aan Oe ea es 1 | ‘. = sf m™ PUBLIC HEACTH | IBRARY % 4 No. 91-13 oe U5 ce mH AUG ¥5 1993 ‘ 1 ethene colenenem, BIB ILIOGIRAIPHIIBS JUN MU IDICCIONTE, PUBL Diagnosis and Treatment of Early Melanoma , National Library [ of Medicine January 1983 through November 1991 447 Citations - U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service ¢ National Institutes of Health DOC. X ''PUBLIC HEALTH LIBRARY j aeacicey | LIBRARY UNIVERSITY OF \. CALIFORNIA ''CBM 91-13 Diagnosis and Treatment of Early Melanoma January 1983 through November 1991 447 Citations Prepared by Karen Patrias, M.L.S., National Library of Medicine Alan N. Moshell, M.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Library of Medicine Reference Section 8600 Rockville Pike Bethesda, Maryland 20894 ''SERIES NOTE Current Bibliographies in Medicine (CBM) is a continuation in part of the National Library of Medicine’ s Literature Search Series, which ceased in 1987 with No. 87-15. In 1989 it also subsumed the Specialized Bibliography Series. Each bibliography in the new series covers a distinct subject area of biomedicine and is intended to fulfill a current awareness function. Citations are usually derived from searching a variety of online databases. NLM databases utilized include MEDLINE®, AVLINE®, BIOETHICSLINE®, CANCERLIT®, CATLINE®, HEALTH, POPLINE™ and TOXLINE®. The only criterion for the inclusion of a particular published work is its relevance to the topic being presented; the format, ownership, or location of the material is not considered. Comments and suggestions on this series may be addressed to: Karen Patrias, Editor Current Bibliographies in Medicine Reference Section National Library of Medicine Bethesda, MD 20894 301/496-6097 Ordering Information: Current Bibliographies in Medicine is sold by the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402. To order the entire CBM series for the calendar year 1991 (20 bibliographies), send $52.00 ($65.00 foreign) to the Superintendent of Documents citing GPO List ID: CBM91. For your convenience an order blank is given inside the back cover. Orders for individual bibliographies in the series ($3.00, $3.75 foreign) should be sent to the Superintendent of Documents citing the title, CBM number, and the GPO List ID given above. Use of funds for printing this periodical has been approved by the Director of the Office of Management and Budget through September 30, 1992. ii ''DIAGNOSIS AND TREATMENT OF EARLY MELANOMA The incidence of malignant melanoma is rising rapidly. This malignancy is often fatal if not diagnosed and treated promptly. However, it has become clear that the specific clinical and histologic criteria for such early diagnosis is not completely agreed upon. Similarly, recent studies have indicated that the treatment for early melanoma may not need to be as aggressive as previously recommended without compromising cure rates. There has been great public awareness of malignant melanoma and, in some cases, unnecessary fear of both the development of the disease and its treatment. At the same time, intervention has the potential of providing greatly improved cure rates in the treatment of this disease. However, for this potential to be recognized, it must be possible to identify melanoma at its earliest stages, clinically and histologically, and to educate the population to the necessity for early diagnosis and treatment. This bibliography was prepared in support of the National Institutes of Health Consensus Development Conference titled Diagnosis and Treatment of Early Melanoma held in Bethesda, Maryland on January 27-29, 1992. It consists of citations to English language journal articles, conference papers, and books and book chapters written