zine, are the most useful, and especially adapted to the chronic form of the disease. In addition to the above medicines, I have found Cimici * Diseases of Women. † Obstetrics, p. 128. Y 92 UTERINE CAUSES. fuga, Gelsemium, Hamamelis, Helonias, Hydrastis, Myrica, Lilium, Phytolacca, Senecio, Trillium, and Xanthoxylum, use- ful in some cases. CIMICIFUGA is especially indicated for the nervous symp- toms accompanying the disease, also when the pains in back, loins, etc., are present. GELSEMINUM is superior to all others in the acute or sub- acute stage. HAMAMELIS when the discharge is "rusty," or the menses continue nearly through the month; (also Trillium, Erigeron, and Senecio.) HELONIAS for chronic albuminous leucorrhoea (uterine), with great debility. MYRICA when the discharges are offensive, bloody, and corrosive; (also Arsen. iod) PHYTOLACCA for nearly the same symptons, especially if syphilis is present. HYDRASTIS if the discharge is ropy, thick, yellow and tenacious, with great debility. There are many points of resemblance between these and the older remedies, which may be studied to advantage. I believe I have cured cases of sterility from endometritis by means of the persevering use of Calcarea, Conium, Mer- curius, Nitric acid, Sabina, and Sepia; also Cimicifuga, He- lonias, Lilium, Phytolacca, and Hydrastis. Some of these remedies I have used topically, by injecting a solution into the cavity of the womb. One case, in particular, is worthy of mention: A lady who had borne one child, had been sterile seven years. She had the most profuse, thick, tena- cious leucorrhoea I have ever seen. The vagina was also af fected with chronic inflammation, and the os abraded. The two latter were cured; the former by injections of Hydrastis, the latter by a few applications of Nitrate of silver. The uterine discharge, however, still continued; a thick rope of mucus constantly hung from the os. With a small syringe, having a long, slender tube, I injected, once a week, 3ij of a solution of Muriate of hydrastia* into the cavity of the * R. Muriate of hydrastia, gr. v; Glycerin, ss.; Water, iss. UTERINE CAUSES. 93 uterus (the cervical canal allowing its return). After six injections she became pregnant, and went her full time. Molesworth's is the safest and best intrauterine syringe, for it allows the fluid to return from the cavity. FIG. 16. Molesworth's double canula and bulb syringe. Another instrument, quite as safe, but less convenient per- haps, is Nott's double canula catheter, through which the medicated injection is thrown by an ordinary syringe. The arrows denote the course of the current. FIG. 17. G. TIEMANN & CO. Nott's double canula catheters-two sizes. The remarks of Sims on the surgical treatment of this disease are so important that I quote them: "The first great principle to guide us is that of insuring a very free exit from the cavity of the uterus for the secretions therein generated. The second is that of appropriate local applica- tions to this cavity, for the purpose of modifying or healing, as it were, the diseased surfaces. When the canal of the cervix is contracted, I have freely divided it, as in cases of dysmenorrhoea dependent upon mechanical obstruction, and this with great relief. The uterine secretions must not remain pent up in its cavity. With a patulous cervix, one may use medicated injections, etc." For intrauterine appli- cations, use small cotton tampons, to which a string is at- tached, medicated with one of the following preparations, 94 UTERINE CAUSES. and applied by means of my intrauterine applicator, or Wylie's cervical protector. FIG. 18. SHEPARD-DUDLEY, NY. In using Wylie's instrument, wrap cotton around the rod, medicate it, and insert it into the tube, which has been passed into and through the cervical canal. Push the rod up to the fundus and move it from side to side a few times, then withdraw both rod and tube. For these intrauterine applications I have found the following the most efficacious: Merrill's fluid hydrastis, 3j to Glycerin Zj. Sulphate of hydrastia, gr. x Muriate of ( gr. v Tinc. calendula, " thuja, "" (( grindelia, cubebs, copaiva, Carbolic acid, Kali bich., (6 (( zij gr. v OG ON ON ON ON EN EN. " " แ แ པ เ " (( པ པ༷ แ (6 (C Wylie's cervical protector. My applicator can be used in the same manner, and is a much cheaper and more convenient instrument. (See page 102.) Dr. Sims has met with several cases of fundal endome- UTERINE CAUSES. 95 tritis, and thus gives its diagnosis: "Place the patient in the left lateral semi-prone position; introduce the speculum; hook a tenaculum slightly into the anterior lip of the os tincæ; draw this gently forwards, pulling the os open, so as to be able to look right into it; then pass the sound, previ- ously warmed, gently along the cervix, using no force what- ever, but almost letting it go by its own gravity, as it were, to the fundus. This is attended by no pain whatever till the sensation point be reached, when it produces the most intense agony a pain that does not cease sometimes for hours after the experiment." In this disease there is little or no discharge, but generally pain in one or the other hip, generally the left, in the in- guinal region, groin, ovary, and even mammary region. Dr. Sims relates one very severe case, which he cured in a few weeks, by dilating the cervix, and simply injecting into the cavity of the uterus a few drops of glycerin, twice or three times a week. In the course of a year, this patient became a mother, and has had three children since. In another similar case, he says: "A single sponge-tent, followed by the injection of half a drachm of the officinal tincture of iodine produced almost complete relief at once. A repetition of the same, ten or twelve days afterwards, produced a perfect cure." Medicated injections into the cavity of the uterus are not always safe, even if the cervical canal is dilated. There are four other methods of applying medicinal sub- stances to the internal cavity of the uterus (the endome- trium), which are preferable to the use of injections, namely: (a) The brush or swab. The brush is made of pig's bristles, and should be not over one-fourth inch in diameter. The swab is simply a bit of "absorbent cotton-wool," or clean, white cotton-wool, wound around the end of a flat probe or applicator to the length of one or two inches, and one-quarter or one-eighth inch thick. The cervix should be previously dilated. When the brush or swab is used it should be passed quickly up to the fundus uteri, and moved from side to side or rotated, so as to bring it in contact with the whole surface of the cavity. (b) The cloth-tent, first introduced by Dr. Taliaferro, of 96 UTERINE CAUSES. Columbus, Georgia, and into our school by Dr. E. W. Beebe, of Wisconsin,* although they have been used for centuries, even by Hippocrates. The following is the method of their manufacture, as described by Dr. C. Leonard: "To make one, you need but a strip of linen, six inches in length by three-quarters of an inch in width, a piece of hair wire four inches long, and a few inches of common thread. Roll one corner of the linen strip lightly between the thumb and finger, then unroll and place the centre of the wire at the corner so rolled, and then roll the cloth at this corner over it (spirally, just as you would go to work to make a paper lamp-lighter), till you get almost to the other corner of the same end, then bend the wire upon itself (double it, in other words), so that the two extremities will point to the unwound portion of the linen; this done, continue rolling the linen, in a spiral manner, about the doubled wire till exhausted, then tie with the thread the last spiral turn about the wire. You now have a tent about two and a half inches in length, and one sufficiently firm to enter any normal uterine canal, and almost any abnormal one. You can bend it to any curve you choose to facilitate its introduction. "It has still another advantage over all other tents, in that you can leave it in situ (as I frequently do, for twenty-four hours) with no danger to your patient, as it is inexpansible, and hence no excitor of metritis, though a stimulator (from its very slight mechanical irritation) to the endometrium. By so doing you can get a prolonged action of a medicament upon the lining membrane of the uterus, which is impossible to get by any other method of application. Further, you need not use such energetic local applications, and you may be sure that they reach the whole uterine cavity; something you cannot do with our intrauterine applicators, unless you are a very skilful manipulator. The shape of the fundus cavity is au anatomical proof of the great difficulty of making a complete application with the common metal applicators; whereas the cloth-tent, by meeting with resistance at the fundus, immediately doubles upon itself, thus occupying the whole cavity. * American Homeopathist, November, 1877 (Dr. E. W. Beebe). UTERINE CAUSES. 97 "You can make them of any size, and of any degree of stiffness, by increasing the thickness of cloth, and the size or number of doublings of your wire. I have them of all sizes, from those suitable for an ante-puberal uterus to one as large as your index finger. "I use them now for cleansing the uterine tract previous to an application of astringents or other medicaments thereto, and find they clean away the tenacious mucus much better than a syringe or a wisp of cotton on Emmet's applicator. Indeed, it is invaluable in many ways. By leaving the thread without the vulva, the patient can as easily and safely re- move it at her residence as can her physician. You have only to remember to tie a string (or a colored thread) to the cotton pledget you leave in the vagina, so that she may be made aware which to remove (pull) first.” Dr. E. W. Beebe claims for them substantially the same advantages as those above mentioned. I have frequently used them, made extempore, without the wire, when the cervical canal is open enough to permit their introduction, or after I have dilated the passage by means of laminaria tents. (c) Packing.—This method has been used by many gynæ- cologists and by myself for years. It has lately been highly recommended by Dr. Carr,* of Galesburg, Ill. It consists of taking narrow strips of clean white linen or cotton, one- quarter inch by six or ten inches long. Saturate this in the medicinal solution, and folding one end over an applicator, push it gently up to the fundus; then, withdrawing the appli- cator or probe, push up another portion, and so on until only a short portion is left hanging in the vagina. It can be removed in a few hours. (d) Slippery elm bougies, made of the proper size, and soaked in the appropriate medicinal solution, or powdered over with the drug. In all cases the drug selected should be that one which corresponds in its topical action to the diseased condition of the mucous membrane. This method is as strictly according to the law of similia as if the drug was given internally by * American Homeopathist, February, 1878. 98 UTERINE CAUSES. the mouth. The curative action exerted by these local applications is "homeopathic," "alterative," or "substi- tutive," as we prefer to call it. The following are the most useful agents for the above methods: Comp. tine. iodine, Tinc. ferr. mur, Conc. sol. carbolic acid, Ext. pinus canadensis, Nitric acid, Chromic acid, and all those mentioned in the list given above. Those mentioned in both lists, all but nitric and chromic acids, can, in old, intractable cases, be used diluted one-half glycerin. Nitric and chromic acids should be diluted one- half with pure water. The bougies should be introduced up to the fundus (first di- lating the cervix with a sponge or laminaria tent if necessary), and allowed to remain there three or six, and even twelve. hours, if they can be borne. If they cause continued pain, the patient should be told to remove them. They should be repeated every four or six days. It rarely requires more than two or three months to cure the most obstinate case, and conception can occur as soon as the mucous membrane is restored to a healthy condition. If the medicated bougie can not be borne, suppositories niedicated with the same reme- dies act well; they soon melt, and cause little or no irrita- tion. I have been successful with medicated suppositories, after the plan of Simpson and Sims. These are an inch and a quarter long, and small enough to pass along the cervix, and medicated with various remedies, so as to bring these into permanent contact with the diseased surface. I know that suppositories medicated with Conium, Calendula, Hy- drastis, Iodine, Sanguinaria, Iodoform, Carbolic acid, Tannin, etc., act very favorably in cervical induration or hypertrophy. The best forceps to use in introducing these suppositories into the cervical canal, or dressings to the os, is Bozeman's. Suppositories, for intrauterine use, are made of cocoa-but- ter, with which are incorporated certain medicinal agents. The chief objection to their use is that they are very brittle and difficult of introduction, unless the cervical canal is open and straight. I have lately been using flexible bougies made of gelatin, which melt in the uterine cavity in an hour or UTERINE CAUSES. 99 two, and are much easier of introduction.* My favorite formula for the suppositories or bougies are, to each one, SHEPARD & DUNLEY- FIG. 19, Bozeman's dressing forceps. one-eighth inch thick and two inches long, Carbolic acid, one grain; or Muriate of hydrastia, two grains; or Iodo- form, two grains; or solidified Copaiva, two grains. These are pushed up with dressing forceps, and a cotton tampon placed against the os to prevent their extrusion. ENDOCERVICITIS is known to us by the synonyms of cer- vical catarrh and cervical leucorrhoea. It is a chronic inflam- mation of the mucous membrane, extending from the os internum to the os externum, and over the vaginal portion of the cervix uteri. Dr. Sims (Uterine Surgery) gives the following reasons why cervical leucorrhea is a cause of sterility: "It is almost always of albuminous consistence, and very difficult of removal. Under the microscope it presents all the characteristics of muco-pus. Sometimes it is merely an exaggerated secretion, without any abnormal qualities. It interferes with conception in two ways, mechanically and chemi- cally: mechanically, by blocking up the canal of the cervix, and preventing the passage of the spermatozoa; chemically, by poi- soning or killing them. I have frequently seen conception. happen while using the nitrate of silver for granular erosion of the os and cervix uteri. Unless there is some special reason for it, I never interdict sexual congress during the treatment of ordinary cases of cervical engorgement. When conception has taken place under these circumstances, I am *They can be ordered of A. Arend, 179 Madison Street, Chicago. UorM 100 UTERINE CAUSES. satisfied that sexual intercourse must have occurred within ten or twelve hours after the use of the remedy, or at least before its eschar began to separate, which is always attended with a secretion of muco-pus, that would be fatal to the spermatozoa. "If I were asked what, next to mere mechanical obstruc- tion of the cervix uteri, constitutes the greatest obstacle to conception, I have no hesitation in saying that it was an abnormal secretion from the cervix. We often see the cer- vical mucus in such large quantities that its mere abundance will mechanically prevent the passage of the semen to the cavity of the uterus. Sir Joseph Oliffe has informed me of the case of the wife of a medical man, who had been sterile for many years, and whose cervix uteri had always presented a little mass of ropy mucus hanging from the os, that ob- structed mechanically the canal. At last the doctor had the rational surgical idea to exhaust the cervix of its inspissated mucus; and sexual congress with his wife, immediately afterwards, was followed by conception. "I am now satisfied that the cervical secretion is often poisonous to the spermatozoa, even when it would seem to be almost normal in appearance. This must depend upon. some other quality than mere alkalinity, for I have often found all the spermatozoa in the cervical mucus dead, while it manifested no unusual degree of alkalinity when tested by litmus-paper; but when placed under the microscope, it showed an uncommon number of epithelial scales. This demonstrated an abnormal action in the glandular apparatus, that gave rise to this secretion, which seemed to kill the spermatozoa more by its density than by its chemical action; for I have noticed that they lived longer in that portion of the mucus that had the fewest number of epithelial scales, and, vice versa, died quicker in that portion that had the most, and that, too, when litmus-paper showed no difference in the chemical character of the two." Professor Meigs, of Philadelphia, adds his testimony to the effect of cervical leucorrhoea in preventing conception. That author observes* that some cases of sterility are caused * On Diseases of the Uterus, p. 56. UTERINE CAUSES. 101 by a plug of viscid lymph filling the canal of the cervix, so obstructing the passage as to render it apparently impossible that any spermatozoa could obtain access to the uterine cavity. "Certain it is," he says, "that some sterile women are always affected with this excessive albuminous produc- tion. Surprise has often been expressed on observing that married women, after years of sterile cohabitation, have sud- denly become fruitful. In these instances, the want of fruitfulness could not depend on failure of the ovulations. May it not be that the spontaneous cure of a protracted and subacute inflammation, of the kind herein treated of, may have restored the health, and so given power to take away the woman's reproach ?" Treatment: Guernsey gives the characteristic indications for seventy-two remedies, the same as recommended in uter- ine catarrh. I have found most useful the medicines which were men- tioned in endometritis. I have also used topical applica- tions of some of the remedies to the canal of the cervix, with Sims's applicator, or my intrauterine and cervical applicator; FIG. 20. Sims's cervical applicator with cotton attached by a thread. or placed them in apposition to the os uteri, and with the effect of hastening the curative process. I adopted this plan several years ago, and I am every year better satisfied with its usefulness. It has been thought, and is still believed by many of our school, that topical applications to the cervix, by any method, could be productive of but little benefit. But no one who has tested them thoroughly can doubt their efficacy. Remedies thus applied act by osmosis, and produce. not only a local but in some cases a constitutional effect. Dr. W. H. Holcombe, one of the most logical thinkers of our school, believes in this method of applying properly chosen remedies.* *Nature and Limitations of the Homoeopathic Law. 102 UTERINE CAUSES. My applicator, as figured in the cut, is made of hard rubber, with a whalebone rod, ten inches long. The tube, c d, is the size of a No. 7 catheter (Eng.), which carries the rod a b, extending two and a half inches beyond its FIG. 21. d a 0000000 Hale's cervical and intrauterine applicator. extremity, represented by the space d b. The rod is flat- tened from d b, and terminates in a rounded blunt end. In using it the cotton is wrapped around the exposed portion of the rod, with a strong thread attached (as in Sims's ap- plicator). This cotton is saturated with the medicinal agent selected, and if the application is to be made to the cavity of the uterus, the cotton is drawn back into the tube before it is introduced, when it is protruded and left in the uterine cavity, or withdrawn after applying it to the endometrium. If the application is to be made to the cervical canal, the cotton is wrapped as above, medicated, and introduced up to the end of the tube. The tube is then pushed, by means of the ball or ring near the handle, until the cotton is pushed off, when both the tube and rod can be withdrawn, leaving the medicated cotton lying in the canal to be re- moved in a few hours. In both applications, the cervical canal may have to be previously dilated by means of sea-tangle tents. This instrument will be for sale by Boericke & Tafel. If Sabina, Conium, Hydrastis, Senecio, or any other remedy is indicated by the symptoms, the nature of the discharge, and the pathological state, give the remedy internally by the mouth, and apply the same to the os uteri, or even the whole length of the cervical canal. I have had patients who could distinctly taste argentum nitrate, iodine, and other medicines, when thus applied to the cervix. Dr. Sims says his patients complain of the taste گر UTERINE CAUSES. 103 of tannin a few minutes after its application to the cervix uteri. ABRASION, EROSION, ULCERATION.-Although these lesions of the os and cervix uteri are generally considered causes of sterility, they are not by any means invariably so. Whitehead, Gardner and Sims enumerate ulceration as a cause of sterility, but admit that it is oftener a cause of mis- carriage. Nevertheless, women do often conceive, and go through the full period of pregnancy, with the os and cervix more or less the seat of one of the varieties of ulceration. It is only when the engorgemeut, poisonous discharge, or occlu- sion of the os, which sometimes attends ulceration, prevents the spermatozoa from passing into the uterine cavity, that sterility results from this condition. According to Donne, the spermatozoa live in pus and blood. Sims says he "has frequently seen conception to happen when the cervix uteri was in a state of profuse sup- puration, so that pus, per se, was no hindrance to this." In the early years of homeopathy, it was a dogma of that school that no application whatever should be made to a dis- eased surface. Consequently, in all the old text-books of our school, no topical application to a diseased uterus was men- tioned, unless with disapprobation. The immediate followers of Hahnemann failed to see that an agent may act according to the law of similars even when applied to the diseased surface externally. I regret that there are a few anti- quated members of our school who still cling to this absurd notion. To deny that a weak, mild application of nitrie or chromic acid to an ulcerated surface is not homeopathic, is to deny the truth of the homeopathic law, which is not limited, but universal in its application. During the first ten years of my practice, I followed faith- fully the dogma above referred to, and although I faithfully prescribed the carefully selected remedies then known to our school, I never cured a case of ulceration or erosion of the os uteri. Even when I supplemented the internal medica- tion with vaginal injections of water, pure or medicated with Calendula and other medicines, my success was but little better. Afterwards I had better success when I touched the 4 104 UTERINE CAUSES. diseased surface with glyceroles of Calendula,* Hydrastis, Thuja, etc. Not content with this treatment, which failed in a ma- jority of cases, I took the rational ground of applying certain agents which I knew would cause similar conditions of the surface if applied in strong solutions, or the crude substance. I commenced with the nitrate of silver, at that time the best known and most generally used of all the eschorotics. At first I used solutions of varying strength, and with them made my first satisfactory cures. I soon learned, however, that this agent was not suited to all cases. The sphere of action of argentum nit. is confined to those cases where the cervix has a deeply congested, red, and angry appearance. The redness is so intense as to be livid, and presents a velvety appearance. It bleeds readily, and dis- charges a muco-pus, although often no discharge occurs The menses are too frequent and profuse; there are sharp quick stitches in the cervix and vagina. The vagina is often intensely red and eroded, and an irritating, corrosive leucor- rhoea is present. In such cases, a sponge moistened with a solution of five or ten grains of the crystals to 3j of water, applied lightly every four or five days, will often act very happily. The solution should be strong enough to coagulate the albumen on the surface (after all the mucus and pus has been care- fully wiped off). But I now adopt the following methods: (a) I rarely use the solution of nitrate of silver, but prefer, in nearly every case, to touch the erosion, abrasion, or ulcer with the solid stick. The application should con- sist of light, quick, delicate touches of the blunt rounded stick. Never use the pointed stick, and never allow it to remain in contact with the surface more than a second. Before the nitrate or any other drug is applied, the sur- face should be wiped dry of all secretions adherent to it. (b) Instead of lint as a dressing to the ulcerated surface, cotton saturated with pure Glycerin (diluted 1), medicated * The best and only proper preparation of Calendula off, for topical use should be made as follows: Calendula flowers, 3j; Water, Ziv; place in an open-mouthed bottle and allow it to stand in a warm place six hours, then add giv of glycerin, and macerate several days; strain or filter. UTERINE CAUSES 105 with the remedy indicated by the condition. To prepare a dressing to apply to the ulcerated surface, which has or has not been touched by the nitrate, take some fine cotton,* made into a ball, with a strong thread passing through it, im-- merse it in tepid water, and squeeze it gently under the water till it becomes perfectly wet; then press all the water out of it, and saturate with pure Glycerin, or a medicated glycerole. To do this, lay the moistened cotton in the palm of the hand, spread it out circularly for an inch and a half in diameter, more or less, as may be needed, scooping it out in the centre; then drop half a teaspoonful of Glycerin on it, thus held, and rub it into the cotton with the point of the finger, then pour a little more Glycerin and rub it in, and so on until the cotton becomes saturated. When finished, the cotton should feel soft and pulpy, should be about an inch and a half in diameter, and about half an inch thick. This dress- ing should be applied immediately after the application of the nitrate, and before the speculum is removed. When I use medicated Glycerin, it is usually of the proportion of one drachm of the mother tincture to one ounce of Glycerin. For dressing after the nitrate, the Calendula glycerole is best; Hamamelis glycerole when there is a varicose condition of the cervix with bleeding. Hydrastia mur. glycerole is often very useful. (See list of preparations on page 94.) There are other agents, however, which I now prefer to the nitrate. In fact, I rarely use that caustic in my practice, pre- ferring in nearly all cases Chronic, Carbolic, and Nitric acids. Chromic acid is superior to all others in granular erosions, which are very irritable, bleed readily, cause swelling of the os and cervix, bloody purulent leucorrhoea, frequent and pro- fuse menses, sometimes as often as every fifteen or eighteen days. In all cases it should be applied strong enough to cause the diseased surface to assume a yellow color. A solution of five grains to 3j of water will suffice. In severe and more ob- stinate cases, thirty grains to 5j must be used. Apply with a bit of cotton closely wound on the end of a flat silver appli- Touch lightly only the diseased surface, which has been thoroughly wiped off. After it has dried, apply the cotton cator. *There are now two elegant preparations of cotton, far better than the ordinary cotton-wool, namely, "borated cotton," and "absorbent cotton." 8 106 UTERINE CAUSES. tampon moistened with a Calendula or Hydrastis glycerole. Once in seven days is often enough to apply this agent. Nitric acid is indicated when the granulations are intensely red, livid, and irritable, or where actual ulcerations exist. The ulcers are round, well defined, with sharp edges, and a lardaceous bottom. It is equally useful in the fissured ulcer. If the ulcers are syphilitic it is quite efficient, although it may have to be superseded by the acid nitrate of mercury. Carbolic acid is called for when the ulceration is superficial and spreading; when the granulations are large, flat, or pointed, but pale and flabby. The discharge from the dis- eased surface is purulent, fetid, and often sanious. The strength of the solution should vary with the intensity of the disease. If recent, and the granulations small, a solution of ten grains of the crystals to 5j of water will suffice. In older cases, 5j of the acid to 5v of water will have to be used. The best dressing to follow the application of carbolic acid is Kennedy's Ext. Pinus canadensis, 3j. Glycerin, ziij. Apply on cotton, to be removed in twelve hours. This dressing alone will cure some mild, recent cases of erosion or abrasion. There are many other agents which are excellent applications, when applied on the cotton tampons, namely: Nitrate of bismuth, grains 60, to Glycerin, 3j. Tannin 3j, to Glycerin, 3j. Tinc. iodine, 3j, to Glycerin, 3ss. Nitrate of sanguinaria, grains v, to water and Glycerin, of each, Zj. Muriate of hydrastia, grains x, to water and Glycerin, of each, 3ss. Merrill's fluid hydrastis, 3j, to Glycerin, 3j. Tinc. thuja, ss, to Glycerin, ss. Tinc. eucalyptus, 3ss, to Glycerin, 3ss. Chloral hydrate, grains x, to water and Glycerin, of each, 3ss. Tinc. Grindelia, 3j, to Glycerin, 3j. If Glycerin is inadmissible, owing to some idiosyncrasy of the patient, Cosmoline or Vaseline can be substituted with advantage for it. Kali bichromicum (1 gr. to 5j), in deepseated ulcerations, with a red margin and fungous appearance. Many others. could be named, but the physician must carefully select the medicine which is indicated by the condition and symptoms. (c) When these acids are used, they should not be applied oftener than every five days. The medicated dressings should UTERINE CAUSES. 107 Fro. 21. be used once a day. The patient can be instructed to apply them in the morning, and remove them at night on going to bed, or vice versa. When these dressings are used no injections are needed for cleanliness; for, as remarked by Dr. Sims, the Glycerin "seems to set up a capillary drainage by osmosis, producing a copious watery discharge, depleting the tissues with which it lies in contact, and giving them a dry, clean, and healthy appearance. When such a dressing is applied to a pyogenic surface on the cervix uteri for a few hours, and then removed, the sore will be as clear of pus as if it were just washed and wiped dry." Dr. Sims gives a cut illustrating an instru- ment, the "porte-tampon," which he says. any woman can use with ease. The tampon is placed in the open cavity, the door shut, the instrument introduced as far as possible, the tampon pushed out by the piston, and the porte-tampon withdrawn. There are now several new instruments for this purpose. A Fergusson's speculum may be used and the tampon pushed up through it by means of a stick the size of a lead-pencil. * LEUCORRHEA in general cannot be consid- ered as a cause of sterility. Such a general- ization is not in accordance with the spirit and scope of modern scientific investigations into uterine pathology. Leucorrhœa may be said to consist of three varieties: (1.) A discharge from the cavity of the fundus uteri. (Endometritis.) (2.) A discharge from the canal of the cer- vix. (Endocervicitis.) (3.) A discharge from the mucous mem- brane of the vagina. (Vaginitis.) The first variety has been considered in another place, namely, in the preceding par- agraph, relating to Endometritis. The second variety has been treated of Sims's Porte-tampon. above, under the head of Endocervicitis. * Uterine Surgery, p. 295. 108 UTERINE CAUSES. The third variety will be considered under the head of Vaginal Causes of Sterility. DYSMENORRHEA.--This condition, as a cause of sterility, will also be found treated of under the heads of "Stricture or Occlusion of the Cervix," "Uterine Displacements," "Uter- ine Tumors," and "Inflammation of the Uterus." Dysmenorrhoea is divided into six varieties: of these, two only are constant causes of sterility; namely, the obstructive and the membranous. The other four are only exceptional causes; namely, the neuralgic, spasmodic, congestive, and inflam- matory. Treatment.--Anything like a thorough consideration of the treatment of these varieties of dysmenorrhoea, would oc- cupy too much space in this volume. A brief enumeration of the most useful remedies will have to suffice: I. For neuralgic dysmenorrhoea, Aconite, Agaricus, Bella- donna, Cimicifuga, Ferrum, Gelseminum, Pulsatilla, Platinum, Senecio, Scutellaria, Xanthoxylum, Zine, Viburnum, etc. II. The congestive requires Aloes, Aletris, Belladonna, Cimi- cifuga, Borax, Sabina, Hamamelis, Lilium, Murex, Secale, Sepia, Ustilago, etc. III. The spasmodic requires Caulophyllin, Cannabis ind., Nux vomica, Ignatia, Viburnum, Secale, Cimicifugu, Ustilugo, Iodoform,* etc. IV. The inflammatory, Aconite, Belladonna, Gelseminum, Veratrum viride, for acute, and a host of remedies, too nu- merous to mention, for chronic. The so-called pseudo-membranous has beeu cured with Bro mine, Guaiacum, Borax, and a few other remedies. Guernsey gives the characteristic, or key symptoms, of ninety medi- cines, for the cure of all the varieties. AMENORRHEA.--The pathological conditions resulting in amenorrhoea may cause sterility, but not the amenorrhoea itself. "I do not know," says Dr. Sims, "that conception has ever occurred previously to the menstrual flow. . . . Many women * See Cincinnati Medical Advance, 1878; also Therapeutics of New Remedies. UTERINE CAUSES. 109 conceive without menstruating, but it is always during men- strual life." There are on record cases of conception occur- ring after the change of life has been passed ten or fifteen years. It may sometimes occur during a temporary amenor- rhoea of a few months. (See Jackson's paper on Ovulation, at the beginning of this work.) If amenorrhoea arises from a failure in the function of ovulation, conception cannot occur. (See "Atrophy of the Ovaries," and other ovarian disorders) If it results from phthisis, or serious chronic diseases, ster- ility is an accompaniment. If from an atonic or torpid con- dition of the ovaries or uterus, the resulting sterility may be cured by remedies homoeopathic to the condition; such as Sabina, Cantharis, Bromine, Aletris, Cannabis indica, Phos- phorus, Helonias, Ruta, Agnus custus, Conium, etc. If the retention of the menses result from some mechanical cause existing in the cervix or vagina, consult the paragraph treating of stricture, occlusion, etc MENSTRUAL IRREGULARITIES.-It sometimes happens that certain irregularities in the quality, quantity, and time of appearance of the menses, are the only symptoms attending sterility which we are permitted to know. Cases will now and then occur, when no examination by the touch or specu- lum will be submitted to, and we are compelled to prescribe for the symptoms as related to us. The chief remedies for menstrual irregularities are: For scanty menses,-Conium, Agnus castus, Caladium, Aletris, Cocculus, Secale, Subina, Graphites, Natrum mur., Senecio, and Sepia. For profuse menses,-Sabina, Erigeron, China, Ipecac, Cro- cus, Platinum, Nux vom., Hydrastis, Trillium, Murex, Senecio, Ruta, Secale. (See the indications for the hundred or more. remedies, in Guernsey's Diseases of Women.) Too frequent and profuse menses are generally controlled by Calcarea, Senecio, Platinum,Crocus, Sabina, Ustilago, Secale, Lilium, and Xanthoxylum. When this condition is unat- tended by any lesion of the uterus the Bromide of Ammo- nium, 5 grains 3 times a day will regulate it. 110 UTERINE CAUSES. For delaying menses,-Pulsatilla, Senecio, Aletris, Natrum mur., Graphites, Helonias, Cimicifuga, etc. Nearly all these irregularities depend on some pathological condition of the generative organs. It will be necessary, then, when possible, to ascertain the nature of the causes, and consult the treatment of the conditions in the preceding pages. AREOLAR HYPERPLASIA OF THE UTERUS. *This disease of the uterus, once known as chronic parenchymatous metritis, is one of the most intractable with which we have to deal. The great pathologist Kolb defines this condition of uterine areolar hyperplasia as "a diffuse growth of connective tissue which constitutes the so called induration, hitherto consid- ered as a result of parenchymatous inflammation of the uterus. . . . The whole uterine connective tissue sometimes proliferates, either without accompanying increase of the muscular substance, or if this does occur, the connective tissue predominates to such an extent that the muscular tissue is comparatively of little account." This condition has also been designated as "uterine hy- pertrophy," "enlargement of the cervix," and "subinvolution of the uterus" (Simpson), also "chronic engorgement of the uterus and cervix." No morbid condition has given gynecologists so much trouble. Allopathists and homeopathists alike find it obsti- nate and intractable. I will not attempt to describe the appearance and symp- toms, but refer the physician to the exhaustive and graphic description given by Thomas, Diseases of Women. I will, however, quote his condensation of the causes, symptoms, etc., namely: Predisposing Causes. A depreciation of the vital forces from any cause. Constitutional tendency to tubercle, scrofula, or span- æmia. * This paper was presented to the Massachusetts Surgical and Gynæco- logical Society, at the June meeting, 1878. With some additions I have incorporated it into this work.-H. UTERINE CAUSES. 111 1 Parturition, especially when repeated often and with too short intervals. Prolonged nervous depression. A torpid condition of the intestines and liver. Exciting Causes. Overexertion after delivery. Puerperal pelvic imflammation. Laceration of the cervix uteri. Displacements, endometritis, neoplasms, cardiac disease. Abdominal tumors pressing on the vena cava. Excessive sexual intercourse. Symptoms. If the cervix alone be affected there are: Pain in the back and loins. Pressure on bladder or rectum. Disordered menstruation. Difficulty of locomotion. Nervous disorder. Pain on sexual intercourse. Dyspepsia, headache, languor. Leucorrhoea. If the body of the uterus is affected there are: A dull, heavy, dragging pain through the pelvis, much in- creased by locomotion. Pain on defecation and coition. Dull pain beginning several days before menstruation, and lasting through that process. Pain in the mammæ, before and during menstruation. Darkening of the areola of the breasts. Nausea and vomiting. Pressure on the rectum, with tenesmus and hæmorrhoids. Pressure on the bladder, with vesical tenesmus. Sterility. Physical Signs. If cervical hyperplasia exists, there will be: Sinking of the uterus in the pelvis. 112 UTERINE CAUSES. Large, swollen, and sensitive cervix. Normal uterine axis changed, the fundus tipping forward or backward. If corporeal hyperplasia exists, there will be: Uterus enlarged, heavy, and sensitive. The uterine cavity enlarged. Sensitiveness of the internal uterine surface. Uterine hyperplasia can only be confounded with: Pregnancy. Neoplasms, fibrous growths in uterine wall. Periuterine inflammations. Treatment.-Putting aside the treatment of the various causes and complications connected with this condition, and confining ourselves to the special treatment of the areolar hy- perplasia, what medicines are indicated in that pathological state? We must first know what the pathological condition really is which obtains in this disease. It is divided into two stages, and although the same remedies may be indicated in both, the dose and method of administration will differ. The first stage is characterized thus: The hypertrophied areolar tissue is congested, containing absolutely more blood than normal, and the whole of the affected part, neck, body, or entire uterus, is greatly increased in size and weight, and the cavity increased in size. This stage may last months, or even years, but as time passes the second stage supervenes, and an opposite state of things is set up. The large, red, soft and engorged uterus decreases in size and becomes small, contracted, hard, white, and anæmic, and the cavity decreased in size. Kolb thus describes advanced cases: "The parenchyma on section appears whiter, or of a whitish-red color, deficient in blood vessels from compression of the capillaries, by the con- traction of the newly-formed connective tissue, or from par- tial destruction or obliteration of the vessels during the growth of tissue. The firmness of the uterine substance is also increased, simulating the hardness of cartilage and creaking under the knife." This constitutes a true sclerosis of the uterus. Now, in order to select the appropriate remedies, the prac- UTERINE CAUSES. 113 titioner must possess an extensive and thorough knowledge of Materia Medica, such as only studious members of our school can possess. He must not only have a knowledge of the symptoms of drugs, but the pathological conditions they are capable of causing in the uterus or analogous organs. No medicine can be useful in areolar hyperplasia, unless it causes the first stage as well as the second, and the first stage (of congestion, etc.) must have preceded the second. In other words, the history and order of sequence of the medicinal disease must be similar to that of the natural one. I believe there are cases of this disease when the second stage I have described may have been the only recognizable stage, as in those cases of "morbid excess in the involution of the uterus after parturition," described by Simpson. But these cases are rare, and require peculiar treatment. The medicines which are useful in this disease are those which are capable of causing both stages of the pathological condition. They must first cause: Congestion of the uterus, or Inflammation " Enlargement" Edema 66 66 Sensitiveness " t Increased weight of the uterus. 66 capacity 66 66 Painfulness of the uterus. Too frequent and profuse (or scanty) menses. With the various concomitant or reflex sufferings which accompany this stage. They must also cause the following conditions: Anemia of the uterus. Edema Selerosis 66 66 (6 Hard, small, and contracted uterus. Scanty and delaying menses. Together with the various pains and sufferings attendant on such a condition of the uterus. Thomas and other prominent authors do not appear to lay 114 UTERINE CAUSES. down any treatment for this second stage, either because they consider it not amenable to treatment, or because there is no necessity for any treatment. I propose to give such treatment for the second stage as the materials of our Materia Medica permit, because it causes one condition, namely, sterility, which we are often called upon to treat, and with such indifferent success. The medicines generally indicated for the first stage of the disease are the following (those italicized are the most im- portant.): Apis. Asurum. Cauloph. Cimicifuga. Podoph. Platinum. Aurum. Calc. carb. Ruta. Ammonium carb. Erigeron. Sanguinaria. Argentum nit. Ferrum. Sabina. Arsenicum. Hamamelis. Sepia. Esculus. Helonias. Secale. Belladonna. Lachesis. Trillium. Borax. Lilium. Terebinth. Cantharis. Merc. cor. Tanacetum. Cannabis ind. Murex. Thuja. Cocculus. Nux vom. Senecio. Crocus. Nux mosch. Ustilago. Cactus. Pulsatilla. Sulphur. All these medicines, by their primary action, cause the following conditions of the uterus: Irritation. Congestion. Inflammation. Enlargements. He NOTE. Prof. R. Ludlam (U. S. Medical Investigator, Nov. 1877) recom- mends Tartar Emetic 3x in "corporeal cervicitis, with concentric hypertrophy due to effusion of serum into its tissues." He says he has used it successfully for ten years, yet he does not mention it in his "Diseases of Women." also asserts it to be one of the best internal remedies for "catarrhal inflam- mation of the glandular portion of the cervix." The conditions for which he recommends it are not exactly "areolar hyperplasia," although they may be precedent or concomitant conditions. The first might be called "œdema of the cervix," for which, on page 118 of this work, I have advised Apis, Ars. iod., Polymnia, etc. From some recent experience, I am inclined to believe that Antimonium iod. or Antimonium ars. will prove more useful than Anti- monium tart., especially in chronic cervicitis with œdematous enlargement. UTERINE CAUSES. 115 Attended by: Sensitiveness and tenderness of the uterus. Increased weight (6 capacity 66 66 66 (6 (6 Painfulness Too frequent menses (with menorrhagia), or, Too scanty menses. Dysmenorrhoea. With all the reflex symptoms belonging to such condi- tions. These remedies should be carefully selected by the symp toms, and also by the "genius" of the medicine. They should be prescribed in the attenuatious from the 6th to the 30th, and not too often repeated. Many of them may be applied to the uterus on cotton tampons, by diluting them to the strength of 1x or 2x, using glycerin as a vehicle. There are a few exceptions to this rule, namely, in cases of subinvolution after parturition or miscarriage, when, if the carefully selected remedy does not bring about a rapid change, we should resort to those medicines which act in material doses in such a way as to contract the blood vessels of the uterus, and thus cut off the nutritive supply, and at the same time contract the muscular fibres to decrease the size of the engorged and soft parenchyma. There are but few medicines capable of such action, namely: Bromides of po- tassa, ammonium, lime, soda, etc., Cuulophyllin, Secale, Usti- lago, and perhaps Gossypium and Viscum alb. These should be given in the following manner : 66 66 Bromide of potassa, etc., 5 to 10 grains every six hours. Caulophyllin, Secale, Ustilago, Gossypium or Viscum album, I to 1 grain 5 to 30 drops of a good extract every six or twelve hours, or 10 grains of the 1x trit. of ergotin every four hours. 5 to 10 grains of the 1x trit. every two or four hours. 5 to 10 drops every two or four hours. 116 UTERINE CAUSES. In the treatment of the first stage there are certain very important auxiliary measures which must be prescribed, for without them medicines can do little. (1) In severe cases rest in the recumbent posture for a few hours each day, with a few hours' walking or riding in the pure open air. The removal of all pressure from the abdo- men from tight corsets, heavy skirts, etc. (2.) The use of plain, non-stimulating food and beverages, and an open state of the bowels. (3.) Nearly complete abstinence from sexual intercourse; at most, a few times midway between the menstrual periods. (4.) Enemas of hot water of a temperature of 100° to 110° F., and in quantity not less than a quart, or more than three or four gallons. This should be thrown in a steady stream against the cervix uteri, by means of an ordinary pump syringe, or a fountain syringe; the latter is the best, as no labor of the hand is required, and the reservoir can be as large as required. It can be used once a day-at night-or in obstinate cases, twice daily. Those who have never tried this method will be surprised at the change in size and color -a diminution of both-which will take place after the use of the hot water for a week or two. It is now the standard and popular practice of all the best gynecologists. (5.) Local depletion by means of leeches, or the scarifi- cator. In the early years of my practice, I closely adhered to the teachings of the leaders of our school at that time (1850 to 1865). But my success in treating uterine disease was neither satisfactory to myself or my patients. I then resolved to adopt the modern teachings of those eminent gynaecologists, who, while they discarded the general deple- tions, painful caustics, and other horrible measures of the allopathic schools, imitated nature's processes as far as possi- ble. Nature causes a congested uterus to bleed to relieve the engorgement, or contracts, by means of vaso-motor nerves, the dilated blood vessels. The application of a single leech to the os uteri relieves the local engorgement, and allows our remedies to act better than they could possibly do before. Scarification of the os and cervix does the same. But I pre- fer to either the spear. This little instrument, first introduced to notice by Dr. Buttles, bears his name. Its sharp, delicate UTERINE CAUSES. 117 16 point is thrust into the enlarged and congested cervix, about the of an inch, and given a single turn before it is renioved. Six or eight punctures will cause a flow of from half to one ounce of blood, according to the severity of the case. There are certain indications for the use of local depletion, and they FIG. 22. Chapman's scarificator. should be closely followed, namely: When the woman com. plains of sensations of fulness, weight, soreness, and aching in the uterus, it should be used. Now these sensations gener- ally occur every week or ten days, during the intermenstrual periods, and denote recurring congestions. They always precede the appearance of the menses, which may occur every two or three weeks. It has been my practice for several years to use the spear whenever these symptoms are complained of, and the relief given to the patient is always gratifying. FIG. 23. Buttles's spear-scarificator. By this means I have regulated the appearance of the menses, that for years had occurred too often. It prevents profuse menorrhagia, and causes the too scanty and painful menses to be natural in quantity. The uterus in this disease may be so congested as to bleed too much (menorrhagia), or so engorged as to bleed too little, or not at all (suppression of the menses). In either case if we relieve the local congestion, we remove the cause of the abnormal menstrual flow. This cannot be done by medicines alone, unless absolute rest be adopted, and then it requires a long time. It must be noted that I do not refer to other conditions of the uterus, or ulceration, atouy, etc., but only to the first stage of areolar hyperplasia. 118 UTERINE CAUSES. Local Depletion as a Cure for Sterility.-But the most valuable and important result which often follows the use of local depletion, is the restoration of the ability to conceive. Long before I adopted its use, I was acquainted with numerous cases, several of them former patients of mine, who after a few applications of leeches, became pregnant, much to their surprise. Some of these patients had never before been pregnant; others had not borne children for many years. One case in particular impressed me profoundly, a lady, married fifteen years, who had never been pregnant. She had been treated by eminent men of both schools. She was under my care nearly a year; there was no abnormal appearance visible except enlargement and chronic conges- tion. The menses were delaying, very sranty, and very pain- ful. After she left my care she was advised by an English nurse to apply a leech to the uterus about the time the menses ought to appear. She became pregnant after the second application. Three years afterwards she suffered from a return of her old troubles; leeches were applied, fol- lowed by another pregnancy; and this occurred the third time! This patient informed other sterile women of this fact, and some of them tried it with success. I have the records of several cases where the use of the spear-scarificator was soon followed by pregnancy in women who had been sterile for several years. Another method of local depletion which should not be neglected, is by means of tampons of medicated or pure Glycerin. I have already given the uses of these in another place; also the method of their application. It remains only to point out the condition requiring them. In many cases the cervix presents a swollen, puffy, and pale appearance. It looks odematous, and is in fact œdema- tous. It is engorged with serum instead of blood. A punc- ture with the spear brings but little blood, but a watery exu- dation. I have seen cases in which the cervix actually pitted on continued pressure. The medicines indicated in this con- dition are Apis, Aquaphobin, Arsenicum, Cantharis, Hamamelis, Iodine, Lachesis, Naja, Murcx, Merc. cor., Phytolacca, Sepia, and Sulphur. The action of Glycerin when applied continuously to such a cervix is to cause profuse drainage, or exosmosis 1 UTERINE CAUSES. 