No. 91-2 GURRENT "ELEOGRAPHEES EN MEDECENE Therapy-Related Second Cancers us. DEPOSITORY WW ()8 1991 National Library of Medicine January 1986 through March 1991 880 Citations US. DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service 0 National Institutes of Health ' P03155917}! mmv ’/ BERKEL2Y Ll BRAR‘! umvmsm of CBM 91-2 Therapy-Related Second Cancers January 1986 through March 1991 880 Citations Prepared by Naomi Miller, M.L.S. US. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Library of Medicine Reference Section 8600 Rockville Pike Bethesda, Maryland 20894 SERIES NOTE Current Bibliographies in Medicine (CBM) is a continuation in part of the National Library of Medicine’s Literature Search Series, which ceased in 1987 with No. 87-15. In 1989 it also subsumed the Specialized Bibliography Series. Each bibliography in the new series covers a distinct subject area of biomedicine and is intended to fulfill a current awareness function. Citations are usually derived from searching a variety of online databases. NLM databases utilized include MEDLINE", AVLINE", BIOETHICSLINE°, CANCERLI'I", CATLINE", HEALTH, POPLINEm and TOXLINE". The only criterion for the inclusion of a particular published work is its relevance to the topic being presented; the format, ownership, or location of the material is not considered. Comments and suggestions on this series may be addressed to: Karen Patrias, Editor Current Bibliographies in Medicine Reference Section National Library of Medicine Bethesda, MD 20894 301/496-6097 Ordering Information: Current Bibliographies in Medicine is sold by the Superintendent of Documents, US. Government Printing Office, Washington, DC. 20402. To order the entire CBM series for the calendar year 1990 (20 bibliographies), send $52.00 ($65.00 foreign) to the Superintendent of Documents citing GPO List ID: CBM90. For your convenience an order blank is given inside the back cover. Orders for individual bibliographies in the series ($3.00, $3.75 foreign) should be sent to the Superintendent of Documents citing Lhe title, CBM ngmber, and the GPO List ID given above. ' Use of funds for printing this periodical has been approved by the Director of the Ofl‘ice of Management and Budget through September 30, 1991. ii THERAPY-RELATED SECOND CANCERS W 333;. Recent years have witnessed major advances in the treatment of malignancy. A negative byproduct of these advances, however, has been the appearance of second malignancies related to treatment. This bibliography lists publications which discuss the relationship between therapy of a cancer and the appearance of a second. Inclusion of an item does not imply that a causal relationship was noted; literature which examined second cancers developing after antineoplastic therapy and found no relationship to treatment is also included. The mechanisms by which antineoplastic treatment may result in subsequent cancers are poorly understood. Direct damage to DNA is a likely contributor to second cancers. Long-term immunosuppression may be another mechanism by which these cancers occur. Thus, this bibliography also includes a section on cancers occurring in patients on long-term immunosuppressive therapy, particularly for organ transplantation. The literature is divided into sections on overviews, chemotherapy-related second cancers, radiotherapy- related second cancers, combined chemotherapy and radiotherapy-related second cancers, endocrine therapy-related second cancers, cytogenetics of