from 1983 to the present. All aspects of the diagnosis and treatment of early melanoma have been covered, as well as articles on epidemiology, etiology, prevention, public health, and public education. Dysplastic nevi, both as part of the dysplastic nevus syndrome and as sporadic occurrences, have also been included. Only items dealing with human studies are present, although occasional articles include both humans and animals. For the most part, citations have been limited to full scale, original articles or reviews rather than editorials, letters, or other similar short communications. Preference has also been given to articles appearing in refereed journals. Arrangement of the bibliography is by the five following subject categories, which parallel the organization of the scientific presentations at the Consensus Conference: clinical characteristics of early melanoma (excluding dysplastic nevi); pathology of early melanoma; dysplastic nevus syndrome and dysplastic nevi; evaluation of the patient and family following the diagnosis of early melanoma; and epidemiology, prevention, and treatment of early melanoma. Individual citations are listed only once in the most appropriate category. ili ''SEARCH STRATEGY A variety of online databases are usually searched in preparing bibliographies in the CBM series. To assist you in updating or otherwise manipulating the material in this search, the strategy used for the NLM’s MEDLINE database is given below. Please note that the search strategies presented here differ from individual demand searches in that they are generally broadly formulated and irrelevant citations edited out prior to printing. SS 1=*MELANOMA OR ALL MELANOMA: (TF) SS 2=1 AND NOT MELANOMA, EXPERIMENTAL SS 3 = *DYSPLASTIC NEVUS SYNDROME SS 4=*NEVUS OR *NEVUS, PIGMENTED OR *MELANOMA SS 5=(TF) NEVI OR NEVUS OR ALL NAEV: SS6=4 OR 5 SS 7=6 AND ALL DYSPLAS: (TW) OR 6 AND ALL MELANOCYT: (TW) SS 8=(TF) ALL DYSPLAS: AND ALL MELANOCYT: SS 9 = (TF) ALL MOLE# AND ATYPICAL OR FAMMM SS10=2 OR 3 OR 7 OR 8 OR 9 SS11 = 10 AND NOT FOR (LA) SS12 = 11 AND HUMAN GRATEFUL MED® To make online searching easier and more efficient, the Library offers GRATEFUL MED, microcomputer-based software that provides a user-friendly interface to most NLM databases. This software was specifically developed for health professionals and features multiple choice menus and "fill in the blank" screens for easy search preparation. GRATEFUL MED runs on an IBM PC (or IBM- compatible) with DOS 2.0 or a Macintosh, and requires a Hayes (or Hayes-compatible) modem. It may be purchased from the National Technical Information Service in Springfield, Virginia, for $29.95 (plus $3.00 per order for shipping). For your convenience, an order blank has been enclosed at the back of this bibliography. iv ''SAMPLE CITATIONS Citations in this bibliographic series are formatted according to the rules established for Index Medicus®*. Sample journal and monograph citations appear below. Note also that a colon (:) may appear within an author’s name or article title. The NLM computer system automatically inserts this symbol in the place of a diacritical mark. Journal Article: Authors Article Title x Dawber RP, Colver GB. The spectrum of malignant melanoma of the nail apparatus. Semin Dermatol 1991 Mar;10(1):82-7. a we ff , oN Abbreviated Journal Date Volume Issue Pages Title Monograph: Authors/Editors Title so \ Balch CM, Milton GW, editors. Cutaneous melanoma. Clinical management and treatment results worldwide. Philadelphia: J. B. Lippincott Company; 1985. 