119 of water from the oedematous tissues. It should be applied undiluted, night and morning. The addition of one-tenth orth part of Iodine, Iodide of potassa, Hamamelis, Can- tharis, Merc. cor., or Phytolacca, also Polymnia,* greatly increase the value of the Glycerin in removing the oedema- tous enlargement. If the whole body of the uterus is be- lieved to partake of this dropsical condition, a small medi- cated tampon may be placed in the uterine cavity by means * Polymnia uvedalia (Bearsfoot) belongs to the genus Compositæ, of the tribe Heliantheœ. It is an erect herb, roughish, hairy, stout, 4 to 10 feet high, leaves broadly ovate, angled and toothed, nearly sessile, the lower palmately lobed, abruptly narrowed into a winged petiole, outer involucral scales very large; rays 10 to 15, linear oblong, much larger than the inner scales of the involucre; flower yellow. Grows in rich soil west of New York to Illinois, and southward. The flower and whole plant exhale a strong odor; they look like a small sunflower. This remedy was introduced into eclectic practice by Dr. Pruitt, of Missouri (?), who found it useful for enlargement of the spleen. He recommended that it be applied externally in the form of an ointment and given internally. It was found so efficacious in this disease, that it was tried in other enlarge- ments, of the joints, glands, etc., and finally in enlargements of the uterus. I have used it in two cases with success-in uterine hypertrophy (areolar hy- perplasia) in the first stages, before condensation and contraction set in. The dose is 10 drops of the tincture or 1x, three times a day, or oftener, and its use continued for months; at the same time apply a glycerole (1 part of the tincture and 2 parts glycerin) in cotton tampons every night, except during the menses. In my two cases the uterus decreased in size fully one-third in two months. Dr. Scuddera gives the following as his experience, with an estimate of the power of this new remedy. "Let me again say that U vedalia is the straight remedy for those en- gorgements of tissue depending upon an enfeebled circulation. The sensation given to the fingers is a want of elasticity and tonicity, sodden, doughy, atonic. I use the Uvedalia ointment freely, and think of rubbing away a hyper- trophied uterus, or an enlarged joint, as much as I would an enlarged spleen or ague-cake. Recently I had occasion to use it in chronic ovaritis and me- tritis, the cavity of the uterus measuring four inches. The organ was reduced to normal size in four weeks. Internally it has not gotten to be such a favorite, but this is because I have not tried it so often. I am satisfied that in many cases of chronic dis- ease it will be found a most valuable remedy, as it very certainly is in chronic ague with enlarged spleen. "I am sure those who have used it will feel much obliged to Dr. Pruitt for his efforts to bring it to the notice of the profession." & Eclectic Medical Journal, February, 1878. 120 UTERINE CAUSES.. of a proper applicator. I have several times seen excellent results follow their use, in addition to the external tampon. Dr. Thomas (Diseases of Women), after giving all the vari- ous methods of treatment, general and local, thus sums up by candidly giving his own experience and its results: "The best local alterative is the compound Tincture of Iodine, which by means of a brush of pig's bristles should be carried up to the os internum, or even to the fundus, should endometritis exist, and over the cervix; then, waiting for a complete drying, this process should be repeated. After these applications a wad of cotton, to which a string has been attached in such a way as to leave its surface flat, should be saturated with glycerin and laid against the cervix. This acts as a local hydragogue and disgorges the tissues. These local applications should be repeated once a week, but others should be made oftener by the patient herself, by means of vaginal injections, by which the drug just men- tioned may be brought in contact with the cervix. “Mild and lacking in vigor as this course may appear, let any one test it side by side with the plan of using the acid nitrate of mercury, potassa fusa, potassa cum calc., and the actual cautery, etc., . . . and unless his experience greatly differs from mine, he will feel that in the former he has reached a resting-place for his faith in the treatment of the most im- portant of all the forms of uterine disease. He will see proof daily spring up before him that his capacity for bene- fiting his patients has greatly increased, while his liability to injure them has greatly diminished." Treatment of the Second Stage.-The second stage of areolar hyperplasia is the stage wherein sterility is sure to occur, even if it did not occur during the first. But it is possible, by the use of carefully selected remedies and appropriate auxiliary measures, to restore the organ to a condition in which conception is possible. The same medicines mentioned as useful in the first stage, are also useful in the second, but they will not be successful in arousing the torpid energies of the uterus unless they are prescribed in the lowest attenuations, or in material doses. In proof of this may be cited the want of success which has attended their use in such cases when given in high poten- UTERINE CAUSES. 121 cies, and the positive success which has followed their use when given in appreciable doses, by members of our school, and of other schools of practice. Thus Cantharis, Cannabis indica, Moschus, Sabina, Phosphorus, Cimicifuga, Sanguin- aria, and others have been successfully used in quite large doses, and have cured sterility due to atony, atrophy, and paretic conditions of the uterus and ovaries. They cure, by increasing the flow of blood to the shrunken and poorly nourished organs of generation, and by imparting to them a normal supply of nervous energy. It is generally necessary to continue their use a considerable period of time, and aid their influence by the action of electricity, appropri- ate diet, change of climate, etc. There is another class of medicines, however, which are capable of bringing on a condition similar to the second stage of areolar hyperplasia, or sclerosis, by their continued pri- mary action. They are: Arnica. Aletris. Aurum mur. Ammon mur. Argentum mur. Arsenicum iod. Baryta mur. Bromine. Culc. mur. Calc. iod. Cuprum. Carbo veg. Chimaphila. Ferrum iod. Iodine. Kali brom. Kali iod. Kali carb. Lachesis. Lapis alb. Lycopodium. Magnesia mur. Manganum mur. Merc. iod. Morphinum. Natrum mur. Nux vom. Plumbum iod. Phytolacca. Pieric acid. Polymnia uvedalia. Platinum mur. Palladium. Silica. Sepia. Sulphur. These remedies should be prescribed in the medium atten- uations and continued a long time. The muriates correspond to a condition wherein the scle- 9 122 UTERINE CAUSES. rosis is the predominant condition. The uterus is con- tracted, hard, and sometimes atrophied. The iodides are useful in a similar condition, but the atro- phy and hardness are not as well marked, the tissues are sof.er and the sclerosis does not predominate. Arnica, when the original cause was of a traumatic nature. Arsenicum, when there is threatened tissue degeneration. Cuprum and Ferrum in deficiency of red blood-globules, with loss of energy in the spinal trophic nerves (also Nux, Ignatia and Phosphorus). Lycopodium, Kali brom., and curb., Natrum mur., and Plumbum, when the menses have grown gradually less in quantity, until they have nearly ceased. Phytolacca, Chimaphila, Conium, and Iodine when there is atrophy of the mammæ. In this stage the menses are usually very scanty and infre- quent. The uterus is nearly in the same condition as after the "change of life." The ovaries may still carry on the manufacture and extrusion of ovules. The ovules may even become impregnated, but owing to the paretic condition of the uterus, they do not make a lodgment therein. The object of treatment, then, is to stimulate that organ to healthy nutrition. Should this stage appear in unmarried women, marriage, by giving the uterus its natural physio- logical stimulus, will often remove the condition. It is pos- sible that the careful but persistent use of Ulmus fulva bougies, with tampons of cotton medicated with Cantharis 3d, Sumbul 1*, or l'hosphorus 2x, or Bromine 3*, would im- part the necessary physiological life. Electricity. It is in this condition that the use of the stimulating Faradic current ought to be productive of great and lasting good. It should be applied by one who thoroughly understands the modus operandi, aud applied directly to the cavity of the uterus. In these cases, also, the intrauterine galvanic pessary, once recommended by Prof. Simpson and lately by Dr. Thomas, may be found very useful. Nutritive Treatment.-The most careful selection and ad- ministration of internal remedies, as well as the most judi- cious use of topical applications, will sometimes fail to cure UTERINE CAUSES. 123 cases of chronic endometritis, endocervicitis, or chronic metritis (areolar hyperplasia), because of the general constitutional de- bility or acquired fault of nutrition, assimilation, etc. IIomo- opathic physicians are more apt to neglect the nutritive and restorative (tonic) treatment, than are the members of the opposite schools. The senseless "diet rules" which, until lately, were followed by the stricter homeopathists, had much to do in inducing this neglect. Many suppose to this day that if the perfect medicinal similimum is found-i one whose symptoms correspond closely to those of the dis- ease or the patient-nothing else was necessary to bring about a cure. This is not, however, the case. It is as much the duty of the physician to prescribe the exercise, the diet, and the bathing and other hygienic agents, as it is to pre- scribe medicines, or make use of surgical means. e These considerations impel me to make the following ob- servations: " The general condition of the patient should be examined and looked after. If the woman is obese, lymphatic, with superabundance of fatty deposit, we should prohibit all starchy foods, fats, vegetables, etc., and direct her to adopt nearly the diet laid down on page 90, by Dr. Cutter, to pre- vent uterine fibroids. Under this regimen the patient will grow stronger, and the disappearance of obesity will allow her muscular system to become more developed by active exercise. The habitual use of mineral waters-Kissingen, Vichy, Seltzer, Hawthorn, or Sheboygan, and other foreign and native springs-will greatly facilitate the cure. If the patient is thin, emaciated, debilitated, and the vic- tim of some chronic cachexia, with all the functions of vege- tative life in an atonic condition, with defective nutrition and deficient vitality in general, we should add to our specific remedial treatment the injunction to eat the most nutritious and easily digested and assimilated foods. Advise chalybeate waters, sea-bathing, exercise in the open air, the removal from a malarious climate, or from unhealthy houses. Order the use of pure wines, porter, ale, or, better than all, that purest of all stimulants and beverages, Kumyss. This Kumyss or Koumiss is a veritable "wine of milk," 1 124 UTERINE CAUSES. and contains in itself all that is necessary to build up an anæmic, atonic, and vitiated constitution. It restores diges- tion, favors the assimilation of other foods, imparts phos- phates and other valuable constituents to the system, and is at the same time a food, a beverage, and a tonic. Kumyss (Vinum lactis, Lac equinum fermentatum) is pre- pared by the fermentation of mare's milk. The fermenta- tion of milk-sugar produces alcohol, carbonic acid, and lactic acid, and to these products the action of Kumyss seems to be chiefly due. It has now been well-established that the milk of the cow is equal, if not superior, to mare's in the production of Kumyss. In fact, the milk of all animals is convertible into this beverage by one and the same method. Kumyss is now manufactured in Paris, London, New York, Cleveland, Chicago, and, I believe, St. Louis. In order to give the reader some idea of its constituents, I quote the chemical analysis as given by the best authorities: New or fresh Kumyss, when a few days old, has a sweetish, acidulous taste and a sparkling effervescence, and looks like rich milk. It contains alcohol, 1.65 per cent.; fat, 2.05; milk-sugar, 2.20; lactic acid, 1.15; solids, 6.80; casein, 1.12; carbonic acid, 0.785; salts, 0.28. Old Kumyss is not as white, has a stronger acid taste, is very sparkling and exhilarating. It contains alcohol, 3.23 per cent.; fat, 1.01; sugar, 0.00; lactic acid, 2.92; casein and salts, 1.21; carbonic acid, 1.86; solids, 5.04. All the sugar is now converted into alcohol. It is interesting to compare this with the analysis of wines and beer. Claret wines contain from 7 to 12 per cent. of alcohol; champagne contains from 10 to 13 per cent.; cider, 5 to 9 per cent; ale and porter, 4 to 7 per cent.; small beer, 1.28. Kumyss stands midway between small beer and the weakest ales or lager beer. Patients can drink with advantage from one to three bot- tles daily. I have had patients so debilitated from chronic, exhaustive uterine diseases, and with such impaired diges- tion and complete loss of all appetite that inanition seemed imminent, rapidly restored to health by the persistent use of UTERINE CAUSES. 125 Kumyss alone for weeks or months, or until they had suffi- cient appetite and digestion to subsist on ordinary foods.* Next in value is the extract of malt, now so much used in this country. The liquid or granulated malt extract is com- bined with other nutrient or medicinal agents. Among the most useful I esteem the following: Extract of malt with Pepsin. " () Hypophosphites. Iron. Cod-liver oil. The experience and judgment of the physician will enable him to advise the preparation most suitable to the particular condition of each patient. These preparations will not inter- fere with the special, specific medicinal treatment which may be instituted. In certain strumous or scrofulous patients the use of Cod- liver oil is almost indispensable. It will enable us to restore to health patients who would otherwise be absolutely incur- able. As stated in my Therapeutics of New Remedies, besides the fatty food, Cod-liver oil contains many remedial agents in minute quantities, which our school values very highly, namely: Iodine, Bromine, Calc., etc. It need not be given in the large, nauseous doses advised by the opposite school, but will cure in very small doses, 15 to 60 drops three times. a day, if used for a considerable time. When the patient, whether anæmic or not, has a feeble, or irregular and weak circulation, the use of Digitalis or Digitalin, combined or alternated with the specific tonic or nutritive remedy, will greatly increase its restorative power. Digitalis increases the force and vigor of the heart's action, and thus aids the curative force. I recommend Digitalis 1, 5 drops, or Digitalin 2, 2 grains, three times a day. ABNORMAL SHAPES OF THE OS AND CERVIX UTERI.-We often see cases of sterility when there is no symptom of dis- ease, so far as physical suffering is concerned. We may even find the uterus of proper size, in normal position, and * Mr. A. Arend, a chemist, of Chicago, is the originator of Kumyss in this country. After many years of experiment, he has discovered a method of making it from cow's milk, so that it nearly resembles the original Tartar beverage made from mare's milk. 126 UTERINE CAUSES. with a straight cervical canal, but the cervix may be of an unnatural shape. There are several abnormalities men- tioned by Sims, namely: (1.) Normal shape, with "pinhole os." (2.) Conical cervix, with or without "pinhole os." (3.) Crescentic-shaped os. (4.) Too close apposition of the lips of the os. (5.) Destruction of one lip of the os. (6.) Overlapping os; curving of the os, etc. These modifications of the shape, size, and relations of the os tincæ may all become causes of sterility by preventing the entrance of the spermatozoa, and require surgical opera- tions for their removal. Dilating with tents, bougies, etc., do no good; the knife is the only trustworthy remedy. (1.) A pinhole os can be readily changed to an open one of normal size by the bistoury cutting slightly each way. (2.) A conical cervix may be treated in the same manner, but it may sometimes be necessary to amputate the terminal portion, or make deep bilateral incisions. (3.) In crescentic-shaped os, Sims cuts out a triangular por- tion, removing the offending lip altogether. (4.) Closed os fron apposition requires a bilateral incision of the circular fibres of the cervix, with such after treatment as will prevent their closure. (5.) In destruction of one lip there is generally a dense fibrous condition of the cervix. This requires the same op- eration as for constriction of the cervix, the bilateral incision as far upward as necessary, and its subsequent dilatation. (6.) Overlapping cervix requires the cutting off of the over- lapping lip, which straightens the canal and opens the door for the entrance of the spermatozoa. I have treated several cases of Nos. 1, 2, 4, and 6, and in all but a few cases the slight operations performed resulted in curing a sterility of several years. A portion of these cases were congenital, others acquired, or were caused by severe local treatment. One case, similar to the case described by Sims, page 181, Uterine Surgery, where the os closed by a fibrous band, and the menses and a intrauterine catarrh of a sanious irritating character escaped through two small orifices about half an UTERINE CAUSES. 127 inch apart. This band was cut from one orifice to the other, the cervical canal dilated by means of a sea-tangle tent, and the woman, who had not been pregnant for six years, aud had suffered intense agony from dysmenorrhoea, became preg- naut before the next menstrual period. I might add another variety to the abnormal forms of the cervix mentioned by Sims. It might be called the "smashed hat" cervix. It looks like a silk hat that had been sat upon. At the vaginal junction it is of the normal shape and size, but from this point to the os it enlarges, the end of the cer- vix is flat, the edge of the circumference sharp and high, like the base of a cone, while the cervix is corrugated. In the three instances I have observed the os was not larger than a pin's head, and the women were sterile. The best instrument for these operations on the os for the purpose of enlarging the orifice, is that known as Skeene's Hys- terotome. When closed the blade is shut against a probe, like FIG. 24. Skeene's hy terotome. a sound, and is thus introduced into the cavity of the cervix. The blade is then opened as much as is considered necessary, and rapidly withdrawn. It is again introduced, and the other side incised in the same manner. The outer os should be made at least one-fourth of an inch wide. The cut sur- faces should be touched with persulphate of iron, and a cotton tampon wet with Calendula-glycerole, be placed against it. This instrument may be used in place of White's hystero- tome, but it is not quite as safe or exact. Another very useful and safe instrument for incising the os and cervix, is Peaslee's Uterotome. The probe-point is in- troduced up to the os internum, and the lancet-shaped knife is pushed up, incising both sides of the os and cervix equally. In a large proportion of cases of deformed cervix with con- 128 UTERINE CAUSES. tracted os, I have found a tortuous canal. This, besides being an additional obstacle to the entrance of the semen, is an obsta- cle to the ready outflow of menstrual blood, and thus a cause FIG. 25. HAVANINZGO Peaslee's Uterotome. of dysmenorrhoea. This condition is readily removed (after enlarging the os) by the use of the laminaria or ulmus-fulva tent, worn a few hours at a time, and placed every three or four days during the ten days previous to the menses. The patient should not walk or ride during the time the tent is worn. If she does she is liable to bring on hæmorrhage or inflammation.* Conoidal Cervix.-One of the simplest methods of treat- ing unimpregnated os uteri with conoidal cervix and pinhole os is that recently proposed by Dr. E. L. Drake, of Fayette- ville, Tenn. It consists in placing some foreign body in the vagina so that the os uteri will rest upon or against it. A soft rubber or glass pessary, a cotton ball covered with rubber "dam," or a small, soft sponge, similarly covered, will have the effect, says Dr. Drake, of "bringing about sufficient dilatation of the os to admit the tip of the finger. Further, when the uterus, from overweight or laxity of support, presses against the perinæum, or from other displacement. the os is fretted against the vaginal wall for some time, char- acteristic changes are set up, namely, a hypersecretion of mucus, a softening of the tissues, and a considerable degree of dilatation. Thus nature in these cases overcomes a stenosed cervix and contracted os with considerable cer- * In even the slightest operations on the generative organs of women, especially on the uterus, the temperature of the body should be carefully watched. The use of the clinical thermometer is now considered indis- pensable in all surgical procedures, and its use should never be neglected. If the temperature in the axilla or under the tongue is above 98.6° or 99°, no operation should be performed until the temperature becomes normal. If after any operation the temperature rises above normal, give immediately, Veratrum viride, 1 or 7th of a drop every hour or two. No other remedy so surely prevents inflammation. † American Journal of Obstetrics, April, 1878, p. 366. UTERINE CAUSES. 129 tainty, and thereby promotes a free menstrual discharge, unless too much obstruction exists from a flexure at the internal os. The pressure of any foreign body against the os will stimulate the menstrual flux, and so become available in the treatment of amenorrhoea, which is often only a form of dysmenorrhoea." Dr. Drake recommends this simple method in place of rapid dilatation, incision, or amputation. The pessary should be worn for two weeks in the intermen- strual period. He claims that it will also dilate the inner os, for he has observed that the sound passes more readily to the funduș after the use of the pessary. He prefers the concavo-convex rubber or glass instruments. 1 FIG. 26. ones. Conical cervix (alter Sin 8). The following case reported by Dr. Drake appears to sub- stantiate his claim: "It was a typical case of couoidal cervix and pinhole os. The patient's sufferings were intense, last- ing nearly through the intermenstrual period, and leaving her in a wretched condition to withstand the succeeding The sympathetic disturbance was great, manifested in sympathetic cramps of the stomach and torturing head- ache, which were barely held in abeyance with excessive doses of Chloral and Morphine. She had been a sufferer for years, dating from an abortion. I used with her a small glass concavo-convex pessary, and have had no occasion to visit her for months; whereas before, my visits were re- quired regularly at her periods. The last time I examined her the os would admit the tip of the finger." Dr. Mundé, in commenting on this method, quotes a curious case in point, related by Dr. Thomas, in his Diseases of Women, where a globe pessary had gradually dilated the os and 130 VAGINAL. cervical canal, and migrated into the uterine cavity, where it remained for some time, causing obscure uterine symp- toms, until it was detected and removed by Dr. Sayre. My own observations corroborate Dr. Drake. I have known the constant wearing of the cotton ball, changing it every twelve or twenty-four hours, moistened with dilute glycerin, to flatten out a conoidal cervix and enlarge the os, and increase decidedly the usual scanty menses. I once placed in the canal of the cervix a Chambers's intrauterine stem pessary, for the purpose of removing a flexion of the cervix. The os was very small, the menses scanty, but after wearing the stem, the menses increased, and the os dilated to a normal size. V. VAGINAL. ATRESIA VAGINA." This of course forms an obstacle to the ingress of the seminal fluid. It may be congenital or accidental, more frequently the latter, and oftener the result of a tedious labor, followed by sloughing."--(Sims.) The vagina may be imperforate at the vulva, or in the course of the canal. The closure may be complete or partial: the former resulting in complete retention of the menses; the latter causing a painful scanty flow, mistaken sometimes for dysmenorrhoea. The following causes may be enumerated as productive of it: Arrest of development. Prolonged and difficult labor. Chemical agents locally applied. Mechanical injuries. Slough- ing from impaired vitality. Syphilitic or other extensive. ulcerations. Congenital atresia, or arrest of development of the vagina in the fœtus, is a rare anomaly. Aristotle, Celsus, Heister, and Amussat, speak of congenital atresia. Sims says he has seen but one case which might be called congenital. Drs. Helmuth, Franklin, Adams, Danforth, and Comstock in- form me they have met with cases. I have met with two cases, occurring in infants: one in a child two years of age, the other a girl of eight years. Both cases I believe to have been caused by arrest of development during fœtal life. The VAGINAL. 131 vulvæ were well developed, with a deep sulcus between, but no opening to a vaginal canal could be discovered. Accidental or acquired occlusion, from any of the above named causes, may occur at the mouth of the vagina, or we may have contraction or closure of the middle portion (of which Meigs and Sims give illustrations); or the upper part of the vagina and the neck of the uterus may be agglutina- ted together in one dense mass of fibro-cellular tissue, while we may occasionally find a complete obliteration of the canal, from the neck of the bladder quite to the os tincæ. Treatment.—In partial atresia, the menstrual fluids may escape, with much suffering and pain, and the difficulty may never be discovered. Cases are on record in which this con- dition, occurring in maiden ladies, and even the married, was not discovered for many years, or during life. The abnormal condition may not attract any attention, until an examina- tion for the cause of sterility reveals it. Complete atresia is generally discovered before the woman is married, but not always. The treatment in all cases is to restore the canal, if possible, and keep it open, by the use of a glass dilator, till the newly expanded surfaces are covered with mucous membrane. Partial atresia is best treated by pressure, or tearing with the fingers, preceded, if necessary, by incisions with scissors. It is best not to use a knife, if it can be avoided, as subse- quent contraction and inflammation are more apt to occur than when the tearing process is adopted. Sometimes a car- tilaginous band seems to close up the canal. If this cannot be broken by dilatation, the knife must be resorted to. Sims gives some interesting cases. I have known of two cases, one of congenital occlusion of the vagina, the other a partial occlusion. In the former case, no trace of a vagina could be found, and the operation per- formed was a delicate one, requiring the most perfect ana- tomical knowledge. It resulted very successfully: a vaginal canal was made, offering no impediment to coitus, pregnancy resulted, and the woman was safely delivered. The other case, reported by Dr. W. H. Holcombe, occurred in a married woman aged 35. During an abortion, vaginitis occurred, with almost complete closure of the vagina. When 132 VAGINAL. the case was examined three years after the accident, there was a shallow sulcus between the labia, and a very small orifice at the bottom, into which a uterine sound could with difficulty be introduced. A canal was found extending sin- uously up to the os uteri. The woman had become pregnant, the spermatozoa passing up through this sinus. This wo- man was safely delivered by Dr. Holcombe, of New Orleans, aided by an eminent surgeon of that city, who operated at the commencement of labor. CONGENITAL ABSENCE OF VAGINA, according to Scanzoni, rarely, if ever, exists without a simultaneous absence of the uterus and rudimentary development of some of the external organs of generation. If an obliterated vagina be present, it may generally be recognized as a hard fibrous cord, by one finger in the rectum and a sound in the bladder. Should deformity of the external genitals exist, the uterus not be discoverable, and no signs of distress at menstrual epochs show themselves, it may be concluded that the case is one of absence of the vagina, and not of complete atresia. Sims says he has seen five cases of congenital absence of the va- gina, and in all of them there was no uterus. Treatment.—If we diagnose the case as one of absence of the uterus as well as vagina, no treatment can be insti- tuted for the removal of the cause of the sterility. Cases may occur, however, in which the uterus may be present. Amussat reported one to the French Institute, in 1835; and this same bold surgeon has demonstrated that an artificial canal to the uterus might be made. NON-RETAINING VAGINA.-Dr. Sims was the first surgeon to call attention to this cause of sterility. "It has been only about three or four years," he says, "since I found out that some vaginas would not for a moment hold a drop of semen. There are no two vaginas alike. They differ in length, in their various diameters, in their relations with the bladder and rectum, in their course with regard to the pelvian axes, and in their relation with the axis of the uterus. They sometimes refuse to retain the semen when they are very capa- cious; again when they are too short." Sims relates a singu- VAGINAL. 133 larly interesting case,* where the forcible "reaction of the distended vagina ejected all the semen that did not at once regurgitate in the very act of ejaculation." This he demon- strated to be the case, by inspection of the vagina a few mo- ments after intercourse, when he found that "the vagina did not contain a drop of semen.' "" In another class of cases, Sims says: "Sometimes the va- gina does not retain the semen, even when it is of large pro- portions. When this is the case, we almost always find the uterus retroverted. I have now but little doubt that, in many cases of retroversion in which I have seen pregnancy follow the rectification of the malposition, the sterile state was due to the fact that the vagina did not retain the semen." Dr. Sims relates several cases illustrating the non-retaining power of the vagina, with retroversion of the uterus, and ex- plains the modus of this abnormal action of the vagina. Treatment. In the first-mentioned instance, the treatment consists in instructing the parties to so conduct sexual in- tercourse that a portion of the semen must be left in the vagina; in other words, the semen must not be ejaculated as far as usual into the canal of the vagina. I have several times advised successfully the use of a ball or tampon of cotton to be placed in the vagina immediately upon the con- clusion of the act of coition, before the vagina can expel the semen. It is singular that Sims never seems to have thought of this simple device. In case of retroversion with non-retention of semen, the uterus must be placed in normal position, and kept in situ by a properly adjusted pessary, which must be worn during coition, as directed in the treatment of retroversion of the uterus. Even in this case, the cotton tampon should be ad- vised, as also in cases where the vagina is too short. IMPERFORATE HYMEN.-Medical literature contains the records of many cases in which the hymen was so tough as to resist all reasonable efforts at penetration; and very many in which it has been found completely occluded, with reten- tion of the menstrual flow. Sims says he has never met *Uterine Surgery, p. 342, 134 VAGINAL. with an example of these conditions. He admits, however, that the hymen may be hermetically sealed, so as to cause retention of the menses and sterility. Treatment.—All surgeons, at present, caution against the operation, simple as it seems, of opening the hymen by "crucial incision," i. e., if there is more than an ounce or two of retained fluid in the uterus. The operation should be performed by an exploring needle, leaving the gradual evacuation of the fluid to nature and time. The object of this is to allow the uterus time to con- tract, as its contents slowly ooze away. If there is not more than an ounce or two of imprisoned fluid, Sims does not think it makes any difference whether we evacuate it sud- denly or slowly. If the uterus and vagina hold six or eight ounces, Sims directs to give Ergot,* until its specific action is produced on the uterus, and then make a small pune- ture in the hymen. Dr. Hewitt, one of the latest and best authorities on diseases of women, directs the opening to be made obliquely in the obstructing membrane, giving it a val- vular character, so that the fluid will be evacuated guttatim. An abdominal bandage should be worn till the fluid is all evacuated. In cases where the hymen is so nearly closed as to admit the escape of the menses drop by drop, and the orifice so small as to prevent the entrance of the semen, it had better be ruptured by pressure, if possible, than by any cutting instrument, as in occlusion of the vagina. VAGINISMUS.-This singular affection is much oftener a cause of sterility than has been supposed. It was first pointed out by Dr. Burns, of Glasgow, and more lately, by Simpson, Scanzoni, Sims, and others; also by our own Helmuth,† who first called attention to it in our journal, and reported a case treated successfully. Definition." By the term vaginismus I mean an exces- sive hyperesthesia of the hymen and vulvar outlet, asso- ciated with such involuntary spasmodic contraction of the * Caulophyllin, perhaps, and would be as good. (II.) † North American Journal, 1864, p. 64. VAGINAL. 135 sphincter vagina as to prevent coition. This irritable spas- modic action is produced by the slightest touch; often the touch of a camel's-hair pencil, or fine feather, will produce such agony as to cause the patient to shriek out, complain- ing at the same time that the pain is that of thrusting a sharp knife into the sensitive part. This is worse in some than in others. In a very large majority the pain and spasm conjoined are so great as to preclude the possibility of sexual intercourse. In some instances it will be borne occasionally, notwithstanding the intolerable suffering; while in others it will be wholly abandoned, even after the act has been re- peatedly, and, as it were, perfectly performed" (Sims). The recognized causes are: The hysterical diathesis; ex- coriations or fissures at the vulva; irritable tubercle of the meatus; chronic metritis or vaginitis; pustular or vesicular eruptions on the vulva; neuromata. Diagnosis.-There is no other affection with which it can be confounded. All that will be necessary to decide con- cerning it will be whether it is an idiopathic or symptomatic disorder. Course and Duration.-In its course it may be unlimited. Cases are recorded in which it lasted for twenty-five or thirty years. In some rare cases it may be removed by medicines acting on the nervous system, or pass away without treat- ment. Prognosis. "From personal experience," remarks Dr. Sims, “I can confidently assert that I know of no disease capable of producing so much unhappiness to both parties. to the marriage contract; and I am happy to state that I know of no serious trouble that can be so easily, so safely, and so certainly cured." Treatment. The surgical treatment is given for this affec- tion by Dr. Franklin and Dr. Helmuth, in their works on Surgery. Guernsey ignores the disease altogether, or includes it in the chapter on "spasms, cramps, constrictions, and neu- ralgia of the vagina," although he does not therein describe the true vaginismus of which we are treating. With char- acteristic boldness he asserts that "these strictures of the vagina may be cured without artificial dilatation, by the aid 136 VAGINAL. of the homoeopathically indicated remedy." This assertion, however, is not supported by a single clinical fact. The rational treatment of vaginismus should be conducted as follows: First ascertain, if possible, the cause of the affec- tion, and whether it is idiopathic or symptomatic. If it arises from the hysterical diathesis, those remedies. indicated in hysteria, and possessing the general and local symptoms, should be selected. Among these the most useful are: Platina, Belladonna (or Atropin), Conium, Asafoetida, Hamamelis, and Gelsemium. The introduction of suppositories of cocoa butter, medi- cated with Conium, Belladonna, Chloral, Atropin, Iodoform,* or Gelsemium, as they are indicated, will aid the internal administration of the remedy. At the same time a glass tube, known as "Sims's vaginal dilator," should be gently inserted into the vagina and kept there for as many hours a day as practicable. Its presence tends to benumb the nervous sensibility, and produce a tolerance of foreign bodies. During the treatment the patient should live apart from her hus- band. If excoriations, ulcers, or fissures at the vulva are present, Nitric acid, Ignatia, Graphites, and Sulphur, may be given internally, but the best results will be gained by applying the fuming nitric acid to the fissures or ulcers. One of the former remedies may be alternated with one of the latter with good effect; at the same time the Graphites cerate, Culendula, Glycerin, or Glycerole of aloes, may be ap- plied locally. The Aloes glycerole is superior to any other known remedy in the treatment of irritable and obstinate rhagades, or fissures, occurring anywhere. An ointment of Chloral hydrate or Iodoform, will also give relief (gr. x to Vaseline 3j). If an irritable tubercle of the meatus or vagina exists, a surgical operation is the only resort. It should be hooked up with a tenaculum and cut out, and immediately the pecu- liar sensitiveness of the part will disappear. * A suppository, made of equal parts of Tannin and Iodoform, is almost destitute of the abominable odor of the latter, but may not act as well in this disease. VAGINAL. 137 Dr. Baker Brown reports many cases of vaginismus cured by excising the enlarged and irritable clitoris. (See obser- vations on that disease below.) Pustular eruptions of the vulva require the use of Tartar emetic, Sabina, Croton tig., Arsenic. Vesicular eruptions call for Rhus tox., rad. or ven., and Euphorbia. Urticaria of the vulva requires Apis mel., Urtica urens, Graphites, Arsenic. Neuromata require to be removed by the knife or curved scissors. I have recently read the report of a case of vaginismus cured by the same process which has been adopted success- fully in the treatment of fissure or irritable ulcer of the rectum, namely, forcible dilatation. The reporter stated that he introduced his thumbs into the vagina, and forcibly stretched it as much as possible, this operation was repeated once or twice a week, and resulted in a cure in six weeks. As his patient was not under the influence of an anesthetic, the case could not have been a severe one. I would suggest that the use of Barnes's dilators, or the inflatable pessary, or my expanding speculum would give better results. Before describing the surgical treatment of vaginismus, it ought to be mentioned that several cases are on record where coition was performed while the wife was under the influence of chloroform or ether, and that conception resulted from such intercourse. In some of these cases the vaginismus disap- peared after confinement; in others no improvement resulted. Dr. T. G. Thomas, of New York, related to Dr. Sims a case in which pregnancy followed coition under the above circumstances. Dr. Sims relates a case in which two conceptions occurred in a state of complete anesthesia, followed by a labor at full terin, and a miscarriage, but without curing the vaginismus. Treatment. The treatment consists in the removal of the hymen, the incision of the vaginal orifice, and subsequent dilatation. The last is useless without the first two, but is essential to easy and perfect success with. "I usually make two operations, but it may be done at once."* "The patient being under the influence of ether, and placed * Sims's Uterine Surgery, p. 326. 10 138 VAGINAL. on the back upon a table, the remains of the hymen are entirely excised by a pair of curved scissors. The slight hæmorrhage resulting from this will soon cease under the application of a compress wet with ice water, or a solution of persulphate of iron. "The index and middle fingers of the left hand are then passed into the vagina, so as to put the fourchette on the stretch. By means of a scalpel, a deep incision is then made on the right of the mediau line, terminating at the raphe of the perinæum. A similar incision is then made on the other side, the two being united at the raphe, and extended to the perineal integument, and through its upper border. Each of these incisions will extend from about half an inch above the upper border of the sphincter to the perineal raphe, thus passing across the muscle, and measuring nearly two inches. They should pass over the sphincter muscle, but not entirely through it. "After this, the vaginal dilator is placed in the canal, either immediately or in about twenty-four hours, and worn for two hours in the morning, and three or four in the even- ing, according to the tolerance for it which is manifested. The vaginal dilator is three inches long, slightly conical, open at one end, and closed at the other, and varying in size from an inch to an inch and a half in diameter. This instru- ment is kept in place by a T bandage, and should be worn for two or three weeks." LEUCORRHEA (VAGINITIS).—Vaginal leucorrhoea is always the result of acute or chronic vaginitis. It may be specific, arising from gonorrhoea, catarrhal, or caused by various kinds of irritation. "I do not know," says Sims, "that vaginitis, properly speaking, is absolutely opposed to the vitality of the sperma- tozoa. It appears to be the character, and not the quantity, of the vaginal secretion, that kills the spermatozoa. "The secretion from the vagina should be slightly acid; if it is very acid it kills the spermatozoa instantly. I have seen many cases in which they were all dead within five or six minutes after coition. In all these cases, the vaginal mucus was by no means abundant, but the surface of the VAGINAL. 139 vagina always had a reddish look, and its papillæ were prom- inent. By simply inspecting the surface of the vagina, and testing the degree of acidity with litmus paper, I have some- times been able to say that the vaginal mucus would poison the spermatozoa. The blue litmus should be slowly turned to a faint pink, when the secretion is normal; but when it is abnormal, the litmus-paper turns quickly to a deeper pink color." Treatment. The treatment of leucorrhoea or vaginitis, in cases of sterility, should be chemical or medicinal, or both. The chemical consists in so changing, temporarily, the abnormally acid condition of the secretion, that it will not be fatal to the life of the spermatozoa. "I have seen," says Dr. Sims, "conception twice (occur) when the vaginal mucus poisoned the spermatozoa. One was remedied by slightly alkaline washes, used before sexual congress. In the other it occurred in this way: A lady, aged twenty-eight, was married six years without issue. She had a contracted os. It was incised, but she did not con- ceive. She had indurated cervix, the consequence of cystic disease. For this she was under treatment nearly two months. It was cured, and her husband came to take her home. Wishing to see the character of the semen, I ex- amined the vaginal mucus four or five hours after coition. The spermatozoa were all dead. On the next day, I examined them in five or six minutes afterwards, and could not find one alive. I then placed in the vagina a small tampon, moistened with a little glycerin, which held in solution some of the bicarbonate of soda (20 grs. to 5j). This application was repeated on the next day. The cotton was tied with a string, for its removal. This was worn from about two o'clock P.M., till eight the next morning. Its removal was followed by connection. Living spermatozoa were afterwards found in the greatest abundance; indeed, there were no dead ones at all. Conception dated from that moment, being just two days before the expected return of the menses, which, however, did not occur. There had been no sexual inter- course for nearly two mouths before." According to Kolliker, the phosphate of soda is peculiarly favorable to the movements of spermatozoa; and this would 140 DISEASES OF THE CLITORIS. probably be superior to the carbonate as an application in ex- tremely acid conditions of the vaginal mucus. The medicinal treatment of acute vaginitis is best con- ducted by the internal administration of Aconite, Cantharis, Copaiva, Cannabis sat., Clematis, Pulsatilla, Mercurius, Thuja, and Sabina. For chronic vaginitis: Merc. cor., Sepia, Cal- carea, Arsenicum, Senecio, Kreosotum, and Sulphur. Besides the remedies mentioned, I have found from recent experi- ence, that in acute vaginitis, with local heat, etc., enemas of Gelsemium, Grindelia or Hamamelis, together with their in- ternal use, are capable of removing the inflammation sooner than any other treatment. In chronic vaginitis, my experience is strongly in favor of the use of tampons of cotton, saturated with dilute Glycer- oles (5j to 3j) of Calendula, Muriate of Hydrastia, Myrica, Grindelia, Bismuth, Chloral, or Borax. DISEASES OF THE CLITORIS. That some congenital and acquired diseases of the clitoris indirectly cause sterility is placed beyond a doubt by the in- vestigations of Baker Brown, whose success in curing not only sterility but insanity, epilepsy, catalepsy, and hysteria, should have prevented the senseless folly of the members of the "London Obstetrical Society," who expelled him from that Society for reasons which will be utterly inexplicable to future surgeons and physicians. In Dr. Brown's Surgical Diseases of Women he devotes a chapter to "Irritation and Hypertrophy of the Clitoris, and writes: 66 Enlargement of the clitoris, sometimes accompanied by a degree of induration approaching that of cartilage, at others by a relaxed, flabby state of the tissues, and always attended by abnormal irritability, is a condition of more frequent occurrence, I believe, than the majority of medical men sus- pect, and is for the most part brought on by self-abuse. The radical cure of the habit is, however, fortunately in our hands. Long-continued irritation of the clitoris figures among the causes of sterility, for, besides its constitutional effects, the habit acts locally on the functions of the womb, DISEASES OF THE CLITORIS. 141 either in the same way, we may presume, as does excessive venery, or by inducing displacement of the organ." The following symptonis are noted by Brown as being pathognomonic of this habit and condition: "Melancholy; restlessness; excited and retiring; listlessness, and indifferent to social influences and domestic life; strange fanciful appe- tite, dyspepsia; pain in head and down the spine; pains more or less constant in the small of the back, or on either side in the lumbar region; wasting of the face and muscles gener- ally; skin dry and hard, or cold and clammy; pupils dilated ; hands clammy; often a hard cordlike pulse; irregularity of the uterine function; amennorrhea, or too frequent menses; dysmenorrhoea, and leucorrhoea. If married the woman has distaste for marital intercourse, and very fre- quently either sterility, or a tendency to abort in the early months of pregnancy. 'On examination of the external genital organs there will be found a straight and hirsute growth, a depression in the centre of the perinæum, a peculiar follicular secretion, an alteration in the structure of the parts, mucous membrane taking on the character of skin, and muscle having become hypertrophied and generally tending toward a fibrous or car- tilaginous degeneration.” Surgical Treatment." When I have decided that my pa- tient is a fit subject for surgical treatment, I at once proceed to operate, after the ordinary preliminary measures of a warm bath and clearance of the portal circulation. The patient hav- ing been placed completely under the influence of chloroform, the clitoris is freely excised either by scissors or knife. I always prefer the scissors. The wound in then firmly plugged with a graduated compress of lint, and a pad well secured by a T bandage. A grain of Opium is introduced into the rectum, the patient placed in bed, and most carefully watched by a nurse to prevent hæmorrhage by any disturbance of the dressing. The diet must be unstimulating, and consist of milk, farinaceous food, fish, and occasionally chicken. The strictest quiet must be enjoined, and the attention of relatives, if possible, avoided, so that the moral influence of the medical attendant and nurse may be uninterruptedly maintained." (Brown.) 142 DISEASES OF THE CLITORIS. - Dr. Brown says: "A month is generally required for the healing of the wound, at the end of which time it is diffi cult for the uninformed or non-medical to discern any trace of any operation. The rapid improvement after the opera- tion is most marked. The woman soon recovers excellent health, mentally and physically, and a healthy pregnancy results. He asserts that this operation no more unsexes the woman than an operation for piles. On the contrary, healthy and natural sexual appetite and pleasure take the place of the abnormal appetite." ( Medicinal Treatment.—It is a very hazardous and delicate matter for a physician to propose this operation, be it ever so necessary, owing to the popular and even professional preju- dice. We are, therefore, driven to our local and internal medicinal remedies, by which we may hope to accomplish results approximating excision. Abnormal irritability of the clitoris may, however, be due not to any pernicious habit, but is often a congenital dis- order of the pubic nerve which supplies that organ. We may not be enabled by medicinal influences to perma- nently remove abnormal irritability of the clitoris when it has been acquired, or when that organ has become enlarged or otherwise changed in structure; but we may be able to palliate the irritation to such an extent that conception can take place, and we may also be able, by the use of appropri- ate remedies, to carry the pregnancy to a final termination. In cases of congenital irritability, remedies have a nuch more permanent effect, especially if masturbation has not been contracted, and the clitoris remain normal in structure. In such cases pregnancy usually arrests the irritability, and after childbirth it disappears altogether. There are but few medicines upon which we can rely in this disorder, and in order to be successful with them we must prescribe them in material doses until their primary physiological effects are established. These medicines are (1) the Bromides, especially the Monobromate of camphor, (2) Pieric acid and Hydrobromic acid, (3) Conium, (4) Ferrocyanuret of potassium and Bro- mide of iron. Monobromated camphor has a prompt and decided action as ' LISEASES OF THE CLITORIS. 143 a sedative to the pubic nerve and the vaso-motor nervous system generally. It not only calms the general nervous system, but those of the genital organs especially. I have used it with such success for several years that I can confi- dently recommend it. ILLUSTRATIVE CASE. Sterility, Congenital Abnormal Irritability of the Clitoris Cured.-Was applied to by Mrs. for the removal of sterility. Had been married six years, without concep- tion. She was a woman of large physique, bilious tempera- ment; had internal hæniorrhoids, and chronic constipation, dysmenorrhoea, and leucorrhoea. Examination showed some follicular inflammation of os uteri, chronic vaginitis, and some vaginismus. The vulva was rough, and the parts pre- sented the appearance described by Dr. Baker Brown, above. quoted, except that the clitoris was not enlarged. It was, however, highly irritable as accidental touching showed. Although I suspected something abnormal, from the spas- modic contractions of the vagina, and the excessive trans- parent mucous secretion poured out by the cervical glands and those of the ostium vaginæ, I did not, from motives of delicacy, ask any questions on that point. Treatment for a few weeks removed the follicular ulceration, the vaginitis, and the constipation. In a conversation with her husband, he asked me if a state of almost constant sexual excitement would not induce sterility. I answered in the affirmative, when he requested me to consult with her on that subject. On personal inquiry she related that she had been the sub- ject of abnormal irritability of the external genitals since her earliest childhood, "as long ago as she could remember any- thing." To get relief she was obliged to resort to rubbing and friction, and this would bring on orgasm. This led to the habit of masturbation, which continued till she was married, when she hoped it would cease, but was disap- pointed, for her husband could not satisfy the unnatural irritation. She had vainly striven to control it, and although she was evidently a woman of strong mind and good princi- ples she failed because the mind was not at fault. When she resisted successfully during waking hours, she involuntarily 144 DISEASES OF THE CLITORIS. 1 X produced orgasm by rubbing during sleep. She suffered much from occipital headache, extending down the spine; had wild and unpleasant dreams, and a "wild feeling in her brain that alarmed her." Gelsemium 1 was prescribed with but little effect, as also was Bromide of potassa, which only gave her better sleep. I then gave her capsules of Camphor mono- bromide each containing 2 grains, of which she took three a day. In a few days she reported herself much better in every respect, and in three weeks the pain in the head had ceased, and sexual functions were about normal. The next month she missed her menstrual period, the first time in her life, and soon found she was pregnant. During pregnancy she had to resort occasionally to the medicine, but went to full term and gave birth to a healthy child. She informs me that since the birth of the child, now over a year, there has been no return of the former unnatural excitement. I have since used the Camphor monobromide in another similar case with like result. With the Bromide of am- monium I once cured a case presenting the above features, with this exception, the abnormal irritation occurred only before, during, and after the menses; the dose was ten grains, three times a day. Pieric acid differs from the above in being primarily homœopathic to the above-mentioned normal condition, when given in small doses; i.e., small doses cause sexual erethism; large doses produce a morbid sexual depres- sion. Dr. L. B. Couch* says he has cured several cases of self-abuse by this medicine. In one case reported, the cure was made by the 30th. This proves my theory of dose to be true. In obstinate cases Dr. Couch says he should not hesitate to give large doses (10 grains of the 1 trit.). X Hydrobromic acid is said to possess nearly all the proper- ties of the bromides, and as it is very pleasant to the taste made into a "lemonade," and never disagrees with the stomach, it may prove a useful remedy. Drop doses, if pure, should represent grain doses of the bromides of soda, lime, and potassa. In cerebral congestion I get good effects from 15 to 25-drop doses. * Homœopathic Times, April, 1878. DISEASES OF THE CLITORIS. 