therapy-related second cancers, cancers after immunosuppression or organ transplantation, and treatment and prevention of therapy-related second cancers. A citation may appear in more than one section. Materials include journal articles, monographs, chapters in monographs, meeting abstracts, and dissertations. Special thanks are given to F. Andrew Dorr, MD, of the National Cancer Institute, for assistance with this bibliography. iii SEARCH STRATEGY A variety of online databases are usually searched in preparing bibliographies in the CBM series. To assist you in updating or otherwise manipulating the material in this search, the strategy used for the NLM’S MEDLINE database is given below. Please note that the search strategies presented here differ from individual demand searches in that they are generally broadly formulated and irrelevant citations edited out prior to printing. SS 1 = NEOPLASMS (PX) AND c1 (SH) OR NEOPLASMS (PX) AND RI (SH) SS 2 = NEOPLASMS (PX) AND DT (SH) SS 3 = NEOPLASMS (PX) AND RT (SH) SS 4 = NEOPLASMS (PX) AND TH (SH) ss 5 = 2 OR 3 OR 4 SS = 1 AND 5 SS = NEOPLASMS (PX) AND ET (SH) SS = NEOPLASMS (PX) AND EP (SH) SS = 7 OR 8 SS 10 = EXP D22/AE, Po, TO OR EXP RADIOTHERAPY/AE, PO, TO OR EXP GLUCOCORTICOIDS/AE, PO, TO OR EXP GLUCOCORTICOIDS, SYNTHETIC/AE,P0,TO OR EXP HORMONES, SYNTHETIC/AB, PO, TO SS 11 = 9 AND 10 SS 12 = 9 AND EXP *ORGAN TRANSPLANTATION SS 13 = *NEOPLASMS, MULTIPLE PRIMARY SS 14 = TS (TI) : SECOND: OR : FOLLOW: OR : AFTER : OR : SUBSEQUENT: SS 15 = NEOPLASMS, MULTIPLE PRIMARY/CI OR NEOPLASMS, MULTIPLE PRIMARY/PC SS 16 = *NEOPLASMS (PX) AND GE (SH) AND ALL SECOND: (TF) SS 17 = 9 AND *RADIATION INJURIES SS 18 = 9 AND REMISSION INDUCTION AND RISK FACTORS SS 19: 60R 11 OR 120R 140R 15 OR 160R 170R 18 GRATEFUL MED‘lb To make online searching easier and more efficient, the Library offers GRATEFUL MED, microcomputer-based software that provides a user-friendly interface to most NLM databases. This software was specifically developed for health professionals and features multiple choice menus and "fill in the blank" screens for easy search preparation. GRATEFUL MED runs on an IBM PC (or IBM- compatible) with DOS 2.0 or a Macintosh, and requires a Hayes (or Hayes-compatible) modem. It may be purchased from the National Technical Information Service in Springfield, Virginia, for $29.95 (plus $3.00 per order for shipping). For your convenience, an order blank has been enclosed at the back of this bibliography. ~ iv SAMPLE CITATIONS Citations in this bibliographic series are formatted according to the rules established for Index Medicus". Sample journal and monograph citations appear below. For journal articles written in a foreign language, the English translation of the title is placed in brackets; for monographs, the title is given in the original language. In both cases the language of publication is shown by a three letter abbreviation appearing at the end of the citation. Note also that a colon (z) may appear within an author’s name or article title. The NLM computer system automatically inserts this symbol in the place of a diacritical mark. Journal Article: Authors Article Title / \ \ Levine EG ; Bloomfield CD. Secondary myelodysplastic syndromes and leukaemias. Clin Haematol 1986 Nov;15(4):1037-80 / / l \ \ Abbreviated Journal Date Volume Issue Pages Title Monograph: Author/Editor Title Green, Daniel M. Long-term complications of therapy for cancer in childhood and adolescence. Baltimore (MD): Johns Hopkins University Press; 1989. 