538 p. | | / | Place of Publisher Date Total No. Publication of Pages *For details of the formats used for references, see the following publication: Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. Bethesda (MD): The Library; 1991 Apr. Available from: NTIS, Springfield, VA; PB91-182030. ''vi ''TABLE OF CONTENTS Clinical Characteristics (excluding Dysplastic Nevus Syndrome) Pathology Dysplastic Nevus Syndrome and Dysplastic Nevi Evaluation of Patient and Family Following Diagnosis Epidemiology, Prevention, and Treatment Vil page ''Vili ''Clinical Characteristics (excluding Dysplastic Nevus Syndrome) Becker JK, Goldberg LH, Tschen JA. Differential diagnosis of malignant melanoma. Am Fam Physician 1989 May;39(5):203-14. Cascinelli N, Ferrario M, Tonelli T, Leo E. A possible new tool for clinical diagnosis of melanoma: the computer. J Am Acad Dermatol 1987 Feb;16(2 Pt 1):361-7. Cassileth BR, Clark WH Jr, Lusk EJ, Frederick BE, Thompson CJ, Walsh WP. How well do physicians recognize melanoma and other problem lesions? J Am Acad Dermatol 1986 Apr;14(4): 555-60. Cassileth BR, Lusk EJ, Guerry D 4th, Clark WH Jr, Matozzo I, Frederick BE. "Catalyst" symptoms in malignant melanoma. J Gen Intern Med 1987 Jan- Feb;2(1):1-4. Cassileth BR, Temoshok L, Frederick BE, Walsh WP, Hurwitz S, Guerry D, Clark WH Jr, DiClemente RJ, Sweet DM, Blois MS, et al. Patient and physician delay in melanoma diagnosis. J Am Acad Dermatol 1988 Mar;18(3):591-8. Chanda JJ. The clinical recognition and prognostic factors of primary cutaneous malignant melanoma. Med Clin North Am 1986 Jan;70(1):39-55. Dawber RP, Colver GB. The spectrum of malignant melanoma of the nail apparatus. Semin Dermatol 1991 Mar;10(1):82-7. Dhawan AP. An expert system for the early detection of melanoma using knowledge-based image analysis. Anal Quant Cytol Histol 1988 Dec;10(6):405-16. Dhawan AP. Early detection of cutaneous malignant melanoma by three-dimensional nevoscopy. Comput Methods Programs Biomed 1985 Oct;21(1): 59-68. Evans JF, Miller OF. Malignant melanoma and its precursors. The growing need for early identification. Postgrad Med 1986 Feb 1;79(2): 215-22. Funk W, Schmoeckel C, H:olzel D, Braun-Falco O. Prognostic classification of malignant melanoma by clinical criteria. Br J Dermatol 1984 Aug;111(2): 129-38. Grin CM, Kopf AW, Welkovich B, Bart RS, Levenstein MJ. Accuracy in the clinical diagnosis of malignant melanoma [published erratum appears in Arch Dermatol 1990 Nov;126(11):1461] [see comments]. Arch Dermatol 1990 Jun;126(6):763-6. Comment in: Arch Dermatol 1990 Dec;126(12): 1651, 1654. Hoss DM, Grant-Kels JM. Significant melanocytic lesions in infancy, childhood, and adolescence. Dermatol Clin 1986 Jan;4(1):29-44. Keefe M, Dick DC, Wakeel RA. A study of the value of the seven-point checklist in distinguishing benign pigmented lesions from melanoma [see comments]. Clin Exp Dermatol 1990 May;15(3):167-71. Comment in: Clin Exp Dermatol 1991 Mar;16(2): 151-3. Kelly JW, Crutcher WA, Sagebiel RW. Clinical diagnosis of dysplastic melanocytic nevi. A clinicopathologic correlation. J Am Acad Dermatol 1986 Jun;14(6):1044-52. Kraus W, Schramm P, Hoede N. First experiences with a high-resolution ultrasonic scanner in the diagnosis of malignant melanomas. Arch Dermatol Res 1983;275(4):235-8. Landow RK. Differential diagnosis and treatment of pigmented skin lesions. Compr Ther 1988 Apr; 14(4):25-32. Larsen TE, Mogensen SB, Holme I. The evaluation of possible melanoma risk groups of patients in a series of pigmented naevi. Clinical and histological intercorrelations. Acta Derm Venereol (Stockh) 1988;68(2):134-9. Lennon GM, Griffin M, O’Briain DS, Cassidy M, Caldwell M, Young M, Tanner WA, Keane FB. Malignant melanoma lately diagnosed. Ir Med J 1989 Sep;82(3):109-11. Lookingbill DP. Yield from a complete skin examination. Findings in 1157 new dermatology patients. J Am Acad Dermatol 1988 Jan;18(1 Pt 