145 Conium will be treated of in a chapter further on. I will only say here that in abnormal irritation of the clitoris, I have used Squibb's fluid extract of Conium, in doses of 5 to 15 drops once or twice a day with good effects, in a few cases. Ferrocyanuret of potassium and Bromide of iron will prove excellent remedies in this affection, in chlorotic or anæmic women subject to cardiac and intercostal neuralgia, when the menses are pale and too frequent. They enrich the blood, while they lower in a marked degree the sexual power aud appetite. This is especially the case with the Cyanuret.* NOTE.-The foregoing Chapter should have been numbered VII instead of V. * See vol. ii, New Remedies (Therapeutics). 146 RENAL. CHAPTER VIII. RENAL. DIABETES." During the course of this disease," says Dr. Morgan,*"the power and function of reproduction are more or less suspended in both sexes, but returns as vigorously as ever on the removal of the diabetes Diabetes mellitus, and perhaps diabetes insipidus, may be a cause of sterility, and not be recognized as such by the physician, who may be treating some uterine trouble which he supposes is the real cause. Treatment. The most important remedies for this disease happen to be at the same time some of our most valuable remedies for sterility, viz.: Acidum phosphoricum, Mercurius, Helonias, Arsenic, Baryta carb., Conium, Digitalis, Eupato- rium purp., Kali carb., Uranium nitrate, Terebinth., Acidum mur. (For the special indications for these and many other medicines, see Dr. Morgan's work.) X I have cured two cases of diabetes in women with Helo- nias, in both of which impotence and sterility were concom- itants. After their recovery sexual power and desire re- turned, and they soon became pregnant. The 1 dilution was used, ten to fifteen drops four times a day. Those who wish to consult the important clinical and pathogenetic his- tory of this remedy will find it in my Therapeutics of New Remedies, 4th edition. Lycopus virginicus has been found curative in several cases of diabetes.t Secale has been used very successfully in polyuria (D. in- sipidus) after the failure of many other medicines. It was given in doses of fifteen to thirty drops of Squibb's fl. ext. three times a day. It also cured the attending impotence. * Diabetes, etc, by Dr. William Morgan, Hom. Pub. Co., London, 1878. + See August number North Amer. Journal of Homœopathy, 1878. VESICAL. 147 CHAPTER IX. VESICAL. IRRITABLE BLADDER AND URETHRA.-These two distressing and obstinate disorders may become very prominent causes of sterility, by the reflex irritation transmitted to the uterus and vagina. I have found that vesical catarrh is nearly always attended by vaginal and uterine catarrh, and the cystic disease may have been the first to appear. The nervous irritation is also transmitted to the uterus, causing spasmodic or neuralgic dysmenorrhoea. There are several varieties of cystic and urethral disease, and a brief mention only will be made. Chronic cystitis, or vesical catarrh, is one of the most painful and annoying affections with which a woman can be afflicted. It commences usually with a simple cystitis from a cold, especially from exposure during the menses. At first the discharge is simple mucus mixed with the urine, but as the disease advances it may become bloody, and is attended with severe dysuria, and lancinating, burning, and spasmodic pains like tenesmus. In the chronic stage the dysuria is intense, the urging to urinate very frequent, attended by vesical tenesmus, the sleep is broken by frequent calls to urinate, the urine is scanty and high-colored, containing a large proportion of pus, muco-pus, blood, epithelium, and in the worst cases, shreds of mucous. membrane from erosion and sloughing. The region of the bladder is sensitive to the touch; walking or riding is pain- ful, and finally hectic fever sets in. In some cases the urine is intensely fetid, owing to rapid decomposition, or excessive quantity of phosphates, especially if the posterior wall of the bladder becomes prolapsed, and pouches into the rectum. Not only does this affection cause sterility by reflex irrita- tion of the uterus, but it renders fruitful marital congress 148 VESICAL.. almost impossible, on account of the pain and irritation it causes, and because of the necessity of getting up to urinate immediately after the act, when the tenesmus of the bladder is attended by sympathetic tenesmus of the uterus and vag- ina, expelling the seminal fluid from those organs. Not only is it necessary to cure the disease before concep- tion can take place, but even should conception occur, the woman would be in a very pitiful condition, for pregnancy, if not cut short by a miscarriage (a common result), would be a continued scene of indescribable suffering Treatment. The diet of the patient must first be regu- lated. All stimulating beverages containing alcohol should be prohibited. All foods containing spices, pepper, mustard, horse-radish, etc., should be avoided. Milk is the best article. of food, with bread and meat. Walking and riding should be indulged in with great moderation. Coition should be very rare, if at all, until a cure is effected. The feet and lower extremities should be dressed warmly. Damp feet should be avoided by wearing woollen hose, thick shoes with. cork soles, or voltaic in-soles. The medicines most efficacious in acute cases are Cannabis, Equisetum, Cantharis, Pulsatilla, Capsicum, Galium, Spirits nitri dulc., etc. In chronic cases the most successful remedies are Galium, Chimaphila, Mitchella, Uva ursi, Pareira brava, Barosma, Grindelia, Monobromate of camphor, Santonin, Benzoic acid and the Benzoate of lithia, Thuja, Terebinth., Copaiva, and Cubebs. With these medicines, if carefully selected, nearly all cases of vesical catarrh can be cured. Some of them, namely, Galium, Chimaphila, Mitchella, and Uva ursi, act best when given in infusion, cool or warm, prepared in the proportion of 5j to 5ss of the herb to a pint of water, a wineglassful taken every few hours. Barosma and Pareira act best in Syrup bal. Peru (5) to 3iv of the Syrup, a tea- spoonful every few hours). Thuja and Terebinth. in the 2× dilution. The others in the 1 trituration, a few grains every two or four hours. The topical treatment of this disease is indispensable in many cases. The medicines in filtered solutions should be thrown into the bladder, by means of a syringe directly, or VESICAL. 149 through a short or long catheter. As a preliminary to this treatment the urethra will often have to be dilated. (See Diseases of Urethra.) The best medicines for topical use are Hydrastis, Grindelia, Copaiva, Terebinth., Thuja, Sali- cylate of soda, Bicarbonate of soda, or Acidum muriaticum. Hydrastis, when the sediment is tough, ropy, and muco- purulent (5j of Merrill's fluid hydrastis, or gr. v of the muriate or sulphate of hydrastia to a pint of warm water). Copaiva, Terebinth., Grindelia, and Thuja, in the form of medicated waters, made as follows: 5j or ij is rubbed up with carbonate of magnesia, then added to a quart of water and filtered. Inject half a pint or more daily. It is best to thoroughly wash out the bladder before the medicated enema, by injecting simply warm water, or very dilute solution of muriatic acid if the urine is alkaline; if the urine is acid, sode bicarb. Some cases have been cured by injecting healthy urine taken directly from another per- sou, and thrown into the diseased bladder. Salicylate of soda, or Salicylic acid, used as enemas, have cured many cases when the urine was intensely fetid and contained vibriones.† (In cases of prolapsus of the bladder I have ap- plied a Thomas's anteversion pessary with great success.) The most intractable case I ever saw was cured by the latter. The woman had been a victim of this disease for years. She was married and childless. The only relief she obtained was by injecting warm water several times a day. She had adopted the plan of her own notion. I found the urethra already dilated, so that I could introduce my index finger. I prescribed the following: R-Salicylic acid, Glycerin, Water, • · 31. 3j. 1 quart. Four ounces of this was thrown into the bladder, previ- * The addition of a grain of Morphia, or 7th grain of Atropin, is an ex- cellent palliative of pain in very bad cases. R--Salicylic acid, Borax,. Water, R.--Salicylate of soda, Water,. gr. xx. gr. XXX. 1 quart. Or, • 3ss. 1 quart. 150 VESICAL. ously emptied and washed out with warm water, and re- peated several times daily. The next most successful cure was made by giving inter- nally, in teaspoonful doses every four hours, a mixture of equal parts of Tincture of Chimaphila and Syrup Balsanı of Peru. She was cured in two weeks, after many of the above medicines, even Chimaphila in drop doses of the tinc- ture, had been used unsuccessfully. Both these women be- came pregnant soon after the cure. (Since the above was written I have cured a severe case with Grindelia robusta, given internally, and applied topically, prepared as a “medi- cated water.") URETHRAL. 151 CHAPTER X. URETHRAL. IRRITABLE URETHRA, or CHRONIC CATARRHAL URETHRITIS may become a cause of sterility, equally with the similar affection of the bladder. In this disease the pain and suffer- ing during and after urination and coition, are more intense than in chronic cystitis. It so wears upon the system that women become nervous, irritable, and almost insane from the constant irritation, the loss of sleep, and the peculiar sufferings. In cases of true irritability of the urethra, no discharge is observed, and a close examination fails to detect any abnormal growths in the canal or at its mouth. It seems to be as purely a nervous affection as are some severe cases of vaginismus. In catarrhal urethritis, which may arise from repeated acute attacks, or from gonorrhea, structural changes often occur, namely, thickening of the walls, fun- gous growths, ulceration, occlusion, or paralysis. Treatment.—The medicinal treatment is far less satisfactory than for chronic cystitis, but the same remedies are indicated. The topical treatment is the most important. In the neu- ralgic variety, atropia* applied to the whole length of the canal by means of a probe wrapped with cotton, or carbolic acid† may be useful in some cases. But the most successful treatment is by means of dilatation. This operation is equally efficacious in nearly all diseases of the female urethra, and is adopted by all our best surgeons. This simple operation is so important and useful that I will give the most approved methods now adopted. Sir Ast- ley Cooper first proposed and practiced it for the purpose of removing stone from the bladder, but he used the slow method, by means of sponge, or sea-tangle tents. But this method has recently been supplanted by the equally safe and thorough * Atropia, gr. i; Glycerin, j. + Carbolic acid, gr. v; Glycerin, 3j. 152 URETHRAL. and much less tedious method of rapid and forcible di'a'ation. As regards the instruments used, Simon employs graduated bougies or special bivalvular specula, first incising the border of the meatus. Noeggerath dilates with graduated steel bougies and the little and index fingers. Thomas with a forceps similar to a dressing forceps. Munde says Good- willie's wire-spring nasal speculum is a good instrument. Dr. Ball's instruments, which he uses for forcible and rapid dilatation of the cervix uteri, might be useful. Any of the forcible dilators of the cervical canal will answer; in many cases the finger alone will do the work, for the urethra is often dilated somewhat by the disease. In all cases the dila- tation occupies but a few minutes or seconds, and is never followed by permanent incontinence of urine all operators agree in this statement. Heath says the urethra splits from beneath the pubis, and that the incontinence rarely lasts longer than twenty-four hours. The operation is always performed under anesthesia. The benefit is instantaneous. The American Journal of Obstetrics, and other journals during the last year or two, have contained many reports wherein. this operation has permanently cured old and hitherto in- tractable cases, and restored the patients to health. CARUNCLES OF THE URETHRA.-This is one of the most com- mon of urethral disorders in the female sex. Dr. Goodell* de- scribes them as intensely vascular and exquisitely sensitive growths, occurring more frequently in married women; they do not appear to be due to gonorrhoea, uncleanly habits, or frequent coition, but are usually accompanied, perhaps pre- ceded, by uterine diseases. Although at times perfectly pain- less, they are often the cause of the most excruciating pelvic and vesical pains, and in the course of time bring about alarming symptoms of general debility, nervousness, and de- pression, apparently quite out of proportion to the size of the tumor. The caruncles may occupy any portion of the urethra, and are the most difficult of treatment when situated near the bladder and sessile in their attachment. Treatment.—It is possible that medicines may be useful in some cases, but doubtful if they will more than palliate. * Affections of the Female Urethra, Philadelphia Medical Times, 1874. URETHRAL. 153 Thuja is the best indicated. Goodell advises their destruc- tion by means of chromic acid, nitric acid, or carbolic acid, applied full strength, or they may be removed by the scissors (followed by the immediate application of fuming nitric acid, or the actual cautery, to check the usually profuse hæmor. rhage), or by the galvano-caustic loop, or its less expensive substitute, a red-hot knitting-needle or hair-pin. Forcible dilatation of the urethra will sometimes be found necessary to prevent their return and effect a permanent cure. GRANULAR EROSION OF THE MUCOUS MEMBRANE is a very painful affection, but generally relieved by the application of undiluted carbolic acid on a fine stick, once a week, followed by the introduction of Olive oil or Cosmoline. FISSURE OF THE URETHRA is a rare and obscure form of ure- thral disease. It occurs near the neck of the bladder. It is readily cured by hyperdilatation and touching with lunar caustic or nitric acid. VESICO-VAGINAL FISTULA is a cause of sterility. For de- tails of the operation for its removal consult the standard works on surgery. VASCULAR TUMOR OF THE MEATUS.—“Few diseases of tri- fling magnitude occasion more distress than a vascular ex- crescence, varying in size from a large pin's head to a horse bean, which is sometimes found growing from the female. urethra. Its exquisite sensibility shows it to be as well sup- plied with nerves as with blood vessels. The tumor some- times arises from the projection which generally exists around the orifice of the meatus, but it frequently grows from the internal surface. The tenderness of the part is so great as not to allow of sexual intercourse, and it may thus become indirectly a cause of sterility." (Dr. Baker Brown; Surgical Diseases of Women.) Diagnosis.—An exquisite sensibility of the part is a lead- ing symptom of the disease. The patient complains of ex- cessive pain in micturition, in coition, and from the slightest pressure on it. Upon separating the vulva there will appear a small tumor, of a florid scarlet color, resembling arterial blood. It springs from the orifice or just within the orifice 11 154 URETHRAL. of the urethra. It easily bleeds on rough handling. Its surface is somewhat granulated. There are sometimes several of these tumors. Treatment." Ligatures," says Baker Brown, " are useless, as they cannot be made to include the whole of the diseased mass, nor can they be tied with any degree of force, so as to strangle it without exciting inflammation, as, in order to effect a cure, some portion of the mucous membrane should be included. The best practice is to excise the tumor with a pair of scissors, taking care to remove not only the ex- crescence itself, but also that small portion of mucous mem- brane from which it grows, a fine pair of forceps being used to take hold of it. To the wound thus made Nitric acid should be applied on a piece of stick pointed like a pencil, the parts around being filled with lint previously soaked with a strong solution of Carbonate of soda." Dr. Brigham, however, says that they are quickest cured by touching their extremity with the actual cautery. I have cured small ones by means of Persulphate of iron, and Nitrate of sanguinaria. RECTAL. 155 CHAPTER XI. RECTAL. "DISEASES of the rectum," says Dr. Baker Brown, "will produce sterility. The rectum and uterus are both supplied. by vessels and nerves from the same source; and, therefore, disease in one organ must interfere with the other. When a female is suffering from bleeding hæmorrhoids during the menstrual period, a diminished supply of blood is sent to the uterus, and its mucous membrane will not undergo those normal changes necessary for the reception of the impreg- nated ovum. The same observations apply to prolapsus ani, with loss of blood at every defecation." In Volumes I and II of the American Journal of Obstetrics appears a series of papers relating to the rectal causes of sterility and uterine diseases, by Dr: H. R. Storer, of Boston. They will amply repay perusal by the physician who desires. to become thoroughly acquainted with this subject. Prof. T. G. Comstock, of St. Louis, communicates the fol- lowing case: FISSURE OF THE ANUS CAUSING STERILITY. "Mrs W., aged 31, married ten years, was never pregnant. Had suffered for seven years with what she supposed was piles. She had been treated by many physicians, who seem to have been mostly in accord as to the diagnosis, they supposing it to be internal piles. She had never allowed any examina- tion by the speculum, until she came under my charge. I gave her case a careful investigation, and selected the reme- dies accordingly; but at the expiration of one month, she had not improved at all, and then I insisted upon an exam- ination, or, if she refused, intended to decline attending her. She consented, and an examination by means of the anal speculum at first gave me no insight into the difficulty ; but with a fenestrated speculum, and by means of my fingers, I detected an erosion in the centre of a fissure, situated half an inch or more within the orifice of the anus. The sides 156 RECTAL. or walls of this fissure felt thickened, granulated, and hypertrophied, and she experienced so much pain from the examination, that I gave her chloroform inhalations; but previous to this, she said: 'Now you touch the spot where I feel all my pains.' "I immediately operated upon this fissure, using very carefully a sharp-pointed curved bistoury, making a simple incision through the mucous coat, so as to completely cut through the fissure to its bottom, and extending it longitudi- nally a little beyond its extremities. "The patient was very irritable, hysterical, and unhappy, and had longed for offspring. The husband was perfectly healthy, and the only thing the wife had ever complained of was the infirmity in question. She always had distress- ing pains during defecation, and great suffering during coitus. These unpleasant symptoms all disappeared as soon as she recovered from the operation, which was within three weeks; and six months after, she became pregnant, and was safely delivered. The fissure of the anus was undoubtedly the cause of her sterility, although it had not been previ- ously suspected. This ailment has been often overlooked by physicians." FISSURE OF THE RECTUM.-In Dr. Baker Brown's classical work on Surgical Diseases of Women he devotes a chapter to "Diseases of the Rectum producing, or resulting from Uterine Disorder." In this chapter he says there are three distinct kinds of fissure. (1.) A small superficial ulceration just within the verge of the anus. (2.) A deeper ulceration in the same position, which goes through the mucous membrane and into the muscular fibres of the external sphincter. (3.) A true fissure or crack, not discoverable by external examination, as it is situated at least an inch from the anus. Polypi usually accompany the two latter forms, and Dr. Brown thinks they are caused by the fissure. The first form of disease, according to Brown, causes the most serious symptoms, referable to the bladder and uterus, namely, frequent desire to urinate, painful mictu- RECTAL. 157 rition, and incontinence of urine; also, dysmenorrhoea of a most painful character, vaginismus, a localized pain, almost constant, about six or eight inches up the bowels, great irri- tation about the anus and vulva; but rarely the painful de ecation set down as a symptom of fissure. This last is a reason why the disease is often overlooked, and treatment applied to the uterus and bladder, instead of the rectum. This variety of fissure is often a cause of sterility, from the irritation which it keeps up in the uterus and vagina. Treatment.-Dr. Brown's treatment, which I have adopted in several cases, is to draw a straight, blunt-pointed bistoury lightly through the ulceration and contiguous skin without the anus for about an inch. Curling, in bis admirable little work, which should be in the library of every physician, thinks that even in these superficial erosions, the muscular fibres "at the bottom of the sore," and for some distance each way, should be cut off. In the second and third kinds a deeper cut, deeper than the fissure, through the fibres of the muscles and for an inch or two through the skin of the anus, is necessary. These operations should be followed by a dressing of borated lint or cotton saturated with Glycerole of calendula. Before the operation the bowels should be thoroughly emp- tied by a laxative, or injections, and not allowed to move for a few days after. In homeopathic practice some surprisingly favorable re- sults have accrued from internal medication, where we are able to select the true similimum. In Volume V of the North American Journal of Homeopathy is an exhaustive paper by Dr. Perry on this subject, in which the indications for the following medicines are given, and several brilliant cures have been made by them: These remedies are: (1) Nitric acid and Ignatia. (2.) Plumbum, Arsenicum, Sulphur, Lachesis, Natr. m., Phos- phorus, and Sepia. Dr. Roth adds Nux to the list, as a most important remedy. It seems, however, from some late ex- perience, that Ratania ought to come after Nitric acid, as the next most important medicine. In the May No. (1878) of the North American Journal of Homœopathy, Dr. T. F. Allen gives * Diseases of the Rectum, p. 12. 158 RECTAL. a complete résumé of the powers of this drug, and reports a case where he made a brilliant cure with Ratania. He suggests Graphites, Poonia, and Silica as good remedies. I have had good results follow the use of Esculus and Aloes. Ratania, or any other indicated remedy, should be applied topically as well as given internally, for they have cured cases, when thus applied, when they were not given in- ternally at all. Ratania is equally valuable for fissures or cracks in the nipple, vagina, or lips, showing that like Nitric acid it is generally useful, and that fissures are not always a purely local affection, but depend upon some constitutional dyscrasia. Dr. Baker Brown believes that fissures, and other diseases of the rectum, especially irritability, spasm, and neuralgia, may be caused by the habit of "delection," or masturbation. In such instances he practices excision of the clitoris, as a means of cure, to be followed, if necessary, by the above surgical procedures on the rectum and anus. He shows con- clusively that vaginismus is often caused by the same per- nicious habit. THE MECHANISM OF CONCEPTION. 159 n CHAPTER XII. THE MECHANISM OF CONCEPTION. A WORK on sterility would be incomplete if it did not men- tion certain important facts relating to the seminal fluid, and the processes which may be termed the "mechanics of conception." This subject will be discussed under three heads, viz: I. The nature and properties of semen. II. The method of its passage to the ovule. III. The successful conditions for such passage. I. THE SEMEN. The seminal fluid is made up of the secretion of the testes, mixed with that of the seminal vesicles, prostate, and Cow- per's glands. It is composed of the liquor seminis, granules, and spermatozoa. Normal semen will drop from the end of a pipette or syringe in drops as easily as water. A small quantity falling into a glass of water is, by slight agitation, immediately dif fused or dissolved in it. Abnormal semen full of mucus will not leave the mouth of the syringe quickly or suddenly, but ropes off for an inch or more before it breaks into a drop; but when it falls into water it preserves its tenacity, and but a small part of it is dissolved. It floats about in shreds, and eventually settles at the bottom of the glass in the form of a whitish sediment. Semen destitute of spermatozoa has the usual sui generis odor, but lacks the appearance of uniformity that belongs to the normal secretion. When viewed by transmitted light, we usually see little whitish flakes of mucus floating through it. This is not always the case, however, for Sims mentions two instances in which it had the color and appearance of good semen, although wanting in spermatozoa. Abnormal semen is insoluble in hot or cold water, and floats about in 160 THE MECHANISM OF CONCEPTION. it in cloudy flakes like ordinary mucus. It is more translu- cent than good semen, less milky, and less opaque. Under the microscope it presents the appearance of ordinary mucns. Good semen may, however, be loaded with mucus, which probably comes from the glandular apparatus at the neck of the bladder. The presence of a large amount of mucus is not necessarily inimical to the life of the spermatozoa. The fructifying power of the semen lies in the spermatozoa alone, and not in the liquor seminis, or any fanciful "seminal aura.” * Dr. Sims, who had paid special attention to the exami- nation of the seminal fluid, says: "If we take a drop of semen from the vagina immediately after sexual intercourse, and place it under the microscope, we shall see the hurried movements of seemingly thousands of spermatozoa. But this is not the best way of studying the phenomena of their move- ments. The best plan is to take a drop of mucus from the caual of a perfectly normal cervix uteri some fifteen or 1. FIG. 27. 2. 3 a Spermatozoa (after Kolliker). 1. Magnified 250 diameters. 2. Magnified 600 diameters. a. Viewed from the side. b. Viewed from the back. 3. Fragment, head and one-fourth ot tail. Magnified 2800 diameters (after Richardson). twenty hours after sexual intercourse. We shall then be better able to examine the spermatozoa; for we shall see them in the fluid that serves as the means of their finding their way towards the ovumi. * Uterine Surgery, p. 315. THE MECHANISM OF CONCEPTION. 161 "We shall find them moving more slowly, more continu- ously, if the term be allowed. Suppose we select any one spermatozoon for observation, and note particularly its va- rious actions and movements. It will swim first one way and then another, or more in a straight line across the field of vision, and perhaps turn abruptly to retrace the path already traversed. If it encounters a large epithelial scale, it stops, places its head against it, as though trying to push it forwards, and when it fails to do so, it turns and moves off slowly in another direction, perhaps to encounter another. opposing obstacle, to pause a moment and make another effort to overcome it, and then to turn again in search of some new field of exploration." One would suppose, after reading this graphic description of the movements of the spermatozoa, that there should be no doubt about their possession of animal life, yet Carpenter, in his Physiology, writes: "Spermatozoa have no more claim to a distinct animal character than have the ciliated epithelia of mucous membrane, which likewise continue in movement when separated from the body. They appear to be nothing else than cell-germs, furnished with a peculiar power of move- ment, by which they are enabled to make their way into the situation where they may be received, cherished, and de- veloped." This statement would deny them all organization and life, as if life could be begotten without life. But let us inquire into the proofs of their possession of organization. Loeuenhoeck, Gerber, Valentine, Dujardin, Wagner, and other eminent microscopists, all testify to have discovered traces of organization in spermatozoa. Valentine says: "The spermatozoa of the bear have a mouth, anus, and stomach, or a convoluted intestine." Commenting on this, Hassallt prop- erly observes: "The determination of the fact that the sper- matozoa are possessed of even the smallest amount of or- ganization, would involve their classification in the animal kingdom." He further says, concerning their motions. "All the spermatozoa contained in a drop of semen which has un- * Muller's Embryology, with illustrations, p 1475, † Microscopical Anatomy, vol. i, p. 225. 162 THE MECHANISM OF CONCEPTION. dergone dilution, will not start into motion at once; many of them will remain for a time perfectly motionless, and then suddenly, as it were by an act of volition, begin to move themselves in all directions." Of their mode of progression, the same writer says: "The motions of the spermatozoa are effected principally by means of the tail, which is moved alternately from side to side, and during the progression the head is always in advance." It is said that the spermatozoa of different animals move in a different manner, because they differ very much in their form and structure. This would not be the case if they were "nothing more than ciliated epithelium." Hassall also states, that in the varied motions executed by the spermatozoa, they exhibit all the characters of volition; thus they move sometimes quickly, at others slowly, alter their course, stop altogether for a time, and then resume their eccentric movements. These movements it is impossi- ble to explain by any reference to any hydroscopic properties which may be inherent in the spermatozoa, they appear to be so purely voluntary. Dr. Morris Wilson* says: "Sperma - tozoa when moving through a fluid turn readily out of the way of any obstructions, but they have not the backward movement of the vibriones." (Would ciliated epithelium avoid obstruc- tions?) Notwithstanding both Dalton and Draper in their works on Human Physiology assert that spermatozoa do not possess animal life nor organization, and affect to believe that the appearances above quoted were due to optical delusions, we feel confident that their distinctive animal nature will some time be fully proven. It will be more in accordance with true scientific modes of thought not to assert of spermatozoa a want of life and organization because we cannot now dis- cover and demonstrate it, but await the result of more min- ute investigations. Not only must there be living, moving spermatozoa in the semen, but their motions must be normal and their life healthy, or they cannot impregnate the ovum. Sims has shown that these organisms may be diseased† or crippled by the un- * Disease of Seminal Vesicles. Uterine Surgery, p. 352. THE MECHANISM OF CONCEPTION. 163 healthy medium in which they are ejected, or poisoned by the secretions of the uterus and vagina. It is important to know under what circumstances the spermatozoa live longest and retain their healthy vitality. Under favorable circumstances they live many hours, even days; under unfavorable circumstances they die quickly. For instance, any great variation of temperature is fatal to their existence. In a temperature of 98° they will live a long time; a variation of ten degrees may cause death. Certain conditions of the secretions of the vagina and uterus destroy their life. According to Donné, they live in pus and blood, but I imagine the pus or blood must be healthy. According to Wagner, they live in blood, milk, mucus, pus, syrup, and very delicate saline solutions. Sims says he has frequently seen conception happen when the cer- vix uteri was the seat of profuse suppuration. But if the secretions of the vagina be abnormally acid, it kills the sper- matozoa instantly. The same may be said of the cervical mucus if it possess acrid or unhealthy properties, or if it is so thick and tenacious that they cannot move freely in it. (I have alluded to this when treating of leucorrhæa, etc.) "They do not exhibit any movements in pure semen, i. e., before mixed with the fluids of the seminal vesicles" (Kolliker). There are certain chemical and toxic agents that are poi- sonous to the spermatozoa, and others that are favorable to their vitality. Of the former are strong alkalies, acids, even when very weak, astringents, salt, alcohol, opium and all narcotic poisons, strychnia, and, indeed, all medicinal sub- stances. They cannot live in urine and bile, or uterine mucus strongly alkaline (Donné). Hassall says the spermatozoa are devoid of life in persons who have died from the poisonous effects of prussic acid. This may be the case in poisoning with other diffusible poisons. In treating the causes of ster- ility we should bear these facts in mind, and allow no me- dicinal substances to be injected or used in the vagina and uterus near the time of a coition which is desired to be fruit- ful. To the last class, or those favorable to the life of the spermatozoa, are weak alkaline soulutions, especially the phosphate of soda (Kolliker), or bicarbonate of soda (Sims). 164 THE MECHANISM OF CONCEPTION. The strength should be about 5 grains to 3j, and the water of the temperature of 98°. We may, therefore, use these alkalies when we wish to neutralize the too acid character of vaginal mucus. In healthy vaginal mucus spermatozoa may live several days, and in it their power of locomotion are certainly very extraordinary. EXAMINATION OF VAGINAL AND CERVICAL MUCUS FOR SPER- MATOZOA.-Dr. Sims* gives the following minute directions for procuring and examining the secretion of the vagina and cer- vix uteri for spermatozoa: "Suppose we wish to examine the vaginal mucus soon after coition-say within an hour; we direct the patient to empty the bladder before the act, and to retain quietly the recumbent position after it. The dorsal decubitus is the best. To remove a few drops of the contents of the vagina, pass the index finger into it; press the pos- terior wall downward and backward, just under the cervix uteri; hold it so for a minute or two; the semen will neces- sarily gravitate to the pouch made by the pressure; then in- troduce the nozzle of the syringe along the finger; let it project slightly over the end of the finger-nail, and it will be easy enough to obtain what we want if there is any semen in the vagina. I am thus minute in explaining this simple. operation, because we may fail in it entirely, even when the vagina contains large quantities of semen, if we neglect these minutiæ; and in this way, if we pass in the syringe in a haphazard manner and begin to draw the piston, the mucous membrane of the vagina is sucked up into the end of the tube, and thus it is possible to slide it around in various di- rections without getting a drop of mucus of any sort. But suppose we fail even with properly directed efforts; then the left lateral position and my speculum will, in a moment, show us the whole contents of the vagina, and we can, with the syringe, remove what we want. When we wish to examine the cervical mucus, we should resort at once to the speculum and the proper position. It is well enough, then, to sponge away all the mucus from the vagina, and especially from about the cervix uteri, when * Uterine Surgery, p 393. THE MECHANISM OF CONCEPTION. 165 we pass the nozzle of the syringe just within the os tincæ, and draw up a drop of its mucus To do this, it is necessary to pull the cervix forwards, so as to be able to look into it, and to see exactly what we are doing. If the cervical mucus is very tenacious we may fail to get it away. Then it will at the next attempt be necessary, after introducing the syringe, and drawing up the mucus, to pass the left index finger to the edge of the os tincæ, and slide the end of the syringe on to the end of the finger without raising it from the surface of the cervix, or breaking its suction power. This may seem to be a little thing to describe so minutely, but really it is a most important matter to know and to do, if we ex- pect to be exact in our investigations. The nicety of this manipulation renders it the more important for us to clear away all the vaginal mucus before we undertake it, lest we get some of this drawn up into the syringe, which would, of course, mar the precision of our observations. Suppose we succeed in this, then we may wish to pass the syringe up for an inch into the cervix to get a portion of mucus nearer the cavity of the uterus. This operation is quite as delicate and quite as important as the first, and is to be conducted in the same way. There is an object in having the end of the syr-- inge bulb-shaped. This bulb fills up the os or the canal of the cervix, and prevents the air from being drawn into the instrument, as sometimes happened with me when it was slender and pointed.” A drop of this mucus procured from either vagina or cer- vix should be placed immediately under the microscope, for the spermatozoa will soon die. In performing these operations or any other, there have been but two specula which could be used with convenience, viz, Sims's and Jackson's. Sims's instrument, or rather combination of instruments, requires an assistant in all cases where the operator has to use both hands. Jackson's was a great improvement on all other valvular specula, because the valves can be separated throughout their whole length. I have, however, designed an instrument much lighter and more convenient than Jackson's. Through the kindness of E. H. Sargent & Co., surgical instrument makers, of Chicago, who manufactured the one I now use, I am enabled to pre- 166 THE MECHANISM OF CONCEPTION. sent a cut of my speculum, of which the following is a de- scription.* The blades are concavo-convex; the upper blade is shorter than the lower, and falls into it when closed. The upper blade is slit, giving a long opening, through which the ure- thral orifice can be seen and any operation on the urethra or meatus performed. The upper blade, which comes under the pubes, is elevated by two methods-one, by applying the finger to the extension which projects upwards from its base, elevating the inner termination, as in Storer's and all other bivalves; the other, by means of a screw, which separates the upper blade through its whole length from the lower or longer blade. This last gives it the quality of Sims's spec- ulum, viz., a wide opening, through which almost any opera- FIG. 28. SARGENT Hale's Expanding Speculum. tion on the uterus can be performed without the aid of an assistant. The small screw which is attached to the upper blade, and projects through the lower arch, is used to fix the upper blade in position after its inner extremity has been elevated. In vaginismus, or small vaginas, the long screw which en- larges the opening between the two blades at their outer ex- tremities can rarely be used without causing pain. But in cases where it is necessary to do so, it is much more power- ful than Sims's, and can be left in situ, while both hands are otherwise engaged. This speculum can be introduced in the * This speculum can be procured of Messrs. Boericke & Tafel, No. 145 Grand Street, New York, or ordered from any of their Branch Pharmacies. THE MECHANISM OF CONCEPTION. 167 ! dorsal or lateral position. I generally use it with the woman on her back and with the lower extremities strongly flexed; although I frequently find it more convenient to use it in Sims's position, on the left side. The foregoing excellent cut shows the mechanism of the instrument very plainly. There should be a small hook projecting from the left side of the under side of the upper blade, to which a tenacu- lum can be attached, but it could not be represented in this cut. II. THE PASSAGE OF SPERMATOZOA TO THE OVULE. Usually in women with healthy organs of generation there occurs during sexual congress, or sexual excitement, a pro- fuse flow of thin, translucent mucus. This not only lubri- cates the vagina and inner surface of the vulva, but flows out upon the external parts. There are many facts recorded which prove unmistakably that if healthy semen be de- posited in, and mixed with this mucus, even at some distance from the ostium vagina, the spermatozoa will, in a few mo- ments, find their way through this secretion into the vagina and cervical canal to the cavity of the uterus. Sims records many cases which fully corroborate this assertion, and he goes on to refute the vulgar opinion, even now taught by some writers, that "to insure conception, sexual congress should be performed with a certain degree of completeness that would give an exhaustive satisfaction to both parties at the same moment." "How often," he says, "do we hear husbands complain of coldness on the part of wives, and at- tribute to this the failure to procreate; and sometimes wives are disposed to think, though they never complain, that the fault lies with the hasty ejaculation of the husband. Both are wrong." The fact is that in either sex, neither passion or desire are necessary to conception. They are of no value except as incentives. "It matters not," says Dr. Sims, "how awkward and unsatisfactory the act of coition may be performed, so that the semen, with the proper fructifying principle, be placed in the vagina at the right moment; and, on the con- trary, it matters not how perfectly and satisfactory it may 168 THE MECHANISM OF CONCEPTION. be done if the semen lacks the fecundating power." My ex- perience agrees with Sims, that both parties may possess in- tense passions and power of enjoyment and have no offspring; while in other cases be almost destitute of both, yet have a large family. Physicians, by teaching their patients the facts in this matter, may do much to render them happier in their domestic relations. There are also some facts relating to conception which have a medico-legal importance. Does conception occur during intercourse, or soon after? Dr. Sims says: "If the uterus is in a normal condition we shall always, as a rule, find spermatozoa in the canal of the cervix immediately after coition." If in the canal of the cervix, why not in the uterine cavity? The spermatozoa certainly travel with con- siderable speed. Sims mentions one instance where a sper- matozoa had travelled three and one-half inches from the surface of the hymen to the os tincæ in three hours! Con- ception or fecundation may take place immediately after, possibly during coition, if an ovum is in the cavity of the uterus ready to be impregnated; or it may be hours or days before impregnation occurs. Dr. S. R. Percy, of New York,* reports a case in which he found "living spermatozoa, and many dead ones," issuing from the os uteri eight and a half days after the last sexual connection. Sims thinks that spermatozoa never live over twelve hours in vaginal mucus; but in cervical mucus he has found living ones after forty hours. He knows of no reason why they may not live much longer. In some of the female maminalia they have been found in vaginal mucus eight days after copulation. III. THE SUCCESSFUL CONDITIONS FOR SUCH L'ASSAGE. It has been already stated that, after the semen has been deposited in the vagina, the spermatozoa find their way into the cervix, pass up into the uterus, and, if not finding the ovum, pass still further into the Fallopian tubes or ovary. Whenever and wherever they meet the ovum they enter it. Contact results in conception. Some microscopists have found * Amer. Med. Times, 1861. - THE MECHANISM OF CONCEPTION. 169 the ovum transfixed by the spermatozoa, the head imbedded, the tail protruding and moving. In rare cases, the ovum after impregnation does not pass into the uterus, but remains where it was impregnated. Then occurs ovarian or tubal pregnancy. But the mechanism of their entrance into the cervix uteri is now a matter of considerable discussion. Gardner states (Sterility, p 48), that "popular opinion de- clares that during copulation, and at the height of venereal sensation on the part of the female, the mouth of the womb opens to receive the semen, which passes into the cavity of the uterus." Since this was written, Dr. Sims writes: "I have over and over again examined the condition of the uterus after coition-often in four or five minutes after it- and I have usually found the following state of things: The uterus presents signs of exhaustion, if I may be allowed such an expression; for instance, if the uterus is in a normal posi- tion, or even moderately anteverted, we shall find the upper part of the vagina relaxed, and passively holding a large quantity of semen, in which the cervix uteri is submerged; the uterus itself seems to be fatigued, and drops by its gravity down towards the rectum, where it lazily sinks to the bottom of the little pool of semen." Dr. Sims believes that, in a normal condition of the uterus and cervix, the semen suddenly enters the cervical canal. His explanation. of the process is: "The cervix is pressed forcibly against the glans (penis) by a contraction of the superior constrictor vagina; that this pressure necessarily forces out the con- tents of the canal of the cervix; that the parts subsequently become relaxed, the uterus returns suddenly to its normal condition, and the seminal fluid filling the vagina necessarily rushes into the canal of the cervix by a process similar to that by which a fluid would pass into an india-rubber bottle slightly compressed, so as to expel a portion of its contents before placing its mouth to a fluid of any sort." . . . "From this it will be seen that I believe the cervix uteri to be short- ened in the erethismal climax of coition by pressure exerted upon it in the direction of its long axis when its position is normal, which is impossible in a greatly abnormal position." This theory has an important bearing on the question of sterility, showing how it may be caused by retroversion or 12 170 THE MECHANISM OF CONCEPTION. anteversion. For instance, in retroversion, "the fundus sinks still lower after coition than before, and this necessarily elevates the os tincæ still further from the seminal fluid, if any of it has been retained." In this case the spermatozoa, to enter the cervical canal, are obliged to "climb up," so to speak, on the cervix, and find their way into the canal. (It is in this condition that the lateral or "spoon-fashion" pos- ture during coition may be advisable.) "In anteversion," says Sims, "we do not find the spermatozoa in the canal immediately after coition, because, with the os tincæ looking in the direction of the hollow of the sacrum, the same act and the same pressure would only force the anterior lip of the os tincæ up against the posterior lip, creating no vacuum and making no room for the newly introduced fluid" (In this instance the reversal of the natural position of the sexes during coition might remedy the defect.) Dr. Montrose A. Pallen,* in a very elaborate and scientific discussion of this subject, says that during coition, "the posterior wall of the vagina is lengthened, and the engorge- ment of the vaginal plexuses further increases its elasticity and tension. When erotic excitement is at its height, the intra-pelvic erectility of the female is equally as tense as is the extra-pelvic erectility of the male organs, and the cavi- ties of the neck and body of the uterus occupy a position midway between the axes of the inlet and the outlet, in a line corresponding to the centre of the upper portion of the vaginal insertion upon the cervix. Therefore, when the ejaculation of the semen takes place, it impinges upon the cavity of the cervix, and in many instances passes directly into the cavity of the uterine body. Many women contend that they can tell the very moment of impregnation from a peculiar sensation of sickening shock, not the excitability of orgasm, but a sickish, sinking pain, and the probabilities are that the germinating fluid is forcibly ejaculated to the very fundus, producing a decided sensation, which, if happening when there are none of the hyperesthetic sensibilities of coition, would give rise to a very marked uterine shock or * The Philosophy of Menstruation, Conception, and Sterility (A Lecture, G. P. Putnam & Co.). THE MECHANISM OF CONCEPTION. 171 colic." All this may be true in women whose pelvic organs are in a normal condition and position. But how many women possess such organs? And when Dr. Pallen insists (p. 67) that conception must always be attended by this pro- cess, and warns us against believing that women are impreg- nated during sleep, intoxication, or when anesthetized, he is going too far. His theory of "generative fixation,” as he calls it, will not stand against the facts of common experi- ence; for, without doubt, the majority of conceptions take place without any such process as he describes. Sims's theory is much more tenable. There is no doubt, however, that during sexual orgasm, the os generally opens or relaxes, and that more or less secretion of transparent mucus flows from the cervix, but that this is necessary to conception cannot be proved. Sims says the semen is "sucked into" the uterus after the uterine erection. Pallen declares it is propelled into the uterus during the "erectile hypertrophy." I do not believe either process is always necessary. If the cervix is filled with normal mucus, neither too thick, or too alkaline, or acrid, and the vaginal secretions are healthy, the sperma- tozoa are capable of "crawling from the posterior vaginal fornix over the infra-vaginal cervix into the uterine cavity," notwithstanding Dr. Pallen doubts their ability. There have been cases of undoubted rape when conception resulted, and to teach, as does Dr. Pallen, that conception without orgasm "uterine fixation" was impossible, would be placing many good and virtuous women who had been violated, in a very painful position, and strip the law of all right to punish such an awful crime. ΟΓ Uor M 172 ERRORS CAUSING STERILITY. CHAPTER XIII. HYGIENIC AND OTHER ERRORS CAUSING STERILITY. THERE are many causes of sterility, in habits of life and conduct, which cannot be classified among the diseases men- tioned in the previous pages. They are of such vital im- portance that to omit mention of them would greatly lessen the practical value of a work of this kind. It will not answer to pass over such errors of life and conduct in a cur- sory manner. Each one must be pointed out and described as minutely as professional delicacy will permit, but without that false modesty which is out of place in medical works. One of the most injurious of all habits and customs to which the women of nearly all highly civilized nations are addicted, consists in improper and injurious arrangements of the clothing which they wear. This matter is so well writ- ten up by Dr. T. G. Thomas* that I take the liberty of quoting his entire section, entitled IMPROPRIETIES IN DRESS "The dress adopted by the women of our times may be very graceful and becoming; it may possess the great advan- tages of developing the beauties of the figure and con- cealing its defects, but it certainly is conducive to the de- velopment of uterine diseases, and proves not merely a predisposing, but an exciting cause of them. For the proper performance of the function of respiration, an entire free- dom of action should be given to the chest, and more especially is this needed at the base of the thorax, opposite the attachment of the important respiratory muscle, the diaphragm. The habit of contracting the body at the waist by tight clothing confines this part as if by splints; indeed it accomplishes just what the surgeon does who bandages the chest for a fractured rib, with the intent of limiting thoracic and substituting abdominal respiration. Mol * Diseases of Women, p. 46. ERRORS CAUSING STERILITY. 