171 p. l l l \ Place of Publisher Date Total No. Publication of Pages TABLE OF CONTENTS Overviews Chemotherapy-Related Second Cancers Radiotherapy-Related Second Cancers Combined Chemotherapy- and Radiotherapy-Related Second Cancers Endocrine Therapy-Related Second Cancers Cytogenetics of Therapy-Related Second Cancers Cancers after Immunosuppression or Organ Transplantation Treatment and Prevention of Therapy-Related Second Cancers vfi page 13 29 32 33 36 43 OVERVIEWS Boivin JF. Second cancers and other late side effects of cancer treatment. A review. Cancer 1990 Feb 1; 65(3 Suppl):770-5. Boivin JF. Wacholder S. [Determination of the risk of a 2d cancer in patients treated for a first cancer]. Rev Epidemic] Sante Publique 1988;36(4-5): 292-300 (Fre). Calvert AH. Introduction: a history of the progress of anticancer chemotherapy. Cancer Surv 1989;8(3): 493-509. Clemm C. [Long-term adverse effects in patients after successful treatment of malignant disease. 2: Effects on fertility and bone marrow function; risk of a secondary malignancy]. Fortschr Med 1989 Oct 20; 107(30):63640 (Ger). Coleman CN. Tucker MA. Adverse effects of treatment: secondary cancers. In: DeVita. V.T. Jr.. et a1.. editors. Cancer: principles and practice of oncology. 3rd ed. Philadelphia: Lippincott; 1989. p. 2181-90. de Vathaire F, Schweisguth O. Rodary C. Francois P. Sarrazin D. Oberlin 0. Hill C. Raquin MA. Dutreix A. Flamant R. Long-term risk of second malignant neoplasm after a cancer in childhood. Br J Cancer 1989 Mar;59(3):448-52. Dorr FA. Coltrnan CA. Second cancers following antineoplastic therapy. Curr Probl Cancer 1985 Feb; 9(2):1-43. Faulkner K. Second malignant tumors after childhood cancer. Radio] Technol 1989 Jan-Feb;60(3):260-2. Fraser MC, TuckerMA. Second malignancies following cancer therapy. Semin Oncol Nurs 1989 Feb;5(l):43-55. Holm LE. Cancer occurring after radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys 1990 Nov;l9(5):l303-8. I-lydzik CA. Late effect of chemotherapy. Implications for patient management and rehabilitation. Nurs Clin North Am 1990 Jun;25(2):423—46. International Cancer Research Data Bank. Late sequelae of cancer therapy in children and adolescents.Washington: US. Government Printing Office; 1989. 70 p. GPO stock number 017-042-00270-2. Kaiser HE. Secondary primary cancers: an overview. Cancer Growth Prog 1989;6z212-3. Kaldor J. Second cancer following chemotherapy and radiotherapy. An epidemiological perspective. Acta Oncol 1990;29(5):647-55. Kaldor JM. Day NE. Estimation of temporal effects in treatment-induced second cancer. Stat Med 1989 Nov:8(11):1371-80. Kingston JE. Second primary tumours in children. Prog Pediatr Surg 1989;22:113-20. Levine EG. Bloomfield CD. Secondary myelodysplastic syndromes and leukaemias. Clin Haematol 1986 Nov;15(4):1037-80. Green. Daniel M. Long-term complications of therapy for cancer in childhood and adolescence. Baltimore (MD): Johns Hopkins University Press; 1989. 171 p. Meadows AT. Risk factors for second malignant neoplasms: report from the Late Effects Study Group. Bull Cancer (Paris) 1988;75(1):125-30. Meadows AT. Second malignant neoplasms in childhood cancer survivors. J Assoc Pediatr Oncol Nurses 1989;6(1):7-11. Meadows AT, Hobbie WL. The medical consequences of cure. Cancer 1986 Jul 15;S8(2 Suppl):524-8. Meadows AT. Silver J. Delayed consequences of therapy for childhood cancer. In: Voute, P.A.. et al, editors. Cancer in children. Clinical management. 