1):31-7, MacKie RM. Risk factors, diagnosis, and detection of melanoma. Curr Opin Oncol 1991 Apr;3(2):360-3. Masri GD, Clark WH Jr, Guerry D 4th, Halpern A, Thompson CJ, Elder DE. Screening and surveillance of patients at high risk for malignant melanoma result in detection of earlier disease. J Am Acad Dermatol 1990 Jun;22(6 Pt 1):1042-8. Milton GW, Balch CM, Shaw HM. Cutaneous melanoma: clinical characteristics. In: Balch CM, Milton GW, editors. Cutaneous melanoma. Clinical management and treatment results worldwide. Philadelphia: J.B. Lippincott Company; 1985. p. 13-28. ''2 Pritchard GA, Hughes LE. Clinical assessment of melanoma thickness. Eur J Surg Oncol 1989 Jun; 15(3):232-5. Rampen FH, R:umke P. Referral pattern and accuracy of clinical diagnosis of cutaneous melanoma. Acta Derm Venereol (Stockh) 1988;68(1):61~4. Rampen FH, R:umke P, Hart AA. Patients’ and doctors’ delay in the diagnosis and treatment of cutaneous melanoma. Eur J Surg Oncol 1989 Apr; 15(2):143-8. Redman JC. All melanomas start sometime: what to do before and after. Postgrad Med 1983;73(1):56-63, 65. Rosenthal JR, Koh HK. Malignant melanoma and pigmented lesions: a review. Compr Ther 1988 May;14(5):16-23. Roush GC, Barnhill RL, Emstoff MS, Kirkwood JM. Inter-clinician agreement on the recognition of clinical pigmentary characteristics of patients with cutaneous malignant melanoma. Studies of melanocytic nevi, VI. Br J Cancer 1991 Aug;64(2): 373-6. Saida T, Yoshida N, Ikegawa S, Ishihara K, Nakajima T. Clinical guidelines for the early detection of plantar malignant melanoma. J Am Acad Dermatol 1990 Jul;23(1):37-40. Steiner A, Pehamberger H, Wolff K. In vivo epiluminescence microscopy of pigmented skin lesions. II. Diagnosis of small pigmented skin lesions and early detection of malignant melanoma. J Am Acad Dermatol 1987 Oct;17(4):584-91. Van Viloten WA. Clinical diagnosis of cutaneous melanomas. Dev Oncol 1984;25:72-80. Pathology Ackerman AB. Malignant melanoma in situ: the flat, curable stage of malignant melanoma. Pathology 1985 Apr;17(2):298-300. Bansal RK, Bhaduri AS, Pancholi YJ, Balar DB. Cellular blue nevus with nevus cells in regional lymph nodes: a lesion that mimics melanoma. Indian J Cancer 1989 Sep;26(3):145-50. Barnhill RL, Mihm MC Jr. Pigmented spindle cell naevus and its variants: distinction from melanoma. Br J Dermatol 1989 Dec;121(6):717-25. Barr LH, Goldman LI, Solomon JA, Sanusi DI, Reed RJ. Minimal deviation melanoma. Surg Gynecol Obstet 1984 Dec;159(6):546-8. Benda JA, Platz CE, Anderson B. Malignant melanoma of the vulva: a clinical-pathologic review of 16 cases. Int J Gynecol Pathol 1986;5(3):202-16. Briggs JC. Melanoma precursor lesions and borderline melanomas. Histopathology 1985 Dec;9(12): 1251-62. Brodell RT, Santa Cruz DJ. Borderline and atypical melanocytic lesions. Semin Diagn Pathol 1985 Feb; 2(1):63-86. Clark WH Jr, Elder DE, Guerry D 4th, Epstein MN, Greene MH, Van Horn M. A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 1984 Dec;15(12):1147-65. Colloby PS, West KP, Fletcher A. Observer variation in the measurement of Breslow depth and Clark’s level in thin cutaneous malignant melanoma. J Pathol 1991 Mar;163(3):245-50. Cook MG, Robertson I. Melanocytic dysplasia and melanoma. Histopathology 1985 Jun;9(6):647-58. Cooper PH, Wanebo HJ, Hagar RW. Regression in thin malignant melanoma. Microscopic diagnosis and prognostic importance. Arch Dermatol 1985 Sep;121(9):1127-31. Curley RK, Cook MG, Fallowfield ME, Marsden RA. Accuracy in clinically evaluating pigmented lesions {see comments]. BMJ 1989 Jul 1;299(6690):16-8. Comment in: BMJ 1989 Aug 5;299(6695):390. Dubow BE, Ackerman AB. Ideas in pathology. Malignant melanoma in situ: the evolution of a concept. Mod Pathol 1990 