173 "As the diaphragm, thus fettered, contracts, all lateral expansion being prevented, it presses the intestines upon the movable uterus, and forces this organ down upon the floor of the pelvis, or lays it across it. In addition to the force. thus exerted, a number of pounds, say from five to ten, are bound around the contracted waist, and held up by the hips and the abdominal walls, which are rendered protuberant by the compression alluded to. The uterus is exposed to this downward pressure for fourteen hours out of every twenty- four; at stated intervals being still farther pressed upon by a distended stomach. "In estimating the effects of direct pressure upon the position of the uterus, its extreme mobility must be con- stantly borne in mind. No more striking evidence of this can be cited than the fact, that in examining it by Sims's speculum, if the clothing be not loosened around the waist, the cervix is thrown so far back into the hollow of the sacrum as to make its engagement in the field of the instru- ment often very difficult, and that attention to this point in the arrangement of the patient will at once remove the difficulty. While the uterus is exposed by the speculum it will be found to ascend with every respiratory effort, and descend with every inspiration; and so distinct and constant are the rapid alterations of position thus induced, that in operations in the vaginal canal the surgeon can tell with great certainty how respiration is being affected by the anæs- thetic employed. Au organ so easily and decidedly influ- enced as to position by such slight causes must necessarily be affected by a constriction which, in autopsy, will some- times be found to have left the impress of the ribs upon the liver, producing depressions corresponding to them. “No one will charge me with drawing upon my imagina- tion, even in the remotest degree, for the details of the fol- lowing picture, for a little reflection will assure all of its correctness. A lady who has habitually dressed as already described, prepares for a ball by increasing all the evil influ- ences which result from pressure. Although she may be menstruating, she dances until a late hour of the night, or rather an early hour of the morning. She then eats a hearty supper, passes out into the inclement night air, and rides a 174 ERRORS CAUSING STERILITY. long distance to her home. This is repeated frequently during each season, until advancing age or the occurrence of disease puts an end to the process. "A great deal of exposure is likewise entailed upon women by the uncovered state of the lower extremities. The body is covered, but under the skirts sweeps a chilling blast, and from the wet earth rises a moist vapor, that comes in contact with limbs encased in thin cotton cloth, which is entirely inadequate for their protection. It is not surprising that evil often results to a menstruating woman thus ex- posed. "To a woman who has systematically displaced her uterus by years of imprudence, the act of sexual intercourse, which, in one whose organs maintain a normal position, is a physio- logical process devoid of pathological results, becomes an absolute, a positive source of disease. The axis of the uterus. is not identical with that of the vagina. While the latter has an axis coincident with that of the inferior strait, the former has one similar to that of the superior. This arrange- ment provides for the passage of the male organ below the -cervix into the posterior cul-de-sac, the cervix thus escaping injury. But let the uterus be forced down as it is by the prevailing styles of fashionable dress, even to the distance of one inch, and the natural relation of the parts is altered. The cervix is directly injured, and thus a physiological pro- cess is insensibly inerged into one productive of pathological results. How often do we see uterine disease occur just after matrimony, even where no excesses have been com- mitted. "It is not an excessive indulgence in coition which so often produces this result, but the indulgence to any degree on the part of a woman who has distorted the natural rela- tions of the genital organs. "But this is by no means the only method by which dis- placement of the uterus may induce disease of its structures. It disorders the circulation in the displaced organ, and pro- duces passive congestion and its resulting hypertrophy, pre- vents the free escape of menstrual blood by pressing the os against the vagina, creates flexion, causes friction of the ERRORS CAUSING STERILITY. 175 cervix against the floor of the pelvis, and stretches the uterine ligaments and destroys their power and efficiency. "These facts should be carefully borne in mind by the physician who attempts to relieve uterine displacements by the use of pessaries. If he merely replaces the displaced organ, and relies for its support upon a pessary, he will often fail in accomplishing the desired result. He is striving at great disadvantage with a short lever power against the weight, not of the uterus alone, but of the superimposed viscera pressed downwards by several pounds of clothing, which add their weight at the same time that they constrict the waist, and substitute abdominal for thoracic respiration. Thus employed, the pessary will often give great pain, and so injure the parts upon which it rests as to necessitate re- moval, and the practitioner will find himself cast off from one of his most valuable resources. Should he, on the other hand, before employing a pessary, remove all constriction and weight from the abdominal walls, apply a well-fitting abdom- inal supporter over the hypogastrium, so as to aid the ex- hausted abdominal muscles in their work, keep the displaced and congested uterus out of the cavity of the pelvis by a tampon of medicated cotton, or bring gravitation to his assistance by the position of the patient, he will ordinarily at the end of a week be able to employ with great advan- tage the same pessary, which at first seemed to accomplish evil and not good." Another subject meutioned by Dr. Thomas, and I have taken the liberty of quoting his remarks, is- IMPRUDENCE DURING MENSTRUATION. This is also a very prolific source of uterine disease. Some women, through ignorance, many through reckless- ness, and a few from necessity, go out lightly clad in the most inclement weather during this period, and many suffer in consequence from violent congestive dysmenorrhea, and often from endometritis. Every practitioner will meet with a certain number of cases of uterine disease which have this origin, and run on for years, ending, perhaps, in parenchym- atous disease, which may prove incurable. 176 ERRORS CAUSING STERILITY. (6 During a period in which the ovaries and uterus are in- tensely engorged, in which the surface of the ovary is broken through by the escaping ovule, and the nervous system is in an unusual state of excitability, ordinary prudence would suggest that the body should be well covered, that the con- gested organs should be left at rest, and that exposure to cold and moisture should be sedulously avoided. I need not say that these rules are commonly neglected, and in evidence of the fact I will venture the assertion that, on this very day, the thermometer 15° above zero, the skating pond of our park contains scores of delicate and refined women, who are showing a disregard of them by their presence there. "The immediate result of exposure during menstruation is most commonly inflammation of the mucous membrane of the uterus. Such an inflammation once excited will go on for years, and in time end in parenchymatous disease, entail- ing in its progress dysmenorrhoea, sterility, pelvic pain, and gastric disorders, which impair digestion and nutrition." Passing on from these hygienic errors, I propose to men- tion certain errors of conduct as likely to prevent conception, namely: EXCESSIVE VENERY AND ORGASM. Too frequent indul- gence in sexual intercourse, and excessive enjoyment of it, may both be causes of sterility. Dr. M. A. Pallen, in his Clinical Lecture heretofore quoted, says: "A very fre- quent cause of sterility is in excessive venery, producing a constant nerve stimulation of the generative circle, a con- stant congestion of the entire organism, which very decid- edly interferes with normal and regular functioning. These causes are not infrequent in young married females, who failing to become impregnated during the earlier months of connubial life, are either taken to task by the husband or taunted by some more fortunate female friend, and as a con- sequence they repeatedly urge the act in the blended hope of offspring, and the fear of losing the respect and affection of their husbands. The result soon tells upon them both, con- stitutionally and sexually, and sterility is ingrafted upon a deteriorated physique, seriously complicating the treatment and prognosis." And again, he says, "The summum of ERRORS CAUSING STERILITY. 177 orgasm intensity is rather predisposed against impregnation in consequence of excessive uterine and vulvar glandular se- cretions, which tend to wash out the seminal fluid from the cervical cavity; besides, women as highly hypersthetic as are those influenced by excessive orgasm, are usually affect- ed by more or less of uterine catarrh, in consequence of the hyperæmia engendered by repeated tense erections, which is of itself one of the most prominent bars to conception. "" Such cases as these are doubtless cases that would be favorably affected by large doses of Conium, as recom- mended and used successfully by Dr. Tully, or by the use of Bronide of camphor (2 or 3 grs., three times a day), which I have prescribed with good results in two cases. Both parties should, however, be acquainted with the bad effects of the practice of excessive intercourse, and enjoined to be temperate, and limit themselves to the recommendation of Sims, namely: "Twice during the four days previous to the menses, and three times during the six days after." I have known several instances where this injunction has been followed by impregnation. IMPROPER TIME FOR COITION.-After reading Dr. Jackson's paper on Ovulation in the introduction to this volume, it must be evident that there is no arbitrary period to be fixed for the time of a fruitful intercourse. A few years ago it was an accepted dogma, that the period most favorable for conception was the ten days after menstruation. It was then announced that there was another equally fruitful period, namely, the three days previous to a period. The Jews are a very fruitful people, and their women are not allowed to accept the visits of their husbands until after the expiration of fourteen days after menstruation. Many persons who desire to avoid couception, abstain from intercourse during both these supposed fruitful periods, but while it lessens the probability of the occurrence of conceptions, it is by no means sure, as the many statements of my patients have shown me. Dr. Sims,* who has paid a great deal of attention to this * Uterine Surgery, page 372. 178 ERRORS CAUSING STERILITY. matter, says that he usually orders his patients who are very anxious to have offspring, to have intercourse on the third, fifth, and seventh days after the flow has ceased, and on the fifth and third before its return, and but once on each day. Dr. Naegele says in his chapter on sterility, that he has often found that intercourse during the menstrual flow has re- sulted in conception, when every other period had been tried. I once advised a husband to have a single intercourse with his sterile wife on the last day of the show, and conception followed this one act. Conception has been known to follow an intercourse on the firs' day of the menses, the flow ceas- ing immediately after the act. COITION DURING THE TREATMENT OF DISEASES OF THE UTERUS. There are certain diseases of the sexual organs of women in which marital intercourse should be absolutely prohibited; others when it may be permitted under certain restrictions, and others in which it is not injurious, and may even be beneficial. sons. Dr. Tyler Smith, On Leucorrhea, says: "In the treat- ment of cervical and vaginal leucorrhoea in the married there is one point which must be noticed, namely, the continu- ance or absence of sexual intercourse. Absolute separation. should never be advised except for good and sufficient rea- In leucorrhoea intercourse should only be forbidden in the worst cases. This is one objection to the use of caus- tics in mild cases of leucorrhoea, because it is necessary to enjoin separation while they are employed. When inter course causes considerable pain and bleeding, or when the os and cervix are secreting pus, it is out of the question, but its moderate use is quite compatible with the successful treatment of profuse mucous leucorrhoea. It may be ques- tioned whether it does not relieve the uterus of states of congestion which occur in the unmarried, and are probably the cause of leucorrhoea in single women, or in the married who live in separation from their husbands. In vaginal leucorrhoea attended with epithelial abrasions, intercourse is almost always painful and injurious, and it is often attended ERRORS CAUSING STERILITY. 179 by such a state of spasm of the ostium vaginæ as to render introition impossible" (vaginismus). Dr. Graily Hewitt, Diseases of Women, writes: "Sexual excesses predispose to chronic congestion of the uterus, inas- much as they involve too frequently-repeated or too long- continued engorgement of the uterus and other generative organs. In young women recently married it is by no means uncommon to meet with a condition plainly brought about by excess of the kind here alluded to, and but little is re- quired under such circumstances to produce a chronic en- gorgement of the organ, and the further train of evils usually following in its wake. It appears to be quite certain also that unnatural excitation of the generative organs in women leads to uterine mischief of various kinds, and promotes and maintains a chronic congestion of the organ and of its ves- sels, tending to give rise to various secondary disorders" Dr. Montrose A. Pallen writing of chronic endometritis, says: "She must live absque marito. She must avoid all ex- citing causes liable to induce pelvic fluxions and congestions. More harm is done a patient by marital congress in one night than good can be attained in a month's treatment by the gynæcologist. . . You will get better and quicker favora- ble results with patients who come from a distance, or who are in well-regulated hospitals, than with those who live at home in conjugal harmony, and who are the recipients of their husbands' erotic embraces." I will add that it is easy enough in the majority of cases to get the consent of the woman to abstain from intercourse, but it is otherwise with most husbands. Many of them have an utter lack of appreciation of the importance of giving their wives rest from intercourse, or if they appreci- ate the importance do not possess that control over their de- sires which all men should possess. They complain of the long time it takes to cure their wives, but will not assist the efforts of the physician by the requisite temperance. IMPROPER POSITION DURING COITION.-It may be asked what is meant by improper position? That depends upon the position of the uterus in the pelvis. There are cases where the natural posture is not the proper one to conduce to con- 180 ERRORS CAUSING STERILITY. ception. Such may be the case in anteversion or flexion, when, as Dr. Thomas says, the os is crowded downward and backward against the posterior wall of the vagina, and the male organ strikes the cervix, but does not pass under the os, as it should. I know of two cases which must have been of this character, where conception occurred only when the relative position of man and wife was reversed. A physician once related to me a case of sterility cured by having inter- course while lying "spoon-fashion" (retroversion ?). And still another case is related by a prominent medical writer, where a sterility of many years was cured by the direction of a travelling quack, who advised the parties to have inter- course in the standing position (elevation of the uterus?). I am aware that these are somewhat repugnant matters to treat of, but in giving explicit directions for the cure of sterility, I feel it my duty to neglect nothing, even if it jar the finer sensibilities of some persons. Improper ConDUCT AFTER COITION.-Many women, purely from motives of cleanliness, arise and bathe themselves about the genitals immediately after coition. I have known sterile women who habitually did this, who were exceedingly anxious to have offspring. When informed that such a habit had probably prevented conception, they expressed themselves grieved and surprised. Notwithstanding Dr. Pallen's asser- tion that in a fruitful coition the semen is impelled directly into the open os, I do not believe it occurs in all cases, and even if such is the fact, not all uteri are possessed of the quick vitality to shut it in immediately. If, therefore, a woman arises and walks about, or sits down to bathe the genitals, the seminal fluid escapes from the vagina or still relaxed os, and conception does not take place. I could record many cases where the direction to remain after coition in the recumbent position till morning, resulted in concep- tion after years of sterility. For this reason, if a fruitful coition is desired, the intercourse should take place just before the hour of sleep. MEANS USED FOR THE PREVENTION OF CONCEPTION.-Among the most common of all the initial causes of sterility are the ERRORS CAUSING STERILITY. 181 various methods adopted by men and women to prevent con- ception. It is incredible that people united in marriage should de- liberately set about preventing the most holy and natural result of love and the sexual union. I know well enough that there are cases where, from incurable diseases of the uterus, conception is uniformly followed by miscarriage and its attendant dangers. But these cases are so very rare that the dictum should lie entirely with the conscientious physi- cian, and he alone should prescribe the method to prevent conception. So, also, are there rare cases of pelvic deformity where conception should be avoided; but, with all the im- proved methods of artificial delivery, the cases are rare in- deed where such precautions are really necessary. As for those unnatural people who apply to physicians for prescrip- tions to prevent conception, I ecause "it is not convenient,' or because" their pecuniary circumstances are not suitable," or because they "wish to take a trip to Europe," I have no patience with or respect for them. No respectable or con- scientious physician will aid and abet such criminality, for it is nearly as criminal to prevent a conception as it is to destroy the fruits of one, unless the above-mentioned irre- movable physical obstacles render it necessary. Among the worst means used for this purpose are: >> (a.) The injection immediately after coition of cold water. This is especially injurious, because the vagina and uterus are flushed, congested, and bathed in mucus just after inter- course, and the cold douche acts as a sudden shock, contract- ing the full blood vessels, suppressing the mucous discharges, and results in secondary abnormal congestion, and even in- flammation. I have known many cases where the cold water was thrown directly into the uterus, through the open cer- vical canal, causing serious uterine colic, and in one case a dangerous attack of pelvic cellulitis. (b.) Strong solutions of sulphate of zinc, plumbum aceti- cum, tannin, etc., are often used; and, even if used with warm water, the results are equally injurious. They set up in time congestion of the cervix, cervical leucorrhœa, etc., and the result is, that when these misguided people wish for chil- 182 ERRORS CAUSING STERILITY. dren, they are surprised to find it impossible. They have brought on an acquired sterility very difficult of removal. (c.) One of the most hurtful and abominable of all methods is the use of a so-called "pessarie" of French manufacture. (The French excel in such abominations.) It is a cup-shaped contrivance, nearly two inches in diameter, made of hard or soft rubber, which fits over the os uteri like a cap. It is not always effectual, but always injurious. One of the worst cases of chronic metritis with metrorrhagia in a beautiful and otherwise healthy woman, who applied to me for the cure of her sterile condition, was brought on by the per- sistent use for years of this infernal contrivance. Her hus- band had insisted upon the use of one made of hard rubber, and the delicate tissues of the cervix had been bruised until an incurable areolar hyperplasia had resulted. Dr. Montrose A. Pallen, in his clinical lecture, says: "When the erection of the uterus subsides (after coition) the germinating fluid is imprisoned in the cavity of the body, and there retained. Hence the folly of many women who syringe themselves with cold water immediately after coition. to prevent conception, unless the shock of the fluid begets some sudden contractile uterine action which expels the contained semen, a very rare occurrence indeed. "The explanation why women who use cold water so rarely conceive, is not in the washing they give themselves, but from the fact that such an unnatural procedure had long since rendered themselves sterile by developing cervical catarrh in consequence of their having so frequently shocked the distended and engorged organs, thereby producing re- peated blood stasis and temporary congestions." A BORTION.-A well-known gynecological writer says: "A single abortion from any cause, either from disease, or drugs, or instrumental interference, may induce sterility." That this is true, the experience of every physician will. substantiate. The pathological changes set up by the un- natural expulsion of the embryo at any period of gestation, are nearly always more or less persistent. After having one miscarriage, and this after a first conception, many women never become pregnant again. This occurs much oftener when ERRORS CAUSING STERILITY. 183 instruments of any kind have been used to effect the purpose. Many women who have applied to me for the cure of their sterility, have tearfully confessed that a miscarriage caused by their own hands, during the first year of their married life, resulted in an entire inability to conceive. This result occurs when no examination which we are at present capa- ble of making discloses any morbid condition of the womb. In these cases it is no stretch of the imagination to believe that the sterile condition was a direct divine punishment for the enormity of the sin committed. I have known the most careful medicinal and topical treatment continued for years fail utterly in curing this con- dition with such antecedent cause. If this fact could be known and appreciated by young women, there would be much less of the crime committed; for, as a rule, women are almost entirely ignorant of the serious consequences of the act. Even when one or more miscarriages do not cause inability to conceive, they generally set up pathological changes in the uterus which result in repeated abortions, which in the end undermine the health of the victim, until complete sterility results. Is it not time that, not only physicians, but clergymen and all public instructors, should boldly teach the lamentable. consequence of this constantly increasing crime? 181 GENERAL THERAPEUTICS OF STERILITY. CHAPTER XIV. GENERAL THERAPEUTICS OF STERILITY. UNDER this head I propose to place those hygienic and therapeutic measures which find no special mention in the preceding pages. In examining a patient about to be treated for the sterile condition, the first object should be to ascer- tain the physiological, psychological, or pathological cause. If such cause be ascertained, the treatment will be found above; but cases will frequenly occur in which the cause can not be satisfactorily ascertained. Either it is not appre- ciable to the senses, aided by the various aids to diagnosis, or it is not physical in its character. In either case, the physician must base his treatment on general principles, such as change of condition as regards climate, diet, exer- cise, etc., or he must follow the directions of Hahnemann, and select the remedy from the similarity of its symptoms with those presented by the patient, taking into special con- sideration the general sphere of action of the remedy (its genius), as well as its characteristic or key symptoms, and also its special or diagnostic symptoms. To further the proper selection of remedies in cases of sterility, the claims of certain medicines will be considered, and their charac- teristic indications pointed out. This cannot be done with absolute accuracy in this, any more than in other diseases or morbid states. By referring to the list of medicinal causes of sterility, it will be seen that many of the same medicines are enumerated that appear below as the curative agents in sterility. That this should be so, is in accordance with the law of cure, which asserts that only those medicines which cause diseases are capable of curing similar ones. No medicine, therefore, can cure sterility without being capable, either directly or indi- rectly, of causing that condition. This law is not confiued to the action of medicinal agents, but extends to all others, such as climate, certain habits of life, mental conditions, and the like. That the curative GENERAL THERAPEUTICS OF STERILITY. 185 influence of climate, particularly, is homœopathic in its action, is admirably demonstrated by Dr. T. K. Chambers.* It is my belief that nearly all the medicines capable of causing sterility, do so by their action on the ovaries. Medic- inal agents may, however, by their pathological action, cause cervical leucorrhoea, displacements of the uterus, stenosis of the cervix, vaginismus, or the various other uterine and vaginal causes of sterility. But the function of ovulation is the central and all-important cause of repro- duction. If this is interfered with, sterility results. Medi- cines which act pathologically on the ovaries, interfere with that function, and thus beconie sterility-causing agents. The ovarian remedies for sterility are more especially: Hamamelis. Iodine. Aurum. Agnus castus. Apis mel. Bromine. Iodide of lead. Iodide of potassa. Baryta carb. Kali carb. Capsicum. Kali brom. Caladium. Cannabis indica. Conium. Lachesis. Phytolacca. Phosphorus. Cantharis. Chimaphila. Platinum. Ustilago. The uterine remedies comprise a few of the ovarian, and some others, namely: Aurum. Aletris. Moschus. Phytolacca. Borax. Ruta grav. Cantharis. Sabina. Cimicifuga. Secale. Caulophyllum. Sumbul. Eupatorium purp. Stillingia. Gossypium. Sepia. Helonias. Senecio. Lilium. Ustilago. Mercurius. Viscum album. * See Monthly Hom. Review, March, 1868. 13 186 GENERAL THERAPEUTICS OF STERILITY. CHARACTERISTIC INDICATIONS.-It is impossible in a work of this size to give the general and special symptoms, as well as the pathological indications for the use of the above enu- merated medicines. Many of them have been mentioned in the preceding pages in connection with the diseases causing sterility. I have, therefore, thought it best to give only the "characteristics" of the remedies as a guide to their selec- tion Aurum. This remedy is secondarily indicated in amenor- rhea dependent on torpor of the ovaries, in scanty menstrua- tion with chronic metritis; in sterility dependent on these states, or due to "coldness," or female impotency with suici- dal depression. (Doses, a few grains of the 2d or 3d trit.) Gold is primarily indicated for symptoms similar to pla- tinum, namely: profuse and frequent menses, congestion of the uterus, increased sexual desire, and mental or emotional irritability. (Dose, the 12th to 30th.) I prefer the Aurum mur. or the Muriate of gold and sodium. 1 Agnus castus -A complete loss of sexual power and de- sire; albuminous leucorrhoea; ovarian atony, or suspension of the function of ovulation; amenorrhea; melancholy. Aletris.-General debility; paleness; inability of the uterus to retain the product of conception; sterility after abortion. Asarum (Can. and Europ.)-Said to cause sterility. Apis mel.-Chronic or acute ovaritis with stinging pains, followed by ovarian enlargement. In women who are troubled with urticaria and pruritus pudenda, also dysuria, with stinging pains during urination. Borax.-" A female had been sterile for fourteen years, on account of a chronic acrid leucorrhoea; she received, among other remedies, Borax, after which she became pregnant, and the leucorrhoea improved. Eusy conception during the use of Borax observed in five women."-(Hahnemann's Chronic Diseases, II.) It is indicated when membranous dysmenorrhoea causes sterility; also for abrasion or erosion of the os uteri, and aphthous affections of the vagina and cervix. Baryta carb.-Loss of sexual desire and power; very scanty menses; general appearance of premature old age; catches cold very casily. (Also Baryta mur. and iod.) GENERAL THERAPEUTICS OF STERILITY. 187 Cantharis. Sterility with great sexual excitement, with irritation of the ovaries (primary effect); or sterility from the opposite condition, viz., loss of ovarian function (secon- dary effect).* For the first-named condition give the 30th, for the latter, the 1st. It has been used successfully by al- lopaths. I have known several cases cured by doses of 5 drops of the tincture three times a day; it caused violent dysuria, but conception resulted. Capsicum. For fat women who are generally chilly, have a masculine appearance; atrophy of the ovaries (?) with amau- rosis. Calcarea. Sterility in adipose women, who have profuse and too frequent menses.† Caladium.-Sterility with melancholy, faint feeling in stomach, fetid urine, asthma, loss of sexual desire, coldness and cold sweat of the sexual organs. Cannabis.—Cannabis ind., is preferable.) "Great excita- tion of the sexual instinct, accompanied by sterility." Pro- fuse menstruation, with various urinary difficulties.+ Chimaphila.—Atrophy of the ovaries (?) and mammæ. The urine is full of mucus; scaly eruptions on the skin. Conium.-One of the chief remedies in sterility. Atrophy of the ovaries and mammæ; albuminous or acrid leucorrhoea; loss of sexual power and. desire; amenorrhea, or very scanty menses; pain and swelling of the breasts before the menses. Professor Tully (allopath) says: "In several cases, where persons had been married eight or ten years without offspring, I have known a thorough use of good extract of conium employed by the party with whom the difficulty was sup- posed to exist, result in the subsequent birth of one, two, or more children. Again, when, in the course of a few years after marriage, there had been one, two, or more children, * Gardner on Sterility, p. 159. t † "Calc. (x) given against a copper eruption in the face, effected preg- nancy in a woman who had not conceived for nine years past."-Ruckert's Therapeutics. ‡ “Cannabis (1st) one drop, and afterwards merc. (3d). Giving both rem- edies twice to husband and wife, effected pregnancy, after a sterility of six years "-Ruckert's Therapeutics. ? Materia Medica. 188 GENERAL THERAPEUTICS OF STERILITY. and then a suspension of childbearing for ten or a dozen years, after a thorough course of good extract of conium, taken by the party in fault, I have known one, two, or more children born. I recollect prescribing extract of conium for a lady who had ceased for a long time to bear children. At the time of my prescribing for her, she had some chronic difficulty, I forget what it was, though it could not have been of long duration. I made several calls, at compara- tively long intervals, and at each was informed that she was better, and apparently continuing to improve. At last, at one of my visits, her conduct was very petulant, to say the least. She told me she had discontinued the medicine, and should take no more of it; but I could not ascertain the rea- son of her rejection and refusal of it. In the mean time, her husband sat by, laughing. At last the lady left the room, apparently quite angry. Her husband then informed me that she had just become gravid, and at a time when she considered that her previous children were too old, and at what she considered too late a period of her life for child- bearing, since she was a little past forty years of age. He said she considered her existing condition as due to my medi- cine. I answered that I thought she must, at least, divide the blame between him and my medicine." (Tincture of Conium should be made from the unripe seeds.) Cimicifuga. Sterility with hysteria, spinal irritation, want of vitality in the ovaries and uterus (congested cervix). She is subject to melancholy, severe congestive headaches, chorea, and acute rheumatism. (I have known many cases of ster- ility cured by Cimicifuga when all other means failed.) Caulophyllum-Sterility with spasmodic dysmenorrhœa ; she is subject to rheumatism of the fingers and hands. Eupatorium purp.-Sterility in women who suffer from nervous exhaustion, have profuse flow of watery urine from the least excitement; loss of sexual desire, uterine and ova- rian atony; sterility from frequent abortions.* Gossypium.-May prove of value in some cases of sterility. Supposed to be useful in uterine atony from frequent mis- carriages.† * New Remedies, p. 369. † Ib., pp. 475, 539. GENERAL THERAPEUTICS OF STERILITY. 189 Helonias. Sterility, with chlorosis, debility, diabetes, atony of the generative organs, female impotence, prolapsus uteri, melancholy, anæmia. Iodine.-Sterility, with emaciation, weakness, especially in the knees; atrophy of the ovaries and mamniæ; goitre. The testimony in favor of Iodine in sterility from allopathic sources, is worthy of our attention. Professor Tully says:* "A free and protracted use of Iodine is said to prove aphro- disiac, i. e., to increase venereal appetite, and the power of gratifying it. Valetudinarian women who have been mar- ried a number of years without children, not infrequently become gravid after a thorough course of Iodine." In the latest pathogenesist the following recorded symp- toms are found: "A case is said to have occurred where the female became barren soon after commencing the use of Iodine. Before she commenced the use of Iodine, she gave birth to a child. annually, but from the time of commencing its use to the present, a period of eight years, she has never become preg- nant." (These symptoms were quoted from Dr. Rivers, American Journal of Medical Sciences, 1831, p. 546.) No clue is given by Dr. R., to the pathological conditions of the sexual organs which it caused. My conviction is, that the sterility was due to arrest of ovulation, but it may have been uterine catarrh. Bromine has an effect on the ovaries similar to Iodine. Iodide of Lead.-In atrophic ovarian sterility. (See N. A. Journal of Hom., vol. ii.) Iodide of Potash.-(See Iodine.) Kali carb.-A prominent medical author asserts that the sterility of American women is, to a great extent, due to the excessive use of carbonate of potassa in bread. (See Hahne- mann's Chronic Diseases.) The Bromides.-All the bromides cause extinction of sexual desire, and a general paralysis of the reproductive organs. They are primarily indicated in sterility from de- * Materia Medica, p. 2. † Encyclopedia of Materia Medica, vol. v. 190 GENERAL THERAPEUTICS OF STERILITY. ficient ovulation and sexual inactivity; and, secondarily, in excessive excitation of the sexual organs, erotomania, etc. Lachesis.-Chronic inflammation and other destructive diseases of the ovaries, also many diseases of the uterus, leading to sterility. Lilium tig. will doubtless prove a valuable remedy. (See pathogenesis in New Remedies, vol. i, or Allen's Encyclopedia.) Mercurius.-It has been observed that women under the action of Mercury easily conceive.* It has the It has the power of causing sterility, as all authors attest. It cures sterility from syphilis; also sterility from poisonous leucorrhoea. Moschus.-This odorous drug is but little used in homo- pathic practice, although it appears to have a sphere of action nearly equal to many of our much-used agents. It is a nearer analogue of Platinum than many suppose. Hahne- mann says: "It compares with Asafetida, Crocus, Coffea, Conium, and Stramonium. Its primary action on the genera- tive organs is decidedly excitant, like Phosphorus, Cantharis, and Platinum." The following symptoms recorded by Halme- mann are proof: "Violent sexual desire, with intolerable titillation; draw- ing and pressing towards the sexual organs, as if the menses would appear; menses too early by six days, and too profuse. Menses appear even when merely smelling of the drug; re- appearance of menses, which had stopped a whole year; vio- lent drawing pains at the appearance of the menses." This violent excitement of the ovaries and uterus must necessarily be followed by impotence and sterility, from ex- hausted vitality. Many lymphatic, obese, and hysterical women present all the above symptoms of its primary action, and are also sterile. In such cases Moschus in the 6th trituration ought to remove the condition. If the secondary effects obtain, give the lower triturations. Mangeti, writing in 1703, thus descants of the virtues of Moschus in female sterility: "There may be various causes of hindered conception, but that they lie very frequently in an excess of cold or wet of the uterus, or an obstruction of the uterine vessels and ducts is established; which fact Hip- * Symptomen Codex. GENERAL THERAPEUTICS OF STERILITY. 191 pocrates (sec. iv, Aphor. 62) expresses in these words: 'They who have cold and crowded (down) wombs, do not conceive. And they who have wet wombs do not conceive; for the germ is extinguished in them."" This choked state, Lud. (i. e. Louis) Mercatus (book iii, chap. iii, on Affections of Women) thinks is the result of abundance of thick or cold humors. But that wombs that have been more hurried than was suited to their nature should be dried, and that fumigation should be applied to them. Hippocrates has shown (book i, on Affections of Women): "From these considerations it is concluded that Musk can relieve this evil, since it warms too cold blood and serum, dissolves those that are too thick, properly dries off too hurried parts, thins phlegm and mucus, and thus opens obstructions, not only of the vessels, but also of the passages and canals. Thus the virile semen may be not molested and weakened, nor prevented from extreme penetration, but nourished by moderate warmth, may be borne away from impediments to the female ovary, and thus the eggs, being fecundated, may in due time receive free transit into temper- ate wombs. To this end, Dom. Leonus (in Medical Art, book vi, chap. xiii, sec. 3) prescribes an electuary (confec- tion), as tried on many, which is compounded with musk." 66 ť John Bapt. Porta tells (Mag. Natur, book viii, chap. vii), that he has found that a fresh-laid egg, with which a single grain of Musk has been mixed, is, when swallowed (absorp- tum) excellent to assist conception. A fumigation (or per- fume) and a pessary with musk, are described in Roderick Castentris, book iii, sec. 1, chap. ii." It will be observed that the old physicians advised it for the symptoms resembling its secondary effects. There may be more hidden under this obsolete language than at first seems. Sumbul, or Castoreum, may be equally useful, as they are nearly allied to Musk. Morphine.—Dr. Allen quotes (Encyc. Mat. Med.) Lerinstein (General Effects of Morphine), who says, in relation to effects on the female generative organs: "The amenorrhea of Mor- phine is gradually developed from dysmenorrhea, or it oc- curs suddenly. Conception has never been noticed in (these) amenorrheic women, who had been repeatedly pregnant pre- 192 GENERAL THERAPEUTICS OF STERILITY. vious to the use of Morphine. Therefore, it seems probable that the cessation of the menses is dependent upon anoma- lies of the ovaries. According to Pflugus's theory, in the am- enorrhoea of Morphine the growth of the cells of the ovaries cease from one period to another, and, in consequence, the irri- tability that is transmitted by the ovarian cells, and causes, on the one hand, bursting of the Graafian follicles, and, on the other, determines the reflex condition of congestion of the sexual organs, is wanting. As a consequence, Morphine affects the ovaries as it does other secretory glands, namely: it renders them unable to perform their functions. It is most probable that menstruation ceases because ovulation. ceases. The supposition that Morphine injections cause the arrest of the functions of the organs of generation is justi- fied by the fact, that after the cessation of Morphine these organs recover their activity. The sexual desire is at first increased by the habitual use of Morphine, but after the graver symptons of poisoning have been developed it almost entirely disappears. "It is also noteworthy that women who have suffered from fluor albus, are generally free from it during the prolonged use of Morphiue; this reappears after the withdrawal of the drug, often with labor-like pains." The same author says Morphine causes impotency in men. It would seem by this testimony that Morphine ought to be a specific for some forms of sterility, namely: where it has been preceded by undue sexual erethism (passion, erotism), and where the excessive indulgence has weakened the virile functions of the ovaries especially, and amenorrhoea occurs from "lapse of the menstrual habit." In a late pamphlet by Dr. Montrose A. Pallen, he contends that menstruation de- pends not alone on ovulation, viz., "that menstruation is a neurosis, indicating anatomical changes, hyperplastic action, degeneration of tissue and reparation process;" but he does not admit that menstruation ever can occur in congenital absence of the ovaries, while "a bleeding, but not menstrua- tion" may occur in cases of extirpation of the ovaries. (See Jackson, On Ovulation.) Morphine evidently does not cause atrophy of the ovaries or paresis, but simply arrest of function, which returns when GENERAL THERAPEUTICS OF STERILITY. 193 # the drug is suspended. When, therefore, we meet with cases in practice where we believe this condition exists in amen- orrheic women, or women with very scanty menses and little or no sexual desire, it seems probable that small doses of Morphine (2 or 3×) might aid in restoring the functions of ovulation and the ability to conceive. Phytolacca may be useful in sterility from syphilis, or from atrophy of the ovaries; uterine leucorrhoea, acrid, with ulceration or erosion of the os. Phosphorus. This remedy has probably a greater reputa- tion for the removal of sterility than any other. It is used successfully by both schools of medicine-by allopathists in large doses, by the homeopathist in minute doses-cures following its administration, whether used in massive or in- finitesimal quantities. There must be some rational explana- tion of this, else homeopathy is not the only true system of therapeutics. The action of Phosphorus on the healthy organs of genera- tion consists of two series of effects, namely: a primary ac- tion, during which it stimulates the ovaries to excessive functional irritation, which often proceeds to hyperemia and inflammation. This ovarian excitation extends to the uterus, vagina, and clitoris, resulting in hyperemia and hyperæs- thesia, with inordinate sexual desire, uterine spasms, albu- minous leucorrhoea, menorrhagia, ulceration, and various other morbid states; all causes of sterility. After the pri- mary irritation has exhausted the vitality of these organs, the secondary effects set in, marked by loss of ovarian func- tion (deficiency or suspension of ovulation), various organic diseases of the ovary, such as atrophy, tumors, etc., and a consequent loss of tonicity in the uterus and other genera- tive organs, resulting in loss of sexual feeling, scanty menses, too pale and delaying, acrid, excoriating acid leucorrhœa, and many others of the various conditions leading to sterility. Phosphorus is, therefore, homeopathic to sterility by virtue of its primary and secondary effects. Material doses will cure sterility if the secondary symptoms are present. It is for these symptoms and conditions that it is used successfully in allopathic practice. In the middle and highest potencies it will cure sterility presenting symptoms similar to those 194 GENERAL THERAPEUTICS OF STERILITY. enumerated among its primary actions. Gardner* quotes Dr. Mackenzie, who, before the Medical Society of London, "recommended Amorphous phosphorus in certain affections. of the uterine organs, attended with weakness and irrita- bility of the nervous system, to be given in doses from 10 to 30 grains, diffused in water. It appears to act as a direct tonic or stimulant to the uterine system." IIe has known pregnancy to supervene upon its employment, after a length- ened period of sterility subsequent to marriage. It is more relied upon than any other remedy in the actual impotence of men, i.e., from loss of power in the testicles to secrete semen. Any remedy that will restore this power in men, will restore the function of ovulation in sterile women. In Ruckert's Therapeutics, we find the observation that Phosphorus appears to be a distinguished remedy against sterility." 66 Several of my colleagues have informed me that they have known conception to occur in women supposed to be sterile, while under the administration of Phosphorus in minute doses. I can recall several instances occurring in my practice, when women who were taking this remedy continuously for pulmonary disorders, unexpectedly became pregnant for the first time in many years. Phosphorus very closely simulates Cantharides in its action ou the reproductive organs. Phosphoric acid or the Hypophosphites may be used instead of Phosphorus in some cases. Platinum. This metal appears to act in somewhat a simi- lar manner to Phosphorus, but its characteristic symptoms differ from that remedy. Thus the sexual excitement of Platinum is attended by melancholy, hysterical symptoms, cramps, with coldness and torpor, while that of Phosphorus is marked by joyous excitement, febrile heat, and nervous erethism. Gollmant has Platinum indicated "when the patient feels oppressed with anxiety, or feels very cheerful one day and low-spirited the next." *On Sterility, p. 160. + Disease of Sexual Organs, p. 251. GENERAL THERAPEUTICS OF STERILITY. 195 It is indicated in subacute ovaritis, with pain as if beaten, congestion of the uterus, induration of the cervix, menor- rhagia, and albuminous leucorrhoea. (I prefer Plat. mur. Murex is its nearest analogue.) Pulsatilla.—Both species of Pulsatilla act on the organs of generation of women in such a manner as to cause sterility. Ovarian irritation, uterine, cervical, and vaginal leucorrhoea, uterine congestions, etc., are the conditions generally cured by them. For characteristic symptoms, consult their patho- geneses. (Clematis is very closely allied to Puls.) Ruta grav. causes abortion, followed by too frequent, scanty menses, with corrosive leucorrhoea and sterility. Sabina. This drug acts as a tissue irritant to the ovaries and uterus; the latter, in particular, causing primarily in- tense active congestion, inflammation, and disorganization ; and, secondarily, passive congestion or anæmia, with torpor and actual paresis. It is, therefore, homoeopathic to ster- ility, with excessive uterine irritation, frequent and profuse menses, acrid leucorrhoea, ulceration, as well as sterility from uterine torpor, chronic congestion, ulceration, amenorrhoea; very scanty menses or passive metrorrhagia. It is analogous in action to Erigeron, Tanacetum, Trillium, Crocus, Senecio, and Calcarea. Sanguinaria and Stillingia both have aphrodisiac properties, and may prove useful remedies in the conditions which lead to sterility. Sanguinaria resembles Calcarea, while Phos- phorus and Stillingia resemble Phytolacca and Iodine. Secale.-Ergot has a different sphere of action from Sabina. It is a uterine motor stimulant. In its primary action it can excite the uterus to such spasmodic irritation that the ovule, before or after impregnation, is thrown from the womb or destroyed in its cavity. In its secondary action it causes an actual uterine paresis, in which it is impossible for the im- pregnated ovum to be retained or nourished. It will cure sterility when prescribed in the medium or the lowest at- tenuations, according as the symptoms resemble its primary or secondary action. Guernsey says it is always indicated. in "thin, scrawny women, with low vitality, subject to hæmorrhage of thin, black blood, aggravated by the least motion." This is a part of its secondary action, however. 196 GENERAL THERAPEUTICS OF STERILITY. Sepia. This agent, by its profound disturbing action on the generative organs, is capable of causing sterility result- ing from a variety of diseased conditions. It is best indi- cated iu torpid, chronic states of congestion, ulceration, and degeneration of the uterine tissues. For a correct appreciation of the genius of this remedy, the physician should study its pathogenesis and the observa- tions of our best authors. Stilingia will remove sterility resulting from secondary syphilis or chronic mercurialization. Its action in this respect compares with Aurum, Phytolacca, Iodide of potassium, and Corydalis. Senecio. This new remedy is not sufficiently appreciated by physicians. It is as important as Pulsatilla, Calcarea, and Sepia in the treatment of the diseases of women. The con- ditions indicating its use in sterility are: Frequent, painful, and profuse menses, cervical leucorrhoea, irritable uterus, subacute ovaritis (primary effects), or delaying and scanty menses, dysmenorrhea, with scanty flow, ovarian torpor, chronic mucous leucorrhoea (secondary effects). In these con- ditions it will rarely disappoint us if we prescribe it in the proper dose and persist in its use. Ustilago. This remedy is likely to prove of value in the treatment of sterility, as well as miscarriage. It appears to be a near analogue of Secule, Cuulophyllin, and Cimirifuga, but causes a more profound degeneration of the tissues and nervous system, exceeding even Secule. The symptoms indi- cating its use may be found in New Remedies, vol. i. In addition to the above remedies the following are recom- mended in the treatment of sterility. Gollmau mentions Dulcamara, Sulphur, Cocculus, Ignatia, Arsenicum, China, Nux vomica. Jahr refers to Borax, Amm., Caust., Graph., Natrum, Sulph. ac., Cicuta, Croc., Dulc., Ferr., Hyos, Nutr., and also those already mentioned. Hempel recommends Canth., Ferr., Plumbum, and Sabina. Dr. Pulte, of Cincinnati, contributes his experience in the use of the following remedies. "The remedies mostly indi- cated in cases of sterility coming under my observation, have generally been those known best under the name of uterine GENERAL THERAPEUTICS OF STERILITY. 197 remedies, such as Belladonna, Sepia, Phosphorus, Calcarea, Carb., Sulphur, etc. Of these I remember to have used oftener Sepia than any other remedy, simply for this reason; that the symptoms present indicated more frequently its use. As the causes of sterility are so various and many, it is evi- dent that a uniform treatment for its cure cannot be estab- lished. Yet I have seen sterility disappear where the lady had not been treated for that special purpose, but for other ailments, which, however, were connected with it, as the result showed. It is to be hoped that this subject will con- tinue to engage the earnest attention of the profession, as a more frequent removal of sterility will counterbalance the evil effects of artificially but criminally instituted abortion; it will be the means to bring happiness in households who deserve to bear children." MISCELLANEOUS THERAPEUTICAL AGENTS. - Galvanism or electricity has obtained considerable reputation for the re- moval of sterility. M. Rouband, in his recent work, states that he "has had greater success than most in the treatment of cases that I am now describing when no disease is ap- parent." Indeed, he claims that, "in six out of ten cases, particularly in those whose sterility is from sexual abuse or prostitution, this treatment is followed by childbirth. The application is made once or twice a week for several months, during which time coition is suspended, and great simplicity and regularity in all the details of life are to be rigorously exacted.”* Gollman recommends galvanism, and advises that it be applied by placing one pole on the os uteri, the other on the sacrum, or at various places along the spine. In Braithwaite we find recommended,† in cases of defec- tive ovarian action, an application of Professor Recamier's galvanic poultices. I have heard of a few cases where the so-called electro-gal- vanic baths appeared to have resulted in the removal of the sterile condition. * Gardner on Sterility. † Part xxiv, p. 348. 198 GENERAL THERAPEUTICS OF STERILITY. CARBONIC ACID GAS.-The topical application of this gas, according to the method of Dr. James Johnson,* is said to have exerted a remarkably powerful influence upon the re- productive organs. "Females who had for years sighed in vain for pregnancy, became fertile in a very short space of time after this gas had been applied in douches to the uterus, by means of a pipe introduced into contact with that organ through the vagina. Cases in which this beneficial result had followed its use were so numerous, that the subject merited consideration." GYMNASTICS.—The systematic adoption of gymnastic exer- cises, and especially the "Swedish Movement Cure," or "new gymnastics," will doubtless be of great value as an aid to the physician in his treatment of sterility, when not caused by any organic obstruction. HYDROPATHY, or the systematic application of water, has doubtless resulted in the removal of the sterile condition. As an adjunct to homeopathic treatment, the water-cure pro- cesses may be advised. MAMMARY IRRITATION.-Dr. Marshall Hall throws out a suggestion on the treatment of sterility, which may be tried under some circumstances. "There is an extraordinary sympathy between the mammæ and the uterus, so that a functional condition of the former influences that of the latter. This sympathy is partly nervous in its character, partly vascular. As a reflex action, the uterus is made to contract after parturition, by applying the newborn infant to the mamma; as a vascular sympathy, uterine hæmor- rhage and leucorrhoea occur from undue lactation." In cases of sterility arising from a temporary suspension of function, it is a question whether or not the uterus can be stimulated so as to assume a healthy functional action in the way suggested by Dr. Hall, who says: "My suggestion, then, is, that when the mammæ are excited at the return of the catamenial period, a robust infant be repeatedly and perse- Braithwaite, part ii, p. 64. GENERAL THERAPEUTICS OF STERILITY. 