2nd ed. New York: Springer-Verlag; 1986. p. 70-81. Najean Y. The iatrogenic leukaemias induced by radio- and/or chemotherapy. Med Oncol ’Ilumor Pharmacother 1987;4(3-4):245-57. Penn 1. Neoplastic consequences of transplantation and chemotherapy. Cancer Detect Prev Suppl 1987;]: 149-57. Penn I. Secondary neoplasms as a consequence of transplantation and cancer therapy. Cancer Detect Prev 1988;12(1-6):39-57. Waskerwitz MJ. Fergusson IH. Late effects of cancer treatment in children. In: Hockenberry, M.J.; Coody, D.K.. editors. Pediatric oncology and hematology. Perspectives on care. St. Louis: CV. Mosby Co.; 1986. p. 469-92. 2 CHEMOTHERAPY-RELATED SECOND CANCERS Abe K. Imamura N, Mtasiwa DM. Inada T, Fujimura K. Kurarnote A. [Multiple myeloma following chronic neutrophilia terminated with acute monocytic leukemia (AML. M 5 b)]. Rinsho Ketsueki 1989 Jun;30(6):910-4 (Jpn). Aggarwal P. Shanna SK, Wali JP. Sahani P. Colonic carcinoma after chemotherapy of Hodgkin's disease. J Clin Gastroenterol 1989 Jun;11(3):340-2. Andersson M, Philip P, Pedersen-Bjergaard J. High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate. 5- fluorouracil. mitoxantrone. and tamoxifen for advanced breast cancer. Cancer 1990 Jun 1;65(11): 2460-4. Aravindan KP. 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Greene MH, Boice JD Jr. Acute myeloid leukemia and other myelopathic disorders following treatment with alkylating agents. Hematol Pathol 1987;1(2):99-104. Bergsagel DE. Chemotherapy of myeloma: drug combinations versus single agents, an overview. and comments on acute leukemia in myeloma. Hematol Oncol 1988 Apr-Jun;6(2):159-66. Bernard J. The epidemiology of leukemias (past, present. future). Nouv Rev Fr Hematol 1989;31(2): 103-9 (Fre). Bhambhani K, Bollinger R. Ravindranath Y. Late effects following successful treatment of childhood acute lymphoblastic leukemia (ALL) [abstract]. Proc Annu Meet Am Soc Clin Oncol 1987;6:A626. Bilik J, Sosnowski JT, Larnm DL. Blumenstein B. Crawford ED. Montie JE. Scardino l’I‘, Stanisic TH, Grossman HB. Comparison of second primaries in bladder tumor patients treated with ECG or doxorubicin: a Southwest Oncology Group study [abstract]. J Urol 1989;14l(4 Pt 2):333A. Blayney DW, Longo DL. Leukemia after treatment of ovarian cancer or Hodgkin's disease [letter]. N Engl J Med 1990 Jun 21;322(25):181_8. Blayney DW, Longo DL. Young RC, Greene MH, Hubbard SM. Postal MG. Duffey PL, DeVita VT Jr. Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin’s disease. N Engl J Med 1987 Mar 19; 316(12):710-4. Boccaccio P, Rosa F, Casciaro S, D'Elia P, Romagnoli M, Ghio R. [Acute leukemia in patients treated for Hodgkin’s disease]. Recenti Prog Med 1988 Jan;79(1):32-7 (lta). Boice JD. Greene MH, Killen JY Jr. Ellenberg SS. Fraumeni JF Jr, Keehn RJ. McFadden B, Chen T'I‘, Stablein D. Leukemia after adjuvant chemotherapy with semustine (methyl-CCNU)-- evidence of a dose-response effect [letter]. N Engl J Med 1986 Jan 9;314(2):119-20. Boice JD Jr. Curtis RE. Kleinerman RA, Flannery JT, Fraurneni JF Jr. Multiple primary cancers in Connecticut, 1935-82. Yale J Biol Med 1986 Sep-Oct;59(5):533-45. Boivin JF, O’Brien K. Solid cancer risk after treatment of Hodgkin's disease. Cancer 1988 Jun 15;61(12):2541—6. Bone marrow stem cell disorders and mitolactel [letter', comment]. J Clin Oncol 1990 Apr;8(4):751-3. Comment on: J Clin Oncol 1989 Sep;7(9):1252-9. Bookman MA, Longo DL. Young RC. Late complications of curative treatment in Hodgkin's disease [clinical conference]. JAMA 1988 Aug 5; 260(5):680-3. Bouillet T. Lepage E. Gisselbrecht C. Boiron M. Acute nen-lymphocytic leukemia following FAM combination adjuvant chemotherapy for gastric and lung adenocarcinoma. Nouv Rev Fr Hematol 1990; 32(3):207-9. Brenez D. Devriendt J. melud C. Schmerber J. Acute nonlymphocytic leukemia following chemotherapy with cisplatin and etoposide for non- small-cell carcinoma of the lung: case report. Cancer Chemother Pharmacol 1990;26(3):235-6. Brenner DW, Schellhammer PF. Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review. J Urol 1987 Jun; 137(6):]226-7. Brizel DM, Winer EP, Prosnitz LR. Scott J, Crawford J, Moore JO. Gockerman JP. Improved survival in advanced Hodgkin's disease with the use of combined modality therapy [see comments]. Int J Radiat Oncol Biol Phys 1990 Sep;19(3):535—42. Comment in: Int J Radiat Oncol Biol Phys 1990 Sep;l9(3):8034. Brusarnolino E, Pagnucco G, Bemasconi C. Acute leukemia occurring in a primary neoplasia (secondary leukemia). A review of biological. epidemiological and clinical aspects. Haematologica (Pavia) 1986 Jan-Feb;71(1):60o83. Brusamolino E. Papa G, Valagussa P, Mandelli F. Bemasconi C, Marmont A. Bonadonna G, 'I‘ura S. Bosi A, Mango G, et al. Treatment-related leukemia in Hodgkin’s disease: a multi-institution study on 75 cases. Hematol Oncol 1987 Apr-Jun; 5(2):83~98. Schmahl, Dietrich; Kaldor. J. M.. editors. Carcinogenicity of alkylating cytostatic drugs. Proceedings of a symposium organized by IARC and the German Cancer Research Centre; 1985 Nov 25 -27, German Cancer Research Centre, Heidelberg, Federal Republic of Germany. Lyon: International Agency 'for Research on Cancer; 1986. 338 p. Carey RW, Kunz VS. Acute non-lymphocytic leukemia (ANLL) following treatment with dacarbazine for malignant melanoma. Am J Hematol 1987 May;25(l):119-21. Cameiro PC. Pereira ED, Mitteldorf CS, Martinez GA, Beitler B, Pozzi DH. [Acute myeloid leukemia after treatment of Hodgkin’s disease]. Rev Hosp Clin Fac Med Sao Paulo 1989 Mar-Apr; 44(2):87-90 (Por). Carrato A, Filippa D. Koziner B. Hodgkin’s disease after treatment of non-Hodgkin‘s lymphoma. Cancer 1987 Aug 15;60(4):887-96. Casini M, Pianezze G, Fabris P, Cemin S, Coser P. Immunoblastic lymphoma following therapy for Hodgkin’s disease. A case report. Haematologica (Pavia) 1986 Jan-Feb;71(l):50-2. Cebreiros I, Ordonez A, Garcia de Paredes ML, Vicente J . Martin G, Gonzalez Baron M. [Second neoplasms in Hodgkin's disease]. Rev Clin Esp 1989 Mar;184(5):247-8 (Spa). Chambers SK, Chopyk RL, Chambers JT, Schwartz PE, Duffy TP. Development of leukemia after doxorubicin and cisplatin treatment for ovarian cancer. Cancer 1989 Dec 15;64(12):2459-61. Chen SJ, Chen Z. Derre J, Le Coniat M. Valensi F. Sigaux F, Berger R. Are most secondary acute lymphoblastic leukemias mixed acute leukemias? Nouv Rev Fr Hematol 1989;31(1):17-22. Cheyne AJ. Allan SG. Second malignancies and Hodgkin's disease [letter]. Lancet 1987 Aug 22; 2(8556):456. Coleman CN. Secondary malignancy after treatment of Hodgkin’s disease: an evolving picture. J Clin Oncol 1986 Jun;4(6):821-4. Coleman MP, Bell CM. Fraser P. Second primary malignancy after Hodgkin's disease. ovarian cancer and cancer of the testis: a population—based cohort study. Br J Cancer 1987 Sep;56(3):349-55. Colman M. Easton DF, Horwich A, Peckham MJ. Second malignancies and Hodgkin’s disease--the Royal Marsden Hospital experience [published erratum appears in Radiother Oncol 1988 Jul; 12(3):251]. Radiother Oncol 1988 