Nov;3(6):734-44. ''Egbert B, Kempson R, Sagebiel R. Desmoplastic malignant melanoma. A clinicohistopathologic study of 25 cases. Cancer 1988 Nov 1;62(9):2033-41. Elder DE, Guerry D 4th, Epstein MN, Zehngebot L, Lusk E, Van Horn M, Clark WH Jr. Invasive malignant melanomas lacking competence for metastasis. Am J Dermatopathol 1984 Summer; 6 Suppl:55-61. Flotte TJ. Malignant melanoma in situ. Hum Pathol 1990 Dec;21(12):1199-201. Gamel JW, McLean IW. Computerized histopathologic assessment of malignant potential. III. Refinements of measurement and data analysis. Anal Quant Cytol 1984 Mar;6(1):37-44. Guerry D, Clark WH, Elder DE, Braitman LE, Trock BJ, Schultz D, Synnestvedt M, Halpern AC. A new prognostic model for clinical stage I melanoma based on tumor progression and multivariate logistic regression [abstract]. Proc Annu Meet Am Soc Clin Oncol 1989;8:A1102. Guldhammer B, Norgaard T. The differential diagnosis of intraepidermal malignant lesions using immunohistochemistry. Am J Dermatopathol 1986 Aug;8(4):295-301. Heenan PJ, Matz LR, Blackwell JB, Kelsall GR, Singh A, ten Seldam RE, Holman CD. _Inter-observer variation between pathologists in the classification of cutaneous malignant melanoma in western Australia. Histopathology 1984 Sep;8(5):717-29. Imam A, Mitchell MS, Modlin RL, Taylor CR, Kempf RA, Kan-Mitchell J. Human monoclonal antibodies that distinguish cutaneous melanomas from benign nevi in fixed sections. In: Reif AE, Mitchell MS, editors. Immunity to cancer. New York: Academic Press; 1985. p. 125-30. Jackson R. Epidermotropic malignant melanoma: the distinction between metastatic and new primary lesions in the skin. Can J Surg 1984 Nov;27(6): 533-5. Jimbow K, Horikoshi T, Takahashi H, Akutsu Y, Maeda K. Fine structural and immunohistochemical properties of dysplastic melanocytic nevi: comparison with malignant melanoma. J Invest Dermatol 1989 May;92(5 Suppl):304S-309S. Jimbow K, Salopek TG, Dixon WT, Searles GE, Yamada K. The epidermal melanin unit in the pathophysiology of malignant melanoma. Am J Dermatopathol 1991 Apr;13(2):179-88. Kibbi AG, Mihm MC Jr. Malignant melanoma with desmoplasia and neurotropism. J Dermatol Surg Oncol 1987 Nov;13(11):1204-8. Klein LJ, Barr RJ. Histologic atypia in clinically benign nevi. A prospective study. J Am Acad Dermatol 1990 Feb;22(2 Pt 1):275-82. Kwittken J. Cutaneous melanocytic dysplasia and malignant melanoma. A critical review. J Med 1991;22(1):1-16. Langer K, Rappersberger K, Steiner A, Konrad K, Wolff K. The ultrastructure of dysplastic naevi: comparison with superficial spreading melanoma and common naevocellular naevi. Arch Dermatol Res 1990;282(6):353-62. Larsen TE, Mogensen SB, Holme I. Clinical and histological intercorrelations in pigmented naevi indicating potential melanoma precursor lesions. APMIS 1988 Feb;96(2):147-54. LeBoit PE, Van Fletcher H. A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. J Invest Dermatol 1987 Jun;88(6):753-7. Lehmann JM, Holzmann B, Breitbart EW, Schmiegelow P, Riethm:uller G, Johnson JP. Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000. Cancer Res 1987 Feb 1;47(3):841-5. Mackie RM, Campbell I, Turbitt ML. Use of NK1 C3 monoclonal antibody in the assessment of benign and malignant melanocytic lesions. J Clin Pathol 1984 Apr;37(4):367-72. Maeda K, Maeda K, Jimbow K. Specification and use of a mouse monoclonal antibody raised against melanosomes for the histopathologic diagnosis of amelanotic malignant melanoma. Cancer 1988 Sep 1;62(5):926-34. Maize JC, Ackerman AB. Pigmented lesions of the skin. Philadelphia: Lea and Febiger; 1987. 