199 veringly applied, in the hope that the secretion of milk may be excited, and that the uterine blood may be diverted from the uterus and directed into the mammary vessels, and that a change in the uterine system and a proneness to conception may be induced. I would propose that the patient should sleep for one week before, and during the catamenial period, with an infant on her bosom." (Braithwaite, part ix, p. 202.) Remarks. It is possible that the irritation of the mammæ, as above recommended, would so change the condition of the uterus as to cure sterility. In such cases, however, other means of irritation might be tried, as an infant is not always "convenient." Poultices or sinapisms might be applied, or what would be better, an application of the leaves of the Ricinus communis, or castor-oil plant. Dr. McWilliams first published an account of the remarkable properties of this plant, which, when applied to the breasts of virgins even, will produce a profuse and natural flow of milk, suffi- cient to enable them to act as wet-nurses. Dr. Tyler Smith bears testimony to the efficacy of the leaves to produce this effect. The whole account of the method of applying the leaves will be found in the Lancet, 1850, p. 294, or Peters's Diseases of Married Women, p. 129. INJECTION OF SEMEN INTO THE UTERUS.-This method of removing sterility is fully described by Dr. Sims in his work on uterine surgery. It has been recommended by several medical authorities, some of them very old. Dr. Sims thinks it may be successful in some cases, and he gives a few in- stances in which he tested the plan in his own practice, with the desired result. When all other means fail, and the desire for an heir is above all other considerations, this method can be advised by the physician. THE TREATMENT OF GENERAL AND SPECIAL DISORDERS AND ACCIDENTS OF PREGNANCY: ALSO OF PAINFUL AND DIFFICULT LABOR. 14 PREFACE. THE two chapters on Dystocia which I contributed to Dr. Richardson's "System of Obstetrics," were so favorably re- ceived, and awakened such an interest in the subject, that I have rewritten them and made copious additions. There are many reasons why the profession should pay greater attention to the subject of Dystocia. They should disabuse their own minds and that of the public of the false idea that the sufferings of pregnant women must be borne without relief. When women become convinced that the sufferings of ges- tation and the pains and anxieties of labor can be alleviated, great good will be accomplished. This belief will remove many of the incentives which lead women to the crime of fœticide. It is the fear of suffering and death which influences most women to desire to avoid pregnancy, and thus to violate the purest instincts of ma- ternity. Free a woman's mind from such fears and anxieties, and a favorable influence will be exerted by the mind of the mother upon the spiritual and mental nature of the child. If anything I have written in the following pages shall prove of benefit to womankind, making her more happy in her maternal relations, I shall feel amply repaid for all my investigations and labor. CHICAGO, 1878. E. M. HALE. DYSTOCIA. CHAPTER I. GENERAL DISORDERS OF PREGNANCY. By Functional Dystocia is meant those forms of preter- natural and painful labors which are due to abnormal con- ditions of the generative organs, not structural in character. The causes of Functional Dystocia may be divided into three classes. Either class may interfere with the regular processes of nature. 1. Those special disorders and accidents occurring during pregnancy; also, those accidents which may occur during labor, all of which may endanger the life or health of the mother or her child. 2. Those labors rendered difficult, impossible, or dangerous, by a deficient or excessive action of the expulsive forces. 3. Those rendered difficult, impossible, or dangerous, by obstacles (non-structural) to the expulsion of the foetus. The treatment of Functional Dystocia may be divided into : 1. Preventive, which includes those hygienic measures and medicinal agents which may be advised during pregnancy and previous to the time of labor. 2. Immediate, or those medicinal agents and auxiliary measures to be adopted during the progress of the labor. PREVENTIVE TREATMENT.-The adoption of a prophylactic treatment for painful or difficult labor has not attracted that attention from physicians that the subject demands. It is a singular and suggestive fact that nearly all barbar- ous and semicivilized tribes or nations do adopt some treat- 206 GENERAL DISORDERS OF PREGNANCY. 1 ment, to which pregnant women are subjected, and which is supposed to have a modifying influence on their confine- ments. This treatment, in some cases, consists merely of certain baths and ablutions; in others, of semi-religious or supersti- tious rites, such as ablutions and alterations in diet; while in some tribes, like the North American Indians, the treat- ment consists almost wholly in the drinking, for several months, weeks or days previous to labor, of the infusions or decoctions of indigenous plants. Some physicians affect to sueer at any medicinal measures used to ward off possible abnormal conditions which may render labor painful and difficult. But if these same phy- sicians could know that any patron would, after a few weeks or days, be attacked by a scarlet fever or rheumatism, would they not prescribe some hygienic or medicinal measures to mitigate the severity of such attacks? Now, although labor is a natural function, and the re- sources of the organism are usually sufficient for its accom- plishment, yet there are a number of circumstances which may interfere with the work of nature, and render the process painful, difficult, and dangerous. If, then, the physician can devise any means by which these obstacles to a normal labor can be prevented or modi- fied, it is his duty to adopt such means for the relief of those who are placed under his care. I do not believe that it is necessary, or normal, that all pregnancies or labors shall be painful. The process of parturition is purely a physiological one, as much so as the process of urination and defecation. The latter especially is closely allied to parturition in its mechan- ism. I do not believe the one should be more painful than the other. Notwithstanding it has been asserted by travellers and residents among aboriginal tribes, that the women of such tribes do suffer from the "pangs of childbirth," I do not believe that their so-called sufferings compare in nature and intensity with those of women in a state of civilization. The fact is, that there are very few tribes on the globe which can be said to be now living in a natural state. The GENERAL DISORDERS OF PREGNANCY. 207 slightest contact with civilization modifies their habits and customs, and every slight modification tends to alter their physiological functions. I have received positive and trustworthy information from those who have spent many years among our native tribes, that they know of hundreds of instances where the process of childbirth was not attended by other than painless ex- pulsive efforts. And more: nearly every physician of large obstetric practice has attended cases in which the woman was confined in so short a time, and with so little suffering, that the labor could be termed painless. In my own practice I have known many instances where pain, as properly understood, was not present. The labor was attended by bearing-down, expulsive efforts, and some vascular and mental excitement, nothing more. Therefore normal labor may be termed a painless function. So long as the human race can never return to a state of existence such as we picture as the ideal, so long will a large proportion of women be subject to dystocia. What are the elements to be taken into account in the preventive treatment of functional dystocia? If possible, we should first ascertain if any structural ob- stacle exists. If we find none, we should then inquire into the history of the patient. If a p imipara, we should get her menstrual history, as this may be some guide as to the probable nature of the labor. (6 'Some writers," says Cazeaux, "have attempted to estab- lish a relation between the phenomena that precede or ac- company the menstrual discharge in the non-gravid state, and the activity or slowness of the contractions of the womb during the labor; for they say, should the periodical flow be difficult, laborious, and painful, and the patient be tormented every mouth with violent colicky pains, either before or during her terms, the irritability of the uterus, and the energy of the contractions will almost invariably be excessive in the hour of childbirth; but, on the contrary, there is reason to anticipate the occurrence of slow and feeble pains when the woman is advised of the return of her nienses only by the 208 GENERAL DISORDERS OF PREGNANCY. appearance of blood, and when they pass off without suf- fering." There is much truth in this theory, for it has been observed that those women who were the subjects of violent dysmen- orrhoea, usually have very painful labors, especially the first; and that the subjects of menorrhagia were more liable to post-partum hæmorrhage. In the case of multipara we may judge of the probable nature of the dystocia by the history of her previous labors. In this way I have known. of hundreds of cases where the sufferings of the woman have been greatly palliated, and even almost prevented. Not only should we inquire into the history of the previous labors, in their relation to the uterus, etc., but into the con- dition of the other organs at the time of labor. If in previous labors or pregnancies, the heart, lungs, kid- neys, or bowels were in an abnormal condition, we should select our remedies to accord with the abnormal condition of those organs. In this connection it should be stated that the commonly received notion among women, that the distressing and pain- ful sensations occurring during pregnancy must be borne without applying for relief, because they occur during preg- nancy, should be abandoned, and it should be the duty of the physician to disabuse the minds of his patients of this erro- neous belief. Normal pregnancy should not be attended by painful symptoms; consequently all such are abnormal, and demand relief, and the carefully selected homeopathic remedies will generally give relief. The principal medicines indicated for the disorders of pregnancy, or as prophylactics of dystocia, are: Arnica, Esculus, Aletris, Bromides, Caulophyllum, Cale. c., Cimicifuga, Collinsonia, Digitulis, Ferrum, Eupatorium pur- pureum, Gelsemium, Gossypium, Helonias, Ignatia, Nux vomica, Pulsatilla, Secale, Scutellaria, Trillium, Senecio, Sepia, Ustilago, Viburnum, and Veratrum viride. In order to have a clear understanding of the nature of these remedies and their indications, we will consider the various causes and conditions which relate to dystocia and mention the remedies indicated for such conditions. GENERAL DISORDERS OF PREGNANCY. 209 Arnica causes a depressed state of the nervous system, es- pecially the cerebro-spinal and the vaso-motor, leading to a stasis of the capillaries. When pregnant women complain of soreness of the muscles, lameness, and weakness of the limbs, and such weakness of the capillaries that discolored spots appear upon the skin after slight pressure, the external use of Arnica-water, and the simultaneous use of Arnica in- ternally, is of great value in preventing painful and difficult labors. It also prevents that extreme soreness and tender- ness of the uterus and genital passages which occurs even after normal labors. Esculus will remove many of the symptoms of painful pregnancy, particularly the lameness in the sacro-ischiatic ligaments, but it is especially useful for the disorders of the rectum, which often cause great discomfort and lead to dys- tocia. It removes the tendency to hæmorrhoids if given in time, and tends to prevent the occurrence of painful and protruding piles after labor. Premature labor is often in- duced by rectal irritation, and in such cases Esculus will prevent that accident. Aletris is a powerful tonic to the muscular system, and the organs concerned in the process of nutrition. It is use- ful if the woman is weak, cannot endure exercise, has loss. of appetite, and a constant sensation of weight and pressure downward in the pelvis. A few drops of a low dilution be- fore meals will often restore the appetite and nutrition in a brief time. If the liver is torpid in addition to the above symptoms, and the woman has gastric catarrh, Hydrastis will be useful. The Bromides are very useful agents in the treatment of the pregnant state. Plethoric patients are often troubled with an undefinable nervous erethism, accompanied by hallucinations, morbid impulses, even sexual appetite in excess, horrible dreams, or exceeding wakefulness. The ordinary household cares worry them exceedingly, they are restless and sleepless, have rush of blood to the head, vertigo, fainting, etc. In such cases I have seen such excellent soothing results from the bromides, with such an evident improvement in the general meutal and bodily he: Ith, that I sincerely advise their use. 210 GENERAL DISORDERS OF PREGNANCY. For the indications, consult the provings in "Symptoma- tology of New Remedies." For general use I prefer Bromide of soda, but if there is decided intracerebral congestion, with pain in the occiput, and hemicrania, the Bromide of ammonium is preferable, while for purely mental aberration the potash salt is the best. If the tendency to congestion of the brain is attended by scanty urine, the Bromide of lithia acts promptly. When hysteria, faintings, and tendency to spasms are imminent, the Monobromated camphor is of great utility. The dose of these preparations must be varied with the exigencies of the case. I have never seen good effects from them in the high attenuations. From one to ten grains, repeated at suitable intervals (one to six hours), will be found to remove the above-named mor- bid manifestations. In cases of threatened cerebral congestion, with cold hands and feet, flushed face, distended carotids, vertigo, incoherent speech, etc., I have often given twenty grains of the Bromide of lithia, with the result, as I believe, of saving life or pre- venting severe illness. In the most violent cases of hysteria, and hysterical spasms, from one to five grains of the 1 trit. of Bromide of cam- phor often arrests them, if repeated every ten or fifteen minutes. During the latter months of pregnancy some women are so oppressed by cerebral congestion that puerperal eclampsia is imminent. I believe this fearful accident may be warded off by the bold and judicious use of the bromides. Even if uræmia is present, the bromides are not contraindi- cated, for they aid in the elimination of the poison, acting as diuretics, especially when their use is associated with the administration of Apocynum, Apis, Cantharis, Helonias, etc. Caulophyllum is one of those indigenous remedies which, from the earliest occupation of America by the whites, has been known to be used by the aborigines as a preventive of difficult labors. Nearly every tribe use this, or some analo- gous plant, the woman drinking a weak decoction of it a few weeks prior to expected labor. We have not yet anything approximating a complete knowledge of its action on the human body; the provings are meagre and unsatisfactory. GENERAL DISORDERS OF PREGNANCY. 211 But from the large mass of clinical evidence, we deduce that it acts upon the smaller muscles, the uterus, and perhaps all other hollow organs. It appears to act on the muscular fibres which engage in expulsive action. Its primary action is to exalt the irritability of such muscular fibre, its second- ary to depress. We may prescribe it in the absence of special indications, in primipara, when the menstrual periods have been very painful, from spasmodic action, and where the pains of the dysmenorrhoea have been like labor-pains, and the discharge small in quantity and short in duration. Or in multipara when the previous labors appear to have been violent, painful, the paius spasmodic, regular, but with rig- idity of the os and soft parts. In very many cases I have prescribed the Caulophyllum for these general indications, and with the happiest results, the following confinement being natural and comparatively free from pain. During the last fifteen years I have published in the vari- ous journals of our school many cases corroborative of its power over dystocia. Many such cases have been reported by physicians of our school in all parts of the world. Besides its value in preventing excessively painful, tedious, and slow labors, it has other powers equally useful. It miti- gates, and often altogether prevents those annoying and dis- tressing "false pains," so common to the women of our cities and large towns. These pains are generally located in the hypogastrium, they appear at nearly regular intervals, the paroxysms coming on every night for weeks, and the pains recurring every few minutes or every hour. They often extend into the limbs, up the sides, and into the abdomen. Some women are so irritated by these pains that premature labor is induced by them. In these cases not only does the Caulophyllum arrest the pain, and make the last few weeks comfortable, but it gives an easy labor, and according to the testimony of some of my colleagues, protracts by several days or a week the duration of pregnancy. The dose of Caulophyllum is an important consideration. It is claimed that good effects have been obtained from the third dilution, or the sixth trit. of Caulophyllin. In a few cases I can verify these claims, but in a majority of instances I prefer the lower attenuations. The violently spasmodic, 212 GENERAL DISORDERS OF PREGNANCY. very painful effects of the drug are primary effects-the atonic, paralytic effects, secondary. Therefore, while the middle attenuations will act curatively in very painful, spas- modic conditions, due to great irritation, the lowest prepara- tions, even the crude drug, may have to be used for atonic conditions. Physicians of the Eclectic school habitually prescribe the tincture in five-drop doses, or the active prin- ciple in doses of fractions of a grain, for weeks before confine- ment, with no alleged bad results. I believe I have seen dystocia, and painful symptoms during pregnancy, warded off by the third attenuation; but I have also seen the hap- piest effects from the 1, 2, and even drop doses of the tincture, repeated every two, three, or four hours. It is well to begin the use of Caulophyllum a month or six weeks be- fore full term; or six or ten weeks, if the woman fears a prem- ature labor at the seventh or eighth month-a dose to be taken once or twice a day. It has been known to enable women to carry children to full term, who habitually had premature labors. It may be well to mention a few practical hints as to the methods of administration. Pellets may be employed if the dilutions are used; large pellets will each absorb nearly a drop of the alcoholic mother tincture. The tincture or first dilution in drop doses often causes an unpleasant burning in the throat. This may be avoided by prescribing it in simple syrup or gum-water. The low triturations of Caulophyllin have the same effect, which may be avoided in the same man- An elegant method of administering a definite dose of the active principle is in the form of a sugar or gum- coated pellet or granule, manufactured by several firms in this country. These granules contain quantities from the 1-10 grain up to 1 grain. The former is best for use during pregnancy; the latter to facilitate labor. ner. Cimicifuga is a near analogue of Caulophyllum, but has some notable differences in its method of action. 1. It acts upon the cerebro-spinal system, giving rise to spasmodic, neuralgic, and myalgic pains. These pains and spasmodic motions are not symmetrical, but irregular, and tend to run into choreic movements. 2. It affects specifically the large muscles, and has the power of causing a variety of muscular GENERAL DISORDERS OF PREGNANCY. 213 pains, such as rheumatic, myalgic, and spasmodic. 3. It affects the brain and mind, causing congestive headache, melancholy, and mania. All these conditions above named are well known to be concomitants of the pregnant state, and lead to the most troublesome forms of dystocia. Dr. Meigs (Obstetrics, page 260), asserts that a large pro- portion of the cases of "false pains" occurring during preg- nancy are due to uterine rheumatism. He gives a clear and graphic description of such cases, and his opinion is very valuable. I have observed that many pregnant women who are troubled with "false pains," and who have very painful labors and severe after-pains, have been subject to dysmenor- rhoea, which was undoubtedly of a rheumatic character. Now, of all remedies for rheumatic affections of the uterus, none are of greater value than Cimicifuga. Its only rival is Guaiacum, Salicin, or possibly Viscum Album. In many instances of abnormal pregnancy it is superior to Caulophyllum, because of its wider range of action and greatly superior power. If the student will consult the latest full pathogenesis of Cimicifuga, he will see the special indications fully set forth. My records of cases contain many wherein this remedy has removed profound melancholy, insanity, and a condition simulating delirium tremens. These women might have been immured in lunatic asylums but for its curative power. A frequent and distressing attendant of some pregnancies is the well known "pain in the left side," under the left breast. This pain may shift to the left ovarian region, or upward to the left arm, and even change to the vertex. All these pains promptly give way to a lower attenuation of Cimicifuga. Many physicians, especially those of the Eclec- tic school, value Cimicifuga more highly than Caulophyllum as an agent for the prevention of dystocia. The Eclectics use it on general principles; they claim that it brings about a normal relaxation of the muscular structures, which if "rigid," would obstruct the progress of natural labor; that it gives tone to those muscles which have an expulsive function; and moreover, that it gives the nervous system that strength and tone so requisite in such cases. When speaking of the imme- 214. GENERAL DISORDERS OF PREGNANCY. diate treatment of dystocia the indications for its use will be more fully set forth. As a general prophylactic of dystocia, it should be pre- scribed to be taken several weeks before full term, or other- wise, as set forth under Caulophyllum; the active principle, Macrotin, can be given in the 2 or 3* triturations. Collinsonia has many points of resemblance to Esculus. It acts upon the same organs and tissues, but has in addition a toning power, especially over muscular fibre. It will re- move the obstinate constipation and hæmorrhoids of the last months of pregnancy. It does this by restoring the nor- mal irritability of the muscular coats of the intestinal canal. It is well known that during pregnancy there occurs a nor- mal or physiological hypertrophy of the heart, to compen- sate for the increased demand for a more powerful circula- tion. If the pregnant woman has a neurosthenic diathesis, this hypertrophy will be attended with an increase of the action of the heart far beyond its proper bounds. The pulse will reach 120, but regular, when it should be 80 or 90. If the conditions above named all occur together, during the last month of gestation, dystocia would be sure to result, fol- lowed by an unfavorable puerperal state. Collinsouia, in the attenuations from the first to sixth, will be found effica- cious if it is used patiently and persistently. Digitalis is a far more potent medicine than the last named, and in many pregnancies is absolutely indispensable. By its judicious use a woman may be carried to full term, when suffering from cardiac disease, when without it she might not survive to reach the last months, or, if surviving, suffer miserably. 1 If a woman enter upon pregnancy with a "weakened heart," whether from functional or organic disease, the physiological "strain," which it is called upon to undergo, soon merges into abnormal conditions. In the so-called "ir- ritable heart," when its action is irregular, intermitting, weak, and excitable, no remedy compares with Digitalis in its con- trolling power. The patient, who before its use could not go up stairs, or take needed exercise, without distressing. palpitations and dyspnoea, soon finds herself more comforta- ble in every respect. Digitalis acts upon the heart as does GENERAL DISORDERS OF PREGNANCY. 215 Cimicifuga upon the uterus, regulating irregular action and imparting strength through its nervous supply. A woman who goes through gestation with any organic heart disease (except hypertrophy with thickening) is liable any moment to exhaustion, and even death from cardiac failure. But if the heart is kept supported by Digitalis, no such accident will occur under ordinary circumstances. A weakened heart implies irregular and generally deficient blood-supply in every organ of the body. In the brain we have anæmia or venous stasis, so also in the lungs, uterus, and kidneys. The kidneys usually suffer most, for the irregular blood-pressure in those organs lays the foundation for those conditions known as Bright's diseases, and consequent uræ- mia. Even if the heart is not complained of, and the patient has irregularity in the quantity of urine, at one time scanty and dark, at another profuse and watery, and especially if oedema of the face or feet is present, Digitalis should be pre- scribed. But it is useless to give Digitalis unless the proper dose is selected. The exclusive high attenuationist will not see any good effects from it in the above conditions, for they all belong to the secondary effects of the medicine, and the scien- tific law of dose calls for material quantities. As a rule, a grain or two of the 1* Digitalis leaves, or the 2ª of Digitalin, or two or three drops of a good tincture, repeated three or four times a day, will bring about good results. In rare cases the 2x will suffice. These doses can be continued days and weeks with none other than favorable effects; no "cumulative action "is ever seen from these doses, and in these conditions. If anamin is present, and the patient fails in obtaining good blood from food, the use of Ferrum should always be associated with Digitalis. These two medicines act very harmoniously in such conditions, the iron cures the malnutrition, and soon enriches the blood, and the Digitalis insures its normal distribution by means of a strengthened heart. I prefer the 1 trit. of Ferrum met. or Ferrum lact. to any other preparation. Give the Digitalis before meals. and the Ferrum after. Digitalis will also prevent hæmor- rhage after labor, when there is a predisposition to it. It acts on the uterus as it acts on the heart, inducing firm con- tractions. X 216 GENERAL DISORDERS OF PREGNANCY. Lycopus virginicus is a near analogue of Digitalis. It will control a weakened, irregularly acting heart, with dyspnoea and cough from pulmonary stasis. It has not, however, the dropsical symptoms of Digitalis, nor the scanty urine. On the contrary, the urine is profuse-a condition simulating diabetes. Helonias has long had a reputation as a true "uterine tonic." The few provings made, seem to show that it re- sembles Cimicifuga, Aletris, Ferrum, and Pulsatilla. Certain it is, that all the generative functions when disordered, seem to improve under its influence. Not only does it exert a profound influence over the uterus and ovaries, but the kid- neys are included in its sphere of action. It has cured many cases of albuminuria and desquamative nephritis, and con- ditions simulating Bright's diseases, and I predict it will be found one of our most efficacious remedies against uræmia. If a pregnant woman in the last months becomes enfeebled, pale, anæmic, dyspeptic, with albuminous urine, excessive or deficient in quantity, and has great depression of spirits, the Helonias should be prescribed in the 2 or 6* dilutions (or triturations of Helonin), several doses a day until her condi- tion has decidedly improved, and then repeated less often, up to the day of her delivery. 66 Gossypium is a medicine about which there is still an at- mosphere of doubt and incredulity. Many physicians be- lieve it to be a valuable uterine tonic, others deny its power altogether. The provings found in " New Remedies" seem to show that it has some action on the uterus. It is probable that the fault lies in the difficulty of preserving intact the virtues of the root in any discovered preparation. The fresh root is certainly a uterine motor, and has been known to bring on labor, or facilitate difficult parturition. It has been used for the same purpose as Caulophyllum, as a preparatory agent for the purpose of bringing about natural and easy labor, and with alleged success. The dose is usually from five to fifteen drops of the tincture daily. Pulsatilla.-I have for many years been convinced that the uterine affinities of this medicine have been greatly over- rated. It may cause uterine blennorrhoea, venous congestion, and neuralgia, but I do not believe it to be a uterine motor. GENERAL DISORDERS OF PREGNANCY. 217 3 It removes many of the sufferings of pregnancy, such as toothache, prosopalgia, vomiting, indigestions, intestinal de- rangements, and anomalous nervous affections of the gener- ative organs. In this way, if selected according to its symp- toms, it may prove a remedy to ward off dystocia. In its pretended power to change abnormal presentations of the fœtus in utero, I have not the slightest confidence. We know that spontaneous version is a common occurrence, and that it happens apparently when most demanded, and at the very time when Pulsatilla would most likely be given for that purpose. Of its use during painful and difficult labor I shall speak in another place. Secale ought, by its undisputed power over the impreg- nated uterus, especially during the last months of gestation, to prove an efficient remedy against dystocia, when prescribed previous to that event. I am not aware, however, that it has been used as such, except in a few instances, and nearly all of those in my own practice. These cases were all char- acterized by the peculiar cachexia belonging to Ergot, in which there is a strong tendency to failure of the vital powers, a predisposition to hæmorrhage, and a lack of vitality in the fluids of the body. If a pregnant woman becomes feeble, emaciated, with dry shrivelled skin, cold hands and feet, sensation of great weight in the uterus, and worrying false pains, and feels as if she should be sick any day during the last month, Ergot in small doses is the remedy, and especially so if her previous labors have been slow, feeble, and followed by hæmorrhage and long-lasting, fetid lochia. This powerful uterine motor ought to prove one of the best of all remedies against dystocia. It is necessary, however, that we should have a correct understanding of its method of action, in order to prescribe it successfully. Primarily in large doses it causes violent, persistent, tonic contractions of the uterus, with expulsive efforts, also vaso- motor spasm of its blood vessels, but this is followed by a corresponding depression of the motor power of the uterus, with vaso-motor paralysis. Thus, secondarily we have uterine atony with tendency to passive hæmorrhage. This gives us a clue to its true curative action as a preventive of dystocia. If we have reason to fear that the woman will be confined 15 218 GENERAL DISORDERS OF PREGNANCY. prematurely from want of tone of the uterine muscular fibre, or, if she goes to full term, only to have a slow, distressing labor, with deficient pains, lack of expulsive power, tendency to hæmorrhage from deficient contraction, and finally sub- involution of the uterus, Secale, in a low dilution, may be given every day during the last month, with every prospect of success. (The dose I advise in such cases is one to five drops of Squibb's Fluid Extract three times a day, up to the day of confinement, beginning ten or fifteen days previously.). Be sure, however, that the preparations used are reliable, for of all medicines Ergot is most likely to be inert. I prefer Squibb's preparations, or the French Ergotin, and am sorry to say that the tinture ordinarily sold cannot be trusted. Ustilago. This fungus, although a near analogue of Ergot, cannot be said to be identical in action. It has more control over the unimpregnated uterus, and over the impregnated in the early months. It is of more value as an anti-abortive than as a preventive of premature labor. It is especially indi- cated in a certain atonic condition of the uterus, when there is a passive hæmorrhagic condition, the blood being black, grumous, or muddy. There is but little pain attending this symptom, ouly a sense of weight in the uterus and much general prostration. During the last months of pregnancy, these symptoms are sometimes annoying and give rise to much anxiety. This anxiety is not without cause, for they portend a slow, difficult, and dangerous labor, on account of the atony of the uterus. During labor, hæmorrhage difficult. to control, may occur, owing to deficient contractility. This condition, however, may be prevented by giving the lower triturations, several doses a day, for a week or more previous to confinement. Viburnum.-This medicine, which has of late become very popular in the treatment of dysmenorrhoea and allied affec- tions of the uterus, has been called by the expressive name of cramp-bark, from time immemorial. I was, I believe, the first in our school to call attention to the peculiar properties of this medicine, although it has been used in domestic prac- tice for a century. Its common name perfectly expresses its remedial power. Its action on the nervous system gives it GENERAL DISORDERS OF PREGNANCY. 219 a decided curative power over painful contractions of muscles, particularly the flexors of the limbs, and those engaged in expulsive actions in hollow organs. Like Caulophyllum, Cimicifuga, and Helonias, it had a reputation among the aborigines and early settlers of this country, as a preventive of painful labor. An infusion of indefinite strength was drank daily for a few weeks previous to expected confinement. Empirical experience has enabled us to define its range of action, and its curative power. It is indicated when the patient has been the subject of exceedingly painful dysmen- orrhæa, or uterine cramps, accompanied generally by cramps in the limbs, abdominal muscles, or other parts of the body. In such cases it is to be considered probable that the woman will have a very painful labor due to cramplike contractions of the uterus, with cramps in the limbs, etc. Associated with these symptoms will appear excessive erethism of the nervous system. All species of the Viburnum, which I have examined, contain a large percentage of Valerianic acid, which gives it great power over abnormal conditions of the nervous system. It is especially indicated for hysterical women, and when we have reason to fear that the labor will be complicated with hysterical spasms Some cases of puerperal eclampsia are purely hysterical, and may be prevented by the previous ad- ninistration of the Viburnum opulus, or Viburnum pruni- folium. The latter possesses great power in preventing mis- carriage and premature labor, and its use should never be neglected when painful cramplike pains attend any period of pregnancy, especially the last months. X The dose found most efficacious varies from a teaspoonful of the tincture, or fluid extract, to single drop doses of the mother tincture, or the 1 dilution. These doses are per- fectly harmless, for it is a uterine sedative, not a uterine mo- tor-excitaut. It is the opposite of Caulophyllum, Ergot, or Ustilago. These doses should be repeated several times a day for weeks before labor, or every hour or two during the pains. Veratrum viride -My own experience and observation has convinced me that this medicine is invaluable in some cases of threatened and apparently inevitable dystocia. In some constitutionally plethoric women the plethora in- 220 GENERAL DISORDERS OF PREGNANCY. creases to a great extent during gestation, and this condition is increased to a dangerous extent by the physiological car- diac hypertrophy. An enormous quantity of blood is manufactured, and the body is not only fed to excess, causing great increase in its weight, but all the important organs are engorged. In such cases it may be expected that convulsions will occur upon the slightest exciting cause. Apoplexy, both of the brain and lungs, is a common occur- rence in such an abnormal state It is well known that cut- ting off the supply of blood-making food will not always re- duce the plethora, and venesection being virtually abandoned by the old school, is never seriously thought of by ours. We have, however, in Veratrum viride a remedy which, associated with a low diet, will, in nearly every case, arrest the inordinate plethora. This it does by slowing the action. of the heart, and lessening its abnormal force. Under its in- fluence I have known the bodily weight decrease several pounds a month, with general relief to the engorged head and lungs. It also decreases the abnormal arterial pressure in the kidneys, and is of great value in preventing serious renal congestion. Its sedative action on the cerebro-spinal system and the convulsive centre in the brain, tends to pre- vent the occurrence of puerperal eclampsia, for which acci- dent it is almost specific. The proper dose varies according to the susceptibilities of the patient, ranging from one drop of the first dilution (1) to five drops of the mother tincture, repeated three or four times daily. It should be given largely diluted with water, and during its administration, strong tea and coffee, or spirits, and animal food should be prohibited. The use of the alka- line mineral waters, Vichy, Seltzer, or Kissingen, aids its ac- tion. Hydrotherapy —The careful and judicious application of some of the measures used in the so-called water-cure system, are very efficacious in removing many of the ailments of pregnancy and thereby preventing dystocia. Very many instances have come under my observation wherein women who have failed to carry the child to full term, owing to laxity of the uterine tissues, or irritability of GENERAL DISORDERS OF PREGNANCY. 221 that organ, have been enabled to give birth to a child at full term by means of the sitz-bath, etc. Other cases I have known, where women have had tedious, difficult, and dangerous labors, when a residence for a few months in a Water-Cure establishment would seem to remove all the abnormal conditions, and their next labor would be easy and natural, nor followed by unpleasant sequelæ. The home-treatment of pregnant women is not carried on as successfully as at a "Cure," unless the patient has every means at her command, and also possesses a persevering and patient disposition. It is probable that the rest and freedom from domestic care, the systematic exercise and the excellent healthful diet, have much to do with the cure of such patients. But when a residence in a "Cure" is not con- venient, or feasible, the physician can give proper directions for the home treatment. The three most useful hydrotherapic appliances are: the sponge friction-bath, sitz-bath and wet bandage. In the majority of cases all three will have to be combined, especially when there is general and local debility. The sponge-bath, associated with smart rubbing or friction, with the hand or brush, is a powerful tonic to the system, providing the patient is strong enough to hear it. In cases of feeble and delicate women it should be used with great cau- tion, not repeated too often, or its use prolonged beyond a few minutes. It is not necessary to expose and bathe the whole body at once, but a portion at a time, leaving the rest clothed. Alcohol or spirits should never be put in the water, unless they leave a warm glow, and a soft, supple skin. In very much emaciated subjects, the use of oil instead of water is a powerful means of nutrition, and should not be neglected. It should be thoroughly rubbed into every por- tion of the body, and repeated every day or two, with a general water-bath once a week. Even dry rubbing by a healthy person is a tonic to the muscular and nervous system if it is agreeable to the patient. The sitz-bath (hip-bath) is best adapted to relieve local con- gestious and weaknesses of the sexual organs. Of all the water-cure appliances this is the most popular among weak 222 GENERAL DISORDERS OF PREGNANCY. and debilitated women. Properly used, it acts as a tonic to the circulation of the pelvic viscera. The modus operandi of the sitz-bath has been variously explained. My views of its action may be briefly stated. The very hot sitz-bath has nearly the same effect as the very cold. Both primarily contract the external blood vessels and determine an unusual flow of blood to the internal organs of the pelvis. But these extremes are rarely useful. The temperature of the water should rarely exceed 100°, or fall below 60°. At this temperature they rather equalize the pelvic circulation, and have a toning effect. They have doubt- less a stimulating effect on other nerves than the vaso-motor, as it is well known that hot or cold sitz-baths increase the power of uterine contractions. But leaving out all theoretical explanations of their value, we know that the regular and persistent use of sitz-baths do greatly assist in the cure of chronic uterine disorders, and avert threatened miscarriage and prevent habitual abortions. We also know that they are a great comfort to delicate women in the last months of pregnancy, relieving false pains and many other abnormal sensations. I have known many feeble women use the sitz-baths daily all through pregnancy, up to the very day of confinement, and more, I have known them pass the hours of labor in a sitz-bath These women had previously suffered intensely all through their pregnan- cies, but they all declared that these baths prevented similar sufferings, and even mitigated greatly the pain of labor. The temperature of the water should be made to suit the feel- ings of each patient. Let each be her own judge. The duration of the bath may be ten or thirty minutes, and this too may be generally left to the sensations of each patient. The depth of the water should be just sufficient to cover the hips and rise to the crest of the ilia The wet bandage is another method of applying water, pure or medicated, that should not be neglected. There are patients who are not able to use hip-baths, or are not pleasantly affected by them, yet these patients suffer from some or all of the following symptoms, namely: sensations of soreness, tender- ness or sensitiveness of the lower abdomen, weight, dragging GENERAL DISORDERS OF PREGNANCY. 223 # and bearing down in the pelvis, constant tearing or burning pains in the sacral region, heat and fulness in the uterine region, and many other symptoms pointing to passive stasis of the uterine circulation and weakness of its muscular structure. In such cases the regular use of the wet bandage every night, and even day and night, is followed by the best results, namely the gradual removal of all the above symptoms. The bandage should be of light towelling, double or treble, and covered by one thickness of flannel or cotton drilling, and should be a foot wide. It should be wrung out in water cool or warm to suit the feelings of the patient (cool is ad- vised), and changed as often as it becomes too warm or dry. The water may be medicated with Aconite, Arnica, Nux, Hamamelis, or Cimicifuga, in proportion of one-half ounce to a gallon. * 224 DISORDERS AND ACCIDENTS OF PREGNANCY. CHAPTER II. SPECIAL DISORDERS AND ACCIDENTS OF PREGNANCY. NAUSEA AND VOMITING In many cases of pregnancy, in- tense nausea, or severe and painful vomiting renders the life of the woman almost insupportable. Not only does it cause. great physical discomfort, but it interferes greatly with the general health and enfeebles the system, rendering the wo- man poorly prepared for the exigencies of labor. Until within a few years it was supposed that little or nothing could be done by the physician to alleviate this symptom. But with the advance of our knowledge of the pathological conditions which may be incident to the pregnant state, and the discovery of the law of similia and the pathogen- etic qualities of medicines, much has been done to relieve the above symptonis. But, as in nearly all pathological conditions, we must as- certain the cause of the vomiting or nausea before we cau remove it. Until lately the theories which were put forth to account for the presence of this vomiting, were vague and unsatisfactory. The general belief, however, was that it was caused by "reflex irritation," and that the source of irrita- tion was to be found in the uterus; but as to the exact condition of the uterus which caused this reflex irritation no satisfactory explanation was given. The assertion that the vomiting was caused by the presence of the impregnated ovum, or growing embryo, or enlargement of the uterus, are all untenable, because only a small proportion of pregnant women have sufficient nausea to be unpleasant, and many none at all. If either of the above conditions caused the vomiting, all pregnant women would suffer from it. After carefully analyzing all the most recent theories of the causes of vomiting during pregnancy, I believe there are three conditions only to which it is due, namely: (1.) The presence of the impregnated ovum. (2.) Flexions and versions of the uterus. (3.) Constrictions of the cervix uteri. DISORDERS AND ACCIDENTS OF PREGNANCY. 225 (1.) Many women assert positively, and many gynæcologi- cal authorities place reliance on their testimony, that nausea sometimes occurs immediately after a successful intercourse, ¿. e., an intercourse during which the semen effects an en- trance into the uterus. * We also know that the mere pass- ing of the sound into the uterine cavity, or the introduction of a few drops of fluid, will, in some women, cause nausea and vomiting. The ordinary nausea of pregnant women, how- ever, usually occurs about the fifth or sixth week, at a time when the embryo begins to exert by its growth some pres- sure upon the parietes of the uterus ; but this ordinary nausea usually passes away in a few weeks. I ought to add that it is Dr. Hewitt's opinion† that not only the severer forms of vomiting of pregnancy, but even this supposed normal nausea of the early months, is due to slight flexions of the uterus. He thus explains it: "It is the fact that the patient generally experiences the symptom in question on first rising in the morning, or while dressing. Why is this? Is it not because the body of the uterus falls a little downward in obedience to the law of gravity, there- by producing a slight flexion and a compression of uterine tissues at the seat of the flexion. During the first three and a half months such a temporary flexion is possible, because the uterus is still in the pelvis Generally after that time. it rises out of the pelvis, and flexion to more than a very slight extent is no longer possible (but version is of fre- quent occurrence). Is it not the fact that for the most part the liability to nausea and vomiting ceases at precisely this period. It is also a fact, which will be confirmed by all who make the experiment, that in ordinary slight cases of nausea and vomiting, by ordering the patient to remain absolutely in the horizontal position the symptom ceases." Dr. Hewitt, perhaps, carries his theory too far, for it is well known that by taking her breakfast in bed, or drinking a glass of cham- pagne before rising, the nausea is ameliorated. Still it is a suggestive fact, that the remedies most useful in flexions of the uterus, namely: Sepia, Lilium, Nux, Puls., etc., are often * See Pamphlet by Dr. M. A Pallen, heretofore quoted. + Disenses of Women, p. 436. 226 DISORDERS AND ACCIDENTS OF PREGNANCY. our best remedies in this nausea, although Ipecac. is generally very useful, for other reasons. (2.) That the really severe and painful vomiting which renders some pregnancies so distressing, is caused by flexions and versions of the uterus, there is now but little doubt in the minds of well-read physicians. We are chiefly indebted to Dr. Grailey Hewitt, of England, for the discovery of this fact. In a paper presented to the Obstetrical Society of Lon- don, 1871, he propounded his views on this subject, which are further set forth as follows in his Diseases of Women, page 429. Ilis argument is (a) that nausea and vomiting are as- sociated with pregnancy. (b) Nausea and vomiting are asso- ciated with disease of the uterus; (c) but nausea and vomit- ing are not always present in cases of pregnancy, nor are these symptoms always present in cases of uterine diseases. (d) It is probable that the nausea and vomiting of pregnancy and that from uterine disease, are both due to a similar cause. (e) Nausea and vomiting are very common in flexions of the uterus, especially when the flexion prevents the escape of any fluid in the cavity of the uterus. Dr. Hewitt arrives at the conclusion that "the sickness of pregnancy is due to the combined effects of the increasing distension of the uterus and an associated flexion of that organ." He offers a large array of proof in support of this theory, and I must say that the testimony which he brings for- ward seenis indisputable, especially so in view of the fact, that for many years my experience substantiates it. Dr. Hewitt says: "Ilaving occasion to treat cases of sickness in young unmarried women suffering from flexion, it has been observed by me that when those patients marry and become pregnant, the sickness observed is liable to be unusually severe and troublesome." He also observes that "cases which have come to me in the course of consultation prac- tice, and when the symptoms of sickness have been still more troublesome, I have always recognized an abnormal condition of the uterus as regards its shape." Treatment. In excessive nausea and vomiting from act- ual flexions of the uterus, the treatment should be more mechanical than medicinal. I do not think it possible that any medicinal agent can restore the bent uterus to its normal DISORDERS AND ACCIDENTS OF PREGNANCY. 227 shape, without the aid of posture and mechanical supports. Says Hewitt: "Over and over again have I observed these troublesome symptoms disappear at once on applying mechan- ical treatment for the restoration of the uterus to its proper shape, whereby the congestion and the irritating pressure on the uterine tissues are removed. Mere attention to the posi- tion of the body often suffices to relieve the patient. The horizontal position on the back in cases of anteflexion, the prone position in cases of retroflerion, unaided, give great relief, a relief which is more effectual if conjoined by suitable in- ternal appliances for aiding the restoration of the uterus to the proper shape." It may be interesting in this place to quote a few cases confirmatory of this theory, reported by physicians of our own school. The following are reported by R. N. Foster, M.D., Professor of Obstetrics in the Chicago Homœopathic College: "CASE I.-Mrs. aged forty, had advanced to the fourteenth week of her second pregnancy. Had been preg- nant for the first time just fifteen years ago, and had then miscarried at the twelfth week-the miscarriage being due to persistent and intractable vomiting. The history of this, her second pregnancy, had thus far been an exact repetition of the first. For ten weeks she had been confined to her bed by frequent vomiting, which was made worse by sitting up or by standing or walking Her appetite was good, but a few minutes after eating any kind of food she vomited it. "She had been under 'regular' treatment, but without any mitigation of the annoyance, besides she was growing weak and emaciated, and dreaded a second miscarriage. “An examination detected the uterus lying, thoroughly retroverted, in the hollow of the sacrum, which the patient informed me had also been the case in her previous preg- nancy. The retroversion was probably a consequence of the increased weight of the womb, as the ready mobility of that organ would indicate that the position had been recently assumed. Moreover, the pelvis was well formed and roomy, and the replacement of the womb was therefore free from difficulty. It was accomplished by alternately lifting the body and fundus up out of the hollow of the sacrum, and 228 DISORDERS AND ACCIDENTS OF PREGNANCY. pushing the cervix back toward the coccyx. This was done gently, and the organ thus gradually restored to its proper position. “To retain it there an inflated ring-pessary was introduced and placed precisely as in cases of prolapse, i. e., so that the os rested in the central opening of the pessary. "The next day the patient resumed her household duties, the vomiting having ceased at once, and she is now approach- ing the fortieth week of pregnancy, and is in perfect health. "In retroversion of the womb, when the condition is not complicated by adhesions, the best repositor' is the index finger, or, if this does not suffice, another inch of progress may be gained by the introduction, within the vagina, of the middle finger also. The elevation of the fundus ought im- mediately to be followed by pressure on the anterior surface of the cervix, directing that portion of the organ back toward the coccyx. This latter manoeuvre will often succeed when the former alone fails." 