Mar;11(3):229-38. Colovic M, Jovanovic V, Ristic M. Acute myelomonoblastic leukemia in a patient with multiple myeloma. Acta Med Iugosl 1989; 43(1):77-82. Coltman CA Jr, Dahlberg S. Leukemia after treatment of ovarian cancer or Hodgkin’s disease [letter]. N Engl J Med 1990 Jun 21;322(25):1820. Coltrnan CA Jr. Dahlberg S. Treatment-related leukemia [editorial; comment]. N Engl J Med 1990 Jan 4;322(1):52—3. Comment on: N Engl J Med 1990 Jan 4;322(1):1-6; N Engl J Med1990 Jan 4; 322(1):7—13. Connors JM. Induction of secondary neoplasms by the treatment of malignant disease: lessons from Hodgkin's disease. Prog Clin Biol Res 1990; 3543:219-26. Cox NH, Jones SK, Downey DJ, Tuyp EJ, Jay JL, Moseley H. Mackie RM. Cutaneous and ocular side-effects of oral photochemotherapy: results of an 8-year follow-up study. Br J Dermatol 1987 Feb; 116(2): 145 -52. Cullen JW. Second malignant neoplasms in survivors of childhood cancer. Pediatrician l991;18(1):82-9. Curtis RE, Boice JD Jr, Moloney WC, Ries LG, Flannery J'I‘. Leukemia following chemotherapy for breast cancer. Cancer Res 1990 May 1;50(9): 2741-6. 4 Cuzick J, Erskine S, Edelman D, Galton DA. A comparison of the incidence of the myelodysplastic syndrome and acute myeloid leukaemia following melphalan and cyclophosphamide treatment for myelomatosis. A report to the Medical Research Council's working party on leukaemia in adults. Br J Cancer 1987 May;55(5):523-9. De Gramont A, Louvet C, Krulik M, Smadja N, Donadio D. Lapone JP, Brissaud P, Delage JM. Drolet Y, Rioux E, et a1. Erythrocyte mean corpuscular volume during cytotoxic therapy is a predictive parameter of secondary leukemia in Hodgkin’s disease. Cancer 1987 Jan 15;59(2):301-4. De Gramont A, Louvet C, Krulik M, Smadja N, Donadio D, Lapone JP, Brissaud P, Smith M, Delage JM. Drolet Y, et a1. Preleukemic changes in cases of nonlymphocytic leukemia secondary to cytotoxic therapy. Analysis of 105 cases. Cancer 1986 Aug l;58(3):630-4. De Gramont A, Remes P, Krulik M, Smadja N, Drolet Y, Donadio D, Louvet C, Brissaud P, Sirinelli A, Dray C, et a1. Acute leukemia after treatment for ovarian cancer. Report of four cases and review of the literature. Oncology 1986;43(3): 165-72. De Renzis C. Cellini N, Ausili Cefaro GP, Mantini G, Parisi S, Smartiotto D. The incidence of long- term side effects--in particular induced leukemias following treatment for Hodgkin’s disease. Rays 1986 May-Aug;11(2)2109-13. De Witte T. Muus P, De Pauw B, Haanen C. [A patient with acute non-lymphatic leukemia 2 years after non-Hodgkin's lymphoma (1etter)]. Ned Tijdschr Geneeskd 1988 Jul 2;132(27):1260 (Dut). Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin’s disease [letter]. N Engl J Med 1987 Sep 10; 317(11):707-9. Deeg HJ. Delayed complications and long-term effects after bone marrow transplantation. Hematol Oncol Clin North Am 1990 Jun;4(3):641-57. Devereux S, Selassie TG, Vaughan Hudson G, Vaughan Hudson B, Linch DC. Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation. BMJ 1990 Nov 10;301(6760): 1077-80. Diaz Mediavilla J. [When can one consider an acute leukemia cured? (editorial)]. Med Clin (Barc) 1989 Jul l;93(5):173-4 (Spa). Dorreen MS, Gregory WM, Wrigley PF, Stansfeld AG, Lister TA. Second primary malignant neoplasms in patients treated for Hodgkin’s disease ‘ at St Bartholomew's Hospital. Hematol Oncol 1986 Apr-Jun;4(2): 149-61. Draper GJ, Sanders BM, Kingston IE. Second primary neoplasms in patients with retinoblastoma. Br J Cancer 1986 May;53(5):661-71. Einhom N, Eklund G, Lambert B. Solid tumors and chromosome aberrations as late side effects of melphalan therapy in ovarian carcinoma [abstract]. 