328 p. Malignant melanoma: biology, diagnosis, and therapy. Cancer Treat Res 1988;43:1-202. Marks R, Dorevitch AP, Mason G. Do all melanomas come from "moles"? A study of the histological association between melanocytic naevi and melanoma. Australas J Dermatol 1990;31(2):77-80. McGovern VJ. Melanoma: histological diagnosis and prognosis. New York: Raven Press; 1983. 197 pp. McGovern VJ, Cochran AJ, Van der Esch EP, Little JH, MacLennan R. The classification of malignant melanoma, its histological reporting and registration: a revision of the 1972 Sydney classification. Pathology 1986 Jan;18(1):12-21. ''4 McGovern VJ, Murad TM. Pathology of melanoma: an overview. In: Balch CM, Milton GW, editors. Cutaneous melanoma. Clinical management and treatment results worldwide. Philadelphia: J.B. Lippincott Company; 1985. p. 29-53. Morishima T, Nagashima N, Hanawa S, Fukada E, Kanematsu S, Shibata A. Quick diagnosis of malignant melanoma with the touch-fluorescence method during operation. Cancer 1986 May 15; 57(10):2037-41. Morishima T, Tatsumi F, Fukada E, Watanabe M, Nagashima N, Hanawa S. Studies on amelanotic melanoma with the fluorescence method (Falck and Hillarp) and biochemical analysis of 5-S- cysteinyldopa in the tissues. Arch Dermatol Res 1983;275(5):329-33. Muhlbauer JE, Margolis RJ, Mihm MC Jr, Reed RJ. Minimal deviation melanoma: a histologic variant of cutaneous malignant melanoma in its vertical growth phase. J Invest Dermatol 1983 Jun;80 Supp!: 63s-65s. Murphy GF, Mihm MC Jr. Histologic reporting of malignant melanoma. Monogr Pathol 1988;(30): 79-93, Nield DV, Saad MN, Khoo CT, Lott M, Ali MH. Tumour thickness in malignant melanoma: the limitations of frozen section. Br J Plast Surg 1988 Jul;41(4):403-7. Penneys NS. Excision of melanoma after initial biopsy. An immunohistochemical study. J Am Acad Dermatol 1985 Dec;13(6):995-8. Peters MS, Goellner JR. Spitz naevi and malignant melanomas of childhood and adolescence. Histopathology 1986 Dec;10(12):1289-302. Phillips ME, Margolis RJ, Merot Y, Sober AJ, Reed RJ, Muhlbauer JE, Mihm MC Jr. The spectrum of minimal deviation melanoma: a clinicopathologic study of 21 cases. Hum Pathol 1986 Aug;17(8): 796-806. Rampen FH, Menzel S, Rumke P. Pathology delay and misinterpretation in melanoma diagnosis [abstract]. Paper presented at: 13th International Pigment Cell Conference; 1986 Oct 5-9; Tucson, AZ. Reed RJ. The histological variance of malignant melanoma: the interrelationship of histological subtype, neoplastic progression, and biological behaviour. Pathology 1985 Apr;17(2):301-12. Reed RJ, Webb SV, Clark WH Jr. Minimal deviation melanoma (halo nevus variant). Am J Surg Pathol 1990 Jan;14(1):53-68. Rhodes AR, Melski JW, Sober AJ, Harrist TJ, Mihm MC Jr, Fitzpatrick TB. Increased intraepidermal melanocyte frequency and size in dysplastic melanocytic nevi and cutaneous melanoma. A comparative quantitative study of dysplastic melanocytic nevi, superficial spreading melanoma, nevocellular nevi, and solar lentigines. J Invest Dermatol 1983 May;80(5):452-9. Rogers GS, Advani H, Ackerman AB. A combined variant of Spitz’s nevi. How to differentiate them from malignant melanomas. Am J Dermatopathol 1985;7 Suppl:61-78. Rosen L, Amazon K, Frank B. Bowen's disease, Paget’s disease, and malignant melanoma in situ. South Med J 1986 Apr;79(4):410-3. Sagebiel RW. Diagnosis and management of premalignant melanocytic proliferations. Pathology 1985 Apr;17(2):285-90. Sagebiel RW. Diagnosis and management of premalignant melanocytic proliferations. Pathology 1985 Apr;17(2):285-90. Saida T, Yoshida N. Guidelines for histopathologic diagnosis of plantar malignant melanoma. Two- dimensional coordination of maximum diameters of lesions and degrees of intraepidermal proliferation of melanocytes. Dermatologica 1990;181(2):112-6. Schmoeckel C. 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