'CASE II.-Mrs. 6 primipara, had been married three months; bad gone over her time' two weeks, a circumstance by no means unusual with her, and therefore creating no suspicion of pregnancy. But just at this time began an era of terrible vomiting. If she ate anything she vomited; if she drank anything she vomited; if she neither ate nor drank she vomited. She retained her food long enough to obtain some little nourishment from it, nevertheless in three weeks she was reduced to a condition of positive danger from starva- tion. She was pallid, weak, emaciated, with a pulse of 100, daily growing more rapid, and occasional streaks of blood in the substances vomited. Moreover, she was a delicate woman of consumptive proclivities. ( She had meanwhile been constantly under treatment, dietetic and medicinal. She had numerous friends, and every one of them had a new diet, which was tried, and each dis- comfited friend retired to make room for the next. Her treatment was somewhat mixed, ranging all the way from Ipecac. to the Oxalate of cerium, in 'regular' doses. The reader may take it for granted that I simply gave everything "according to the symptoms,' and not according also, and that my patient daily grew worse. DISORDERS AND ACCIDENTS OF PREGNANCY. 229 "At length I asked for an examination. Everything in the pelvis seemed normal, both as to condition and location. The womb was no lower in the pelvis than is usual in per- haps one-third of our cases examined, whether pregnant or non-pregnant. Nevertheless I determined to introduce an inflated ring-pessary, by which means I would at least alter the position of the womb, and bring what little pressure there was to bear on new points and in new directions. Possibly an oversensitive nerve might thereby be relieved, and this reflex irritation stopped. · "Therefore the pessary was introduced, and the vomiting ceased immediately; occasional slight nausea was experienced during the next two mouths, but not so as to cause the pa- tient any real discomfort. The pessary was not felt by the patient at all, and was retained for three months, when it was removed She is now in her thirty-sixth week and well." "CASE III.-Dr. A. W. Woodward lately reported to me a case equally intractable with the two preceding, when I re- lated to him this story of the two pessaries,' thereby in- ducing him to try the same experiment. The result in his case was a total failure, wherefrom we may reasonably con- clude that inflated ring-pessary is not a 'specific' in this disease, and indeed we do not as such recommend it. But the second case suggests as one cause of the vomiting in these cases a hyperesthesia of the uterine nerves, of such a character and so located that simply altering the position of the uterus may chance to settle the whole difficulty. The pessary is therefore worthy of trial in such cases, especially as the experiment, if not successful, is at least perfectly harm- less. Besides, how can we by medication cure a case which is of such a nature as to yield at once to this simple mechani- cal method ?” If Dr. Foster had used Thomas's, Ilewitt's, or Jackson's pessary, I think he would have been more successful in Case 3. The following cases were reported by myself in the March number of the American Homeopathist, 1878: “CASE I.—A young, healthy married woman, whom I had treated a year previous for retroversion, became preg- nant, and about the fifth week was attacked with violent and 230 DISORDERS AND ACCIDENTS OF PREGNANCY. almost constant vomiting. Her mother and friends dissuaded her from calling a physician, because 'the vomiting belonged to pregnancy, and there was nothing to be done.' About the seventh week, however, the husband became anxious and called nie in. From my previous knowledge of her history I immediately suggested the probability of a retroflexion. She was loath to have an examination, and her mother never heard of such a thing.' I therefore gave Nux vomica, which seemed indicated; but in a few days I was summoned again. I then made an examination, and found the uterus retroflexed. Dr. Thomas's retroversion pessary was placed in position, which changed the retroflexion into the normal position of the uterus. After this she had no vomiting or nausea, ex- cept the ordinary morning sickness. Iitalicize the last phrase in order to call attention to the fact that in the majority of cases, where the vomiting or nausea grows worse as the day advances, we may safely diagnosticate some uterine displace- ment." "CASE II.-Mrs. B., multipara, pregnant with her third child. Four years ago she miscarried at three months, ‘from excessive vomiting,' as her medical attendant said. She was now about two months advanced, and vomited everything she ate or drank. The empty retching was very agonizing. When I was called it was for dysenteric symptoms, and here I wish to make another point, namely, that when a preg- nant woman, before the fifth month, complains of tenesmus, with small mucous or watery evacuations, look for retroversion of the uterus. In this case I insisted on an examination, and found not only a retroverted but a very sensitive and inflamed uterus. It was with difficulty replaced, and required a long Jackson's retroversion pessary to retain it in its proper posi- tion. The next day all but the morning nausea ceased, but it required absolute rest, with side and face position in bed for several days before the pain, soreness, and rectal irrita- tion disappeared. The use of Arnica and Caulophyllum proved valuable." "CASE III was one of a more unfortunate character. Mrs. C., married a few months, passed over her time' ten days, when she was suddenly attacked with violent vomiting, occurring from walking or riding, or when expelling a cousti- DISORDERS AND ACCIDENTS OF PREGNANCY. 231 pated stool. I gave her Nux v., Cocculus, and Argentum, which corresponded with the three above given causes; but no benefit followed their use I had treated her before her marriage for retroflexion, and I now suspected the same con- dition. An examination proved the correctness of my opinion. The uterus was pushed up, an Albert Smith pessary placed under it, and the vomiting ceased. She wore the pessary two weeks, then at her request I removed it. For ten days all went well, when, after a long walk and climbing many stairs, the vomiting again occurred, and continued two days, or until a pessary was inserted. Again at the third month the pessary was removed, and, notwithstanding the persistent use of Sepia and Lilium, the uterus became retroflexed at three and a half months, this time from straining at stool, she thought. Again the pessary was inserted with prompt arrest of the vomiting, which was this time so violent as to lead to spasmodic retching and vomiting of bloody mucus. She wore this last pessary two weeks, when, contrary to my ad- vice, she removed it herself. I then cautioned her very im- pressively against any severe exercise, such as going rapidly upstairs or down, riding over rough roads, or straining at stool. For about two weeks she was perfectly free from any pain or discomfort, and everything bid fair for a perfectly normal advance of pregnancy. At this time I visited the Centennial Exposition, and then went abroad with my family. A few days after my departure, she entertained at her house some friends from California, and unfortunately felt obliged to attend them to places of amusement, and on long rides over the rough wooden pavements of Chicago. On one of these rides, her husband informed me that she was attacked with such severe pain in the back and lower bowels, with extreme nausea, that he was obliged to place her on a street- car and take her to his residence. After arriving home she was attacked with violent retching and vomiting of watery mucus mixed with blood. A prominent homeopathic sur- geon of this city, now deceased, was called in, but from some inexplicable reason did not recognize the cause of the trouble, notwithstanding the woman's suggestion as to the nature of the previous attacks, and the means I had taken to remove them. She rapidly grew worse, the pain in the back and 232 DISORDERS AND ACCIDENTS OF PREGNANCY. hypogastrium became agonizing, the vomiting became gru- mous, and delirium supervened. At this juncture, the at- tending surgeon, for an equally inexplicable reason, trans- ferred the case to a neighboring physician, whose utter ignorance of the pathological condition of the uterus, and the cause of the attack, was manifested by his absurd symp- tomatic treatment. In consequence of the total neglect of the ordinary and simple treatment of this case, the poor victim died on the fourth day, after expelling in her last agonies a fœtus of nearly five months. "These cases, especially the last, should serve as practical lessons to all physicians, not to overlook the displacements of the pregnant uterus, but to act promptly and decidedly, and not to rely upon medicines to remove a condition only amenable to replacement and mechanical support." For general directions relating to the mechanical treat- ment of flexions and versions of the uterus, by the use of pessaries, refer to the chapter on that subje.t. I will only add, that if the proper pessary is selected, and properly placed, so that it does not cause irritation by being too large, too small, or of improper shape, there is not the least danger of inducing miscarriage, but, on the contrary, it will do more to prevent that accident than any other means at our command. The medicinal treatment of the nausea and vomiting of pregnancy may be arranged in three classes: (1.) Those homeopathic to the flexion and congestion of the uterus. (2.) Those homeopathic to a localized gastric irritability. (3.) Those homœopathic to abnormal reflex irritation. To the first class belong Aletris, Belladonna, Cimicifuga, Nux, Lilium, Sepia, Apis, Pulsatilla. To the second class belong Antimonium, Ipecae., Iris, Nux, Kreosote, Oxalate of Cerium, Pepsin, Bismuth, Columbo, Veratrum, Pulsatilla, Sanguinaria, and Mercurius sol. To the third class belong the Bromides of Potassa, Am- monia, and Camphor; also, Chloral hydrate, Cocculus, Calabar, and Jaborandi. Electricity has relieved many cases where I have advised it, when all medicines failed. For the special DISORDERS AND ACCIDENTS OF PREGNANCY. 233 indications for the above remedies I refer the reader to the Materia Medica and special works on Obstetrics. I will, however, add my own experience with some of the medicines I have mentioned. I have met with cases of vomiting during pregnancy, so severe that the life of the woman was almost despaired of; cases where not a drop of water or a particle of food could be tolerated by the stomach, and where the uterus appeared to be in a normal condition. In these cases there may have been abnormal conditions of the uterus which could not bẹ ascertained, such as fibrous tumors, presence of exudative products, tumefactions of the uterine tissues, inflammations of the placenta, decidua, and other membranes. In these cases all the ordinary remedies proved unavailing. But I have never failed to carry my patient through, although I was obliged to resort to procedures which are not put down in our text-books, namely: In four cases I kept the women in the horizontal posture for several weeks, giving meanwhile from 20 to 40 grains of Bromide of potassa twice a day, in an enema of a pint of milk, beef tea, or mutton broth, allowing nothing what- ever to be swallowed, thus giving the stomach perfect rest. I had every reason to be gratified by the result of this treat- ment, for in a few weeks they became conscious of an ability to retain food, and the trial was successful. In many cases, two or three enemas of Bromide of potassa, 20 grains at night, has completely arrested the violent moruing vomiting. The same results have often followed the administration of 15 grains in an ounce or two of milk, Lefore rising in the morning. I have used Chloral hydrate in the same manner, and with excellent success, being led to its use by seeing its good effects in sea-sickness. These remedies do not cure by acting on the uterus or stomach, but by lessening and even arresting altogether the hyperæsthetic condition of the reflex nervous system, giving the stomach rest until it recovers its tone. Associated with the vomiting of pregnancy, there is often a condition which may be designated as "extreme bilious- ness." The tongue is foul, coated with a brown, dirty fur, the breath is fetid, the complexion dirty-yellow, and consti- 16 234 DISORDERS AND ACCIDENTS OF PREGNANCY. pation is obstinate. In this condition no remedy will relieve so well as Merc. sol., Hahn., two or three grains of the 2*, or even 1*, given every three or four hours until the tongue cleans and the bowels are opened. Podophyllin 2x, or Euono- min 1*, will often do as well, and should be used if the woman has ever been salivated, or cannot bear mercurial prepara- tions. On several occasions I have verified both Hahnemann's and Ringer's recommendation of the value of Ipecac. in ob- stinate and continuous vomiting during pregnancy. I have cured cases with the 6th dil., and have made equally good cures with five-drop doses of the mother tincture, or the wine of Ipecac. Kreosote and Carbolic acid in minute doses have helped me out in some obstinate cases, while in those cases where undigested food was invariably vomited, I have seen the best results from Pepsin, iu the form of saccharated powder, wine of pepsin, or lacto-peptin, a dose given before each meal, even if the meals were taken every few hours. Bismuth sub. nit, in doses varying from 1 to 5 grains of the crude, taken before or after food was taken, often acts magically in removing oppressive pain, eructations, and vom- iting of food. Ferrum, especially the lactate, in grain doses of the 1, is often useful in similar cases in pale, anæmic patients. Digitalis 1 will often give surprisingly good re- sults when, in persons of slow, languid, irregular circulation, they complain of palpitation, sinking at the stomach, ver- tigo, faintness, etc. Koumiss often arrests the vomiting of pregnancy, and at the same time affords excellent nutrition. 1 100 I cured two cases with Cuprum acet., when with the vomit- ing there were cramps in the stomach and suffocative par- oxysms. In another case, where the womb was very painful and sensitive, a Belladonna plaster on the hypogastrium arrested both the pain and the vomiting.* In several cases, where there was the most obstinate and uncontrollable constipation, it, with the vomiting, were both removed by 5 drops of tincture Calabar bean, given at night for a week. In another case I was led to the use of Jabor- * Cazeaux (Obstetrics) recommends as often successful, painting the cervix uteri with Ung. bell, or applying a tampon moistened with the diluted extract. DISORDERS AND ACCIDENTS OF PREGNANCY. 255 andi 2*, by the excessive salivation which annoyed the pa- tient. That medicine removed in a week both the salivation and the distressing nausea. The treatment of those cases of vomiting which occur after the seventh month of gestation, depends on the nature of the cause, which is supposed to depend on constriction of the fibres of the os and cervix uteri. These instances are not usually continuous with the vomiting of the earlier months, but occur after a long interval of quiet. In one case reported within a few years, the vomiting was so violent and exhaustive that a sponge-tent was introduced for the purpose of inducing premature labor, when, to the astonishment of the physician, its removal the next day was followed, not by labor, but by a complete cessation of the vomiting. In another case of vomiting in the ninth month, the attending accoucheur attempted forcible dilatation of the os with his fingers, in the hope that premature labor would occur, but instead a permanent cure of the vomiting resulted. Since these cases were published, several reports have ap- peared in American and foreign journals, confirming the value of gentle dilatations of the os uteri in this late vomit- ing. One such case occurred last year in my own practice. All that is necessary is to carefully insert the forefinger in the os, and press gently in all directions, so as to slightly relax the constricting circular fibres It is possible that some of the medicines kuown to exert a relaxing effect on these muscular fibres, might be used successfully for this form of vomiting. Belladonna, inter- nally and topically; Stibium, interually; Gelsemium, Cimi- cifuga and Cannabis indica. Recent observations seem to prove that Morphia has this effect; it is said to relax the os when its rigidity causes slow and retarded labor, and it might be given in minute doses for the vomiting, for it is certainly very homeopathic to vomiting of a reflex or sec- ondary character. Some singular facts have come to my knowledge relating to the little understood and complex relations of the uterus to other organs, and the exceptional great tolerance of the uterus under certain circumstances. (1.) During the meeting of the National Medical Asso- 236 DISORDERS AND ACCIDENTS OF PREGNANCY. ciation (allopathic) in Chicago, in 1878, Dr. M. O. Jones of that city informed Dr. J. Marion Sims that he had for years arrested the obstinate vomiting of pregnancy by placing a piece of lunar caustic, half an inch long, in the cervical canal, allowing it to remain there fifteen or twenty minutes. Dr. Sims seemed much interested in the relation, but made no comments at that time. But afterwards, while in Europe, he published an account of the procedure in the London Lancet, and stated that he had tried the method in many cases with success, and without causing miscarriage. This would seem. to show that there was a point of irritation somewhere in the cervical canal that caused the vomiting of pregnancy, and perhaps the vomiting which sometimes occurs in non-preg- nant women with uterine disease. The supposition is that the "charring" of the cervical mucous membrane produced a "sedative" effect on its nerves, and arrested the reflex irri- tation. It would seem to show that flexion was not always the cause of the vomiting, but some other irritating factor. Of course miscarriage would be caused if the caustic was pushed through the inner os. I cannot recommend the prac tice, for I have never tried it. It should not be forgotten, however, in those cases which seem to threaten life. (2.) During the meeting of the Illinois State Society in 1878, Dr. G. C. McDermott, a delegate from Milwaukee, in- formed me that Dr. Ford of that city recently had a severe case of intractable vomiting in a pregnant woman, who had suffered similarly in three previous pregnancies, in one of which miscarriage was brought on, as it was deemed neces- sary to save her life, at least such was the decision of a con- sultation of eminent physicians. In this fourth pregnancy a similar decision was reached after serious consultation. A uterine sound was used, but could not be introduced; a sponge tent was introduced, but doubtless only part way up to the inner os. This arrested the vomiting for a week, and on its return another tent was used with like effect, and this procedure was repeated several times. In this case the amelioration was not permanent; but if a flexion was the cause, a retroversion pessary might have continued the pal- liation to a permanent improvement. It is possible that the DISORDERS AND ACCIDENTS OF PREGNANCY. 237 tent acted like the lunar caustic, and benumbed the sensitive point in the cervix. These cases are suggestive, and should lead to more care- ful study of the singular anomalies of uterine disturbance. ALBUMINURIA. By albuminuria, it is implied that through the medium of the kidneys the albumen is filtered off from the blood to a greater or less extent, and discharged from the system in the urine. When this occurs it is believed, also, that the kidneys fail in some measure to depurate the blood by eliminating urea. Albuminuria and uræmia are not identical terms, as either condition may exist and the other be absent; but I suppose that albuminuria cannot be developed to any considerable extent without being accompanied by more or less uræmia (Barker). Albuminuria of pregnancy is not Bright's disease, for the albumen of Bright's disease differs essentially from that occurring in the temporary albuminuria of pregnancy, as can easily be shown by its chemical reactions. The albumen of the urine in Bright's disease when brought in contact with the Oxide of copper assumes a beautiful reddish-violet color, and produces a more or less abundant flocculent black precipitate. The urinary albumen of pregnancy, when Bright's disease does not exist, while it coagulates readily by heat and Nitric acid, does not exhibit any such reaction with the Oxide of copper. Robin has demonstrated that granular casts are not characteristic of any particular morbid state or pathological change of structure of the kidneys. It is an accepted fact that in a large number of cases, gestation develops a temporary albuminuria which may dis- appear during or soon after puerperal convalescence. The phenomena pertaining to this condition are rarely manifested before the sixth month of pregnancy. Statistics seem to prove that it occurs more frequently in first than in subse- quent pregnancies. It has been supposed that there is some close relation between albuminuria and convulsions during labor; but when careful and repeated examinations of the urine during gestation have failed to detect albumen in the 238 DISORDERS AND ACCIDENTS OF PREGNANCY. urine, convulsions have occurred during labor, and afterwards the urine has been found loaded with albumen. It is now settled that mechanical obstruction of the circulation during pregnancy, while it may be one cause of albuminuria, is not always the cause. A sudden cold may develop the disease. The presence of albumen in the urine has been regarded as the cause of many of the pathological conditions occurring during pregnancy and the puerperal state, when, in reality, it was only an effect. Albuminuria when present during pregnancy usually causes: (1.) Headache, severe and persistent, usually associated with sleeplessness, impaired vision, hesitation or embarrassment in speech, and great nervous irritability. It may culminate in delirium, coma, paralysis, hemiplegia and convulsions. (2.) Edema, first of the face, worse in the morning; then of the lower extremities and even general anasarca. (3.) Gastric irritability; sometimes obstinate constipation, and sometimes diarrhoea. (4.) Miscarriage or premature labor. Treatment. There are three important indications for treatment, namely: I. To relieve the hyperamia or congestion of the kidneys. II. To prevent the impoverishment of the blood which results from the loss of albumen. III. To prevent the various disturbances which often terminate in paralysis or convulsions. Before proceeding to the special therapeutics of albuminu- ria, I deem it my duty to enter my serious protest against the manner in which it is treated by our best homœopathic text-books. In Guernsey's Obstetrics, the etiology of the disease is very fairly given, but when it comes to that all- important point, the treatment, what do we find? A careful examination into the merits of medicines having a specific action on the kidneys? Medicines capable of curing the symptoms and pathological conditions accompanying the disease? Not at all! Nothing but three pages of a "repertory,' or an enumeration of medicines causing such symptoms as relate to color, sediment, smell, and painful sensations in the kidneys, bladder, and urethra. Nine-tenths of the medi- cines mentioned are not renal remedies at all, and the symp- toms they cover have very little, if any relation to the renal دو DISORDERS AND ACCIDENTS OF PREGNANCY. 239 functions, or the abnormal condition of the urine found in albuminuria. He refers us to another section entitled "Uri- nary Difficulties," in which thirty-three medicines are men- tioned, and their supposed characteristics given. But out of the thirty-three, only ten at most have any specific action on the kidneys or the urine. And this is called the correct homoeopathic treatment of albuminuria! To make matters. worse, the senseless plan of enumerating the medicines in alphabetical order is retained, instead of giving preference to those which experience has found most efficacious. Further comment on such so-called "treatment" is unnecessary. It is like the "apples of Sodom"- "Fair to the eye, But turn to ashes on the lip." I do not claim for the following treatment anything in- fallible, for our knowledge of the specific treatment of al- buminuria is still in its infancy. But I do claim that it has a basis of common sense, and has in many hands besides my own proved efficacious in many cases. I. To relieve the hyperemic or congested kidneys. If the woman is plethoric, and there is persistent redness of the face, injection of the conjunctiva, hot skin, sharp pains in the head, a hard labored pulse, denoting arterial tension, and an elevation of temperature, there are three medicines which are capable of removing the hyperemia by lessening the abnormal blood pressure. In these cases, the condition of the urine is of less moment than the threatening constitutional, pathological state. Veratrum viride by its secondary symptoms corresponds exactly to this general hyperæmic condition. In the experi- ments narrated in the "Therapeutics of New Remedies," after the first stage of depression had passed, or even when a toxic dose was given, the arterial blood-pressure rose enormously, and every organ became congested-even the convulsive centre in the medulla-and violent convulsions set in. Ac- cording to my law of dose, which I believe to be as important as our law of cure, Veratrum viride should be prescribed in the lowest dilutions, or the crude preparation. I have suc- ceeded best by giving one to five drops of the tincture or 1* 240 DISORDERS AND ACCIDENTS OF PREGNANCY. every two hours, until the pulse, temperature, and other symptoms showed that the arterial tension was normal. It will not do to suspend the medicine at this point, but con- tinue it at longer intervals, in order to hold the advantage gained, and alternate with it some other remedy correspond- ing to the special symptoms of the urine, etc. Gelseminum corresponds to nearly the same general condi- tion, but the pulse is not as large, hard, and heavy, nor is the urine as scanty as under Verat. vir. The dose is, however, nearly the same. There is moreover a tendency to stupor, and a dimness of vision not found in Verat. vir. Aconite is indicated when with a small, hard, wiry pulse, there is great restlessness and anxiety, fear of death, scanty urine, and acute rheumatic-like pains all over the body. The dose will vary from five drops of the 1x to the same quantity of the 2x dilution. I have made no mention of albumen in the urine or dropsy as indicating these medicines, because they are only indicated in the first stage of the disease, or for dangerous conditions. of arterial excitement, which may arise in the later stages. If the constitutional symptoms are not of a nature to in- dicate the above three arterial sedatives; if there is not gen- eral increased blood-pressure or congestion to the brain, but we believe the kidneys to be highly congested, with only sufficient intracranial hyperemia to cause frightful dreams, incoherency of speech, temporary attacks of delirium, etc., another class of remedies becomes necessary. These remedies should have a specific influence, not only on the kidneys, but the capillary circulation in general. They need not be primarily homeopathic to renal hyperæmia, but to general hyperæmia. One of the most important of this class, I believe to be the Bromide of lithia. Its action in albuminuria, and the conditions tending thereto, is as fol- lows: (1.) It relieves the renal hyperemia by contracting the arterioles of the kidneys. The blood-pressure in those vessels being lessened, the urine increases in quantity, and the elimination of urea is increased. It thus prevents an accu- mulation of this toxic agent in the blood, and the tendency to uræmia is lessened. The action of this medicine can be favored and increased DISORDERS AND ACCIDENTS OF PREGNANCY. 241 by the use of certain mineral waters, namely, Gettysburg, Pethesda, Vichy, or Seltzer; if these are not readily ob- tainable, pure soft water, filtered rain-water, or a weak solu- tion of Bitartrate of potassa, or Citrate of potassa. No active diuretics should be used in this stage of the disease, for they all tend (in material doses) to increase the renal hyperæmia. (In some cases the Benzoate of lithia may be substituted, namely, when the appearance of the urine corre- sponds to the indications found under Benzoic acid.) The Bromide of lithia controls admirably the cerebral irritation, the rheumatic pains, and many of the abnormal mental phenomena. The dose which I have used and advised most successfully, is five grains three or four times a day, and if obstinate insomnia occurs, with nocturnal frightful dreams, or delirium, I give an additional dose of fifteen or twenty grains at bedtime. For this last purpose, however, the Bromides of lime, soda, or potassa may be used. Another class of remedies, more important for the radical. cure of albuminuria, are those medicines which are primarily homœopathic to the pathological condition existing in the kidneys, viz.: Turpentine, Cantharides, Apis mel., Copaiva, Erigeron, Equisetum, Nitrate of uranium, Phytolacca, Eupa- torium purp., Helonias, Aurum muriaticum, Merc, corrosivus, and Arsenic. These are the most important, and it is rare that any others will be found more than palliative, because their action is not powerful enough in the direction of the real pathological state of the kidneys. Turpentine is probably the closest similimum to both acute and chronic albuminuria. Primarily it causes the acute stage, secondarily the chronic. But the disease must be idio- pathic, i. e, not originated by, or kept up by disease of the heart. In the attenuatious, from the 3 upward to the 30th, it is primarily indicated in active congestion of the capillaries, the Malpighian tufts, and the glomeruli, with exudation of albumen. It also destroys and expels the glandular surface of the tubuli uriniferi. The urine contains blood, epithelium, cylindrical casts, and coagula, and coagulates under the action of heat and nitric acid. Its ultimate secondary effects are complete denudation of the surface of the tubuli, of all 212 DISORDERS AND ACCIDENTS OF PREGNANCY. of its glandular cells, paralysis of its nervous supply, passive hæmorrhage, uræmia, and convulsions. When the stage of acute congestion, or inflammation of the kidneys subsides, and structural changes set in, the higher dilutions of Turpentine are useless. When pus, disorganized blood-corpuscles, fat-globules, and very scanty urine, loaded with albumen, appears, then Turpentine should be given in the lowest dilutions. The action of Erigeron and Erechthites is closely analo- gous to that of Turpentine, and may sometimes be substituted for that drug. Cantharides, next to Turpentine, is the closest similimum of acute congestive albuminuria. When the patient seems suf- fering from some feverish erethism, with scanty and frequent urinations, irritation of the generative organs, burning or scalding pains during micturition, and pain in the back, Cantharis 3d or 6th will ward off impending albuminuria, or arrest the disease even after albumen has appeared in the urine. It is of little value after cædema has appeared, for it causes not so much structural changes in the glandular ele- ments of the kidneys as paralysis of its nervous supply. If homœopathic to dropsy at all, it is a dropsy from renal paralysis. If homeopathic to uræmia, it is from the same cause. In allopathic practice it has warded off uræmic con- vulsions with suppression of urine when given in material doses The material doses acted curatively because the paralytic condition was similar to the secondary action of Cantharis. Apis has many symptoms in common with Cantharis. It causes both congestion and paralytic conditions in the kid- neys with cerebral hyperæmia. But it differs from Cantharis in its specific power of causing cedema of almost every organ, and effusion of serum into almost every cavity. Very soon after the renal irritation of Apis commences we find symptoms of general dropsical effusion. Even ædema of the brain and lungs sets in. Feverish symptoms are rarely present, but the blood is soon poisoned, and this causes a condition known as uræmic fever, which finds relief in eruptions on the skin (urticaria, erysipelas, etc.). In this respect it closely resem- bles the preparations of Arsenic. DISORDERS AND ACCIDENTS OF PREGNANCY. 243 I Copaiva is a medicine of much greater value in albuminuria than is generally supposed. It is especially indicated when the origin of the disease is a cold or sudden check of per- spiration, and the affection of the uriniferous tubes are ca- tarrhal as well as congestive. It has caused acute attacks of albuminuria, with feverish symptoms, bloody urine, and all the symptoms of acute congestion of the kidneys. In the middle attenuations it will effectually remove these condi- tions. It has been found singularly efficacious in dropsy after all other remedies had failed, and when the urine was almost entirely suppressed; but in these cases it was pre- scribed in material doses (five to fifteen drops of the bal- sam repeated every few hours). The dropsy of Copaiva is a secondary effect of that drug, due to conditions of the kidneys somewhat similar to those caused by Cantharis. Equisetum is recommended by Dr. Marsden as having proved curative in many cases of "painful dysuria with al- buminous urine in pregnant women," but our knowledge of its pathological effects is quite limited. (See Pathogenesis. in Allen's Encyclopedia of Materia Medica.) Nitrate of uranium seems indicated where an attack of congestive albuminuria has set in after diabetic symptoms. Helonias is indicated in the same condition, but it is a much more useful remedy on account of its specific relation to the uterus. Albuminuria is supposed by some to be due to reflex irritations transmitted from the uterus to the kid- neys. Helonias may be useful when this variety exists. But it is also homoeopathic to acute albuminuria, for it has caused that condition when taken in large doses. It is best indicated when the blood is impoverished by the drain of albumen, diabetes, or from failure of nutritive processes. Eupat purp. closely resembles Helonias, but will be found more useful when general edema is present. Here the low- est dilutions or the tincture will have to be used in order to restore the normal quantity of the urinary secretion. Mercurius cor. has been found one of the most valuable and trustworthy remedies we possess when albumen appears in great abundance in the urine of pregnant women. Under the use of the 3 trit. the albumen has rapidly disappeared, and serious results been prevented. But I must warn the 244 DISORDERS AND ACCIDENTS OF PREGNANCY. physician not to continue Merc. cor. but a few days in this low trituration, as it may cause serious general disturbances and a final aggravation of the albuminuria. I would advise that as soon as improvement fairly set in to change the 3× for the 3º, or the 6× trituration. Aurum, Cuprum, Arsenicum, and Argentum are excellent. remedies, but will be considered in the next section. I ought to add that in all acute cases where congestion of the kidneys is evidenced by pain and tenderness in that region, and the urine is scanty, "smoky," and high-colored, that great relief may be obtained, and the action of specific remedies favored, by the application of dry cups over the lumbar region, or a poultice of flaxseed meal, in which is mixed a spoonful of tincture of aconite root. IIot "sitz" baths act in the same. mauner, by attracting the blood to the surface capillary blood- vessels, and thus lessening the amount of blood in the kid- neys. II. To prevent the impoverishment of the blood which results from albuminuria. Next in value to these medicines, which are strictly ho- mœopathic to the morbid condition existing in the kidneys, are those remedies which arrest the chloro-anæmia from loss of albumen. The physician must not confound the hydramia which often exists with the anemia, with true plethora. Hydræmia is a kind of serous plethora, which closely simulates true plethora, causing great disturbances of the circulation and even serious local congestions. The most valuable remedy for this condition of the blood is Ferrum. Iron is purely homeopathic to many forms of anæmia, chloro-anæmia, and even hydræmia, but it cures by its secondary action, for the true plethora caused by large doses of iron is often followed by unmistakable anæmia. It is very important that we select the proper preparation of Fer- rum. According to all trustworthy observers the Ferrum muriaticum is the best. It not only acts by increasing the red globules, but it also acts on the kidneys, increasing the watery portion of the urine. The large doses of Tincture of chloride of iron prescribed by the opposite schools, have doubtless done great injury by causing primary pathogenetic effects, which secondarily ag- DISORDERS AND ACCIDENTS OF PREGNANCY. 245 gravated the chloro-anæmia. The 2 or 3* dilution of Tine. ferr. mur. in 10-drop doses after each meal is amply sufficient for all curative purposes. Next in value, I consider the Al- buminate of iron, a few drops of the officinal syrup given in the same manner. X The trophic spinal nerves which influence nutrition have much to do in the production of anæmia. The condition of the blood in albuminuria tends to paralyze these nerves. When Ferrum alone does not seem to act favorably, Ferrum et Strychnia citras 1 will be found an admirable remedy. If there is deficient digestion of food, vomiting of ingesta, lientery, give Pepsin or Lacto-peptin, 5 grains after each meal. If actual hydræmia exists, with general adema, irregular circulation, and congestive symptoms, Digitalis is a power- ful curative remedy. The action of the heart in this con- dition is one of excessive action, irregular, but with insuffi- cient radical power. Digitalis, by imparting regular and normal force to that organ, prevents the congestive phe- nomena, and increases the favorable effect of restorative medicines. Five to ten drops of the 1 dilution may be given before each meal, and Ferrum after. A favorite preparation of mine in hydræmia with weak and irritable heart is Digi- talin 3 and Ferrum met. 1, equal parts, triturated together, of which I prescribe two or three grains three times a day. Should there exist an unnaturally profuse flow of the urine with anæmia, instead of scanty flow, I have found Lycopus, 5 or 10 drops four times a day, to have a better effect than Digitalis in regulating the irritable heart. X There are other medicines which should be consulted in these cases, medicines which are eminently restorative in their effects on the blood and the processes of nutrition. Among the best are Metris, Helonius, Cule. hypophos., Vibur- num prun., China, Hydrastis, Phosphoric acid, and Kali chlor. They have also another action, especially useful in hydræmie albuminuria and anemia, namely: to prevent miscarriage, premature labor, or the death of the fortus. Nor should we forget in such cases to resort to Cauloph., Cimicifuga, and Mitchellu. Gallic acid should not be forgotten when we are selecting medicines to prevent the chloro-anæmia due to loss of al- bumen. It is not only powerfully palliative in albuminuria, 246 DISORDERS AND ACCIDENTS OF PREGNANCY. but may prove curative in some cases. No medicine so surely prevents the loss of albumen after scarlatina, and it also arrests the loss of blood from the kidneys which some- times occurs as a sequel to that disease. If, during the obstinate albuminuria of pregnancy, other medicines fail to arrest the loss, and the woman begins to look pale, bloated, and anæmic, give her 5 to 10 grains of the 1* trituration of Gallic acid, watching the urine to observe if the percentage of albumen is decreasing. Ferrum can be given at the same time, the former before, the latter after meals. So soon as the waste of albumen is arrested, change from Gallic acid to some more radically curative remedy. III. To prevent the nervous disturbances which often terminate in paralysis or convulsions. Medicines alone cannot be relied upon for this purpose. We should advise and insist that all emotional excitement should be avoided, and all overtaxing the physical powers in any way. The digestive organs should be carefully watched; the diet so regulated as to avoid indigestion, and, above all, the patient should not become constipated. We should see that the woman sleeps and lives in apartments which are well ventilated and free from sewer-gas, or air impregnated with carbonic oxide, for these two agents poison the blood in a most dangerous manner, and serve to precipitate an attack of uræmia. If the woman shows signs of a mania in which fear of death is the prominent symptom, give Aronite 6th or 30th, or Arsenicum 6th or 30th. If a suicidal mania obtains, no rem- edy is so efficient as Aurum, especially Aurum muriaticum, or the "Muriate of gold and soda," as both these latter salts have potent diuretic and eliminant properties, and are use- ful in dropsy or uræmia. They should be prescribed in about the 34 trituration. A mania with melancholy is usually controlled by Cimirifu ga, Helonias, or Hellebore. If violent delirium with insom- nia occurs, it is of little use to select the medicine by the ensemble of its merc symptoms. We must select that medi- cine which will have the twofold action of calming the irri- tated brain and rapidly eliminate the noxious poison in the blood. I have already mentioned the value of the Bromide DISORDERS AND ACCIDENTS OF PREGNANCY. 247 of lithia, and I cannot too strongly recommend that it be used freely (twenty to thirty grains every four or six hours) until the delirium is controlled. The obstinate sleeplessness, which sometimes precedes the mania, can be controlled by Scutellarin 1, Cypripedin, 1×, or Caffein cit. 2. (A new preparation, the Bromohydrate of Caffein, in the 2 trit., has acted promptly in a few cases in my practice.) There is a group of symptoms and conditions denoting uramic poisoning, which may occur, and which demand the promptest action if we would save life, namely, coma, paral- ysis, general dropsy with suppression of urine, and constipation. In this condition I have several times adopted the following treatment with success. Mix two to four drops of Croton oil with a little butter, and force it back upon the posterior portion of the tongue. It soon dissolves and gets into the stomach, causing very soon profuse watery discharges from the bowels, which relieves the brain, nervous system, and kidneys, and allows us to select the proper specific remedy. 10 In less grave cases, where the above condition is impend- ing, and the danger is imminent, the patient's life has been saved by the timely administration of th or th of a grain of Extract of elaterium. This dose causes in four or five hours very profuse watery evacuations from the bowels, sometimes a quart at a time, followed by profuse diuresis. Not only in the uramia of pregnancy have I warded off coma and convulsions with this medicine, but I believe I have saved life in the extreme dropsical conditions which occur during the progress of organic diseases of the heart. The above dose can be repeated three or four times during twenty-four hours, until the patient is relieved. X If we fail, as in rare cases we may, in causing proper evac- uations from the bowels or kidneys, we have in the new remedy, Jaborandi, a drug which for its action on the skin and salivary glands has no equal. Fifteen to thirty drops of a good tincture, or a few grains of the 1 trit. of its active principle, the Muriate of pilocarpin, will cause such profuse sweating that the thickest bed-clothing will be saturated, and such profuse flow of saliva that it has been known to amount to twenty ounces in a few hours. Cases have been 248 DISORDERS AND ACCIDENTS OF PREGNANCY. ! reported where, in dropsy with coma or convulsions after scarlatina, or puerperal uræmia, the action of Jaborandi has doubtless saved life by its rapid elimination of morbid mat- ters and water through the skin. CONVULSIONS.—If puerperal convulsions occur, even when albuminuria has not been suspected, or from evident uræmia, there are but few remedies which can control them. It is useless to waste time in selecting from the list given in our text-books. (Of the thirty-five mentioned by Guernsey only three are of any value, Gels., Verat. vir. and Bell.) Veratrum viride, when we have the violent tonic convul- sions, tetanic, with turgid head and face, pulse large and hard and bounding. Give large doses, five to ten drops every half hour, until the spasms are arrested, and the pulse soft- ened. In New Remedies many cases of fearful severity are reported, cured by doses as large as twenty to forty drops, repeated in an hour or two if necessary. So long as the in- tense blood-pressure exists in the arterial system, even such large doses are safe. Ge'semium ranks next, but corresponds to a milder form of spasms, with less pressure in the great arteries, but more in the capillaries, a softer pulse, redder face, and suppressed urine. Chloral hydrate has been used very successfully in ante- and post-partum convulsions. The dose is twenty to thirty grains, repeated in two hours if necessary. (See New Remedies.) Bromide of lithia (or any bromide) when the convulsion has the characteristics of epilepsy or hysteria. Cuprum acet. 2x, when the characteristic of the spasm is the terrible suffocative phenomena, and the "beginuing in the fingers and toes." Belladonna, Agaricus, Cicuta, Solanum, Hyoscyamus, and Stramonium may each be valuable in cases where these symptoms closely correspond to those of the convulsive dis- order, but I cannot recommend them in cases where the blood poisoning is evidently the cause, while I believe they may be promptly efficacious when the convulsions arise from some other excitement of the nerve-centres than uræmia. DISORDERS AND ACCIDENTS OF PREGNANCY. 249 CONSTIPATION is a far more important abnormal condition than many writers would have us suppose. Many women whose alvine evacuations are perfectly normal and regular when not pregnant, become very constipated so soon as concep- tion occurs. This fact would go to prove that constipation is caused by some undiscovered cause, and not from mechani- cal obstruction. It has generally been supposed that it was due to the pressure of the growing uterus on the upper part of the rectum. It is thus explained by Guernsey: "The mechanical pressure exerted on the rectumn, by which its calibre is diminished and its action paralyzed, and the habits of inactivity in which some pregnant women indulge, especially in cities, combine to produce costiveness, and as a final result of the constipation, hæmorrhoids, either blind or bleeding, appear in many cases. And the very great amount of vital force consumed in the womb may also tend to draw away from the intestinal canal some of the energy that might have sustained its regular and daily evacua- tions." This last sentence explains the cause of many cases of constipation in pregnant women, and should be borne in mind in our treatment. When constipation occurs at or after the sixth week, I believe it is due in many instances to retroversion, for I have found the uterus retroverted in such cases, and the constipation was removed promptly by re- placing the uterus and keeping it in proper position by a well-selected pessary. But constipation may cause retrover- sion both by the accumulation of fecal matter above the uterus, and by the efforts in straining at stool which some women improperly make. Besides this result, constipation may cause headache, anxiety, giddiness, sleeplessness, dis- tressing dreams, vomiting, fissure of the anus, swelling of the veins of the legs, tedious labor, irregular and deficient pains, obstruction to the passage of the child, and puerperal fever. It may even produce febrile excitement, loss of appe- tite, erratic pains in the bowels, simulating false pains. The efforts of straining to relieve the bowels may also result in abortion. I have met with cases where the pains were so severe that it seemed as if retroversion or miscarriage must occur, but an examination would reveal a rectum enormously 17 250 DISORDERS AND ACCIDENTS OF PREGNANCY. enlarged and obliterating the vagina, requiring copious and repeated enemas, and even the use of small placental forceps or the fingers to remove the hardened masses. Campbell had a case in which the bowels were so overloaded that after the birth of the child the attendant thought the woman had another child to bear. The rectum was found distended to the size of a quart bottle, and the woman died of inflammation of the bowels. Fourteen pints of fecal matter were removed after death from the small bowels, after the colon and rectum had been relieved during life. Churchill once attended a labor in which the hollow of the sacrum was nearly filled up with a hard mass; but a more careful examination proved it to be the lower bowel filled up with hardened fæces, giving to the finger the sensation of a large growth upon the bone. Great difficulty was experi- enced in emptying the bowels, and not until then did labor progress favorably. Ashwell mentions many similar cases. Treatment.--It is evident that the constipation of preg- nant women should receive judicious and effectual treat- ment if we wish to avoid many of the sufferings of that period, and also difficult and painful labor. The treat- nient is to be based on somewhat different principles than would guide us in prescribing for ordinary cases of consti- pation. When called upon to prescribe for a case, we should in- quire into the diet, habits of life, and previous state of health. We should advise active exercise, walking is better than riding; also regulate the diet by advising coarse bread, fruit, etc. If these means fail we may then select the med- icine which seems appropriate. Out of the fifty-five medi- cines recommended by Guernsey, only eleven are of much value, namely: Alumina, Bryonia, Ignatia, Lycopodium, Nux vom, Opium, Plumbum, Ratanhia, Se, ia, Sulphur, and Verat alb. Of these I have succeeded best with Alumina 30th, Bryonia in five-drop doses, Ignatia 30th, Lycop. 6th trit., Nux vom. 2x, Opium 12th, Plumbum 2, Ratanhia 3d, Sepia 6th, Sulphur 1 trit. (See special indications in any text-book.) X But there are other remedies which I value more highly. Calabar bean (Physostigma) is very efficient when we have DISORDERS AND ACCIDENTS OF PREGNANCY. 251 a lax, distended state of the intestines, with large quantities of flatulence, fæces dry, hard, and very large. Five drops of the 1× dil. four times a day will promptly remove the inactivity, by contracting the half-paralyzed muscular coats and restoring peristaltic action. I have seen better results in some cases from giving ten drops of the crude tincture at night, than from smaller doses repeated during the day. Strychnia in the 6th trit. will often act favorably when Nux or Ignatia fails. Opium 2 trit. will often restore the action of the bowels when the higher attenuations do not act. Podophyllin is one of our most efficient medicines, but it must be given in appreciable doses, for it secondarily causes. constipation. It is indicated by the constantly furred tongue (yellow or brown coating, the sallow complexion, anorexia, and a tendency to piles, fissure, or prolapsus recti. I first try the 2x trit., three or four doses a day. If this fails give granules, each containing the th or eventh grain, once, twice, or thrice daily, until free laxative effects occur; then lessen the dose for a few days, when it will be found that the bowels will remain regular. The alternation, or even combination of Podophyllin with Physostigma or Nux vomica, will often give better effects than either alone. There will now and then occur cases so obstinate that all the above remedies will fail, and we feel that we must use some palliative measures. This fact has time and time again been recognized by the best men of our school, and even the most bigoted high-dilutionists have been forced to use them. I cannot too highly commend Dr. Madden's ex- cellent article on this subject in the British Journal of Homeopathy, vol. vii, page 310. In such intractable cases when the bowels must be moved occasionally, we should select those laxative and aperient agents which produce the least irritation, and do not run counter to the idiosyncrasies of our patient. I have generally succeeded with the Podophyllin above mentioned. But some women cannot take it in sufficient doses without "griping." A pill of Aloes, 1 gr.; Ext. Hyos., gr.; Soap, 2 grs., combined (one at night), is often very 252 DISORDERS AND ACCIDENTS OF PREGNANCY. easy and effectual, but they should not be too long con- tinued. A powder composed of Sulphur, Seuna and Liquorice root (from a formula found in the Prussian Pharmacopœia), is a great favorite with many physicians and patients. It is prescribed as "Comp. Glycyrrhiza powder-30 to 60 grs. in a wineglass of water at night." It usually gives one or two free evacuations the following morning. In some cases in plethoric women, with rush of blood to the head, feverishness, abdominal congestion, etc., a wine- glass of Hungarian or German bitter-water, taken in the morning before breakfast, acts very favorably, especially if a glass of common water be drank afterwards. In very acid states of the stomach, with sick headache, a teaspoonful of Tarrant's Seltzer Aperient before breakfast is very efficient. Some non-medicinal substances will often act as excellent. palliatives, namely: (1.) A tablespoonful of wheat bran, mixed with milk and taken at night or morning. (2.) An equal quantity of flaxseed or white mustard seed, taken in the same manner. (3.) A dozen stewed prunes, taken at night on going to bed, or in the morning before breakfast. (4.) A teaspoonful of tamarinds mixed with a wineglass of water, taken in the same manner. (5.) The eating of any ripe fruit before breakfast--oranges, bananas, apples, pears, berries, etc. I trust that the importance of inquiring into the condition of the bowels during the few days or hours preceding labor will not be forgotten. Nature usually attends to that matter by causing consid- erable relaxation, with several free discharges the day before, or just before the commencement of labor. Women should be told of the importance of an open state of the bowels, and advised to use enemas to bring about that result if na- ture proves delinquent. The first question that the physician should ask on entering the lying-in room and examining his patient, should relate to the state of the bowels and blad- der. If these have not been evacuated, it should be done. immediately, else he may have to conduct a painful, pro- tracted, and otherwise disagreeable labor. MEDICATION OF THE FETUS IN UTERO. 