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Increased frequency of posttransplant lymphomas in patients treated with cyclosporine. azathioprine. and prednisone. Transplantation 1989 Feb;47(2):293-6. Witherspoon RP. Fisher LD. Schoch G, Martin P, Sullivan KM. Sanders J. Deeg HJ. Doney K. Thomas D, Storb R. et a1. Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia [see comments]. N Engl J Med 1989 Sep 21;321(12):784-9. Comment in: N Engl J Med 1990 Mar 22;322(12):853. Witherspoon RP, Fisher LD. Sullivan KM. Storb R. Thomas ED. Secondary cancers after bone marrow transplantation [letter]. N Engl J Med 1990 Mar 22; 322(12):853. Xeni L. Payan MI, Choux R, Gros N. Hassoun J. Chamlian A, Blin D. Monties JR. An exceptional 18-year follow-up after cardiac transplantation. How can malignancies occur during irnmunosuppressive therapy? Cancer 1989 May l;63(9):1697-9. Yabu K. Warty VS. Gorelik E. Shinozuka H. Cyclosporine promotes the induction of thymic lymphomas in C57BL/6 mice initiated by a single dose of gamma-radiation. Carcinogenesis 1991 Jan; 12(1):43-6. Yasumura T. Ohmori Y. Aikawa I. Arakawa K. Nakaji K. Nakai I. Oka T. Nakane Y. Breast cancer arising de novo in recipients of kidney allograft. Jpn J Surg 1989 May;19(3):370-5. Yoshimura N, Oka T. Medical and surgical complications of renal transplantation: diagnosis and management. Med Clin North Am 1990 Jul;74(4): 1025-37. Zamora Martinez E. Gutierrez Ortega MC, Martin Moreno L. de Castro Torres A. [Kaposi's sarcoma in a HIV-negative patient with kidney transplant (letter)]. Rev Clin Esp 1990 Mar;186(5):241 (Spa). Zermani R. el Mezni F. e1 Ouekdi M. Ben Abdallah T. Ben Jilani S. [Plurivisceral Kaposi's sarcoma appearing after kidney transplant (letter)]. Ann Pathol l990;10(2): 143 (Fre). Zutter MM. Durnam DM. Hackman RC. Loughran TP Ir. Kidd PG. Ashley RL. Petersdorf EW. Martin P], Thomas ED. Secondary T-cell lymphoproliferation after marrow transplantation. Am J Clin Pathol 1990 Dec;94(6):714-21. TREATMENT AND PREVENTION OF THERAPY-RELATED SECOND CANCERS ' Bandini G. Rosti G. Calori E. Albertazzi L, Tura S. Allogeneic bone marrow transplantation for secondary leukaemia and myelodysplastic syndrome [letter; comment]. Br J Haematol 1990 Jul;75(3): 442-3. Comment on: Br J Haematol 1990 Feb; 74(2):151-5. Bami S. Frigerio F. Lissoni P. Crispino S, Paolorossi F. Anal squamous cell carcinoma arising on radio- derrnatitis cured with chemotherapy alone: case report. 'hrmon' 1987 Aug 31;73(4):423-4. Basso-Ricci S. Lovo GF. Bartoli C. Surgery in the treatment of sequelae in the soft tissues from radiotherapy. Ital J Surg Sci 1987;17(4):287-94. Brito-Babapulle F. Secker-Walker LM. Shippey C. Whitrnore DN. Gotlieb D. Prentice HG. Myelodysplasia and acute myeloid leukaemia following bone marrow transplantation for acute lymphoblastic leukaemia: Secondary leukaemia or stem-cell relapse? Br J Haematol 1989 Nov;73(3): 417-9. Darbyshire PJ. Mott MG. Secondary acute myeloid leukaemia in a boy with T-cell lymphoma: Successful treatment by bone marrow transplantation. Clin Lab Haematol 1986;8(1):71-S. De Vries N. Maier H. Snow GB. [(Chemo-) prevention of second tumors in patients with head and neck neoplasms]. HNO 1990 Jun;38(6):208-13 (Ger). De Vries N, Van Zandwijk N, Snow GB. (Chemo) prevention of second primary head and neck tumors]. Ned Tijdschr Geneeskd 1990 Sep 8; 