253 CHAPTER III. MEDICATION OF THE FETUS IN UTERO, CONSIDERED AS A MEANS OF PREVENTING DYSTOCIA. ONE of the most important questions now under discussion by the medical professions is, "Can we influence the foetus by administering medicine to the mother?" The The literature of this subject is exceedingly meagre regular text-books on obstetrics merely give the physiologi- cal theories of the placental circulation or gaseous inter- change; not one of them (except Richardson's) refers to the transmission of medicinal agents to the child through the maternal blood. Schroeder alone mentions the experiments. of Reitz, who, after injecting Cinnabar into the blood of a pregnant rabbit, found the red particles of that chemical in the blood of the fœtus particularly distinct in the capillaries of the pia mater. Schroeder therefore considers the trans- migrations of maternal blood-cells into the blood of the foetus easily conceivable. The older journals contain only investi- gations on the normal placental respiration, which leaves the question more or less undecided. In later journals, all Ger- man, occur a few papers on this subject. Gusserow injected Tincture of iodine and a solution of Ferrocyanide of potas- sium into the stomach of pregnant rabbits, guinea pigs, and dogs, but was unable to find any traces of the drugs in the liquor amuii and in the urine of the foetus, even when the dose had been given five days before. On the other hand, he was able to detect Iodine in the liquor amnii and in the urine of the newborn infant after administering Iodide of potash for some time (about two weeks) to the mother before. her delivery. Zwisfel, in 1874, claimed that in five cases where Chloro- form had been inhaled during labor, traces of it were found in the placenta and in the urine of the child. He claims that the foetus respires through the placenta, and that "this respiration is subject to the same conditions as that of the animal after birth." 251 MEDICATION OF THE FETUS IN UTERO. Benicke reported to the German Medical Association, in 1875, that he gave Salicylic acid to twenty-five women dur- ing labor, and found it in the urine of the children imme- diately after birth, the shortest time after its administration being forty minutes. Ruge and Martin report precisely the same observation with Salicylic acid; but Iodide of potash was found by them only in small quantities after prolonged use by the mother. Fehling failed to get any effects on the fœtus by giving Woorara to the mother rabbit. He got no effect on fœtal rabbits by giving Chloroform to the mother. Fehling and Korman's observations seem to show that the hypodermic injection of Morphine during labor does affect injuriously the foetus before and after birth. In a number of the American Journal of Obstetrics, for 1877, this subject of poisoning the foetus by giving Opium or Morphine to the mother, was discussed at length by many of the most promi- nent obstetricians of this country. Dr. Paul F. Mundè said: "With reference to the influence of medicinal agents on the infant during pregnancy, there was not much to be said. We all know that by giving the mother tonics and various nutritious medicinal agents, we aid in securing a vigorous and healthy offspring; we also know that by putting a syphi- litic mother under specific treatment during her pregnancy, we are preserving the child from premature death, or for a time, at least, from venereal disease. But still we do not know why the foetus in utero is not poisoned by a drug, given to the mother in a dose, adapted to her, it is true, but large enough to be fatal to the child after birth." Dr. Fordyce Barker concluded his paper by laying down the following proposition as his belief: "1. There is no evi- dence which can be accepted in science that narcotic drugs administered to the mother ever produce their specific effects on the fœtus in utero." He says nothing about other medi- cines, however. Dr. Peaslee reasons from a very material ground, namely : because the fœtus having no vascular connection with the mother, derives no part from her of its blood-therefore: mere solutions in the mother's blood of medicinal substances are not absorbed into the fœtal blood in any appreciable amount. His argument, however, disproves nothing, for MEDICATION OF THE FETUS IN UTERO. 255 he would say the same of the administration of attenuated medicines, and we know that in this his argument would be fallacious. Dr. Mundè, after listening to this celebrated discussion in the New York Obstetrical Society, said: "It matters not if in one hundred experiments the substance injected into the maternal blood is not discovered in that of the fœtus in ninety- nine, if it be so discovered in the hundredth, it shows that such a thing is possible." The homoeopathist will bear in mind that in all these ex- periments and investigations crude medicines were used. Now we know that attenuated or material medicines do not depend altogether upon their mixture with the blood for their action on the organism. Many medicines act as do ernotions, dynamically. We all know that mental influences affecting the mother during pregnancy or lactation, do cer- tainly affect the fœtus in utero or the infant at the breast. Surely the blood has nothing to do with the influence in such cases. I have watched closely the various papers and investiga- tions, as well as the discussions going on in the journals and societies of the allopathic school during the last few years, and I have no hesitation in expressing the opinion that there is no reasonable doubt that medicines of all kinds do affect the child in utero when given to the mother. I think also that we can entertain no doubt as to the specific action of homeopathic medicines on the foetus in utero when admin- istered to the mother. This leads to a discussion of DYSTOCIA DUE TO THE FETUS. In the previous chapters we have considered only those causes of dystocia which belonged to the maternal organism ; but there is a dystocia which is due to the fœtus, and the causes may be classified as follows: UNNATURAL OSSIFICATION OF THE SKULL.-A variety of this condition is that known as complete ossification. Dr. Joulin describes one kind as " the development of ossa Wor- miana in the fontanelle, causing solidification." But all the sutures may be united by ossification to such an extent 256 MEDICATION OF THE FETUS IN UTERO. that the head is unyielding, and has to be forced through the genital canals without undergoing any change. It is probable that this condition may be amenable to treatment, by so arranging the diet of the mother as to leave out all or nearly all the earthy salts which go to make bony tissue. (This will be treated of in another place.) Another cause of dystocia is HYDROCEPHALUS OF THE FETUS.-The hydrocephalic head sometimes reaches an enormous size. Cazeaux says Meckel has a skull of an infant whose transverse diameter is 16 inches, and its height from the occipital foramen to the vertex, 16 inches. Burns gives a case of hydrocephalus where the circumference was 23 inches. The management of a labor obstructed by a hydrocephalic head is not within the scope of this work. It is possible that we may be able to prevent this abnormal condition by medicating the mother. If the mother has been delivered of one hydrocephalic fœtus, she may give birth to another. If we have reason to fear this, the treatment should consist in placing the mother upon a diet of animal food almost ex- clusively, a diet the opposite of that advised for too rapid and complete ossification. We may also administer to the mother such remedies as Sulphur, Calcarea, and Phos. (as recommended by Grauvogl), also Apis and Arsenirum, in the highest potencies, or Kali hyd., Merc. iod., and Cule. iod., in the lowest attenuations, or in nearly a crude state. The treatment of ascites or hydrothorax in the fœtus should consist of the administration of the same remedies. TUMORS OF THE FETUS -Large tumors may Large tumors may form upon the body, or in the body of the fœtus. They may attain such a size as to prevent delivery without mutilation of the child or mother. It is possible that knowing the kind of tumors affecting a previous fœtus we may give remedies to the mother which may prevent their recurrence. Tumors are sometimes hereditary, and when the mother is affected with them it is possible that the persevering use of appropriate remedies would prevent their appearance in the fœtus. MONSTROSITIES.-The various anomalies which have been described under this head are usually the result of two general causes, namely: (1.) Some psoric, scrofulous, or strumous taint MEDICATION OF THE FETUS IN UTERO. 257 in the blood of the parents, and (2.) Mental emotions, shocks, etc., to which the mother may have been subjected. Homoeo- pathic remedies have such a decided action over mental aber- rations and emotional shocks, that there is good reason to suppose that if Aconite is given to a pregnant woman imme- diately after a fright, it might prevent an injury to the foetus in utero. For the effect of any of the injurious mental shocks, select the appropriate remedy recommended in our Repertories, and we may succeed in arresting deficient or ab- normal development. Dr. Croserio, now dead, and a distinguished physician of our school, wrote a small work entitled Homeopathic Obstet- rics, the first of that kind which appeared in our literature. He quotes "a distinguished physician" (name not given) as having "just published a very interesting memoir upon this subject," in which he recommends giving the mother, at different periods of pregnancy, and at long intervals, Sulph. 30th, and Calc. carb. 30th, to purify the foetus from the psoric (scrofulous) taint which it may have inherited from its parents. Several homeopathic physicians claim to have seen good results from such a procedure. But Sulphur and Calcarea are not the only remedies to be prescribed. The whole history of both parents should be obtained, and, after a careful comparison of all the symptoms, the specific remedy should be fixed upon, and given at least once a week all through the pregnant state. Some mothers invariably give birth to rickety children. To such should be given Silica, Cale. phos., or Cale. hypophos., in the triturations from the 3d to the 30th. When tuberculosis is feared, give the mother Cale., Silica, Kali carb., Iodine, etc. The Hypophosphites of lime, soda, and potassa, in small doses, using glycerin as a vehicle, are admirable prophylac- tics of tuberculosis. But of all remedies Oleum jecoris is probably the best, for it contains all of the above remedies in an attenuated form, and is more readily assimilated in the oil than in any other way. It is not necessary to give massive and nauseous doses. The 1* or even 3* trituration is efficacious, a few grains three times a day. If, however, the mother was greatly emaciated, 258 MEDICATION OF THE FOETUS IN UTERO. and her stomach would readily tolerate it, I would prescribe a teaspoonful three times a day. It is not best to rely on medicine alone. Advise the mother to remain much in the pure open air, and live on an appropri- ate diet, else all remedies may fail of preventing disease in the offspring. HARDNESS OF THE BONES OF THE FETUS.-One of the chief obstacles to easy and natural labor is often the unnatural size, the strength, and unyielding character of the osseous structure of the child. A child weighing ten pounds can be delivered easily through a natural pelvis and soft parts, if the bones of the head are soft and yielding. The head readily elongates and becomes smaller in diameter, assuming a wedge or cone shape, permitting its easy expul- sion. But if the bones are very unyielding, a long, tedious, and painful labor results, with more or less injury to the mother and child, even if the forceps are skilfully used. It is said that this condition of the foetus can be remedied and prevented by placing the mother upon a diet composed of such articles as contain the least amount of bone-making materials, namely: earthy salts, lime, silica, common salt, etc. This diet is sometimes called the fruit diet, although other articles than fruit may enter into the diet of the mother. Drs. Lewis, Cummins, and Richardson have called attention to this matter, and allege good results from its use. The following is the history of the discovery of the method, and the details of the method itself and its results. Fruit Diet. In 1841, there was privately printed in Eng- land, a small pamphlet of twenty-two pages, in which a gentleman, who was a chenist, gave an account of an exper- iment he himself tried in the case of his wife, whose labors had been so excessively painful that there was much reason to fear that she would not survive the next one. The result was so favorable that he felt it his duty to publish it, with his name and residence. A few experiments were made in Boston and vicinity with distinguished success, when the discovery of Ether rather threw it into the shade. As, however, there are persons, es- pecially out of New England, who do not use Ether, the following extracts are made from the pamphlet in question, MEDICATION OF THE FETUS IN UTERO. 259 which has now become very scarce, and indeed practically inaccessible. It will be best to begin by stating the principle of the system, with which the experimenter ends his account. In proportion as a woman subsists during pregnancy upon aliment which is free from earthy and bony matter, will she avoid pain and danger in delivery; hence the more ripe fruit, acid fruit in particular, and the less of other kinds of food, but particularly of bread or pastry of any kind, is con- sunied, the less will be the danger and sufferings of child- birth. "The subject of this experiment had, within three years, given birth to two children, and not only suffered extremely in the parturitions, but for two or three months previous to delivery her general health was very indifferent; her lower extremities exceedingly enlarged and painful; the veins so full and prominent as to be almost bursting; in fact to pre- vent such a catastrophe, bandages had to be applied, and for the few last weeks of gestation her size and weight were such as to prevent her attending to her usual duties. She had on this occasion, two years and a half after her last de- livery, advanced full seven months in pregnancy before she commenced the experiment, at her husband's earnest instance; her legs and feet were as before, considerably swollen, the veins distended and knotty, and her health diminishing. She commenced by eating an apple and an orange the first thing in the morning and again at night. This was con- tinued for about four days, when she took just before break- fast, in addition to the apple and orange, the juice of a lemon mixed with sugar, and at breakfast two or three roasted apples, taking a very small quantity of her usual food, viz., wheaten bread and butter. During the forenoon she took an apple or two and an orange For dinner she took fish or flesh in a small quantity, and potatoes, greens, and apples, the apples sometimes peeled and cut into pieces, sometimes boiled along with the potatoes, sometimes roasted before the fire and afterward mixed with sugar. In the afternoon she sucked an orange or ate an apple or some grapes, and always took some lemon-juice mixed with sugar or treacle. At first the fruits acted strongly on the stomach and intestines, but this soon ceased, and she could take several 260 MEDICATION OF THE FETUS IN UTERO. lemons without inconvenience. For supper she had again roasted apples or a few oranges, and rice or sago boiled in milk; sometimes the apples peeled and cored were boiled with the sago. On several occasions she took for supper apples and raisins, or figs with an orange cut among them, and sometimes all stewed together. Two or three times a week she took a teaspoonful of a mixture made of the juice of two oranges, one lemon, half a pound of grapes, and a quarter of a pound of sugar or treacle. The sugar or treacle served mainly to cover the taste of the acids, but all saccha- rine matter is very nutritious. The object in giving these acids was to dissolve as much as possible the earthy or bony matter which she had taken with her food in the first seven months of her pregnancy. She continued in this course for six weeks, when much to her surprise and satisfaction the swelled and prominent state of her veins, which existed be fore she began, had entirely subsided; her legs and feet, which were also swollen considerably, had returned to their former state, and she became so light and active she could run up a flight of more than twenty steps with more ease than usual when she was perfectly well. Her health became unwontedly excellent, and scarcely an ache or a pain affected her up to the night of her delivery. Even her breasts, which at the time she commenced the experiment, as well as during her former pregnancies, were sore and tender, became en- tirely free from pain, and remained in the very best condition after her delivery also, and during her nursing. "At nine o'clock on the evening of March 3d, after having cleaned her apartments, she was in the adjoining yard shak- ing her own carpets, which she did with as much ease as any one else could have done. At half-past ten she said she be- lieved her 'time was come,' and the accoucheur was sent for. At one o'clock the surgeon had left the room. He knew nothing of the experiments being made, but on being asked, on paper, by the husband, two days afterward, if he could pronounce it as safe and as easy a delivery as he generally met with?' he replied, on paper, 'I hereby testify that I at- tended Mrs. Rowbotham on the 3d iust., and that she had a safe labor, and more easy than I generally meet with.' On his asking the female midwife if she thought it as easy as MEDICATION OF THE FETUS IN UTERO. 261 usual, she replied, Why, I should say that a more easy labor I never witnessed. I never saw such a thing, and I have been at a great many labors in my time.' "The child, a boy, was finely proportioned and exceedingly soft, 'his bones being all in gristle,' but he became of large size and very graceful, athletic, and strong as he grew up. The diet of his mother was immediately changed on his birth, and she ate bread and milk and all articles of food in which phosphate of lime is to be found, and which had been left out before. She also got up from her confinement immedi- ately and well. Mr. Rowbotham made a table of substances, with the proportion of phosphate of lime in each, so that it may be avoided in the food during pregnancy, and used after- ward in nursing, when the bones and teeth of the child are made. (6 Beans, rye, oats, and barley, have not so much earthy mat- ters as wheat. Potatoes and peas not more than half as much; flesh of fowls and young animals one-tenth; rice, sago, fish, eggs, etc, still less; cheese, one-twentieth ; cabbage, savoy, broccoli, artichokes, coleworts, asparagus, endives, rhubarb, cauliflower, celery, and fresh vegetables generally, one-fifteenth; turnips, carrots, onions, radishes, garlic, parsley, spinage, small salad, lettuce, cucumbers, leeks, beet-root, parsnips, mangelwurzel, mushrooms, vegetable marrows, and all kinds of herbs and flowers, average less than one-fifth; apples, pears, plums, cherries, strawberries, gooseberries, raspberries, cranberries, blackberries, huckleberries, currants, melous, olives, peaches, apricots, pineapples, nectarines, pomegranates, dates, prunes, raisins, figs, lemons, limes, oranges, and grapes, on the average are two hundred times less ossifying than bread or anything prepared from wheaten flour. Some articles, as honey, treacle, sugar, butter, oil, vinegar, and alcohol, if unadulterated, are quite free from earthy matter. But still worse than wheaten flour is common salt, and nearly as bad are pepper, cinnamon, nutmeg, cloves, ginger, coffee, cocoa, Turkey rhubarb, licorice, lentils, cinchona or Peru- viau barks, cascarilla, sarsaparilla, and gentian. “With regard to drinks, no water except rain and snow, as it falls, and distilled water, is free from earthy matter, and every family should have a distilling apparatus; and perhaps 262 MEDICATION OF THE FETUS IN UTERO. it would pay capitalists to form a company for the purpose of distilling water on a large scale. Filtering water is not suf ficient to purify it of earthy matter, because a filter can only remove such particles as are mechanically mixed. "An American lady, who usually suffered terribly in labor, immediately procured the pamphlet and governed her diet by it partially, and had the easiest labor she ever had. Another who governed herself wholly by it from the first moment she was aware of being pregnant, like the English lady never experienced a moment's discomfort before de- livery. She had taken nothing made of our grains, but cou- fined herself to the best Indian ones, rice, sago, tapioca; and taking a disgust to our summer fruits, subsisted largely on oranges, tamarinds, marmalades, and also took a great many lemons. At first the fruits made her bowels too loose, but she did not abandon them on that account, but took mutton broth with rice in it to correct this effect. She also took fish and sardines, and the young of meats; for the older ani- mals are the greater quantity of earthy matter is contained in their secretions, and so it is even with milk. She had so little thirst that she drank nothing but a little tea made with distilled water. This lady and her husband were neither of them very young, she was thirty-five and he forty at the birth of her eldest child: and she had been an invalid in her chamber from fifteen to thirty years of her life, though very well at the time of her pregnancy, and for the first time in her life taking much exercise in the open air. Conse- quently, and because of her extreme nervous delicacy, she did not escape pain in the labor the first time, and the pro- cess was several hours. But in the two succeeding times, at the last of which she was forty, the labors were very short and not at all severe. In all the cases she rigidly adhered to the diet without a single day's exception, and her three children were perfectly splendid instances of large, healthy, strong, and beautiful physique. The youngest of them is now eighteen years of age." A common error is, that during gestation the mother needs to "eat for two;" that is, that more food is necessary to support properly herself and her growing infant than at other times. This is a thorough delusion. On this point, MEDICATION OF THE FETUS IN UTERO. 263 and on diet during pregnancy generally, Dr. Bull, a very sensible and experienced English physician, says: "We habitually take more food than is strictly required for the demands of the body; we therefore daily make more blood than is usually wanted for its support. A superfluity amply sufficient for the nourishment of the child is thus fur- nished, for a very small quantity is requisite without the mother on the one hand feeling the demand to be oppres- sive, and on the other, without a freer indulgence of food being necessary to provide it. Nature herself corroborates this opinion; indeed, she solicits a reduction in the quantity of support rather than asks an increase of it; for almost the very first evidence of pregnancy is the morning sickness, which would seem to declare that the system requires reduc- tion rather than increase, or why should this subduing pro- cess be instituted? The consequences, too, which inevitably follow the free indulgence of a capricious, and what will afterward grow into a voracious appetite, decidedly favor this opionion; for the severest and most trying cases of in- digestion are by these means induced, the general health of the female disturbed and more or less impaired, and through it the growth and vigor of the child.. "If the appetite in the earlier months, from the presence of morning sickness, is variable and capricious, let her not be persuaded to humor and feed its waywardness from the be- lief that it is necessary to do so; for if she does, she may de- pend upon it, from such indulgence it will soon require a larger and more ample supply than is compatible with her own health or that of her little one. "If the general health before pregnancy was delicate and feeble, and, as a consequence of this state, it becomes invigo- rated and the powers of digestion increase, a larger supply of nourishment is demanded, and may be met in such case without fear; for instead of being injurious, it will be useful. "Lastly, a woman, toward the conclusion of pregnancy, should be particularly careful not to eat in the proportion of two persons, for it may not only bring on vomiting, heart- burn, constipation, etc., but will contribute, from the accu- mulation of impurities in the lower bowel, to the difficulties of labor." 264 MEDICATION OF THE FETUS IN UTERO. A few figures given by Dr. Dewees, whose discussion of this subject is exactly in harmony with Dr. Bull's, show very clearly the absurdity of the idea that it is necessary to “eat for two." They are in substance as follows: "On an average, a new-born child, together with all the ac- companying materials expelled at birth, weighs not more than ten pounds, viz.: eight pounds for the child itself, and two pounds for the placenta, etc. A table of 7077 births in Paris gave an average of about two pounds less than this, being for the child itself just six pounds. Now, a daily sup- ply of less than three-quarters of an ounce, during the aver- age of two hundred and eighty days of pregnancy, will amount to this ten pounds; and this daily supply is de- cidedly less than the average quantity of unnecessary food which is usually eaten. Since, therefore, we almost always eat too much, and since the ordinary overplus is more than enough to supply the requirements of pregnancy, and par- ticularly since the natural symptoms of that state usually indicate less food rather than more, it is mere common sense to conclude that pregnant women neither want nor need to 'eat for two. The fact is more likely to be the seeming paradox that enough for one is too much for two; i. c., that less food than usual, rather than more, is best during preg- nancy. Regularity in hours of eating is advantageous to the health, and more care even than usual should be taken during preg- nancy to observe this practice. Another, almost, or quite equally important rule is, to eat nothing for four hours, or at least for three hours before going to bed. Eating should also be, as indeed it should always be, in moderation. It should be deliberate, and it should be cheerful. Deliberation is almost indispensable to moderation; for it is the sense of satisfaction of hunger that tells us when to stop eat- ing, and this sense is blunted and almost useless when the food is swallowed rapidly and without thorough chewing; and the appetizing effect and healthful stimulus of cheer- fulness at meals are too well known to require any detailed enforcement in this place. "I once heard a physician object to the fruit diet on the ground that it would not give enough strength to the preg- MEDICATION OF THE FETUS IN UTERO. 265 nant woman to undergo the severe trial of parturition. But if the trial be robbed of its severity, where is the need of the extra strength? Again, what strength is imparted by rich strong animal food, that is ejected from the stomach, or else passes out of the system undigested and unassimilated? Or, if this food be digested and assimilated, what is the re- sult? Why, plethora, that most dreaded foe of the pregnant woman, leading either to miscarriage or to a terrible con- finement, in which the chances of death are greatly aug- mented." (Dr. Cummings.-"Richardson's Obstetrics.") Dr. Verdi says, in his advice to mothers:* "It will do no harm to avoid what is repugnant to you, but it may be det- rimental to your health to satisfy the longing for slate-pen- cil, chalk, or other deleterious substances which sometimes women in your condition crave. "But above all, keep a cheerful mind and do not yield to grief, jealousy, hatred, discontent, or any perversion of dis- position. It is true that your very condition makes you more sensitive and irritable; still, knowing this, control your feelings with all your moral strength. "If you believe that strong impressions upon the mother's mind may communicate themselves to the foetus, producing marks, deformity, etc., how much more should you believe. that irritability, anger, repinings, and spiritual disorders, may be impressed upon your child's moral and mental nature, rendering it weakly or nervous, passionate or morose, or iu some sad way a reproduction of your own evil feelings; and, indeed, this is more frequently found to be the case than is the physical marking of a child by its mother's impressions. "If a woman needs culture and expansion, both of her per- ceptions and conceptions of the beautiful, in order to pro- duce a grand poem or painting and sculpture, or to conceive noble measures for the relief of the sufferings of others, then does she also need all these for that highest of all her efforts, when it seems as every fibre of her being was put upon the stretch to do its share in the grand donation to love and to humanity of a child.” * On Maternity. By T. S. Verdi, M.D. 18 266 MEDICATION OF THE FETUS IN UTERO. SUMMARY. It appears then that painless parturition may be secured by attention to the following points during preg- nancy (besides correct previous bringing up, moral, mental, and physical): Moderate healthful exercise and avoidance of shocks, fatigue, and overexertion. Comfortable or at least quiet and patient mental condition, avoiding all bad tempers. Amusement and agreeable occupation as far as possible. Judicious use of bathing, particularly of the sitz-bath. The fruit diet, and avoidance of unsuitable food, and of alcoholic, narcotic, and other stimulants. Watchfulness and prompt treatment of the various ail- ments of the situation, should they appear. Cheerfulness on the part of the patient, and kindness and indulgence by the husband and friends.-(Dr. Cummings.) IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 267 CHAPTER IV. THE IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCI A. By the immediate treatment is meant the application of medicinal agents which have the power to control or modify those conditions and symptoms which may arise during the progress of labor, and tend to produce an abnormal mani- festation of that condition. EXTREME SLOWNESS OF THE LABOR.—A duration of eighteen or twenty hours in a primipara cannot be regarded as an alarming circumstance. But if labor is prolonged beyond this period, some assistance is demanded. Assistance may be given before, however, if certain symptoms arise. The first stage of labor, that of dilatation of the cervix, may be pro- longed without danger; but the second cannot pass beyond certain limits without greatly endangering the health of the patient, or the life of the child. It is found that the latter is lost at least one time in four, when the head remains in the excavation longer than seven or eight hours after the complete dilatation of the os uteri and the rupture of the bag of water; whilst it nearly always survives when the first period is prolonged to forty, fifty, or even sixty hours. (Cazeaux.) The first stage of labor, even prolonged as above, rarely presents any serious symptoms, except great fatigue, nervous irritation, loss of sleep, depression of spirits, and alarm. These symptoms may be met successfully by proper food, gruels, and broths, and the use of Coffea, Cimicifuga, Ignatia, Aconite, and Erythroxylon Coca. It is during the first stage of labor that we meet with those two conditions of the os and cervix, which cause great trouble and anxiety, namely: 1. Rigidity of the cervix. 2. Spasmodic contraction of the cervix. Rigidity is a passive force by which the fibres of the neck of the uterus resist the dilatation they have to undergo. $ 268 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. Spasmodic contraction is an active force by which the fibres. contract and diminish the size of the opening, previously exhibited by the mouth of the womb. In rigidity the tissues seem dense and like a piece of leather soaked in grease. The labor continues without dilatation of the orifice, which retains a certain thickness, against which contractions strive in vain, until the woman is exhausted with her fruitless efforts. Pain in the loins, according to Madanie Lachapelle, is a diagnostic sign of rigidity of the os. Spasmodic contraction may occur after the cervix has at- tained considerable dilatation. The orifice presents a thin cutting edge, and is warmer, drier, and more sensitive to the fingers, and very irritable. This extreme sensibility-tenderness-of the neck is often the only symptom by which we can decide that we have a spasmodic contraction to deal with. These two conditions must not be confounded with a neck which continues thick, simply because the contractions are insufficient, badly directed, or lost against some mechanical obstacle in the pelvis. The obstetric authors of our school have always advised the same remedies for both conditions. Nothing could be more unscientific or irrational, for the conditions are oppo- site. In rigidity the true remedies are-Gelsemium, Lobelia, Veratrum viride, Passiflora (or Curare), and Nux vomica. Gelsemium, when the face is flushed, the woman is pleth- oric, dull, and apathetic, the pains irregular in force and frequency, and not in their proper place-passing from before backward, or occupying one side of the uterus-and the os is thick, sodden, but unyielding. The efficient dose is a drop or two of the tincture or 1 every half hour until the cervix relaxes. (Dr. Page asserts that it acts better when admin- istered in hot water.) Lobelia is next in value. It is indicated for the thick, leathery, unyielding cervix, and the reflex symptoms which arise from the obstruction,-the dyspnoca and nausea. In some rare cases this medicine will have to be given until it causes general relaxation, but no vomiting need be induced. IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 269 However, I think I should not hesitate to give it until vomiting ensued if the rigidity did not yield, for I should only be imitating nature. In such cases vomiting often occurs spontaneously, with immediate relaxation of a rigid Dose usually the same as Gelsemium. OS. 60 Stibium, in doses of th of a grain, or a few grains of the 2 trit., will often act better than Lobelia, while the in- dications are nearly identical. Veratrum viride is useful in those cases where the old phy- sicians considered "bleeding" absolutely necessary, i. e. when the woman was very plethoric, the head and chest congested, the pulse full and bounding, and eclampsia threatening. It should be given in doses of one to five drops of Norwood's tincture, repeated every hour. Usually three or four doses bring down the great blood-pressure, the congestion, and the cervix relaxes normally. Passiflora or Curare are indicated if the rigidity seems almost tetanic, with a general tendency to tetanic stiffness, such as we will sometimes meet with in hysterical subjects. The dose is, of the former, ten to twenty drops of the tinc- ture every hour; of the latter, a few drops of the 1 or 2x dilution. Nur vomira is also indicated in the same condition, espe- cially if the woman feels the peculiar pains in the "loins and a constant urging to stool. Ignatia may better suit some women. A These two last remedies being primarily indicated should be prescribed in the tenth or thirtieth attenuations. single dose is often sufficient. I have induced the needful relaxation in some cases with- out the use of medicine, by placing the woman in a hot (100° F.) sitz-bath for half an hour or more, and injecting, at the same time, warm water against the os. I think I have observed that the internal administration of the remedy, particularly Gelsemium, was aided by ap- plying it topically. Saturate a tampon of cotton or soft sponge, with a warm solution of glycerin and water, equal parts, and pour upon it 15 or 20 drops of the medicine. Apply this to the rigid os, and allow it to remain. 270 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 33 Spasmodic contraction of the os and cervix requires the fol lowing remedies: Aconite, Amyl, Belladonna, Hyoscyamus, Solanum, Cactus, Lachesis, Conium, Caulophyllum, Cimicifuga, Morphia, and Viburnum. (Also Ether and Chloroform.)* Aconite, when the patient has the usual restlessness, anxi- ety, and fear of death, some fever, with fine, small hard pulse, the vagina and os dry, hot, and sensitive. Here the 3* or 6* acts promptly-especially so if we apply it topically, as above recommended. Amyl Nitrite.-Although no cases are on record where this agent has been used for the specific purpose of relaxing a spasmodically constricted os, it has been used by some Eng- lish and Continental physicians in "very painful labors,” and with alleged good results. The most painful of all labors are those in which there is spasmodic constriction of the os, with spasmodic contractions of the uterine body. The pathological condition is similar to that which obtains in angina pectoris, or dysmenorrhoea from coustricted cervix. The value of Amyl in both these conditions has been estab- lished. It should prove equally useful in dystocia from spasm of the os. A few drops, not more than five, should be poured into a small vial, on a little cotton, or upon a hand- kerchief, and the patient be directed to inhale deeply eight or ten times, or until the face flushes and the head throbs. When this occurs, the constriction of the os will be observed to relax, and allow the expulsive efforts of the womb to ac- complish their purpose. Instead of inhalation, the Amyl may be given internally, a few drops of the 2x dilution every ten minutes. · Belladonnat has been alternately praised and denounced as * The special indications, and contra-indications, for the use of Ether and Chloroform, are to be found in all text-books on Obstetrics. They frequently relax spasmodic rigidity of the cervix and os, when internal medicines fail. † Atropin in Spastic Rigidity of the Cervix in the First Stage of Labor.— In the July No. of the American Journal of Obstetrics (1878), appeared a paper by H. L. Horton, M.D., in which he strongly advocates the use of atropin when the os is spasmodically rigid, and the pains fail to cause any normal relaxation. He applies it by means of a hypodermic syringe, having a needle hooked at the end. After hooking the index finger of the right hand into the anterior lip of the cervix, and drawing it slightly forward, IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 271 a remedy in "rigid os." This conflict of opinion is explained by Cazeaux, who writes: "The belladonna, so highly lauded by some accoucheurs, is by others thought to be useless. It seems to me that this difference of opinion has arisen from con- founding simple rigidity with spasmodic contraction. Though without action in the former case, I think it very useful in the latter." We have the same difference of opinion in our school, often from the same cause, but generally on account of a want of understanding of the relation of dose to primary and secon- dary effects of medicine. In order to prescribe Belladonna with any approach to scientific precision or curative effect, we must know something as to its method of action; which of its effects are primary and which secondary. The primary action of Belladonna (also Conium, Hyoscyamus, Stramo- nium, and Solanum) is to relax and paralyze the sphincters of the orifices of hollow organs, but not the muscles of the organs themselves. Its secondary effects are just the opposite, the sphincters are affected with spasm and constriction, and the muscular fibres of the walls of the organs themselves, weakened. Now according to the only law of dose known, Belladonna should be given in a high potency when we have symptoms simulating its primary effects, and in low attenuations when the symptoms resemble its secondary effects. In cases of spasmodic constriction of the cervix, Belladonna is seconda- rily indicated, and no possible benefit can arise from its ad- ministration in highly attenuated doses.* The low dilutions. the needle is carried along the palmar surface of the finger, keeping the point firmly pressed against it, so as to avoid wounding the maternal parts. After carrying the point of the needle within the cervix, it is raised from the finger and buried by slight traction somewhat deeply into the muscular structure of that portion of the uterus. After discharging its contents, it is retained in position a few moments, in order that the atropin shall be retained. This injection should be done in the interval between the pains. He injects gth of a grain, dissolved in 10 or 15 drops of water. It caused no unpleas- ant symptoms in the eight cases reported; only a slight dryness of the throat, flushed face, and dimness of vision, which soon passed off. Proba- bly the th of a grain would be as effectual. 50 100 * No rational physician can believe that the 30th of Aloes or Podoph. will purge, or the 6th of Ipecac. vomit, nor can we expect the 30th of Bel- ladonna to relax a sphincter. 272 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. X must be used, and often the material substance itself. Give internally the 1 or 3x, and apply to the cervix with the finger a mixture of one grain of the solid extract, or ten drops of the tincture, in a drachm of glycerin, lard, or cosmoline, or a small ball of cotton can be saturated with the glycerole, and placed against the os. Conium has some reputation in spasmodic conditions of the sphincters and circular-muscle-fibres. It has removed laryngismus and oesophageal spasm. I cannot, however, sub- scribe to the dogma that "any remedy will remove rigid os, if its other symptoms correspond," for if it does have all the other symptoms, it may not have that symptom of the os, and cannot therefore be completely homoeopathic to the case. Hyoscyamus and Stramonium both cause primarily paraly- sis of circular-muscle-fibres, and if the patient has other characteristic symptoms of these medicines, they may be indicated instead of Belladonna. I once removed a spasm of the cervix with Solanum (a close analogue of Belladonna), selecting it for the peculiar occipital headache and amaur- otic symptoms. Cactus causes, primarily, a spasm of the circular fibres of the heart, and has been successful in spasmodic dysmenor- rhoa. If the woman has the cactus-heart-symptom, so well known, I believe it would remove a constriction of cervix. Perhaps it would be successful even if that symptom were not present. The 6th would be indicated, or even the high potencies. Lachesis would be indicated, especially if its throat symp- toms were present, and here the 30th, or the very highest potencies, will be useful. Caulophyllum irritates all circular muscles by its primary action; the constriction is intermittently manifested. This is precisely the condition of the cervix in the worst cases. The uterine pains will be very severe, the contractions of the fundus strong, but the cervix will also contract powerfully, and neutralize the uterine contractions, and the head cannot engage. In the 1 or 2 dilution (or trituration of Caulo- phyllin), it will promptly remove this condition. Larger, and often-repeated doses would aggravate; they are only use- ful in general uterine atony. IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 273 Cimicifuga has a similar action, but the pains are irreg- ular, the contractions irregular, and the cervical constriction irregular. One moment it would seem as if the os would sufficiently expand, the next it is firmly closed by spasm. Moreover, the patient is nervous, depressed in spirits, her hands and legs tremble, her pulse is quick and weak, and there is irregular twitching and choreic movements, and a dull heavy headache in the brow and eyes. When these symptoms occur, the attenuations from the 3* to 6x will be found useful; they should be repeated every few minutes. Viburnum, from its wonderful power over spasmodic dys- menorrhoea, ought to prove very useful, and act very promptly in spasmodic stricture of the cervix, especially so when the patient has very violent pains, almost driving her distracted, attended by uncontrollable nervous excitement, cramps in the legs, thighs, and abdomen. It is primarily a uterine seda- tive; its spasmodic effects are secondary. Empirically it has acted best in appreciable doses. I have never observed it to remove spasmodic pains when given in the attenuations. above the 2, but have seen the most happy effects from doses ranging from 10 to 30 drops of the tincture, or 1 di- lution, frequently repeated. No aggravation need be appre- hended, for it is harmless, and I have known much larger doses used, with only pleasant results. Morphia.-This medicine has been very successful in the hands of many physicians of all schools in certain cases of dystocia, but its sphere of action and the symptoms indicat- ing its use have never been clearly defined. It has generally been prescribed for "excessive pain and uncontrollable nerv- ousness," and in certain cases it has been remarked that a rapid and favorable termination of labor resulted from its administration. Some of my professional friends claim to get excellent effects from the 1 trituration. In several cases I have been agreeably surprised at the favorable turn of affairs following similar doses. Instead of the Sulphate usually prescribed, I prefer the Valerianate of morphia, in the 1 or 2 trituration. X X In the April number of the Eclectic Medical Journal, Prof. Edwin Freeman has a paper "On Morphia as a Partus Ac- 274 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. celerator," and his views appear so clear and logical that I present them in full. He says: 'Eight or ten years ago I noticed in the Medical and Surgical Reporter of Philadelphia, reports of cases of rigidity of the os uteri favorably affected by the use of Morphine. A physician was called in the night to a case of labor. An examination revealed a rigid os. He concluded that the labor would be somewhat protracted, and that he might as well go home and en- joy a night's rest in his own bed. A moderate dose of Morphine was given to allay unnecessary pains, and he retired. In a very short time, however, he was aroused in haste and summoned to the bedside, which he barely reached in time to assist in the birth. He was led to regard Morphine as a parturifacient, classing it with Ergot and other remedies of that kind. Sub- sequent observers of a similar action have regarded it as directed to the nerves supplying the lower parts of the cervix and os uteri, obtunding their sensitiveness, and thus preventing their reflex action upon the muscular tissues. This latter explanation probably approximates the truth, with the exceptions to be hereafter mentioned, so that the agent is rather a partus accelerator. Its action may also be referred to a lessening of the irritability of the muscular fibre, which irritability in that region is often increased by any unnatural condition of the part, such as previous cervical endometritis, granular os, wearing an instrument to support the uterus, a highly nervous and excitable temperament, too frequent examinations, etc. The muscular fibres of the uterus are of the involuntary kind, consisting of transverse fibres passing around the neck, acting as a kind of sphincter, and oblique and longitudinal fibres continuous with those of the middle layer of the muscular wall of the body of the organ. Involuntary muscular fibres are excited to activity by mechanical agencies; those of the alimentary canal by the contact of the contained alimentary material. They may be aroused to activity, or modified in their action, through the sympathetic system, or even through the cerebro-spinal system, but this is not the normal method. In like manner they are excited to unusual activity when the contained ma- terial is of an irritating nature, or when the canal itself is in a state of irri- tability, arterial blood being in excess, they are excited by the presence of ordinary material "In the progress of the evolution of the foetus and the womb which con- tains it, the muscular fibres having become fully developed, the sphincter of the neck is gradually distended from above downwards by the gravitating pressure of the fœtus and amniotic bag that surrounds it, until at last only the external os remains to be loosed, and the uterus appears as a sac with an os and without a neck. At this latter stage of utero-gestation at the com- pletion of the above process, and as its result, the child sinks down below its previous position low into the pelvis. The loosing of the transverse fibres still goes on, the settling of the child making space above, upon which the uterus contracts. The action thus set up in the body of the womb is con- tinued to the oblique fibres of the neck, which, by then contracting, pull upon or stretch the constricting fibres of the os, still further enlarging that opening, until at last it is sufficiently open to allow the foetal head to pass. * X- * * IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 275 "Now if these sphincter fibres at the os be unduly excited, they may rigidly close it, or being less excited, they may seem relaxed, but as soon as the expulsive effort forces the child against the margin of the opening, con- traction is set up, and it grasps it as rigidly as before. This is evidently the hyperexcited action of the non-striated muscular fibre, which ordinarily is excited to action by mechanical pressure. "The objections to the theory that these contractions are produced en- tirely by direct reflex-motor action from the spinal cord, or even from the sympathetic, are: 1st. The fourth sacral nerve from the spinal cord joins the inferior hypogastric plexus of the sympathetic below where the uterine branches are given off, while above that point the spinal fibres join only the sacral sympathetic ganglia. 2d. The nerves distributed to the lower part of the womb are from that plexus, accompany the arteries, and belong to the sympathetic system, and their office is to regulate the functional activi- ties of the womb by their influence over the circulation. 