134(36):1728-31 (Dut). De Witte T. Allogeneic bone marrow transplantation for secondary leukaemia and myelodysplastic syndrome (I: Reply). Br J Haematol 1990;75(3): 443-4. De Witte T. Muus P. De Pauw B. Haanen C. Intensive antileukemic treatment of patients younger than 65 years with myelodysplastic syndromes and secondary acute myelogenous leukemia. Cancer 1990 Sep 1;66(5):831-7. De Witte T. Zwaan F. Gratwohl A. Vemant J. Kolb HJ, Vossen J. Lonnqvist B. Beelen D. Ferrant A, Gmur J. et al. Timing of marrow transplantation in secondary leukemias and myelodysplastic syndromes. Transplant Proc 1989 Feb;21(l Pt 3):2958-9. 43 De Witte T. Zwaan F, Hermans J, Vemant J. Kolb H, Vossen J. Lonnqvist B. Beelen D, Ferrant A. Gmur J, et a1. Allogeneic bone marrow transplantation for secondary leukaemia and myelodysplastic syndromes. Leukaemia Working Party of the European Bone Marrow Transplantation Group (EBMTG). Bone Marrow Transplant 1989 Dec;4 Suppl 3:38-9. De Witte T. Zwaan F. Hermans J. Vernant J, Kolb H, Vossen J. Lonnqvist B, Beelen D. Ferrant A. Gmur J, et a1. Allogeneic bone marrow transplantation for secondary leukaemia and myelodysplastic syndrome: A survey by the Leukaemia Working Party of the European Bone Marrow Transplantation Group (EBMTG) [see comments]. Br J Haematol 1990 Feb;74(2):151-5. Comment in: Br J Haematol 1990 Jul;75(3):442-3. Fenaux P. Jouet JP. Bauters F. Lai JL. Lepelley P. 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Bowen T. Poon MC. Bone marrow transplantation for acute monocytic leukemia following the treatment of Hodgkin‘s disease. Med Pediatr Oncol 1986;14(6):319-22. Russell JA, Jones AR. Houwen B. Poon MC. Ruether BA. Double autologous bone marrow transplantation for acute myelogenous leukemia in a patient treated for Hodgkin’s disease. Med Pediatr Oncol 1989;17(6):524-7. Sargur M. Buckner CD. Appelbaum FR. Stewart P. Deeg HJ. Weiden PL. Sullivan KM. Fefer A. Thomas ED. Marrow transplantation for acute nonlymphocytic leukemia following therapy for Hodgkin’s disease. J Clin Oncol 1987 May;5(5): 731-4. Schmahl D. Second malignancies--risk reduction [abstract]. In: Anticancer drugs: therapeutic index improvement by toxicity reduction. Proceedings; 1987 Apr 6-7; London. [place. publisher unknown]; 1987. Abstract 3.10. Soutar RL. Dawson AA. Breast carcinoma and secondary acute lymphoblastic leukaemia responding to leukaemic chemotherapy. Clin Lab Haematol 1990;12(3):355-6. Thyss A. Viens P. Petit E. Caldani C. Namer M. Schneider M. Low-dose cytosine arabinoside for treatment of chemo- and/or radio-induced leukemias and myelodysplastic syndromes [abstract]. In: ECCO-4. 4th European Conference on Clinical Oncology and Cancer Nursing; 1987 Nov 1—4; Madrid. [place unknown]: Federation of European Cancer Societies; 1987. p. 178. *US. GOVERNMENT PRINTING OFFICE: l99l - 293-I37/40287 GRATEFUL MED® Software For Macintosh & IBM Mm Please send me___ ' ‘ copies of GRATEFU L 5 ; MED for the ‘ Macintosh. NJ. Order No.PB89- I 196083/GBB at $29.95 each. Please send me copies of GRATEFU L MED for IBM and compatibles. Order No. PB86- 158482/GBB at $29.95 each. Total Mac versions Handling $3.00 + Billing Fee“ P.O. it: + Total IBM versions + * Add $7.50 Billing Fee if using a Purchase Order. Please attach this form to any purchase order you use. = Total Enclosed is check / money order payable to NTIS for $ Charge to (check one): American Express E] VISA E] MasterCard El Card Number Exp. 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