3d. There are no striated muscular fibres at the mouth of the womb to be affected by fibres of spinal nerves. Thus both these nerves and the sympathetic have, if any, only an indirect action. Now what is the probable method of action of Morphine? We give it or Opium in diarrhoea, and it lessens the peristaltic movement of the bowels, not through the nerves, but through the blood by direct action upon the fibres. So in the case of the uterus, its action is di- rect through the blood, lessening the irritability. The action of the fibres of the os are thus brought to harmonize with that of the rest of the womb, when it again begins, and labor proceeds without the previous interruption. I was called to a case of labor recently in which the os was soft to the touch, but quickly contracted as the pain came on. The patient remarked that she was a week in labor with her previous child. The waters' were coming away since the previous day. I waited awhile after having her get up and sit and walk a little, and then examined her, but there was no change, and the pains seemed lessening, although I gave her a dose of flu. Ext of ergot. I gave her then Morphine sulph. gr. granule, and left her with directions to send for me as soon as the pains were severe. In an hour and a half I was called and found the labor progressing well, and she was speedily deliv- ered of a child without further trouble." ( But the second stage of labor, if extended beyond ten or twelve hours, presents symptoms which need attention. The pains become irregular, both in frequency and intensity, the fœtus seems to retrograde instead of advance, because the pains are not expulsive. "This local disorder is soon fol- lowed by violent trembling, the woman vomits bilious mat- ters, she is uneasy and excited, and changes her position every moment, the skin is hot and dry, the pulse runs up to 100 or 150 per minute, the tongue is dry, and sordes on the teeth. The vagina and cervix are hot, sensitive to the touch, and a yellowish liquid escapes from them, which occasion- ally has a fetid odor, the pressure of the child's head on the 276 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. neck of the bladder prevents the emission of urine.” (Ca- zeaux.) Be- The above picture is one of an extreme case, a condition which I cannot imagine could obtain in the hands of a com- petent physician, for we have many remedies which can prevent such an array of symptoms, the chief of which are Aconite, Baptisia, Cimicifuga, Caulophyllum, and Pulsatilla. This will be seen by a brief comparison of the symptoms of these remedies with those of the abnormal condition. sides these medicines I consider the sitz-bath to be of the greatest efficacy. Should I find a patient in the second stage of labor with the above serious symptoms, I would immediately give her the remedy indicated, and have her placed in a deep sitz-bath of a temperature of 100° F., and kept there till she felt faint, or till the natural pains and expulsive efforts came on actively. I would do this before resorting to the use of forceps, because the patient and the child would be better off for it. But we will now consider the special causes that may bring about the above abnormal second stage, namely: Slowness or feebleness of the contractions. This condition may occur at the very commencement of labor, and persist to the end, unless the appropriate remedy is given. It is sometimes, but not often, due to general debility of the muscular system, for it is a well-known fact that the most feeble patients, as those in consumption, often have the most powerful pains, and the most rapid labor. When the feeble pains are due to general atony, words of encouragement, small quantities of broth or beef-tea, or a few spoonfuls of wine, or Elixir of Coca, frequently repeated, are of great service. Caulophyllum tincture in drop doses, or Caulophyllin, 1 or grain pills, repeated every half hour, even before the os is dilated, will have an excellent effect in increasing the natural uterine action. This remedy seems to affect specifically all the muscular fibres of the womb in a manner simulating natural labor. This explains why it appears to relax the os in cases of rigidity. Cimicifuga is best indicated where the pains, besides being IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 277 feeble, are irregular, and are not always in the same place, now on one side, now on the other, now in front, then in the back. The os does not relax, and the woman is depressed in spirits, taciturn, and has jactitation of the limbs. The lower attenuations are indicated. Pulsatilla is indeated for these changing, erratic pains, but the woman weeps, sco'ds, frits, and tosses about in bed, and is very "fidgety." China is of great value in such cases, but it should be given in appreciable doses, namely, a teaspoonful of the wine of Cinchona, repeated every hour or two. Its alkaloid, Qui- nine, however, gives the best results. Many eminent obstet- ricians believe that Quinine possesses parturient power sim- ilar to Ergot, but I doubt its supposed excito-motor power over the uterus. It causes natural uterine pains, because it is secondarily homeopathic to muscular atony when due to inefficient blood-pressure, and decreased nervous supply. In many cases of general exhaustion, with cool sweating skin, feeble quick pulse, and very feeble pains, I have seen almost. magical results from the administration of half a grain or a grain of Quinine every half hour. The pains begin imme- diately to increase, the pulse is stronger, and the woman be- comes greatly encouraged. The obnoxious taste of the drug is readily disguised by mixing it with Syrup of glycyrrhiza (gr. 1 to 1 drachm), or the use of gelatin-coated pills, of a grain or a fraction of a grain each. In cases of alarming prostration, five or ten grains at a single dose has often seemed to rescue the woman from collapse. This I ought to add that the physician must not mistake the condition of the womb in cases of feeble pains. Excessive distension of the uterine walls often causes very feeble and ir- regular pains. The uterine walls become so thin that they are benumbed, and cannot contract while so distended. condition may be diagnosed by an examination, when the bag of waters will be observed not to bulge during the pain. In such cases, if the os is not rigid, the remedy is to rupture the bag of waters, and then, if good pains do not set in, give one of the remedies just mentioned. Slowness or feebleness of the contractions may depend upon sanguineous engorgement or plethora of the uterine tissues. 278 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. This condition may be diagnosed by the following signs: The pains are at first quite energetic, but soon diminish, both in frequency and intensity, the cervix uteri is soft, supple, and non-resistant, but the presenting part of the child does not engage during the pain, which latter is equally diffused over the whole abdomen. The phenomena of general plethora nearly always manifest themselves at the same time, the res- piration becomes laborious, the pulse hard and full, and the pains irregular both in force and frequency. In these cases the old practice is, or was, to bleed, for it is very rarely re- sorted to now. We have remedies, fortunately, that will control this con- dition without debilitating the system. Gelsemium, if the face is flushed, the pulse full, but not very hard, the head feels heavy, the senses apathetic, and the pains feeble and irregular; it will soon remove the plethora if administered in the low dilutions. Veratrum viride is indicated in a higher grade of conges- tive phenomena; when the head aches violently, the pulse is very full, very hard and quick, and convulsions or apoplexy threatens; and especially if the temperature of the patient is high-103° or 105°. Prompt results will accrue from two or three drops of the tincture, or 1* dil., repeated every hour, or oftener. Cactus will be useful if the heart is violently excited, and there is a sense of constriction about it. Bromide of soda (5 grains every half hour) has often re- moved this plethoric condition, when actual fever was not present, and there was great nervous erethism. Aconite is not indicated, and should not be used unless the pulse is small, hard, and quick, and there is great anxiety and fear of death. If the feebleness of the contractions be solely due to uter- ine debility, a weakness of its muscular tissue, while the gen- eral muscular system is healthy and strong, we must select remedies which specifically cause this condition. In such cases the woman will exert great strength; will "bear down" very powerfully, and pull violently on the hands of the attendants; but the physician will observe by IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 279 66 touching" that the head does not advance, although no obstacle to its progress is present. Here we have admirable remedies in Caulophyllum, Cimi- cifuga, Cannabis indica, Secale, Ustilago, and Phoradendron. (See page 281.) The same medicines are equally useful in sudden cessation of the pains, either from exhaustion, or some unknown cause. Caulophyllum is preferable where the pains are exceedingly feeble and far apart, or when they have been very violent, but intermittent, and then cease altogether. Give the tinc- ture, ten to thirty drops every fifteen or twenty minutes, or the Caulophyllin in one-tenth or one-fourth grain doses as often, or until good pains appear. Cimicifuga is superior to Caulophyllum, if the feeble and inefficient pains are irregular, both in intensity and recur- rence. The general system partakes somewhat of the same aberration. It is a greater neurotic remedy than Caulo- phyllum, and its power over the uterus depends on its action through the spinal and sympathetic system. In cases of sudden suspension of pain and expulsive efforts due to de- pression of mind or nervous exhaustion, Cimicifuga is specific. The most efficient dose lies between the tincture and second dilution, in drop doses, or from the 1 or 2 trit. of macrotin, in one-grain doses, repeated every fifteen or twenty minutes, until the pains are efficient. X Cannabis indica in doses of five or ten drops of the tinc- ture repeated every twenty minutes has been found to in- crease inefficient pains, or bring back suspended ones. It doubtless acts upon the enfeebled nerves which supply the uterus, stimulating them to normal action. Electro-magnetism properly applied has been known to act well in such cases, after all medicines have failed. The posi- tive pole should be applied to the lumbar region, the negative to the os, in the vagina, and a mild current (induced) should be applied between the pains, and suspended during their continuance, or, if no pains are present, the current should be applied for five minutes, with intervals of the same duration. Secale has been used by the dominant school for nearly a century, for the purpose of inducing uterine expulsive efforts. 280 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. At first its powers were not understood and it was given in all stages of labor, when the pains were feeble or absent It was found that in many cases its effects were unpleasant and dangerous, or no apparent effects were observed. As its action became better understood, it was found that if given before the os was dilated or easily dilatable, it caused vio- lent, persistent, painful contractions, which were not only useless to expel the child, but were the means of its death. The intense and unintermitting pressure cut off the foetal circulation, and the child died of asphyxia in utero. Even in cases where the os is dilated, the constant pres- sure caused by Ergot will produce the death of the child be- fore it is thrust into the world. Its use among the best ac- coucheurs of the old school is now limited to those cases where, after the os is dilated, labor does not advance, owing to feeble expulsive power, the size of the child, or smallness. of the passage. Many of the more cautious do not advise it until just before the head escapes from the vulva, and then only for the purpose of insuring a firm, final contraction, in order to prevent hæmorrhage, open or concealed, or the formation of an intrauterine clot. They prefer the use of forceps, for the purpose of facilitating the labor. In this I think they are judicious, for the safety of the child and the integrity of the perinæum are greatly enhanced by their skil- ful use. If the pains are simply feeble and inefficient, the careful application of the pocket-forceps (page 288), in such a man- ner as to imitate the natural expulsive efforts, and aid the in- efficient pains, is much more efficacious and desirable than a resort to such a powerful agent as Secale. If, however, the accoucheur has not the forceps with him (but he always should have), and the pains are very feeble, slow, and ineffi- cient, or altogether absent, and the os is dilated, the presen- tation favorable, and perinæum distensible, Secale should be administered. I must here protest against the absurd ad- vice given by some writers of our school, of giving the 30th or 200th in such cases. As well might we expect to cause diar- rhoea with the 200th of Epsom salts. Only appreciable, ma- terial doses of Ergot will excite or originate uterine contrac- IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 281 tions. Any observations to the contrary are based on a de- lusion or coincidence. There are several methods of administering Ergot in such cases. (1) The old method of infusion-30 to 40 grains of the powder in an ounce or two of hot water; a teaspoonful every ten minutes, or all in three or four doses, half an hour apart; (2) 15 or 30 drops of a fluid extract at similar in- tervals; (3) a teaspoonful of the wine of Ergot, as above; or, (4) Ergotin in gelatin-coated pills, containing three grains each, one every quarter or half hour. (5) A hypodermic injection of 15 to 20 drops of Squibb's, or any other good aqueous extract, will act with greater certainty and prompt- ness than any other method of administration. The drug should be suspended on the appearance of strong bearing- down pains. Ustilago, or the Corn ergot-is supposed to have similar properties as Secale, but it has not been sufficiently tested to enable us to use it with confidence. The dose is the same as Secale. Gossypium, or Cotton-root, is praised by many southern physicians as a good substitute for any of the above medi- cines. In several cases of slow labor in the last stage, I have given teaspoonful doses of the fluid extract. It appeared to stimulate to more efficient expulsive efforts. It is said that a decoction of the fresh root is the most efficient preparation, but the use of this would be restricted to the localities where the plant grows. We need further experience with Ustilago and Gossypium to determine their real powers. Viscum album.*-This new remedy has lately been intro- duced as a partus accelerator. In my Therapeutics of New * Since the appearance of Dr. Long's statement, Dr. E. S. Crosier has in- vestigated the botanical relations of the Mistletoe used by Dr. Long, and he announces in the Louisville Medical News, that it is not the Viscum album, but the Phoradendron flavescens of Nuttall. Therefore the Viscum album cannot be used for this purpose, although it may possess similar prop- erties (see New Remedies, 4th edition), and resembles Cimicifuga in many respects. Dr. A. G. Hobbs, contributes to the same journal a report of three cases, two of them obstetrical and one of menorrhagia, and says, "My experience with this parasite is that it acts more promptly and more decidedly as an oxytoxic than Ergot." (See also a case in Amer. Jour. Obstets., July, 1857). 19 282 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. Remedies I refer to its use by Dr. Huber, of Germany. He used it successfully in retained placenta, metrorrhagia, and menorrhagia, and his cases appeared to show that the condi- tion was that of uterine inertia. I have never tested it fully, and therefore cannot give my favorable testimony. But I will quote the testimony of Dr. Long, which seems con- clusive. ( "Dr. William H. Long, of Louisville, says that for ten years he has used the Mistletoe as an oxytoxic, having been led to do so from observing that farmers, in the part of the country where he formerly had practiced, were in the habit of giving Mistletoe to such of their domestic animals as failed to clean themselves,' or expel the placenta after the delivery of their young. In 1857 he first used an infusion in the case of labor, in which the second stage was delayed through inefficiency of the uterine action. Con- tractions followed in twenty minutes. He has since used it in decoction in a large number of cases, and does not recall an instance of its having failed to stimulate the uterus to contract. "He believes in its superiority to Ergot- "1st. Because it acts with more certainty and promptness. "2d. That instead of producing a continuous or tonic contraction, as Ergot does, it stimulates the uterus to contractions that are natural, with regular intervals of rest. Consequently it can be used in any stage of labor, and in primiparæ where Ergot is not admissible. "3d. It can always be procured fresh, does not deteriorate by keeping, and is easily prepared. "He has used Viscum in many cases of menorrhagia and bæmorrhage from the uterus with gratifying results, and has taken pains in such cases to give Ergot and Mistletoe a competitive trial, with the object of test- ing their relative merits; he unhesitatingly pronounces in favor of the latter. Indeed, cases in which Ergot given in powder, decoction, and fluid extract failed to give any relief, the Viscum acted promptly. "In post-partum hæmorrhage, the results have been no less satisfactory than in labor and menorrhagia, firm contractions of the uterus being secured in from twenty-five to fifty minutes after administering from one to two doses of the Mistletoe. According to Dr. Long, the remedy may be administered either as an infusion, tincture, or fluid extract, but he considers the latter to be the most convenient. The former he directs to be made by taking two ounces of the dried, or four ounces of the green leaves; pour on these one pint of boiling water, cover closely, and allow to stand until cool enough to drink. Two or four ounces may be given at a dose, and repeated in twenty minutes if necessary. The green leaves impart a disagreeable taste that is lost in the process of drying. "He has also used an alcoholic tincture made by taking eight ounces of the dried leaves and saturating them with boiling water, and adding alcohol to make one pint; but he does not think this as efficient as either the decoc- tion or fluid extract. It should stand ten days before ready for use. Vis- IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 283 cum makes a fluid extract of a dark-brown color, which possesses all the vir- tues of the parasite. "The best time for gathering the Mistletoe is in November, after a few frosts have fallen, and before the sap freezes, though it may be gathered and used at any period of the year. When gathered, it should be at once spread out to dry, as it will mould in a very short time if kept in a box or sack. It is best to dry it in the shade. "Viscum abounds in the Western country, and is found in greatest quan- tities on the walnut and elm trees, though it grows sparingly on a few others, as the red and black locust, oak, etc. So far as Dr. Long is aware, there is no difference in its properties or strength made by the kind of tree on which it grows." Sudden cessation of the pains may be caused by influences. from without. Disagreeable impressions occurring during labor-like the presence of disagreeable persons, the arrival of a physician, especially if he be not the one expected- may determine the cessation of the pains. Aconite is the remedy if the cause is akin to fright. Chamomilla, if the patient is vexed or made angry. Other remedies may be selected according to the causative influence, not because the medicine affects the uterus direct- ly, but because it acts upon the mental or moral origin. During the progress of labor acute pains in some other por- tions of the body may occur and arrest the labor until the ex- traneous pain is removed. Violent vomiting may occur, and will require the adminis- tration of Ipecac, Iris, Nux vom, Stibium or Verat. alb. Lumbar pains, severe and sharp, may require Belladonna, Cimicifuga, or Rhus. Colic may require Chamomilla, Dioscorea or Colocynth. Viol nt cramps in the thighs, legs or calves, so graphically described by Prof. Meigs, may set in with such severity as to totally arrest the uterine contractions. They are sup- posed to be caused by the pressure of the child's head upon the sacral nerves, and no remedy is capable of relaxing them until the pressure is removed. Here the forceps should be promptly used, and Chloroform or Ether given. Should the cramps continue-as they sometimes do after the pressure is removed-Arnica, Colocynth, Verat. Alb, or Viburnum are useful. Congestion to the head has been known to occur suddenly during labor, with sudden disappearance of the pains. In 284 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. such cases, nurses say, "The pains have gone to the head." I have met with several such cases. The patient suddenly puts her hands to her head-the pain is severe; there is flushed face, vertigo, dimness of vision, throbbing, ringing in the ears, pulse full, hard, etc. One such case was soon relieved by ten drops of tincture Verat. viride; and another by the administration of thirty grains of Bromide of lithia, which effected amelioration in thirty minutes. In the former case Verat. viride was selected because the pulse was very hard. In the latter the pulse was not hard, but full and soft. Solanum, Gelsemium, and Belladonna will be useful if other symptoms call for them. Violent pains in the uterus, or pelvis, from pressure of the child's head, may be so intense that the woman cannot make any effort, at a time when her efforts are necessary to the termination of labor. I have met with cases where the pains were so spasmodic, cramplike, and agonizing, that labor actually came to a standstill. In some cases a hot sitz-bath will give almost immediate relief, so much that the woman will beg to be allowed to remain in the water. In other cases there is nothing to be done but to remove the child with forceps, or give Chloroform to induce anesthesia. In a few cases I have known medicine to allay these pains. In one instance a tea- spoonful of tincture of Caulophyllum gave relief in ten min- utes, probably by changing the position of the child's head. In another case Viburnum opulus, in a similar dose, relieved the pain after three doses half an hour apart. Theoretically Secale 30th ought to relieve the agonizing, constant pain which sometimes occurs. Cases are on record where Hyoscyamus, Coffea, and Cham- omilla are said to have relieved these unnatural pains. Irregularity of the pains.-Under this head Cazeaux de- scribes certain kinds of pains, which he also terms uterine tetanic pains. He mentions several varieties: 1. "There is not a complete and perfect interval between them, they are continuous, and only interrupted by the parox- IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 285 ysms, during which the intensity of the suffering is terrible." This variety, as above stated, would call for Secale, accord- ing to a strict application of the law of similia. Here, evi- dently, Chloroform ought to be given, until the pains cease or give way to natural ones. If Chloroform was not admis- sible I would try Amyl, Calabar, or Chloral hydrate, either of which, in proper doses, should, in a short time, ameliorate the sufferings. 2. "The pains return, it is true, at intervals, but some- times it is only the fundus, again one of the cornua, and at others, some part of the uterine body, which contracts spas- modically, while the remainder scarcely does so at all." They have no effect on the progress of labor, except to retard it. The hand on the abdomen notes the irregular con- tractions of various parts of the uterus. The membranes do not bulge, nor the head press down. In these cases the warm hip-bath may do much good. Cimicifuga may prove an excellent remedy if the woman is nervous and depressed, the whole body jerks, and the limbs twitch (choreic motions). (See Cannabis indica.) Gelsemium has proved the curative remedy in several such cases under my care; and recently Dr. Fauntleroy re- ported a case to the Virginia Medical Society, which verifies my experience. He writes: "I was called in consultation, and the following history was elicited: In the three previous confinements, from the exhaustive continuance, for two or three days, of the inefficient contractions, marked by fre- quent pulse, coated tongue, and mental wandering, the doctor had been forced to relieve his patient by a resort to instru- ments. When called upon, the labor had commenced, the os uteri was partially dilated, not at all rigid, but the contrac- tions evidently involved different planes of the uterine mus- cular tissue, first in one part, then in another. The writer suggested the use of Gelsemium. Eight drops of the fluid extract were given every hour. After the second dose the uterine contractions became more general, and when the pa- tient had taken eight doses, she was delivered by the un- aided forces of nature, of a large healthy child.” Pulsatilla.-If this medicine is ever indicated in unnatural labor, it is applicable in this variety. The genius of this 286 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. remedy makes it applicable, not only for irregular contrac- tions of the uterine muscles, but contractions which fly from one set of muscles to another in the uterus, or from the uterine muscles to those of other parts of the body. The mental state of the patient affords valuable indications for Pulsatilla. With irregular, inefficient pains the woman often weeps, complains, is greatly agitated, and cannot be encour- aged. Here Pulsatilla will be indicated. Aconite will be useful if the patient has an uncontrolla- ble anxiety and fear of death, the skin is cold, and the pulse small and feeble (primary), or she becomes hot, feverish, with hard small pulse, thirsty, delirious, and has slight con- vulsive motions. (Secondary.) Ignatia covers many of the symptoms of this condition. Dioscorea may prove useful, especially if the uterine mus- cular-cramps suddenly cease, and appear in the bowels, hands, or feet. (See Symptomatology of New Remedies.) Before closing this chapter I cannot omit to mention a remedy, which under certain circumstances proves most efficient and harniless in the treatment of false labor, or irregular uterine contraction. I allude to Opium and its preparations. They are not ho- mœopathic to this condition, any more than Chloroform or Ether, but act as palliatives, giving the tortured organ needful rest, after which it takes up its normal action. Cazeaux says: "Under the influence of Opium, given in the form of enema (into the rectum), twenty or thirty drops in a few ounces of water, the pains entirely disappear in the course of half an hour. During this period the patient gen- erally slumbers, and then the good pains, that is, the natural and regular ones, come on, and the labor terminates happily." In several cases of peculiar obstinacy, where neither the homœopathic remedy nor Chloroform changed the unnatural character of the pains, I resorted to an enema of twenty drops of McMunn's Elixir of Opium, and the improvement set in in less than half an hour, and after an hour or two of sleep, natural labor commenced in earnest. In one case, two doses, half an hour apart, of one-eighth of a grain of Mor- phiæ acetas had the same effect. (See Dr. Freeman's obser- vations on Morphia, p. 274.) IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 287 Position. A woman in labor should not be obliged to lie in one position, unless it is appropriate, and she desires to. To confine a woman to the left-side position in all cases, would be to greatly retard labor in many cases. In lateral oblique positions of the uterus, or oblique presentations of the head, the woman should lie on the side opposite to that of the fundus uteri. This allows the uterus to fall to that side, and changes the abnormal presentation of the head to a nor- mal one. In anterior obliquity, the proper position is on the back, with the head as low as comfortable. This obliquity may also be removed by a properly-adjusted bandage worn during the last month of pregnancy, and also during labor. It should be so applied as to hold the womb upward, and press it backward. A finger hooked into the os, and drawing the anterior lip forward will often remedy this condition. In posterior obliquity (see Cazeaux, page 714), the woman ought to remain seated or standing, or, if possible, reclining a little forward. I have in two cases of this nature delivered the woman while she was kneeling by the side of a bed or chair, with the body bent forward. The hands of the ac- coucheur, reaching from behind, and pressing on the child's head just above the pubes, assists in aiding the head to en- gage. In all these obliquities the head is often greatly obstructed by the rim of the cervix getting between the head and the passages. This should be pushed forcibly back, between the pains, and held there, if possible, during the pains, until it will recede permanently. Abdominal pressure, made by the hands of the physician or nurse, or by means of a properly-adjusted bandage, will often facilitate a slow and tedious labor. The external pres- sure should be made during the pain, and, if possible, the pressure should be maintained in the intervals to keep what was gained by each pain. Many obstetricians of the present day strongly advocate this method. Unfortunately, some women cannot bear any pressure on the abdomen during labor, unless they are under the influence of Chloroform, Ether, or Chloral hydrate. The Forceps.—I do not propose to mention those Forceps 288 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. whose sole use in difficult or abnormal labor is to extract the child by force, but shall briefly mention a variety which can be used as a simple and valuable aid to the natural or defi- cient pains. My first experience with forceps was with Davis's, after- wards with Simpson's, but recently I have used Comstock's with decided satisfaction, especially when the head was high in the pelvis. When the head has passed the brim and the obstruction is below the promontory of the sacrum, unless there is some very great obstacle to overcome, I prefer Roler's. But from the first I was struck with the absence of any instrument, which, without being a compressor, or powerful tractor, would be an aid to the mother in the expulsion of the head from the lower strait, or when it rests on the peri- næum. Every practitioner has had cases where the head comes naturally down upon the perinæum, and then from some cause, as fatigue or exhaustion of the mother, a head that would not readily mould, rigidity of the soft parts or perinæum, or dryness of the passage, refuse to progress with that celerity which was desirable. I hold with Dr. Goodell, of Philadelphia, that it is only very rarely that there is any necessity for waiting hour after hour in slow labors, when we can facilitate it by means safe to the mother and child. But must we always use the heavy and formidable instru- ments which up to this time have been invented? The modern tendency of all the instruments used by surgeons, has been to- ward lightness and delicacy; not only in surgery, but in all the arts, and in every department of labor where machinery is used. Why has it not been so in midwifery? It is only within a few years that Roler's light forceps were introduced, and this has met with much opposition. Years before I saw Roler's I had made a drawing of a small light. forceps, which should be of the same shape as Davis's, only shorter and very much lighter; but I shrank from intrud- ing my idea upon the profession. However, when I saw the extremely light and delicate forceps, having ouly a "scissors handle," invented by Dr. Newman, of Denver, I hunted up my old drawing, in which the handle was the ordinary club- IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 289 shaped one of Davis's and Roler's latest. I then conceived the idea of modelling the handle of my small forceps so that it would resemble that found upon some of the older styles of pistols. I finally adopted the following shape, as shown by the accompanying cut. CH.SARGENT Hale's Forceps for Rotation and Extension. I have named my instrument the "Pocket Forceps," and a brief description is as follows: Length of blades from point of crossing, six inches. Total length, ten inches. Length of handles, three and one-half inches. A gradual pelvic curve of two inches, beginning near the extremity of the shanks. Breadth of the cephalic portion averages one and one-half inches. The distance across the widest part when the instrument is closed is two and three-quarter inches, the points being separated one-half of an inch. The branches fit easily in a "button lock." The diameter of the closed handles is one inch. The fenestræ are nearly elliptical; their length the same as most other for- ceps. Total weight only five and one-half ounces. These forceps are all nickel-plated. * [By way of comparison I give the relative dimensions of * Since the introduction of my small forceps, many physicians of both schools have urged me to enlarge them so as to give them more traction- power. They highly approve of the shape of the handle as being the most convenient ever introduced. I have complied with their solicitations, and have designed a forceps which I have named Hale's Larger Traction Forceps, of which the following is a description : Length of blades, sir inches; total length, fifteen inches. Length of handle, four and a half inches. Length of curve, and breadth of cephalic portion and other measurements same as small forceps. The handle is placed more at an angle with the blades than in the small forceps, and its diameter is one inch near the lock, and one inch and a half at the butt. The shank between the blades and the lock diverges as in Comstock's. The weight about ten ounces. This forceps can be substituted for any one of the large forceps, as it possesses traction-power equal to any one of them, and is much more convenient on account of its peculiar handle. (Messrs. Boericke & Tafel will supply either instrument to order.) 290 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. my forceps, Comstock's, and Elliot's. The total length of Comstock's is fourteen inches; weight, thirteen ounces. Total length of Elliot's, seventeen inches; weight, twenty ounces.] It will be seen that while I have followed the general out- line of Roler's blades, I have increased their curve at the point of divergence from the lock, giving an opportunity for the placing of the forefinger as a guide and slight tractor. The shape of the handle I claim to be altogether original. It affords the best grasp for the hand, and does not interfere with its free movement. Its small size enables the physician to carry it in his pocket. Its appearance is not in the least formidable. It can readily be applied in nearly all the various positions in which women place themselves during labor, and thus afford, with but the slightest show of an operation, very important assistance during the last stage. It can be used to rectify those annoying oblique positions of the head, which, even when the head is resting on the perinæum, retards its progress. Here it is used as a lateral lever, as recommended by Meigs. In cases where the head is placed transversely to the lower pelvic strait it can be used successfully to rotate the occiput under the pubic arch. In face presentations, these forceps can be used effectually to cause the chin to escape more readily from under the pubes, or assist it in escaping from the perinæum. In occipito-posterior positions this little instrument will greatly assist in causing the chin to approach the breast, and allow the vertex to escape more readily. Even in that most natural phase of labor, the occipito-anterior, the attendant and patient are annoyed and fatigued by the tendency of the head to retrograde, or "slip back," at each pain, just at the time when it seems as if it was about to escape from the vulva, or reach a position where it could be grasped by the hand. How often have we waited hours for the escape of the head under these circumstances. We feel that all that is wanting is a little harder pain. We know that if we only had one hand on the head we could extract it, but just as we seem able to grasp it it slides back into the pelvis. It is in just such cases that these small forceps are a great assistance to both physician and patient. IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 291 I here wish it to be distinctly understood that I do not recommend my forceps as an instrument for forcibly extracting the child, but for guiding the head, for effecting rotation, flexion, and extension, and assisting weak or even normal pains. For the purpose of forcibly impressing upon physicians the value of my short forceps, I quote from a recent lecture by Dr. E. W. Sawyer, of Chicago, who claims for it great value in saving the perinæum by effecting flexion at a certain period of labor. He says: "The remarks which I have to offer, relate to those labors in which the vertex is in advance, and only to that stage of labor when the head has almost passed through the bony portion of the obstetric canal, but is still opposed chiefly by the woman's soft parts at the floor of the pelvis, and the outlet of the canal. "It will perhaps elucidate the point I hope to establish, if I may be per- mitted to describe the manner in which the forces of the woman will com- plete the expulsion of the head, if no interference is offered by the attendant. "At the moment we speak of, the antero-posterior diameter of the fœtal head approximately corresponds to the same diameter of the parturient canal. In the great preponderance of labors, the back of the head looks upward-the woman being upon the back. A little further advance brings the vertex to look through the vulvar aperture, and the nape of the neck in contact with the inner surface of the pubes; while that part of the occiput just inferior to the protuberance, is lodged against the sides of the pubic arch. The occiput is too broad to be received into the pubic arch as far as its sum- mit, as one may convince himself by sweeping the tip of the finger between the inferior border of the symphysis and the head, during the expulsion of the latter. "Till this time the foetal head has been in a state of flexion; but when the occipital plane becomes arrested against the pubic arch, the frontal part of the head receives the propelling force more directly, and is soon in advance. The head is now made to describe a movement of extension, or evolution, by which it becomes unfolded into the world, around the point of the pubic arch, against which the occiput is lodged, as around a pivot. "Two forces operate to produce this extension. The propelling power of the uterus and its auxiliaries, the vis-a-tergo, advance the head until the larger portion of the forehead looks over the margin of the perinæum. When the soft parts become still further distended by the fœtal head, the perinæum draws itself backward over the face, urging forward successively the margin of the orbit, the malar prominences, nose, lips, and chin, the part of the head to be freed last being that part which was lodged against the pubic arch. This retraction of the perinæum is the second force which extends the head. "Such is an outline of the manner in which the head is delivered by na- ture. A movement which, while it succeeds in its object, at the same time jeopardizes the woman's soft parts. This is even more apparent when we recall the successively increasing dimensions of the head which pass through 292 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. the vulvar outlet. I have given the name pubo-facial diameter to that axis, one end of which rests upon the highest part of the pubic arch, while the opposite extremity is lost upon different parts of the face. Their names indicate the limits more exactly. The length of these several axes show the extent to which the vulvar aperture is opened to give exit to the head. Thus the pubo-frontal, 4½ inches; pubo-malar, or nasal, 4 inches; pubo- mental, 51 to 5 inches. I believe it practically impossible for the vulva of the primiparous woman to be stretched to this degree without a rupture of the perinæum occurring. I am aware that a primipara may be delivered of a large child, and her perinæum be left intact, but this is because the judi- cious interference of her attendant compelled the head to pass out in a shorter axis than nature can do if left to herself. "I have had an opportunity of an ocular demonstration of the moment and manner in which the perinæum was torn. Just as the upper margin of the orbits looked over the edge of the perinæum, the little fold of mucous membrane known as the fourchette, or frænum, gave way; this tear was continuously deepened by the malar prominences and chin. This is, I think, the usual order. Writers have described, in exceptional cases, its first giving way at the centre, but all agree that it tears on the median line. "I know some hold that it is the bis-acromial diameter, the shoulders, which causes the tear. But I cannot believe that the perinæum, left abso- lutely intact by the head, will be torn first by the shoulders, under the care which the woman always receives. Such an accident can always be averted by delivering the pubic shoulder first. "The interference which I would recommend to anticipate the hazardous stretching of the vulva is, in a word, of a nature to hold the head in a state of extreme flexion, and force it to pass through the vulva in a diameter a little superior to the pubo frontal, and which has a length in the full-grown child of about four inches. "I cannot assume that preventing the extension of the head at this time is an original procedure; only that its significance is not generally under- stood. Many practitioners interfere during this stage of labor, and really Thus some hook the index prevent the complete extension of the head. It would seem at first finger over the chin through the woman's rectum. sight that they attempted just what we would prevent, that is, extension of the head; but really they accomplish what we have recommended, for the thumb of the same hand is pressed upon the perinæum, which is being bulged out by the forehead. In this way, with the face held between the thumb and finger, in easy cases, the sinciput is kept back. "Others apply the hand to the perinæum in such a way that the commis- sure between the thumb and finger corresponds with the posterior commis- sure of the vulva. Judicious support continuously supplied is of the greatest advantage, but the object to be attained by this palmar pressure is not always understood, for I have often been told to hold the forehead back for a time to allow the perinæum to become thin and the vulva more easily stretched. Possibly this is accomplished, but the greatest advantage comes from the flexion into which the head has, by this means, been forced. "In addition to holding the sinciput back with one hand, others attempt IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. 293 to tease the occiput forward with the fingers of the other hand applied to the head just in front of the symphysis pubis. "Besides the objections to the introduction of the finger in the rectum, it can be said against all these measures that they are not sufficient, in the ma- jority of labors, to hold the head in a state of flexion. "I am assured that this can be most certainly and easily accomplished with the forceps. For a long time I have been using my short forceps for this purpose with the most satisfactory results." I will add that Dr. Sawyer's forceps are similar to my short forceps, with the exception of the handle, which, like Comstock's, has a hook to each half, which projects outward. I consider the "pistol handle," as applied to obstetric forceps, as one of the greatest advances in the improvement of that instrument. When placed upon the large forceps, it will give to them a strength, a convenience, and a facility for manipulation which will render it universally popular. Dr. Sawyer gives correctly the proper method of the use of the small forceps: "Let us assume that the forceps is to be used to flex the head, and to hold it in a state of flexion. At this stage in the labor the woman is usually upon the back. Her position need not be changed, only to have the limbs strongly flexed in the lithotomy position. Nor is it necessary for the operator's body to be in a line with the pelvic axis. The introduction and locking of the blades is a matter of extreme simplicity. While the head is loosely held, the handles should be elevated so as to nearly approach the symphysis. Choose the interval of uterine action. Now clasp the head firmly in the blades, and slowly depress the handles until the edge of the perinæum is approached. The following diagram illustrates this movement of forced flexion: "C shows the forceps applied. The handle is to be depressed to D, when the chin will recede to the dotted line. 294 IMMEDIATE TREATMENT OF FUNCTIONAL DYSTOCIA. "It may be that one movement is not sufficient to flex the head; this is the more likely to result if the operator is overtaken by a contraction of the uterus. It is only necessary, in this event; to repeat the elevation and de- pression of the handles, and the operator will have the satisfaction of feeling the sinciput recede, when a moment before it was causing the perinæum to bulge out in a most threatening manner. "The most important step in the operation remains to be mentioned. When the head has been flexed, the hold of the instrument should be re- laxed, and the handles elevated to that degree that the general axis of the handle is nearly perpendicular to the plane of the bed. It is in this position that the head is to be held if the operator waits for the uterus to complete the delivery; and it is in this direction only that the operator lifts the head if he sees fit to make traction. "If, in addition to this use of the forceps, the ends of the fingers of the disengaged hand are placed upon the head in such a way that the convex surfaces of the nails rest upon the edge of the perinæum, and during the in- terval of uterine action gentle efforts are made to tease back this edge, and to prevent it from being caught upon the advancing head, the operator has by this conjoined manipulation given the soft parts the greatest possible security. " Finally, in an exceptional case of posterior position of the occiput, which refused to rotate forward to appear beneath the pubic arch, I was able, by reversing the movement I have described, to lift the head into marked flexion, and to deliver a primipara of a large child without injury to the soft parts. "As injuries of the soft parts, I have in the foregoing remarks alluded particularly to those rents which are apparent upon an inspection of the perinæum. But it seems reasonable that the liability to those not infre- quent tears of the mucous membrane about the outlet would be lessened by the same measures which would prevent the dangerous distension of the perinæum." INDEX. Absence of uterus, 62 ovaries, 58 vagina, 132 Atrophy of vagina, 59 uterus, 66 Atresia of uterus, 63 cervix, 63 vagina, 130 Amenorrhoea, 65, 108 Anteversion of the uterus, 73 Anteflexion of the uterus, 73 Amputation of cervix, 81 Applicator, Sims' cervical, 101 Hale's intrauterine, 102 . Abrasion of os uteri, 103 Areolar hyperplasia of uterus, 110 Abnormal shapes of cervix, 125 os uteri, 125 Abortion a cause of sterility, 182 Albuminuria, 237 treatment of, 238 Bougies, slippery elm, 97 medicated gelatin, 98 Bozeman's dressing-forceps, 99 Bladder, irritable, 147 Causes of sterility, 43 Constitutional causes of sterility, 50 Change of climate, 53 Cervix uteri, stricture of, 68 occlusion of, 63 division of, 68 dilatation of, 68 rapid and forcible, 79 amputation, 81 elongation, 83 oedema, 114, 118 enlargement, 110 abnormal shapes of, 125 conoidal, 126 "smashed hat," 127 rigidity of, in labor, 267 Climate, influence of, 53 Convulsions, puerperal, 248 Chambers' intrauterine stem pessaries, 74 Cotton pessaries, 78 Cloth tents, 95 Cervical protector (Wylie's), 94 applicator, Sims', 101 Hale's, 102 hyperplasia, 111 Calendula glycerole, 104 Conical cervix, 129, 126 Crescentic os, 126 Coition, improper time for, 177 position during. 179 during disease, 178 conduct after, 180 Clitoris, diseases of, 140 enlargement of, 140 abnormal irritability, 142 Carbonic acid gas douche, 198 Cases of retroversion during pregnancy, 227 Case of sterility, 143 fissure of the anus, 155 Cystitis, 147 Catarrh, vesical, 147 Constipation during pregnancy, 249 Conception, 159 prevention of, 180 Diet, improper, as a cause, 54 in obesity, 51 Degeneration of ovaries, 59 Dropsy of ovaries, 60 during pregnancy, 244 Dysmenorrhoea, 68. 108 pseudo-membranes, 108 Dilatation, rapid and forcible of cervix, 79 Dressings, medicated, for ulceration, etc., 106 Depletion, local, curing sterility, 118 | Diabetes, 146 Dress, improprieties in, 172 DISORDERS OF PREGNANCY, 201 DYSTOCIA, 201 preface, 203 due to the foetus, 255 fruit diet for, 258 Erotism, 57 Exercise, want of, 54 Elongation of cervix, 83 Elevator for retroversion, 77 Endometritis. 91 fundal, 94 Erosion of cervix and os, 103 Enlargement of uterus and cervix, 110 Engorgement, chronic of, 110 Enemas of hot water, 116 ! Eruptions in vulva, 137 296 Electricity in areolar hyperplasia, 122 in sterility, 197 Frigidity, 57 Fallopian tubes, stricture of, 61 Fundal endometritis, 94 Fitch's sound, 64 Flexions of uterus, 72 cervix, 79 INDEX. rapid and forcible dilatation of, 79 Fibroid tumors, 86 ergot in, 89 diet in, 90 Forceps, Bozeman's dressing, 99 Hale's pocket, 280, 289 Fissure of vulva or vagina, 136 urethra, 153 anus, 155 Fistula, vesico-vaginal, 153 Foetus in utero, medication of, 253 Fruit diet in dystocia, 258 Galvanic pessary, 122 Granular os and cervix, 103 Galvanism in sterility, 197 Gymnastics, 198 Hæmatometra, 63 Hale's intrauterine applicator, 102 Hale's speculum, 71 forceps, 289 Hysterotomes. 69 White's, 70 Skeene's, 70, 127 Peaslee's, 128 Hypertrophy of uterus, 110 cervix, 110 Hot water enemas in metritis, 116 Hymen, imperforate, 133 Hysterical diathesis, 136 Hæmorrhoids, 155 Hygienic causes of sterility, 172 Hydropathy, 198 Hydrotherapy in dystocia, 220 Hardness of the bones of fœtus, 258 Illustrations, list of, 11 Inordinate sexual intercourse, 53 Improper diet, exercise, etc., 54 Incompatibility, 56 Inflammation of ovaries, 59 Fallopian tubes, 62 uterus, chronic, 110 vagina, 138 bladder, 147 urethra, 151 Inversion of uterus, 84 Irregularities, menstrual, 109 Irritable tubercle of vagina, 136 Imperfect development of ovaries, 58 uterus, 65 Imperforate hymen, 133 Intrauterine pessary, 74 stem, 72 Intrauterine tampons, 105, 107 packing, 97 syringes, 93 bougies, 98 suppositories, 98 applicator, 102 Iodine in areolar hyperplasia, 120 Incision of cervix uteri, 68 Kumyss, nutritive value of, 124 Lateroflexion of uterus, 80 Leucorrhoea, 107 vaginal, 138 Leeches in engorgement of the uterus, 116 curing sterility, 118 Local depletion in chronic metritis, 116 curing sterility, 118 Labor, slowness of, 267 Phoradendron in, 281 cessation of pains during, 283 vomiting during, 283 cramps in legs during, 283 congestion to bead during, 283 irregularity of pains during, 284 position during, 287 obliquity of uterus during, 287 forceps in difficult, 287 pains, cessation of, 283 irregular, 284 violent, 284 Medicinal causes of sterility, 45 Mercurialization, 51 Mineral waters, 54, 123 Menses, retention of, 63 suppression of, 108 irregularities, 109 frequent and profuse, 109 scanty, 109 delaying, 110 Metrorrhagia, 109 Menstruation, imprudence during, 175 Metritis, chronic, 110 Mammary irritation, 198 Medication of foetus in utero, 253 Neuromata of vagina, 135, 137 Neuralgia of vagina, 135 Non-retaining vagina, 132 Nutritive treatment, 122 Ovulation (introductory), 11 Obesity, 51 Ovaries, absence of, 58 imperfect development, 58 atrophy, 59 inflammation, 59 degeneration, 59 tumors, 59 dropsy of, 60 Edema of cervix, 114 Os uteri, abnormal shapes of, 125 INDEX. 297 Os uteri, "pinhole,” 126 crescentic, 126 closed, 126 Predisponent causes of sterility, 49 Plethora, 51 Prostitution, 52 Psychical causes, 56 Prolapsus uteri, 80 Procidentia uteri, 81 Packing the uterus, 97 Phoradendron in dystocia, 281, 282 Pessaries, intrauterine, 74 galvanic, 122 Chambers' stem, 74 Thomas' anteversion, 75 retroversion, 76 Albert Smith's, 76 Jackson's, 76 cotton ball, 78 for lateroflexion, 80 elastic ring, 81 Zwang's pessary, 82 in conoidal cervix, 129 concavo-convex, 129 Polypi of the uterus, 86 Polymnia uvedalia, 119 Porte-tampon, 107 Pinhole os, 126 Peaslee's uterotome, 128 PREGNANCY, DISORDERS OF, 200 vomiting of, 224 1 Slippery elm tents, 74 bougies, 97 Syringes, intrauterine, 93 Suppositories, medicated, 98 in vaginismus, 136 Scarificator, Skeene's, 117 Butler's spear, 117 Semen, nature of, 159 injection into uterus, 199 Spermatozoa, 160 examination for, 164 passage to ovule, 167 Special disorders of pregnancy. 224 Twin-births, 52 Tumors of ovaries, 59 of uterus, 86 of meatus, 153 Tampons, cotton, intrauterine, in vaginitis, 138 in leucorrhoea, 139 Tenaculum, Nelson's, 72 Thermometer, clinical, 128 Temperature, 128 Tortuous cervical canal, 128 Therapeutics of sterility. 184 102 PAINFUL AND DIFFICULT LABOR, 201 Preface to Sterility, 3 ļ Preface to Dystocia, 203 Retention of menses, 63 Retroversion and flexion, 75 a cause of vomiting in pregnancy, 226 Renal causes of sterility, 146 Rectal causes of sterility, 155 Rectum, ulceration of, 156 fissure of, 156 Remedies for sterility, 185 for dystocia, 208 Statistics of sterility, 45 Scrofula, 50 Syphilis, 50 Sexual intercourse, inordinate, 53 in uterine hyperplasia, 116 Stricture of Fallopian tubes, 61 uterine cavity, 63 cervix uteri, 68 vagina, 131 Subinvolution of uterus, 110, 115 Sound, Fitch's measuring, 64 Sims' and Simpson's, 77 Simpson's hysterotome, 69 Skeene's hysterotome, 70, 127 Sims' operation for stricture of cervix uteri, 68 Speculum, Jackson's, 71 Hale's, 70, 166 Uterus, absence of, 62 atrophy. 66 imperfect development, 65 atresia, 63 displacement of, 72 anteversion, 73 flexions, 73 retroversion and flexion, 75 lateroflexion, 80 prolapsus, 80 elevation, 83 inversion, 84 tumors of, 86 polypi, 86 areolar hyperplasia, 110 hypertrophy, enlargement, etc., 110 subinvolution of, 115 erosions, 103 ulceration, 103 abrasions, 103 Uterine elevator, Sims' and Gardner's, 77 sounds, Sims' and Simpson's. 77 applicator, 102 pessaries, 74, 75, 76 Ulcers of vagina, 136 uterus and cervix, 103 Uterotome, Peaslee's, 128 Uræmia, 247 Urethra, irritable, 147 dilatation of, 152 caruncles of, 152 granular erosion of the mucous mem- brane, 153 fissure of the, 153 vesico-vaginal fistula of, 153 vascular tumor of the meatus, 153 Urethral catarrh, 151 20 298 INDEX. Vaginismus, 134 forcible dilatation for, 137 Sims' operation for, 137 Vagina, atresia of, 131 congenital absence of, 132 non-retaining, 132 Vaginitis, 138 Vesical causes of sterility, 147 catarrh, 147 salicylic acid in, 149 Vesico-vaginal fistula, 153 Venery, excessive, 176 51 . LUBI O!